Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain

FASEB Journal

Volumn 22, Issue 8, 2008, Pages 3024-3034

  Moussaieff, Arieh ^a,b   Rimmerman, Neta ^c   Bregman, Tatiana ^d   Straiker, Alex ^c   Felder, Christian C ^e   Shoham, Shai ^f   Kashman, Yoel ^g   Huang, Susan M ^h   Lee, Hyosang ^h   Shohami, Esther ^b   Mackie, Ken ^c   Caterina, Michael J ^h   Walker, J Michael ^c   Fride, Ester ^d   Mechoulam, Raphael ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c INDIANA UNIVERSITY   (United States)

^d ARIEL UNIVERSITY   (Israel)

^e ELI LILLY AND COMPANY   (United States)

^f HERZOG HOSPITAL   (Israel)

^g TEL AVIV UNIVERSITY   (Israel)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Boswellia; Depression; Frankincense

Indexed keywords

ANTIDEPRESSANT AGENT; INCENSOLE ACETATE; PROTEIN C FOS; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BRAIN REGION; CATALEPSY; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; EMOTION; FEMALE; FORCED SWIMMING TEST; HUMAN; HUMAN CELL; KERATINOCYTE; MASS SPECTROMETRY; MOTOR ACTIVITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BOSWELLIA; BRAIN; CELL LINE; DITERPENES; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-FOS; PSYCHOTROPIC DRUGS; RECOMBINANT PROTEINS; TRPV CATION CHANNELS;

BOSWELLIA; BOSWELLIA SACRA; MUS;

EID: 48749095422     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-101865     Document Type: Article

References (49)

