Cyclic nucleotide-gated ion channels

Physiological Reviews

Volumn 82, Issue 3, 2002, Pages 769-824

  Kaupp, U Benjamin ^a   Seifert, Reinhard ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALMODULIN; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; ION CHANNEL; POTASSIUM CHANNEL; PROTEIN SUBUNIT;

CAENORHABDITIS ELEGANS; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMOSENSITIVITY; COLOR BLINDNESS; COMPLEX FORMATION; DROSOPHILA; GENE MUTATION; HUMAN; ION PERMEABILITY; LIMULUS; MOLECULAR RECOGNITION; NERVE CELL PLASTICITY; NONHUMAN; OLFACTORY RECEPTOR; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RECEPTOR GENE; RETINA CONE; RETINA DEGENERATION; RETINA ROD; REVIEW; SENSORY NERVE CELL; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; SYNAPTOGENESIS;

EID: 0036301043     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00008.2002     Document Type: Review

References (445)

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82. Molecular and structural basis of target recognition by calmodulin
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98. 2+ blockage, and ionic selectivity
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100. 2+ interactions
101. The ionic requirements for the production of action potentials in crustacean muscle fibres
102. Expression of photoreceptor cyclic nucleotide-gated cation channel α subunit (CNGCα) in the liver and skeletal muscle
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104. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human
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108. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels
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110. Mechanism of tetracaine block of cyclic nucleotide-gated channels
111. Mechanisms of regulation and functions of guanylyl cyclases
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116. Photochemical properties of new photolabile cAMP derivatives in a physiological saline solution
117. + channels in Drosophila and mammals
118. Cyclic GMP and the second messenger hypothesis
119. Molecular basis of fertilization
120. Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
121. 2+ blockage, and permeation of olfactory cyclic nucleotide-gated channels
122. Molecular cloning and functional characterization of a new modulatory cyclic nucleotidegated channel subunit from mouse retina
123. Photochemistry of phosphate esters: α-keto phosphates as a photoprotecting group for caged phosphate
124. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel
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126. Light adaptation in Pecten hyperpolarizing photoreceptors
127. "Light" reading: Targeting tryptophans in cyclic nucleotide-gated channels
128. Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods
129. Diacylglycerol analogs inhibit the rod cGMP-gated channel by a phosphorylation-independent mechanism
130. Modulation of the cGMP-gated ion channel in frog rods by calmodulin and an endogenous inhibitory factor
131. Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels
132. Direct interaction between amino- and carboxyl-terminal domains of cyclic nucleotidegated channels
133. A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors
134. Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels
135. 2+ in cyclic nucleotide-gated channels
136. + channels closed by light and opened by cyclic GMP in molluscan extra-ocular photoreceptor cells
137. Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons
138. Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels
139. Molecular mechanism of cyclic-nucleotide-gated channel activation
140. Kinetics of light-sensitive channels in vertebrate photoreceptors
141. The calcium feedback signal in the phototransduction cascade of vertebrate rods
142. Does calmodulin play a functional role in phototransduction?
143. Identification of a domain on the β-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin
144. Molecular determinants of the modulation of cyclic nucleotide-activated channels by calmodulin
145. Calcium modulation of ligand affinity in the cyclic GMP-gated ion channels of cone photoreceptors
146. Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors
147. Highly efficient and ultrafast phototriggers for cAMP and cGMP by using long-wavelength UV/Vis-activation
148. Synthesis, photochemistry and application of (7-methoxycoumarin-4-yl)methyl-caged 8bromoadenosine cyclic 3′,5′-monophosphate and 8-bromoguanosine cyclic 3′,5′-monophosphate photolyzed in the nanosecond time region
149. Novel caged compounds of hydrolysis-resistant 8-Br-cAMP and 8-Br-cGMP: Photolabile NPE esters
150. Caged compounds of hydrolysis-resistant analogues of cAMP and cGMP: Synthesis and application to cyclic nucleotide-gated channels
151. cGMP-dependent channel protein from photoreceptor membranes: Single-channel activity of the purified and reconstituted protein
152. Voltage-dependent calcium channels regulate melatonin output from cultured chick pineal cells
153. Cyclic GMP-sensitive conductance in outer segment membrane of catfish cones
154. Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by L-cis-diltiazem
155. Permeation and block by internal and external divalent cations of the catfish cone photoreceptor cGMP-gated channel
156. Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane
157. Modulation of rod, but not cone, cGMP-gated photoreceptor channels by calcium-calmodulin
158. Single-channel measurement from the cyclic GMP-activated conductance of catfish retinal cones
159. Constraining the subunit order of rod cyclic nucleotide-gated channels reveals a diagonal arrangement of like subunits
160. + channels
161. Probing the transmembrane topology of cyclic nucleotide-gated ion channels with a gene fusion approach
162. Calcium channel selectivity for divalent and monovalent cations
163. Activation kinetics of retinal cones and rods: Response to intense flashes of light
164. Calcium channel activation facilitated by nitric oxide in retinal ganglion cells
165. Direct ion channel gating: A new function for intracellular messengers
166. The effect of light adaptation on the response of the light-sensitive current of toad rods to changes of Ca and Na
167. The ionic selectivity and calcium dependence of the light-sensitive pathway in toad rods
168. + channel can be trapped in the open state by an intersubunit metal bridge
169. Modulation of the cGMP-gated channel of rod photoreceptor cells by calmodulin
170. Single-channel study of the cGMP-dependent conductance of retinal rods from incorporation of native vesicles into planar lipid bilayers
171. Gating of retinal rod cation channel by different nucleotides: Comparative study of unitary currents
172. The 220-kDa rim protein of retinal rod outer segment is a member of the ABC transporter superfamily
173. Carbon monoxide: An endogenous modulator of the nitric oxide-cyclic GMP signaling system
174. Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons
175. A superfamily of ion channels
176. Cyclic GMP is involved in the excitation of invertebrate photoreceptors
177. Rotational movement during cyclic nucleotide-gated channel opening
178. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway
179. A novel role for cyclic nucleotide-gated cation channels in lung liquid homeostasis in sheep
180. Lack of a role for cyclic nucleotide gated cation channels in lung liquid absorption in fetal sheep
181. Cyclic GMP evoked calcium transients in olfactory receptor cell growth cones
182. Cloning of a cGMP-gated cation channel from mouse kidney inner medullary collecting duct
183. Interactions between divalent cations and the gating machinery of cyclic GMP-activated channels in salamander retinal rods
184. Cyclic GMP-activated channels of salamander retinal rods: Spatial distribution and variation of responsiveness
185. Gating kinetics of the cyclic-GMP-activated channel of retinal rods: Flash photolysis and voltage-jump studies
186. Family of cyclic nucleotide gated ion channels
187. Applications of caged compounds of hydrolysis-resistant analogs of cAMP and cGMP
188. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel
189. Molecular diversity of pacemaker ion channels
190. AMPA receptor activates a G-protein that suppresses a cGMP-gated current
191. Cyclic AMP-induced slow inward current in depolarized neurons of Aplysia californica
192. Cyclic AMP-induced slow inward current: Its synaptic manifestation in Aplysia neurons
193. Basis of guanylate cyclase activation by carbon monoxide
194. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: Novel targets for cAMP/cGMP functions
