Voltage sensor of Kv1.2: Structural basis of electromechanical coupling

Science

Volumn 309, Issue 5736, 2005, Pages 903-908

  Long, Stephen B ^a   Campbell, Ernest B ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CONFORMATIONS; ELECTRIC POTENTIAL; ELECTROMECHANICAL DEVICES; LIPIDS;

ELECTROMECHANICAL COUPLING; ION CHANNELS; MEMBRANE VOLTAGE; VOLTAGE SENSORS;

SENSORS;

ARGININE; LINK PROTEIN; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL;

PHYSICS;

ALPHA HELIX; ARTICLE; BIOSENSOR; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTRIC FIELD; ELECTRIC POTENTIAL; EXCITATION CONTRACTION COUPLING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ARGININE; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; POTASSIUM CHANNELS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 23244441222     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1116270     Document Type: Article

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44. We thank A. Lee, V. Ruta, and. members of the MacKinnon laboratory for helpful discussions; R. Jain for initial experiments with lipids; R. Dutzler for assistance with data collection; O. Pongs for Kv1.2 DNA; J. Trimmer for β2 subunit DNA; Brookhaven National Laboratory (National Synchrotron Light Source beamlines X25 and X29) and the Swiss Light Source (beamline PX1) staff for assistance in data collection; and W. Chin for help with manuscript preparation. This work was supported in part by NIH grant no. GM43949 to R.M. R.M. is an Investigator in the Howard Hughes Medical Institute. Atomic coordinates and structure factors have been deposited in the Protein Data Bank with accession ID 2A79.