N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino} -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2- carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I [S]

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 2, 2008, Pages 432-442

  Thorneloe, Kevin S ^a   Sulpizio, Anthony C ^a   Lin, Zuojun ^a   Figueroa, David J ^a   Clouse, Angela K ^a   McCafferty, Gerald P ^a   Chendrimada, Tim P ^a   Lashinger, Erin S R ^a   Gordon, Earl ^a   Evans, Louise ^a   Misajet, Blake A ^a   DeMarini, Douglas J ^a   Nation, Josephine H ^b   Casillas, Linda N ^a   Marquis, Robert W ^a   Votta, Bartholomew J ^a   Sheardown, Steven A ^b   Xu, Xiaoping ^a   Brooks, David P ^a   Laping, Nicholas J ^a   Westfall, Timothy D ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; AMIDE; BENZOTHIOPHENE DERIVATIVE; GSK 1016790A; MESSENGER RNA; N 1 [[4 [2 [[(2,4 DICHLOROPHENYL)SULFONYL]AMINO] 3 HYDROXYPROPANOYL] 1 PIPERAZINYL]CARBONYL] 3 METHYLBUTYL] 1 BENZOTHIOPHENE 2 CARBOXAMIDE; VANILLOID RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; UROTHELIUM; WESTERN BLOTTING;

ANIMALS; BODY WEIGHT; FEMALE; LEUCINE; MALE; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHORBOLS; SULFONAMIDES; TRPV CATION CHANNELS; URINARY BLADDER; URODYNAMICS; UROTHELIUM;

EID: 47949102906     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.139295     Document Type: Article

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