A physiological view of the primary cilium

Annual Review of Physiology

Volumn 67, Issue , 2005, Pages 515-529

  Praetorius, Helle A ^a   Spring, Kenneth R ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Ca2+; Chemo sensation; Flow; Function; Mechano sensation; Polycystin; Signal transduction

Indexed keywords

ANIMAL CELL; BONE; CAENORHABDITIS ELEGANS; CALCIUM TRANSPORT; CARTILAGE; CELL STRAIN; CENTRIOLE; ELECTRON MICROSCOPY; EMBRYO; EUKARYOTIC FLAGELLUM; FLOW RATE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE EPITHELIUM; MOUSE; MUCOCILIARY TRANSPORT; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECRETORY CELL; SENSOR;

ANIMALS; CHEMORECEPTORS; CILIA; KIDNEY; MECHANORECEPTORS; SIGNAL TRANSDUCTION;

EID: 15544367400     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.67.040403.101353     Document Type: Review

References (67)

1. th ed.
2. Zimmermann KW 1898. Beiträge zur Kenntnis einiger Drüsen und Epithelien. Arch. Mikr. Anat. Entwicklungsmech. 52:552-706
3. Wheatley DN. 1995. Primary cilia in normal and pathological tissues. Pathology 63:222-38
4. Jensen CG, Jensen LC, Rieder CL. 1979. The occurrence and structure of primary cilia in a subline of Potorous tridactylus. Exp. Cell Res. 123:444-49
5. Nonaka S, Tanaka Y, Okada Y, Takada S, Harada A, et al. 1998. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of embryonic fluid in mice lacking KIF3B motor protein. Cell 84:829-37
6. Nonaka S, Shiratori H, Saijoh Y, Hamada H. 2002. Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 418:96-99
7. Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS. 1999. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc. Natl. Acad. Sci. USA 96:5043-48
8. -/- mice analysis. J. Cell Biol. 145:825-36
9. Yoder BK, Tousson A, Millican L, Wu JH, Bugg CE Jr, et al. 2002. Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium. Am. J. Physiol. Renal Physiol. 282:F541-52
10. Supp DM, Brueckner M, Kuehn MR, Witte DP, Lowe LA, et al. 1999 Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Development 126:495-504
11. Okada Y, Nonaka S, Tanaka Y, Saijoh Y, Hamada H, Hirokawa N. 1999. Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol. Cell 4:459-68
12. McGrath J, Brueckner M. 2003. Cilia are at the heart of vertebrate left-right asymmetry. Curr. Opin. Genet. Dev. 13:385-92
13. Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, et al. 2002 The ion channel polycystin-2 is required for left-right axis determination in mice. Curr. Biol. 12:938-43
14. Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, et al. 2003 The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development 130:1725-34
15. Barnes BG. 1961. Ciliated secretory cells in the pars sistialis of the mouse hypophysis. J. Ultrastruct. Res. 5:453-61
16. Wheatley DN, Bowser SS. 2000. Length control of primary cilia: analysis of monociliate and multiciliate PtK1 cells. Biol. Cell. 92:573-82
17. Handel M, Schulz S, Stanaius A, Schreff M, Erdtmann-Viourliotis M, et al. 1999. Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience 89:909-26
18. Brailov I, Bancilia M, Brisorgueil M, Miquel M, Hamon M, Verge D. 2002. Localization of 5-HT6 receptor at the plasma membrane of neuronal cilia in the rat brain. Brain Res. 872:271-75
19. Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB. 2002. Polycystin-2 localizes to the kidney cilia and the ciliary level is elevated in ORPK mice with polycystic kidney disease. Curr. Biol. 12:R378-80
20. Yoder BK, Hou X, Guay-Woodford LM. 2002. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J. Am. Soc. Nephrol. 13:2508-16
21. Poole CA, Jensen CG, Snyder JA, Gray CG, Hermanutz VL, Wheatley DN. 1997. Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells. Cell Biol. Int. 21:483-94
22. Jensen CG, Poole CA, McGlashan SR, Marko M, Issa ZI. 2004. Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ. Cell Biol. Int. 28:101-10
23. Kellogg DR, Field CM, Alberts BM. 1989. Identification of microtubule-associated proteins in the centrosome, spindle, and kinetochore of the early Drosophila embryo. J. Cell Biol. 109:2977-91
24. Rosenbaum JL, Child FM. 1967. Flagellar regeneration in protozoan flagellates. J. Cell Biol. 34:345-64
25. Johnson KA, Rosenbaum JL. 1992. Polarity of flagellar assembly in Chlamydomonas. J. Cell Biol. 119:1605-11
26. Kozminski KG, Johnson KA, Forscher P, Rosenbaum JL. 1993. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc. Natl. Acad. Sci. USA 90:5519-23
27. Kozminski KG, Beech PL, Rosenbaum JL. 1995. The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane. J. Cell Biol. 131:1517-27
28. Pazour GJ, Wilkerson CG, Witman GB. 1998. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J. Cell Biol. 141:979-92
29. Piperno G, Mead K. 1997. Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella. Proc. Natl. Acad. Sci. USA 94:4457-62
30. Cole DG, Diener DR, Himelblau AL, Beech PL, Fuster JC, Rosenbaum JL. 1998. Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons. J. Cell Biol. 141:993-1008
