메뉴 건너뛰기
Epigenetics
Volumn 7, Issue 7, 2012, Pages 680-688
Global heterochromatin loss: A unifying theory of aging?
Author keywords

Aging; Chromatin; Epigenetics; Free radical; Genome instability; Heterochromatin; Histone; Reactive oxygen species; Senescence; Telomere
Indexed keywords

FREE RADICAL; HETEROCHROMATIN PROTEIN 1; HISTONE; INSULIN; SIRTUIN;
EID: 84863806968     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.20540     Document Type: Article
Times cited : (155)
References (137)
  • 1
    • 0036089388 scopus 로고    scopus 로고
    • Conformational dynamics of the chromatin fiber in solution: Determinants, mechanisms and functions
    • PMID:11988475
    • Hansen JC. Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms and functions. Annu Rev Biophys Biomol Struct 2002. 31:361-392. PMID:11988475. http://dx.doi.org/10.1146/annurev.biophys.31.101101.140858.
    • (2002) Annu Rev Biophys Biomol Struct , vol.31 , pp. 361-392
    • Hansen, J.C.1
  • 2
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2.8 A resolution
    • PMID:9305837
    • Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 1997. 389:251-260. PMID:9305837. http://dx.doi.org/10.1038/38444.
    • (1997) Nature , vol.389 , pp. 251-260
    • Luger, K.1    Mäder, A.W.2    Richmond, R.K.3    Sargent, D.F.4    Richmond, T.J.5
  • 3
    • 20044379872 scopus 로고    scopus 로고
    • Exercise and hormesis: Oxidative stress-related adaptation for successful aging
    • PMID:15834665
    • Radak Z, Chung HY, Goto S. Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 2005. 6:71-75. PMID:15834665. http://dx.doi.org/10.1007/s10522-004-7386-7.
    • (2005) Biogerontology , vol.6 , pp. 71-75
    • Radak, Z.1    Chung, H.Y.2    Goto, S.3
  • 4
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • PMID:17320507
    • Kouzarides T. Chromatin modifications and their function. Cell 2007. 128:693-705. PMID:17320507. http://dx.doi.org/10.1016/j.cell.2007.02.005.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 5
    • 0032055402 scopus 로고    scopus 로고
    • Unfolding the mysteries of heterochromatin
    • PMID:9610404
    • Wallrath LL. Unfolding the mysteries of heterochromatin. Curr Opin Genet Dev 1998. 8:147-153. PMID:9610404. http://dx.doi.org/10.1016/S0959-437X(98)80135-4.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 147-153
    • Wallrath, L.L.1
  • 6
    • 0042528729 scopus 로고    scopus 로고
    • Heterochromatin and epigenetic control of gene expression
    • PMID:12907790
    • Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science 2003. 301:798-802. PMID:12907790. http://dx.doi.org/10.1126/science.1086887.
    • (2003) Science , vol.301 , pp. 798-802
    • Grewal, S.I.1    Moazed, D.2
  • 7
    • 27644589675 scopus 로고    scopus 로고
    • The diverse functions of histone lysine methylation
    • PMID:16261189
    • Martin C, Zhang Y. The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 2005. 6:838-849. PMID:16261189. http://dx.doi.org/10.1038/nrm1761.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 838-849
    • Martin, C.1    Zhang, Y.2
  • 8
    • 0034026194 scopus 로고    scopus 로고
    • The HP1 protein family: Getting a grip on chromatin
    • PMID:10753776
    • Eissenberg JC, Elgin SC. The HP1 protein family: getting a grip on chromatin. Curr Opin Genet Dev 2000. 10:204-210. PMID:10753776. http://dx.doi.org/10.1016/S0959-437X(00)00058-7.
    • (2000) Curr Opin Genet Dev , vol.10 , pp. 204-210
    • Eissenberg, J.C.1    Elgin, S.C.2
  • 9
    • 0031437950 scopus 로고    scopus 로고
    • The case for epigenetic effects on centromere identity and function
    • PMID:9433139
    • Karpen GH, Allshire RC. The case for epigenetic effects on centromere identity and function. Trends Genet 1997. 13:489-496. PMID:9433139. http://dx.doi.org/10.1016/S0168-9525(97)01298-5.
    • (1997) Trends Genet , vol.13 , pp. 489-496
    • Karpen, G.H.1    Allshire, R.C.2
  • 10
    • 79960484375 scopus 로고    scopus 로고
    • Gene silencing in X-chromosome inactivation: Advances in understanding facultative heterochromatin formation
    • PMID:21765457
    • Wutz A. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nat Rev Genet 2011. 12:542-553. PMID:21765457. http://dx.doi.org/10.1038/nrg3035.
