TRPM4 regulates calcium oscillations after T cell activation

Science

Volumn 306, Issue 5700, 2004, Pages 1374-1377

  Launay, Pierre ^a,c   Cheng, Henrique ^b,d   Srivatsan, Subhashini ^a   Penner, Reinhold ^b   Fleig, Andrea ^b   Kinet, Jean Pierre ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c INSERM   (France)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); DEPOLYMERIZATION; OSCILLATIONS; POSITIVE IONS;

CALCIUM-ACTIVATED NONSELECTIVE (CAN); CATION CHANNELS; MOLECULAR INHIBITION;

CALCIUM;

CALCIUM; CATION CHANNEL; INTERLEUKIN 2; MEMBRANE PROTEIN; TRPM4 PROTEIN; UNCLASSIFIED DRUG;

CALCIUM;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; MEMBRANE CURRENT; MEMBRANE DEPOLARIZATION; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CATION TRANSPORT PROTEINS; CELL LINE; CELL LINE, TUMOR; HUMANS; IMMUNOPRECIPITATION; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; PHYTOHEMAGGLUTININS; RNA INTERFERENCE; SODIUM; T-LYMPHOCYTES; TRPM CATION CHANNELS;

EID: 8844265321     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098845     Document Type: Article

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22. We thank M. K. Monteilh-Zoller and C. E. Oki for technical assistance, L. Glimcher's laboratory for providing the murine T cell clone D10.G4, and S. Kraft for insightful advice on the RNAi method. This work was supported in part by NIH grants R01-AI46734 (J.-P.K.); R01-NS40927, R01-AI50200, and R01-CM63954 (R.P.); and R01-CM65360 (A.F.). P.L. was supported by a fellowship from the Human Frontier Science Program Organization.