31. Rosenbaum JL, Witman GB. 2002. Intraflagellar transport. Nat. Rev. Mol. Cell Biol. 3:813-25
32. Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, et al. 2000. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J. Cell Biol. 151:709-18
33. Haycraft CJ, Swoboda P, Taulman PD, Thomas JH, Yoder BK. 2001. The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 128:1493-505
34. Allen C, Borisy GG. 1974. Structural polarity and directional growth of microtubules of Chlamydomonas flagella. J. Mol. Biol. 90:381-402
35. Binder LI, Dentler WL, Rosenbaum JL. 1975. Assembly of chick brain tubulin onto flagellai microtubules from Chlamydomonas and sea urchin sperm. Proc. Natl. Acad. Sci. USA 72:1122-26
36. Goodson HV, Kang SJ, Endow SA. 1994. Molecular phylogeny of the kinesin family of microtubule motor proteins. J. Cell Sci. 107:1875-84
37. Scholey JM. 1996. Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles. J. Cell Biol. 133:1-4
38. Praetorius HA, Spring KR. 2003. Removal of the MDCK cell primary cilium abolishes flow sensing. J. Membr. Biol. 191:69-76
39. Dentler WL, Adams C. 1992. Flagellar microtubule dynamics in Chlamydomonas: cytochalasin D induces periods of microtubule shortening and elongation; and colchicine induces disassembly of the distal, but not proximal, half of the flagellum. J. Cell Biol. 117:1289-98
40. Schwartz EA, Leonard ML, Bizios R, Bowser SS. 1997. Analysis and modeling of the primary cilium bending response to fluid shear. Am. J. Physiol. Renal Physiol. 272:F132-38
41. Praetorius HA, Spring KR. 2001. Bending the MDCK cell primary cilium increases intracellular calcium. J. Membr. Biol. 184:71-79
42. i response of principal and intercalated cells in cortical collecting duct. Am. J. Physiol. Renal Physiol. 285:F998-1012
43. + secretion in cortical distal tubules of the rat. Am. J. Physiol. Renal Physiol. 256:F932-41
44. + channels in MDCK cells. J. Membr. Biol. 191:193-200
45. + secretion in the cortical collecting duct is mediated by a maxi-K channel. Am. J. Physiol. Renal Physiol. 280:F786-93
46. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, et al. 2003. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33:129-37
47. Koulen P, Cai Y, Geng L, Maeda Y, Nishimura S, et al. 2002. Polycystin-2 is an intracellular calcium release channel. Nat. Cell Biol. 4:191-97
48. Montell C. 2001. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci. STKE 90:E1
49. Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW. 2001. The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr. Biol. 11:1341-46
50. Scheffers MS, van der Bent P, van de Wal A, van Eendenburg J, Breuning MH, et al. 2004. Altered distribution and co-localization of polycystin-2 with polycystin-1 in MDCK cells after wounding stress. Exp. Cell Res. 292:219-30
51. Morgan D, Eley L, Sayer J, Strachan T, Yates LM, Craighead AS, Goodship JA. 2002. Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum. Mol. Genet. 11:3345-50
52. Nauli SM, Zhou J. 2004. Polycystins and mechanosensation in renal and nodal cilia. BioEssays 26:844-56
53. Fuchs JL, Schwark HD. 2004. Neuronal primary cilia: a review. Cell Biol. Int. 28:111-18
54. Whitfield JF. 2003. Primary cilium - is it an osteocyte's strain-sensing flowmeter? J. Cell Biochem. 89:233-37
55. Knothe Tate ML, Knothe U, Niederer P. 1998. Experimental elucidation of mechanical load-induced fluid flow and its potential role in bone metabolism and functional adaptation. Am. J. Med. Sci. 316:189-95
56. Knothe Tate ML, Steck R, Forwood MR, Niederer P. 2000. In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation. J. Exp. Biol. 203:2737-45
57. Smit TH, Burger EH, Huyghe JM. 2002. A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment. J. Bone Miner. Res. 17:2021-29
58. Iomini C, Tejada K, Mo W, Vaananen H, Piperno G. 2004. Primary cilia of human endothelial cells disassemble under laminar shear stress. J. Cell Biol. 164:811-17
59. Ware RW, Clark D, Crossland K, Russell RL. 1975. Nerve ring of nematode Caenorhabditis elegans-sensory input and motor output. J. Comp. Neurol. 162:71-110
60. Apfeld J, Kenyon C. 1999. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402:804-9
61. Stepanyan Z, Kocharyan A, Pyrski M, Hubschle T, Watson AM, et al. 2003. Leptin-target neurons of the rat hypothalamus express somatostatin receptors. J. Neuroendocrinol. 15:822-30
62. Shyy JY, Chien S. 2003. Interactions of mechanotransduction pathways. Biorheology 40:47-52
63. Wang N. 1998. Mechanical interactions among cytoskeletal filaments. Hypertension 32:162-65
64. Maroto R, Hamill OP, Brefeldin. 2001. A block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction. J. Biol. Chem. 276:23867-72
65. Praetorius J, Spring KR. 2002. Specific lectins map the distribution of fibronectin and beta 1-integrin on living MDCK cells. Exp. Cell Res. 276:52-62
66. 2+ signaling. Am. J. Physiol. Renal Physiol. In press
67. Aughsteen AA. 2001. The ultrastructure of primary cilia in the endocrine and excretory duct cells of the pancreas of mice and rats. Eur. J. Morphol. 39:277-83