    • (2011) Nat Rev Genet , vol.12 , pp. 542-553
    • Wutz, A.1
  • 11
    • 34948839944 scopus 로고    scopus 로고
    • Facultative heterochromatin: Is there a distinctive molecular signature?
    • PMID:17936700
    • Trojer P, Reinberg D. Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell 2007. 28:1-13. PMID:17936700. http://dx.doi.org/10.1016/j.molcel.2007.09.011.
    • (2007) Mol Cell , vol.28 , pp. 1-13
    • Trojer, P.1    Reinberg, D.2
  • 12
    • 0030759780 scopus 로고    scopus 로고
    • The heterochromatin loss model of aging
    • PMID:9315443
    • Villeponteau B. The heterochromatin loss model of aging. Exp Gerontol 1997. 32:383-394. PMID:9315443. http://dx.doi.org/10.1016/S0531-5565(96)00155-6.
    • (1997) Exp Gerontol , vol.32 , pp. 383-394
    • Villeponteau, B.1
  • 13
    • 33745016642 scopus 로고    scopus 로고
    • Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
    • PMID:16738054
    • Shumaker DK, Dechat T, Kohlmaier A, Adam SA, Bozovsky MR, Erdos MR, et al. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci USA 2006. 103:8703-8708. PMID:16738054. http://dx.doi.org/10.1073/pnas.0602569103.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8703-8708
    • Shumaker, D.K.1    Dechat, T.2    Kohlmaier, A.3    Adam, S.A.4    Bozovsky, M.R.5    Erdos, M.R.6
  • 14
    • 28044460514 scopus 로고    scopus 로고
    • Age-related changes of nuclear architecture in Caenorhabditis elegans
    • PMID:16269543
    • Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout A, et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci USA 2005. 102:16690-16695. PMID:16269543. http://dx.doi.org/10.1073/pnas.0506955102.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16690-16695
    • Haithcock, E.1    Dayani, Y.2    Neufeld, E.3    Zahand, A.J.4    Feinstein, N.5    Mattout, A.6
  • 15
    • 47349118629 scopus 로고    scopus 로고
    • The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies
    • PMID:18494863
    • Brandt A, Krohne G, Grosshans J. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Aging Cell 2008. 7:541-551. PMID:18494863. http://dx.doi.org/10.1111/j.1474-9726.2008.00406.x.
    • (2008) Aging Cell , vol.7 , pp. 541-551
    • Brandt, A.1    Krohne, G.2    Grosshans, J.3
  • 16
    • 84857477619 scopus 로고    scopus 로고
    • Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis
    • PMID:22291607
    • Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, et al. Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet 2012. 8:1002473. PMID:22291607. http://dx.doi.org/10.1371/journal.pgen.1002473.
    • (2012) PLoS Genet , vol.8 , pp. 1002473
    • Larson, K.1    Yan, S.J.2    Tsurumi, A.3    Liu, J.4    Zhou, J.5    Gaur, K.6
  • 17
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • PMID:16645051
    • Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006. 312:1059-1063. PMID:16645051. http://dx.doi.org/10.1126/science.1127168.
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 18
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • PMID:17662938
    • Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007. 130:223-233. PMID:17662938. http://dx.doi.org/10.1016/j.cell.2007.07.003.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 19
    • 33644692330 scopus 로고    scopus 로고
    • Cellular senescence in aging primates
    • PMID:16456035
    • Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science 2006. 311:1257. PMID:16456035. http://dx.doi.org/10.1126/science.1122446.
    • (2006) Science , vol.311 , pp. 1257
    • Herbig, U.1    Ferreira, M.2    Condel, L.3    Carey, D.4    Sedivy, J.M.5
  • 20
    • 34447343780 scopus 로고    scopus 로고
    • Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells
    • PMID:17643369
    • Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD. Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell 2007. 27:183-196. PMID:17643369. http://dx.doi.org/10.1016/j.molcel.2007.05.034.
    • (2007) Mol Cell , vol.27 , pp. 183-196
    • Ye, X.1    Zerlanko, B.2    Kennedy, A.3    Banumathy, G.4    Zhang, R.5    Adams, P.D.6
  • 21
    • 34147182401 scopus 로고    scopus 로고
    • Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
    • PMID:17544228
    • Adams PD. Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 2007. 397:84-93. PMID:17544228. http://dx.doi.org/10.1016/j.gene.2007.04.020.
