Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate

Journal of Neuroscience

Volumn 25, Issue 19, 2005, Pages 4835-4843

  Liu, Beiying ^a   Zhang, Chunguang ^a   Qin, Feng ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Analgesic; Capsaicin; Pain; PIP2; Sensory neurons; TRP channels

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAPSAICIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE C; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LEVEL; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIPID HYDROLYSIS; LIPOGENESIS; NOCICEPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANIMALS; CAPSAICIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; ENZYME INHIBITORS; HUMANS; MEMBRANE POTENTIALS; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; NERVE GROWTH FACTOR; OXYGENASES; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, MUTANT STRAINS; RECEPTOR, TRKA; RECOVERY OF FUNCTION; SERINE; THREONINE; TRPV CATION CHANNELS;

EID: 18644381102     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1296-05.2005     Document Type: Article

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