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196. Localization of nitric oxide synthase in the mouse olfactory and vomeronasal system: A histochemical, immunological and in situ hybridization study
197. Origin of the chloride current in olfactory transduction
198. Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists
199. High-gain, low-noise amplification in olfactory transduction
200. Spontaneous gating of olfactory cyclic-nucleotide-gated channels
201. 2+/calmodulin-dependent protein kinase II
202. Biochemical mechanism of light adaptation in vertebrate photoreceptors
203. Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism
204. 2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells
205. Mutations in the CNGB3 gene encoding the β-subunit of the cone photoreceptor cGMP gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21
206. Total colour blindness is caused by mutations in the gene encoding the α-subunit of the cone photoreceptor cGMP-gated cation channel
207. A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells
208. Cyclic nucleotide-activated channels in the frog olfactory receptor plasma membrane
209. Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells
210. Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans
211. Cytoplasmic free calcium concentration in dark-adapted retinal rod outer segments
212. The pineal organ as a component of the biological clock
213. Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors
214. A 240 kDa protein represents the complete β subunit of the cyclic nucleotide-gated channel from rod photoreceptor
215. The cGMP-phosphodiesterase and its contribution to sensitivity regulation in retinal rods
216. Regulation of sensitivity in vertebrate rod photoreceptors by calcium
217. Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action
218. 4 parts in the voltage dependency of Na channel gating
219. Identification of ligands for olfactory receptors by functional expression of a receptor library
220. Regulation of olfactory signalling via cGMP-dependent protein kinase
221. Neuronal nitric oxide synthase is localized in extrinsic nerves regulating perireceptor processes in the chemosensory nasal mucosae of rats and humans
222. Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt
223. The response induced by intracellular cyclic AMP in isolated olfactory receptor cells of the newt
224. Mechanism of odorant adaptation in the olfactory receptor cell
225. 2+-dependent adaptive properties in the solitary olfactory receptor cell of the newt
226. Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells
227. Modulation of ion channels in rod photoreceptors by nitric oxide
228. cGMP-mediated effects on the physiology of bovine and human retinal Müller (glial) cells
229. Calcium homeostasis in the outer segments of retinal rods from the tiger salamander
230. Imaging odor-induced calcium transients in single olfactory cilia: Specificity of activation and role in transduction
231. Ultrasensitive pheromone detection by mammalian vomeronasal neurons
232. Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: Spatiotemporal dynamics
233. A calcium-permeable cGMP-activated cation conductance in hippocampal neurons
234. Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide
235. Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells
236. It is calmodulin after all! Mediator of the calcium modulation of multiple ion channels
237. Ion-concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction
238. Single-channel kinetics of the rat olfactory cyclic nucleotide-gated channel expressed in Xenopus oocytes
239. Cyclic nucleotide-gated channels: Structural basis of ligand efficacy and allosteric modulation
240. Nitric oxide synthase in Müller cells and neurons of salamander and fish retina
241. Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells
242. A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP
243. TRP2: A candidate transduction channel for mammalian pheromone sensory signaling
244. Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity
245. Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers
246. Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function
247. Change of pore helix conformational state upon opening of cyclic nucleotide-gated channels
248. Calcium-calmodulin modulation of the olfactory cyclic nucleotide-gated cation channel
249. Ultrastructural localization of retinal guanylate cyclase in human and monkey retinas
250. Photoreceptors of the retina and pinealocytes of the pineal gland share common components of signal transduction
251. Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander
252. Silver as a probe of pore-forming residues in a potassium channel
253. Blockade of a retinal cGMP-gated channel by polyamines
254. Primary structure of cAMP-gated channel from bovine olfactory epithelium
255. Cation selectivity of the cGMP-gated channel of mammalian rod photoreceptors
256. Nitric oxide inhibition of the rat olfactory cyclic nucleotide-gated cation channel
257. Rectification of the olfactory cyclic nucleotide-gated channel by intracellular polyamines
258. Drugs affecting phospholipase C-mediated signal transduction block the olfactory cyclic nucleotide-gated current of adult zebrafish
