Identification of a tetramerization domain in the C terminus of the vanilloid receptor

Journal of Neuroscience

Volumn 24, Issue 23, 2004, Pages 5307-5314

  García Sanz, Nuria ^a   Fernández Carvajal, Asia ^a   Morenilla Palao, Cruz ^a   Planells Cases, Rosa ^a   Fajardo Sánchez, Emmanuel ^a   Fernández Ballester, Gregorio ^a   Ferrer Montiel, Antonio ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Ion channel; Nociceptors; Oligomerization; Sensory transduction; Synaptic transmission; TRP domain

Indexed keywords

ARGININE; GLUTAMINE; POLYMER; RECEPTOR SUBUNIT; TETRAMER; TRANSIENT RECEPTOR POTENTIAL VANILLOID RECEPTOR SUBTYPE 1; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; DOMINANT NEGATIVE PHENOTYPE; GENE CONVERSION; GENE DELETION; HEAT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PURIFICATION; PROTON TRANSPORT; RAT; RECEPTOR POTENTIAL; TWO HYBRID SYSTEM;

ARGININE; GENE EXPRESSION; GLUTAMINE; HUMANS; POLYMERASE CHAIN REACTION; PROTEIN SUBUNITS; RECEPTORS, DRUG; SEQUENCE ANALYSIS, DNA; SYNAPTIC TRANSMISSION;

EID: 2942597685     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0202-04.2004     Document Type: Article

References (40)

1. Bai C, Elledge SJ (1997) Searching for interacting proteins with the two-hybrid system I. In: The yeast two-hybrid system (Bartel PL, Fields S, eds), pp 11-28. Oxford: Oxford UP.
2. Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau IV RW (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35:721-731.
3. Bhave G, Hu H-J, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau IV R (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci USA 100:12480-12485.
4. Birnbaumer L, Yidirim E, Abramowitz J (2003) A comparison of the genes encoding for canonical TRP channels an their M, V and P relatives. Cell Calcium 33:419-432.
5. Blanes-Mira C, Ibañez C, Fernandez-Ballester G, Planells-Cases R, Perez-Paya E, Ferrer-Montiel A (2001) Thermal stabilization of the catalytic domain of botulinum neurotoxin E by phosphorylation of a single tyrosine residue. Biochemistry 40:2234-2242.
6. Cabedo H, Luna C, Fernandez AM, Gallar J, Ferrer-Montiel A (2002) Molecular determinants of the sensory and motor neuron-derived factor insertion into plasma membrane. J Biol Chem 277:19905-19912.
7. Caterina MJ, Julius D (2001) The van illoid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24:487-517.
8. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824.
9. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313.
10. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517-524.
11. Clapham DE, Runnels LW, Strübing C (2001) The TRP ion channel family. Nat Rev Neurosci 2:387-396.
12. Cortes DM, Cuello LG, Perozo E (2001) Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J Gen Physiol 117:165-180.
13. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA (2000) Vanilloid-receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183-187.
14. García-Martínez C, Morenilla-Palao C, Planells-Cases R, Merino JM, Ferrer-Montiel A (2000) Identification of an aspartic residue in the P-loop of the Vanilloid receptor that modulates pore properties. J Biol Chem 275:32552-32558.
15. García-Martínez C, Humet M, Planells-Cases R, Gomis A, Caprini M, Viana F, De La Pena E, Sanchez-Baeza F, Carbonell T, De Felipe C, Perez-Paya E, Belmonte C, Messeguer A, Ferrer-Montiel A (2002) Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci USA 99:2374-2379.
16. Guerois R, Nielsen JE, Serrano L (2002) Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J Mol Biol 320:369-387.
17. Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-Pdb Viewer: an environment for comparative protein modelling. Electrophoresis 18:2714-2723.
18. Harteneck C, Plant TD, Schultz G (2000) From worm to man: three subfamilies of TRP families. Trends Neurosci 23:159-166.
19. Higgins D, Thompson J, Gibson T, Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680.
20. Jenke M, Sánchez A, Monje F, Sthümer W, Weseloh RM, Pardo LM (2003) C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J 22:395-403.
21. Ji RR, Samad TA, Jin SX, Schmoll R, Woolf CJ (2002) p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36:57-68.
22. Kedei N, Szabo T, Lile JD, Treanor JJ, Olah Z, Iadarola MJ, Blumberg PM (2001) Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem 276:28613-28619.
23. Kuzhikandathil EV, Wang H, Szabo T, Morozova N, Blumberg PM, Oxford GS (2001) Functional analysis of capsaicin receptor (vanilloid receptor subtype 1) multimerization and agonist responsiveness using a dominant negative mutation. J Neurosci 21:8697-8706.
24. Lupas A (1996) Coiled-coils: new structures and new functions. Trends Biochem Sci 21:375-382.
25. Lupas A, Van Dyke M, Stock J (1991) Predicting coiled coils form protein sequences. Science 252:1162-1164.
26. Minke B, Cook B (2002) TRP channel proteins and signal transduction. Physiol Rev 82:429-472.
27. Montell C, Birnbaumer L, Flockerzi V (2002) The TRP channels, a remarkably functional family. Cell 108:595-598.
28. Numazaki M, Tominaga T, Toyooka H, Tominaga M (2002) Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cε and identification of two target serine residues. J Biol Chem 277:13375-13378.
29. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M (2003) Structural determinants of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci USA 100:8002-8006.
30. Paoletti P, Young EC, Siegelbaum SA (1999) C-linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. J Gen Physiol 113:17-33.
31. Premkumar LS, Ahern GP (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature 408:985-990.
32. 2 binding site as a determinant of capsaicin receptor sensitivity. Science 300:1284-1288.
33. Ca channels. Neuron 32:13-23.
34. Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: an automated protein homology-modelling server. Nucleic Acids Res 31:3381-3385.
35. Suenaga M, Ohmae H, Tsuji S, Itoh T, Nishimura O (1998) Renaturation of recombinant human neurotrophin-3 from inclusion bodies using an aggregation suppressor. Biotechnol Appl Biochem 28:119-124.
36. Vlachová V, Tisinger J, Suŝánková K, Lyfenko A, Ettrich R, Vyklický L (2003) Functional role of the C-terminal cytoplasmic tail of rat vanilloid receptor 1. J Neurosci 23:1340-1350.
37. Vriend G (1990) WHAT IF: a molecular modeling and drug design program. J Mol Graph 8:51-55.
38. Wainger BJ, Degennaro M, Santoro B, Siegelbaum SA, Tibbs GR (2001) Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 411:805-810.
39. Zagotta WN, Olivier NB, Black KD, Young EC, Olson R, Gouaux E (2003) Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425:200-205.
40. Zerangue N, Jan YN, Jan LY (2000) An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1. Proc Natl Acad Sci USA 97:3591-3595.