Structural basis for modulation and agonist specificity of HCN pacemaker channels

Nature

Volumn 425, Issue 6954, 2003, Pages 200-205

  Zagotta, William N ^a   Olivier, Nelson B ^b   Black, Kevin D ^a   Young, Edgar C ^b   Olson, Rich ^b   Gouaux, Eric ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ELECTRIC PROPERTIES; PACEMAKERS; SEDIMENTATION;

ELECTRICAL SIGNALING;

BIOELECTRIC POTENTIALS;

NUCLEOTIDE; CYCLIC AMP; CYCLIC GMP; HYPERPOLARIZATION ACTIVATED CATION CHANNEL; HYPERPOLARIZATION-ACTIVATED CATION CHANNEL; ION CHANNEL; LIGAND; NERVE PROTEIN; PROTEIN SUBUNIT;

BIOLOGY; ELECTRICAL PROPERTY; SIGNALING;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; HEART RATE; HYPERPOLARIZATION; MEMBRANE STEADY POTENTIAL; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; ELECTRIC CONDUCTIVITY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; MOUSE; PATCH CLAMP; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CYCLIC AMP; CYCLIC GMP; ELECTRIC CONDUCTIVITY; HYDROGEN BONDING; ION CHANNEL GATING; ION CHANNELS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PROTEIN SUBUNITS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0141831003     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01922     Document Type: Article

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