259. Direct physical measure of conformational rearrangement underlying potassium channel gating
260. Does carbon monoxide have a physiological function?
261. Activation of single ion channels from toad retinal rod inner segments by cyclic GMP: Concentration dependence
262. Molecular rearrangements in the ligand-binding domain of cyclic nucleotide-gated channels
263. Free calcium concentrations in bullfrog rods determined in the presence of multiple forms of Fura-2
264. Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA
265. Voltage-dependent block by L-cis-diltiazem of the cyclic GMP-activated conductance of salamander rods
266. The effect of pH on the block by L-cis-diltiazem and amiloride of the cyclic GMP-activated conductance of salamander rods
267. Light response of vertebrate photoreceptors
268. Ionic basis of hyperpolarizing receptor potential in scallop eye: Increase in permeability to potassium ions
269. Ultrastructural localization of G-proteins and the channel protein TRP2 to microvilli of rat vomeronasal receptor cells
270. Currents carried by monovalent cations through cyclic GMP-activated channels in excised patches from salamander rods
271. The ionic selectivity of the light-sensitive current in isolated rods of the tiger salamander
272. A cGMP-signaling pathway in a subset of olfactory sensory neurons
273. Differences in transduction between rod and cone photoreceptors: An exploration of the role of calcium homeostasis
274. Sperm chemo-orientation in the Metazoa
275. Molecular cloning and taste bud-specific expression of a novel cyclic nucleotide-gated channel
276. Taste buds have a cyclic nucleotide-activated channel, CNGgust
277. Molecular cloning and characterization of a putative cyclic nucleotide-gated channel from Drosophila melanogaster
278. The cGMP-gated cation channel of bovine rod photoreceptor cells is associated with a 240-kDa protein exhibiting immunochemical cross-reactivity with spectrin
279. Calmodulin regulation of cyclic-nucleotide-gated channels
280. Molecular properties of the cGMP-gated channel of rod photoreceptors
281. The cGMP-gated channel of the rod photoreceptor cell. Characterization and orientation of the amino terminus
282. Molecular properties of the cGMP-gated cation channel of rod photoreceptor cells as probed with monoclonal antibodies
283. Mechanism of inhibition of cyclic nucleotide-gated channel by protein tyrosine kinase probed with genistein
284. Activity-dependent modulation of rod photoreceptor cyclic nucleotide-gated channels mediated by phosphorylation of a specific tyrosine residue
285. Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein
286. Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation
287. On the nature of allosteric transitions: A plausible model
288. Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity
289. 2 subunit from the bovine cone cGMP-gated channel is modulated by protein kinase C but not by calmodulin
290. 2+-calmodulin-dependent odor adaptation
291. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate
292. A cyclic nucleotide-gated conductance in olfactory receptor cilia
293. 2+ concentration by second messengers in newt olfactory receptor cell
294. 2+ modulation of the cGMP-gated channel of bullfrog retinal rod photoreceptors
295. Calcium and light adaptation in retinal rods and cones
296. Calcium and magnesium fluxes across the plasma membrane of the toad rod outer segment
297. Sodium-dependent calcium extrusion and sensitivity regulation in retinal cones of the salamander
298. Divalent cation interactions with light-dependent K channels
299. o, but not phosphodiesterase, in retinal bipolar cells
300. Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells
301. The use of fura-2 for estimating Ca buffers and Ca fluxes
302. New photo-activatable cyclic nucleotides produce intracellular jumps in cyclic AMP and cyclic GMP concentrations
303. A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block
304. Seeing two domains
305. The calcium channel antagonist, pimozide, blocks the cyclic GMP-activated current in rod photoreceptors
306. A derivative of amiloride blocks both the light-regulated and cyclic GMP-regulated conductances in rod photoreceptors
307. Evaluating sensitivity changing mechanisms in light-adapted photoreceptors
308. Ionic permeability ratios of the cyclic GMP-activated conductance in the outer segment membrane of salamander rods
309. Alternatively spliced forms of the cGMP-gated channel in human keratinocytes
310. 2+ through cGMP-gated ion channels of intact rod and cone photoreceptors
311. How calmodulin binds its targets: Sequence independent recognition of amphiphilic α-helices
312. 2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases
313. C-linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating
314. Immunocytochemical localization of a large intrinsic membrane protein to the incisures and margins of frog rod outer segment disks
315. Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse
316. Divalent cation selectivity in a cyclic nucleotide-gated ion channel
317. Response properties of cones from the retina of the tiger salamander
318. Ion transport across the frog olfactory mucosa: The action of cyclic nucleotides on the basal and odorant-stimulated states
319. The permeability of the cGMP-activated channel to organic cations in retinal rods of the tiger salamander
320. Permeation and interaction of monovalent cations with the cGMP-gated channel of cone photoreceptors
