A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 16222-16229

  Zhang, Wenyi ^a   Chu, Xin ^a   Tong, Qin ^a   Cheung, Joseph Y ^a,b   Conrad, Kathleen ^a   Masker, Kathryn ^a   Miller, Barbara A ^a,b  

^a WEIS CENTER FOR RESEARCH   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CALCIUM; CELL MEMBRANES; CHEMICAL ACTIVATION; MECHANICAL PERMEABILITY; OXIDATION; PHYSIOLOGY;

CELL DEATH;

CYTOLOGY;

CATION TRANSPORT PROTEIN; CLUSTERIN; HYDROGEN PEROXIDE; ISOPROTEIN; UNCLASSIFIED DRUG; CALCIUM; CALCIUM CHANNEL; ION CHANNEL; MEMBRANE PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BONE MARROW; BURST FORMING UNIT E; CALCIUM TRANSPORT; CELL DEATH; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOP CODON; CELL LINE; METABOLISM; MOLECULAR CLONING; PHYSIOLOGY;

APOPTOSIS; CALCIUM; CALCIUM CHANNELS; CELL LINE; CLONING, MOLECULAR; HUMANS; HYDROGEN PEROXIDE; ION CHANNELS; MEMBRANE PROTEINS; PROTEIN ISOFORMS; TRPM CATION CHANNELS;

EID: 0038521288     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300298200     Document Type: Article

References (30)

1. Herson, P. S., Lee, K., Pinnock, R. D., Hughes, J., and Ashford, M. L. (1999) J. Biol. Chem. 274, 833-841
2. Klonowski-Stumpe, H., Schreiber, R., Grolik, M., Schulz, H. U., Haussinger, D., and Niederau, C. (1997) Am. J. Physiol. 272, G1489-G1498
3. Hara, Y., Wakamori, M., Ishii, M., Maeno, E., Nishida, M., Yoshida, T., Yamada, H., Shimizu, S., Mori, E., Kudoh, J., Shimizu, N., Kurose, H., Okada, Y., Imoto, K., and Mori, Y. (2002) Mol. Cell 9, 163-173
4. Wehage, E., Eisfeld, J., Heiner, I., Jungling, E., Zitt, C., and Luckhoff, A. (2002) J. Biol. Chem. 277, 23150-23156
5. Harteneck, C., Plant, T. D., and Schultz, G. (2000) Trends Neurosci. 23, 159-166
6. Montell, C. (2001) Science's STKE 2001, RE1
7. Montell, C., Birnbaumer, L., and Flockerzi, V. (2002) Cell 108, 595-598
8. Duncan, L. M., Deeds, J., Hunter, J., Shao, J., Holmgren, L. M., Woolf, E. A., Tepper, R. I., and Shyjan, A. W. (1998) Cancer Res. 58, 1515-1520
9. Hunter, J. J., Shao, J., Smutko, J. S., Dussault, B. J., Nagle, D. L., Woolf, E. A., Holmgren, L. M., Moore, K. J., and Shyjan, A. W. (1998) Genomics 54, 116-123
10. Xu, X. Z., Moebius, F., Gill, D. L., and Montell, C. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 10692-10697
11. Perraud, A. L., Fleig, A., Dunn, C. A., Bagley, L. A., Launay, P., Schmitz, C., Stokes, A. J., Zhu, Q., Bessman, M. J., Penner, R., Kinet, J. P., and Scharenberg, A. M. (2001) Nature 411, 595-599
12. Prawitt, D., Enklaar, T., Klemm, G., Gartner, B., Spangenberg, C., Winterpacht, A., Higgins, M., Pelletier, J., and Zabel, B. (2000) Hum. Mol. Genet. 9, 203-216
13. Tsavaler, L., Shapero, M. H., Morkowski, S., and Laus, R. (2001) Cancer Res. 61, 3760-3769
14. Runnels, L. W., Yue, L., and Clapham, D. E. (2001) Science 291, 1043-1047
15. Paulsen, M., El Maarri, O., Engemann, S., Strodicke, M., Franck, O., Davies, K., Reinhardt, R., Reik, W., and Walter, J. (2000) Hum. Mol. Genet. 9, 1829-1841
16. Nagamine, K., Kudoh, J., Minoshima, S., Kawasaki, K., Asakawa, S., Ito, F., and Shimizu, N. (1998) Genomics 54, 124-131
17. Sano, Y., Inamura, K., Miyake, A., Mochizuki, S., Yokoi, H., Matsushime, H., and Furuichi, K. (2001) Science 293, 1327-1330
18. Zhang, M. Y., Harhaj, E. W., Bell, L., Sun, S. C., and Miller, B. A. (1998) Blood 92, 1225-1234
19. Vannier, B., Peyton, M., Boulay, G., Brown, D., Qin, N., Jiang, M., Zhu, X., and Birnbaumer, L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 2060-2064
20. Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., and Schultz, G. (1999) Nature 397, 259-263
21. Chu, X., Cheung, J. Y., Barber, D. L., Birnbaumer, L., Rothblum, L. I., Conrad, K., Abrasonis, V., Chan, Y. M., Stahl, R., Carey, D. J., and Miller, B. A. (2002) J. Biol. Chem. 277, 34375-34382
22. Miller, B. A., Barber, D. L., Bell, L. L., Beattie, B. K., Zhang, M. Y., Neel, B. G., Yoakim, M., Rothblum, L. I., and Cheung, J. Y. (1999) J. Biol. Chem. 274, 20465-20472
23. Miller, B. A., Cheung, J. Y., Tillotson, D. L., Hope, S. M., and Scaduto, R. C., Jr. (1989) Blood 73, 1188-1194
24. Cheung, J. Y., Elensky, M. B., Brauneis, U., Scaduto, R. C., Jr., Bell, L. L., Tillotson, D. L., and Miller, B. A. (1992) J. Clin. Invest. 90, 1850-1856
25. Cheung, J. Y., Zhang, X. Q., Bokvist, K., Tillotson, D. L., and Miller, B. A. (1997) Blood 89, 92-100
26. Xu, X. Z., Chien, F., Butler, A., Salkoff, L., and Montell, C. (2000) Neuron 26, 647-657
27. Balzer, M., Lintschinger, B., and Groschner, K. (1999) Cardiovasc. Res. 42, 543-549
28. Xu, X. Z. S., Li, H.-S., Guggino, W. B., and Montell, C. (1997) Cell 89, 1155-1164
29. Wilson, H. L., Dipp, M., Thomas, J. M., Lad, C., Galione, A., and Evans, A. M. (2001) J. Biol. Chem. 276, 11180-11188
30. Birnbaumer, L., Boulay, G., Brown, D., Jiang, M., Dietrich, A., Mikoshiba, K., Zhu, X., and Qin, N. (2000) Recent Prog. Horm. Res. 55, 127-162