The TRP ion channel family

Nature Reviews Neuroscience

Volumn 2, Issue 6, 2001, Pages 387-396

  Clapham, David E ^a   Runnels, Loren W ^a   Strübing, Carsten ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

CALCIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ANIMAL; CALCIUM SIGNALING; CELL MEMBRANE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MEMBRANE; HUMANS; SIGNAL TRANSDUCTION; TRPC CATION CHANNELS;

EID: 0035378510     PISSN: 14710048     EISSN: None     Source Type: Journal    
DOI: 10.1038/35077544     Document Type: Review

References (70)

1. Harteneck, C., Plant, T. D. & Schultz, G. From worm to man: three subfamilies of TRP channels. Trends Neurosci. 23, 159-166 (2000). The first comprehensive review of TRP channels from many species. It contains the most widely used nomenclature of the members of this family. The original contributions by Montell, Rubin, Hardie, Minke and co-workers in Drosophila are detailed.
2. Clapham, D. E. Calcium signaling. Cell 80, 259-268 (1995).
3. 2+ channel in Drosophila photoreceptors. Neuron 8, 643-651 (1992).
4. 3R).
5. 3 receptor gene. Mol. Cell. Neurosci. 15, 429-445 (2000).
6. 2 levels in Drosophila photoreceptors. Neuron 30, 1-20 (2001).
7. Rebecchi, M. J. & Pentyala, S. N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291-1335 (2000).
8. Rhee, S. G. & Bae, Y. S. Regulation of phosphoinositide-specific phospholipase C isozymes. J. Biol. Chem. 272, 15045-15048 (1997).
9. Berridge, M., Lipp, P. & Bootman, M. Calcium signalling. Curr. Biol. 9, R157-159 (1999).
10. 1, is activated by capacitative calcium entry that follows phospholipase Cβ activation upon bradykinin stimulation. J. Biol. Chem. 274, 26127-26134 (1999).
11. Putney, J. W. Jr Muscarinic, α-adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland. J. Physiol. 268, 139-149 (1977). The first paper describing the store-depletion hypothesis (capacitative coupling).
12. CRAC by Hoth and Penner (reference 13).
13. 2+ release activated current.
14. 2+-permeable cation channel activated by calcium store depletion. Neuron 16, 1189-1196 (1996).
15. 2+-sensitive cation channels. J. Biol. Chem. 275, 27799-27805 (2000).
16. q-linked receptors, but not by store depletion.
17. 2+ channel from mouse brain. J. Biol. Chem. 273, 10279-10287 (1998).
18. Schaefer, M. et al. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J. Biol. Chem. 275, 17517-17526 (2000).
19. Hofmann, T. et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397, 259-263 (1999).
20. Tang, Y. et al. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J. Biol. Chem. 275, 37559-37564 (2000).
21. 2+-selective.
22. Philipp, S. et al. A novel capacitative calcium entry channel expressed in excitable cells. EMBO J. 17, 4274-4282 (1998).
23. 2+ but not by store depletion.
24. Li, H. S., Xu, X. Z. & Montell, C. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24, 261-273 (1999).
25. Estacion, M., Sinkins, W. G. & Schilling, W. P. Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms. J. Physiol. 530, 1-19 (2001).
26. 3 receptors and store-operated Htrp3 channels. Nature 396, 478-482 (1998).
27. 2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J. Biol. Chem. 274, 27359-27370 (1999).
28. 2+-permeable cation channel. Circ. Res. 88, 325-332 (2001).
29. Liman, E. R., Corey, D. P. & Dulac, C. TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl Acad. Sci. USA 96, 5791-5796 (1999).
30. 2+ entry channel. Proc. Natl Acad. Sci. USA 96, 2060-2064 (1999).
31. Wes, P. D. et al. TRPC1, a human homolog of a Drosophila store-operated channel. Proc. Natl Acad. Sci. USA 92, 9652-9656 (1995).
32. Hofmann, T., Schaefer, M., Schultz, G. & Gudermann, T. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem. J. 351, 115-122 (2000).
33. 2+ into mouse sperm triggered by egg ZP3. Nature Cell Biol. 3, 499-502 (2001).
34. 4 for the zona pellucida-induced acrosome reaction. Science 292, 920-923 (2001).
35. Caterina, M. J. & Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487-517 (2001).
36. Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997). The initial identification of the capsaicin-receptor channel, founding member of the TRPV subfamily. This work led to the identification of VR-1 and VRL-1 channels, and their role in pain pathways.
37. Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J. & Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441 (1999).
38. Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G. & Plant, T. D. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nature Cell Biol. 2, 695-702 (2000).
39. Liedtke, W. et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525-535 (2000).
40. 3-responsive epithelia. J. Biol. Chem. 274, 8375-8378 (1999).
41. 2+ channel. J. Biol. Chem. 275, 3963-3969 (2000).
42. 2+ channel ECaC. J. Physiol. 527, 239-248 (2000).
43. Tsien, R. W., Hess, P., McCleskey, E. W. & Rosenberg, R. L. Calcium channels: mechanisms of selectivity, permeation, and block. Annu. Rev. Biophys. Biophys. Chem. 16, 265-290 (1987).
44. 2+ channel. J. Biol. Chem. 276, 1020-1025 (2001).
45. Peng, J. B. et al. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol. Chem. 274, 22739-22746 (1999).
46. CRAC current identified by Cahalan and co-workers under divalent-free conditions.
47. Runnels, L. W., Yue, L. & Clapham, D. E. TRP-PUK, a bifunctional protein with kinase and ion channel activities. Science 291, 1043-1047 (2001). Characterizes the ion channel and kinase properties of the novel protein TRP-PLIK, showing that the kinase activity of the protein is required for proper channel function. It is also the first electrophysiological study of a member of the TRPM subgroup.
48. 2+ channel protein (TRPC7) highly expressed in brain. Genomics 54, 124-131 (1998).
49. Perraud, A.-L. et al. ADP-ribose gating of the calcium-permeable LTRP62 channel revealed by Nudix motif homology. Nature (in the press).
50. Bessman, M. J., Frick, D. N. & O'Handley, S. F. The MutT proteins or 'Nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes. J. Bol. Chem. 271, 25059-25062 (1996).
51. Tsavaler, L., Shapero, M. H., Morkowski, S. & Laus, R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 61, 3760-3769 (2001).
52. Duncan, L. M. et al. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res. 58, 1515-1520 (1998).
53. Hunter, J. J. et al. Chromosomal localization and genomic characterization of the mouse melastatin gene (Misn1). Genomics 54, 116-123 (1998).
54. Fang, D. & Setaluri, V. Expression and up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem. Biophys. Res. Commun. 279, 53-61 (2000).
55. Deeds, J., Cronin, F. & Duncan, L. M. Patterns of melastatin mRNA expression in melanocytic tumors. Hum. Pathol. 31, 1346-1356 (2000).
56. Duncan, L. M. et al. Melastatin expression and prognosis in cutaneous malignant melanoma. J. Clin. Oncol. 19, 568-576 (2001). This clinical study validates that expression of the melastatin gene assists with the prognosis of melanoma. It is also the first report linking TRP channels to a specific pathology.
57. Prawitt, D. et al. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression. Hum. Mol. Genet. 9, 203-216 (2000).
58. 2+ entry by expression of antisense cDNAs.
59. Kamouchi, M. et al. Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells. J. Physiol. 518, 345-358 (1999).
60. Ohki, G. et al. A calcium-activated cation current by an atematively spliced form of Trp3 in the heart. J. Biol. Chem. 275, 39055-39060 (2000).
61. Philipp, S. et al. A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J. 15, 6166-6171 (1996).
62. 2+ channel isoforms in mouse brain. Neuroreport 9, 507-515 (1998).
63. q class of G protein. J. Biol. Chem. 272, 29672-29680 (1997).
64. Walker, R. L., Hume, J. R. & Horowitz, B. Differential expression and alternative splicing of TRP channel genes in smooth muscles. Am. J. Physiol. Cell Physiol. 280, C1184-1192 (2001).
65. Premkumar, L. S. & Ahern, G. P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985-990 (2000).
66. Kanzaki, M. et al. Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nature Cell Biol. 1, 165-170 (1999).
67. Peng, J. B. et al. A rat kidney-specific calcium transporter in the distal nephron. J. Biol. Chem. 275, 28186-28194 (2000).
68. Peng, J. B. et al. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278, 326-332 (2000).
69. Enklaar, T. et al. Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Genomics 67, 179-187 (2000).
70. Saitou, N. & Nei, M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4, 406-425 (1987).