321. 2+ with cGMP-gated ion channels differ in retinal rod and cone photoreceptors
322. Spontaneous ligand-independent activity of the cGMP-gated ion channels in cone photoreceptors of fish
323. Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel
324. The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes
325. Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila
326. Chemosensation: Molecular mechanisms in worms and mammals
327. Anatomical and physiological characteristics of pineal photoreceptor cell in the larval lamprey, Petromyzon marinus
328. Cyclic GMP calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors
329. Phototransduction in vertebrate rods and cones: Molecular mechanisms of amplification, recovery and light adaptation
330. Voltage-dependent gating and block of the cyclic-GMP-dependent current in bovine rod outer segments
331. A voltage-gated ion channel expressed specifically in spermatozoa
332. 2+-dependent, diffusible factor modulates the cGMP-gated ion channels differently than in rods
333. Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane
334. 2+ extrusion governs response recovery in frog olfactory receptor cells
335. A sperm ion channel required for sperm motility and male fertility
336. A depolarizing chloride current contributes to chemo-electrical transduction in olfactory sensory neurons in situ
337. Extracellular proton alters the divalent cation binding affinity in a cyclic nucleotide-gated channel pore
338. Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion
339. Cooperativity and cooperation in cyclic nucleotide-gated ion channels
340. A cGMP-gated current can control exocytosis at cone synapses
341. The blocking effect of L-cis-diltiazem on the light-sensitive current of isolated rods of the tiger salamander
342. Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel
343. Two identical noninteracting sites in an ion channel revealed by proton transfer
344. Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons
345. Temporal and spatial pattern of expression of cyclic nucleotide-gated channels in developing rat visual cortex
346. The single-channel dose-response relation is consistently steep for rod cyclic nucleotide-gated channels: Implications for the interpretation of macroscopic dose-response relations
347. Single-cyclic nucleotide-gated channels locked in different ligand-bound states
348. Opening mechanism of a cyclic nucleotide-gated channel based on analysis of single channels locked in each liganded state
349. Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart
350. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells
351. The action of cytoplasmic calcium on the cGMP-activated channel in salamander rod photoreceptors
352. Depolarization exposes the voltage sensor of the sodium channels to the extracellular region
353. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotidegated channels
354. Intracellular biochemical manipulation of phototransduction in detached rod outer segments
355. Molecular cloning of cyclic nucleotide-gated cation channel subunits from rat pineal gland
356. An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons
357. Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide
358. + transport mechanisms
359. Deactivation behavior and excited-state properties of (Coumarin-4-yl)methyl derivatives. 1. Photocleavage of (7-methoxycoumarin-4-yl)methyl-caged acids with fluorescence
360. Fractional contribution of calcium to the cation current through glutamate receptor channels
361. Cation selectivity of and cation binding to the cGMP-dependent channel in bovine rod outer segment membranes
362. A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans
363. Binding of the cGMP-gated channel to the Na/Ca-K exchanger in rod photoreceptors
364. TRP, TRPL and trouble in photoreceptor cells
365. Mutating three residues in the bovine rod cyclic nucleotide-activated channel can switch a nucleotide from inactive to active
366. Predicted ligand interactions for 3′,5′-cyclic nucleotide-gated channel binding sites: Comparison of retina and olfactory binding site models
367. Molecular interactions of 3′,5′-cyclic purine analogues with the binding site of retinal rod ion channels
368. Three residues predicted by molecular modeling to interact with the purine moiety alter ligand binding and channel gating in cyclic nucleotide-gated channels
369. A functioning chimera of the cyclic nucleotide-binding domain from the bovine retinal rod ion channel and the DNA-binding domain from catabolite gene-activating protein
370. 2+-binding site in the pore of cyclic nucleotide-gated channels: S5/S6 segments control affinity of intrapore glutamates
371. Stoichiometry and arrangement of subunits in rod cyclic nucleotide-gated channels
372. Total colour blindness: An introduction
373. Opsin genes, cone photopigments, color vision and colorblindness
374. Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein
375. Properties of the cGMP-activated channel of retinal on-bipolar cells
376. Antagonistic chromatic mechanism in photoreceptors of the parietal eye of lizards
377. S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds
378. Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and L-cis-diltiazem
379. Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: Implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide
380. Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain
381. + current of molluscan neurons is resistant to kinase inhibitors and is gated by cAMP in the isolated patch
382. The amino acid sequence of a glutamic acid-rich protein from bovine retina as deduced from the cDNA sequence
383. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease
384. Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating
385. Mechanism of allosteric modulation of rod cyclic nucleotide-gated channels
386. Genetic basis of total colour blindness among the Pingelapese islanders
387. The avian pineal, a vertebrate model system of the circadian oscillator: Cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis
388. Guanosine cyclic 3′,5′-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families
389. Photoreceptor channel activation by nucleotide derivatives
390. + channel
391. Conductance and kinetics of single cGMP-activated channels in salamander rod outer segments
392. Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels
393. A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site
394. Cyclic nucleotidegated cation channel expression in embryonic chick brain
395. Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3′,5′-phosphate dependent protein kinase
396. Characterization of a plasma membrane calcium oscillator in rat pituitary somatotrophs
397. Different channel-gating properties of two classes of cyclic GMP-activated channel in vertebrate photoreceptors
398. Real-time patch-cram detection of intracellular cGMP reveals long-term suppression of responses to NO and muscarinic agonists
399. Cyclic nucleotide-gated cation channels mediate sodium absorption by IMCD (mIMCD-K2) cells
400. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels
401. Interdomain interactions underlying activation of cyclic nucleotide-gated channels
402. Carbon monoxide: A putative neural messenger
403. Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells
404. Molecular events mediating sperm activation
405. A distinct potassium channel polypeptide encoded by the Drosophila eag locus
406. The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina
407. Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 25 Å resolution
408. Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel α-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor
409. Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel
410. Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: A mechanism for attenuation of olfactory signals
411. Calmodulin controls the rod photoreceptor CNG channel through an unconventional binding site in the Nterminus of the β-subunit
412. Ion selectivity predictions from a two-site permeation model for the cyclic nucleotide-gated channel of retinal rod cells
413. Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus laevis oocytes
414. Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm
415. 2+ entry into sperm
416. CNGA 3 mutations in hereditary cone photoreceptor disorders
417. Cloning, chromosomal localization and functional expression of the gene encoding the α-subunit of the cGMP-gated channel in human cone photoreceptors
418. Antibodies against synthetic peptides used to determine the topology and site of glycosylation of the cGMP-gated channel from bovine rod photoreceptors
419. Lectin binding and enzymatic deglycosylation of the cGMP-gated channel from bovine rod photoreceptors
420. Do phosphatidylinositides modulate vertebrate phototransduction?
421. Ionic blockage of sodium channels in nerve
422. "Caged" compounds to probe the dynamics of cellular processes: Synthesis and properties of some novel photosensitive P-2-nitrobenzyl esters of nucleotides
423. Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cells
424. An unusual cGMP pathway underlying depolarizing light response of the vertebrate parietaleye photoreceptor
425. Expression of cyclic nucleotide-gated cation channels in airway epithelial cells
426. 2+ channels
427. Rod-type cyclic nucleotide-gated cation channel is expressed in vascular endothelium and vascular smooth muscle cells
428. Phototransduction mechanism in retinal rods and cones
429. Cyclic GMP-activated conductance of retinal photoreceptor cells
430. Cation selectivity of light-sensitive conductance in retinal rods
431. Light-induced reduction of cytoplasmic free calcium in retinal rod outer segment
432. Light-suppressible, cyclic GMP-sensitive conductance in the plasma membrane of a truncated rod outer segment
433. Light-dependent control of calcium in intact rods of the bullfrog Rana catesbeiana
434. Molecular cloning, functional expression and chromosomal localization of a human homolog of the cyclic nucleotide-gated ion channel of retinal cone photoreceptors
435. Canine rod photoreceptor cGMP-gated channel protein α-subunit: Studies on the expression of the gene and characterization of the cDNA
436. X inactivation of the OCNC1 channel gene reveals a role for activity-dependent competition in the olfactory system
437. Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit
438. Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells
439. Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores
440. Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments
441. Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels
442. Identification of a long-lasting form of odor adaptation that depends on the carbon monoxide/cGMP second-messenger system
443. From odor and pheromone transduction to the organization of the sense of smell