1. O'Connor, K. A., and Roth, B. L. (2005) Screening the receptorome for plant-based psychoactive compounds. Life Sci. 78, 506-511
2. Schultes, R. E., and Hofmann, A. (1980) The Botany and the Chemistry of Hallucinogens, 2nd Ed., Charles C. Thomas, Springfield, IL, USA
3. Elferink, J. G. (1983) The narcotic and hallucinogenic use of tobacco in pre-Columbian Central America. J. Ethnopharmacol. 7, 111-122
4. MacCulloch, J. A. (no date) Encyclopaedia of Religion and Ethics, Vol. 7 (Hastings, J., ed) p. 201, Charles Scribner's Sons, New York, NY, USA
5. Moore, P. D. (2006) Conservation biology: unkind cuts for incense. Nature 444, 829
6. Encyclopaedia Britannica, 15th Ed. (1975) Micropaedia, Vol. 5, p. 322, University of Chicago, Chicago, IL, USA
7. Gunther, R. T. (1959) The Greek Herbal of Dioscorides, Hafner, New York, NY, USA
8. Shachter, J., and Epstein, I., eds. (1935) Seder Nezikin, Sanhedrin Tractate. In The Babylonian Talmud, p. 43a, Suncino Press, New York, NY, USA
9. Getahon, A. (1976) Some Common Medicinal and Poisonous Plants Used in Ethiopian Folkmedicine (mimeographed), Addis Abeba University, Addis Abeba, Ethiopia
10. Menon, M. K., and Kar, A. (1971) Analgesic and psychopharmacological effects of the gum resin of Boswellia serrata. Planta Med. 19, 333-341
11. Moussaieff, A., Shohami, E., Kashman, Y., Fride, E., Schmitz, M. L., Renner, F., Fiebich, B. L., Munoz, E., Ben-Neriah, Y., and Mechoulam, R. (2007) Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappaB activation. Mol. Pharmacol. 72, 1657-1664
12. Moussaieff, A., Shein, N. A., Tsenter, J., Grigoriadis, S., Simeonidou, C., Alexandrovich, A., G., Trembovler, V., Ben-Neriah, Y., Schmitz, M. L., Fiebich, B. L., Munoz, E., Mechoulam, R., and Shohami, E. (2008) Incensole acetate - a novel neuroprotective agent isolated from Boswellia carterii. [E-pub ahead of print] J. Cereb. Blood Flow Metab. doi:10.1038/jcbfm. 2008.28
13. Corsano, S., and Nicoletti, R. (1967) The structure of incensole. Tetrahedron 23, 1977-1984
14. Hamm, S., Bleton, J., Connan, J., and Tchapla, A. (2005) A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples. Phytochemistry 66, 1499-1514
15. Ramsey, I. S., Delling, M., and Clapham, D. E. (2006) An introduction to TRP channels. Annu. Rev. Physiol. 68, 619-647
16. Chung, M. K., Lee, H., Mizuno, A., Suzuki, M., and Caterina, M. J. TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J. Biol. Chem. 279, 21569-21575
17. Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., DiStefano, P. S., Curtis, R., and Clapham, D. E. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186
18. Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J. P., Ooi, L., Egerton, J., Charles, K. J., Smart, D., Randall, A. D., Anand, P., and Davis, J. B. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190
19. Chung, M. K., Lee, H., Mizuno, A., Suzuki, M., and Caterina, M. J. (2004) 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J. Neurosci. 24, 5177-5182
20. Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S., Andahazy, M., Story, G. M., and Patapoutian, A. (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472
21. Xu, H., Delling, M., Jun, J. C., and Clapham, D. E. (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci. 9, 628-635
22. Chung, M. K., Guler, A. D., and Caterina, M. J. (2005) Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J. Biol. Chem. 280, 15928-15941
23. Guler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., and Caterina, M. (2002) Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408-6414
24. Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., and Julius, D. A. (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441
25. Crawley, J. N. (2000) What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, Wiley-Liss, New York, NY, USA
26. Treit, D., and Menard, J. (1998) Animal models of anxiety and depression. In In vivo Neuromethods (Boulton, A., Baker, G., and Bateson, A., eds) p 89, Humana Press, Totowa, Canada
27. Harkin, A., Connor, T. J., Burns, M. P., and Kelly, J. P. (2004) Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test. Eur. Neuropsychopharmacol. 14, 274-281
28. Petit-Demouliere, B., Chenu, F., and Bourin, M. (2005) Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177, 245-255
29. Fride, E., Perchuk, A., Hall, F. S., Uhl, G. R., and Onaivi, E. S. (2006) Behavioral methods in cannabinoid research. Methods Mol. Med. 123, 269-290
30. Fride, E., and Mechoulam, R. (1993) Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent. Eur. J. Pharmacol. 231, 313-314
31. Richards, M. H. (1990) Rat hippocampal muscarinic autoreceptors are similar to the M2 (cardiac) subtype: comparison with hippocampal M1, atrial M2 and ileal M3 receptors. Brit. J. Pharmacol. 99, 753-761
32. 3H]glibenclamide in the rat cerebral cortex does not recognize K-channel agonists or antagonists other than sulphonylureas. Fundam. Clin. Pharmacol. 5, 107-115
33. O'Dell, D. K., Rimmerman, N., Pickens, S. R., and Walker, J. M. (2007) Fatty acyl amides of endogenous tetrahydroisoquinolines are active at the recombinant human TRPV1 receptor. Bioorg. Med. Chem. 15, 6164-6169
34. Chung, M. K., Lee, H., Mizuno, A., Suzuki, M., and Caterina, M. J. (2004) TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J. Biol. Chem. 279, 21569-21575
35. Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., and Wotjak, C. T. (2007) Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J. Neurosci. 27, 832-839
36. Smith, G. D., Gunthorpe, M. J., Kelsell, R. E., Hayes, P. D., Reilly, P., Facer, P., Wright, J. E., Jerman, J. C., Walhin, J. P., Ooi, L., Egerton, J., Charles, K. J., Smart, D., Randall, A. D., Anand, P., and Davis, J. B. (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190
37. Sheehan, D. V., and Sheehan, K. H. (2007) Current approaches to the pharmacologic treatment of anxiety disorders. Psychopharmacol. Bull. 40, 98-109
38. Nurnberg, H. G., Hensley, P. L., Gelenberg, A. J., Fava, M., Lauriello, J., and Paine, S. (2003) Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. JAMA 289, 56-64
39. Keller, M. B. (2003) Past, present, and future directions for defining optimal treatment outcome in depression: remission and beyond. JAMA 289, 3152-3160
40. Bandelow, B., Wedekind, D., and Leon, T. (2007) Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention. Expert Rev. Neurother. 7, 769-781
41. Haberfellner, E. M. (2007) A review of the assessment of antidepressant-induced sexual dysfunction used in randomized, controlled clinical trials. Pharmacopsychiatry 40, 173-182
42. Werme, M., Ringholm, A., Olson, L., and Brene, S. (2000) Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine. Brain Res. 863, 112-119
43. Dragunow, M., Robertson, G. S., Faull, R. L., Robertson, H. A., and Jansen, K. (1990) D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience 37, 287-294
44. Thompson, B. L., and Rosen, J. B. (2006) Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs. Neuropharmacology 50, 57-68
45. Henry, B., Vale, W., and Markou, A. (2006) The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J. Neurosci. 26, 9142-9152
46. Dhaka, A., Viswanath, V., and Patapoutian, A. (2006) Trp ion channels and temperature sensation. Annu. Rev. Neurosci. 29, 135-161
47. Smith, P. L., Maloney, K. N., Pothen, R. G., Clardy, J., and Clapham, D. E. (2006) Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J. Biol. Chem. 28, 129897-129904
48. Vogt-Eisele, A. K., Weber, K., Sherkheli, M. A., Vielhaber, G., Panten, J., Gisselmann, G., and Hatt, H. (2007) Monoterpenoid agonists of TRPV3. Br. J. Pharmacol. 151, 530-540
49. Paxinos, G., and Franklin, K. B. J. (2001) The Mouse Brain in Stereotaxic Coordinates, Academic Press, Oxford, UK