    • (2007) Gene , vol.397 , pp. 84-93
    • Adams, P.D.1
  • 22
    • 33847703331 scopus 로고    scopus 로고
    • Cellular senescence and chromatin organisation
    • PMID:17311013
    • Narita M. Cellular senescence and chromatin organisation. Br J Cancer 2007. 96:686-691. PMID:17311013. http://dx.doi.org/10.1038/sj.bjc.6603636.
    • (2007) Br J Cancer , vol.96 , pp. 686-691
    • Narita, M.1
  • 23
    • 34547626390 scopus 로고    scopus 로고
    • Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK-and mTOR-independent process
    • PMID:17551002
    • Jeyapalan AS, Orellana RA, Suryawan A, O'Connor PM, Nguyen HV, Escobar J, et al. Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK-and mTOR-independent process. Am J Physiol Endocrinol Metab 2007. 293:595-603. PMID:17551002. http://dx.doi.org/10.1152/ajpendo.00121.2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. 595-603
    • Jeyapalan, A.S.1    Orellana, R.A.2    Suryawan, A.3    O'Connor, P.M.4    Nguyen, H.V.5    Escobar, J.6
  • 24
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • PMID:17242207
    • Zhang R, Chen W, Adams PD. Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 2007. 27:2343-2358. PMID:17242207. http://dx.doi.org/10.1128/MCB.02019-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 25
    • 19944427674 scopus 로고    scopus 로고
    • Formation of MacroH2Acontaining senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
    • PMID:15621527
    • Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, et al. Formation of MacroH2Acontaining senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 2005. 8:19-30. PMID:15621527. http://dx.doi.org/10.1016/j.devcel.2004.10.019.
    • (2005) Dev Cell , vol.8 , pp. 19-30
    • Zhang, R.1    Poustovoitov, M.V.2    Ye, X.3    Santos, H.A.4    Chen, W.5    Daganzo, S.M.6
  • 26
    • 43049162647 scopus 로고    scopus 로고
    • Aging by epigenetics-a consequence of chromatin damage?
    • PMID:18423606
    • Sedivy JM, Banumathy G, Adams PD. Aging by epigenetics-a consequence of chromatin damage? Exp Cell Res 2008. 314:1909-1917. PMID:18423606. http://dx.doi.org/10.1016/j.yexcr.2008.02.023.
    • (2008) Exp Cell Res , vol.314 , pp. 1909-1917
    • Sedivy, J.M.1    Banumathy, G.2    Adams, P.D.3
  • 27
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • PMID:12809602
    • Narita M, Nũnez S, Heard E, Narita M, Lin AW, Hearn SA, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003. 113:703-716. PMID:12809602. http://dx.doi.org/10.1016/S0092-8674(03)00401-X.
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nũnez, S.2    Heard, E.3    Narita, M.4    Lin, A.W.5    Hearn, S.A.6
  • 28
    • 79952268809 scopus 로고    scopus 로고
    • Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
    • PMID:21336312
    • Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, et al. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol 2011. 13:292-302. PMID:21336312. http://dx.doi.org/10.1038/ncb2170.
    • (2011) Nat Cell Biol , vol.13 , pp. 292-302
    • Di Micco, R.1    Sulli, G.2    Dobreva, M.3    Liontos, M.4    Botrugno, O.A.5    Gargiulo, G.6
  • 29
    • 79952268699 scopus 로고    scopus 로고
    • A damage limitation exercise
    • PMID:21364567
    • Ivanov A, Adams PD. A damage limitation exercise. Nat Cell Biol 2011. 13:193-195. PMID:21364567. http://dx.doi.org/10.1038/ncb0311-193.
    • (2011) Nat Cell Biol , vol.13 , pp. 193-195
    • Ivanov, A.1    Adams, P.D.2
  • 30
    • 0344321897 scopus 로고    scopus 로고
    • Impact of aging on DNA methylation
    • PMID:12726774
    • Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003. 2:245-261. PMID:12726774. http://dx.doi.org/10.1016/S1568-1637(03)00010-2.
    • (2003) Ageing Res Rev , vol.2 , pp. 245-261
    • Richardson, B.1
  • 31
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • PMID:19150625
    • Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009. 130:234-239. PMID:19150625. http://dx.doi.org/10.1016/j.mad.2008.12.003.
    • (2009) Mech Ageing Dev , vol.130 , pp. 234-239
    • Bollati, V.1    Schwartz, J.2    Wright, R.3    Litonjua, A.4    Tarantini, L.5    Suh, H.6
  • 32
    • 84860881828 scopus 로고    scopus 로고
    • Global DNA methylation in old subjects is correlated with frailty
    • PMID:21336567
    • Bellizzi D, D'Aquila P, Montesanto A, Corsonello A, Mari V, Mazzei B, et al. Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) 2012. 34:169-179. PMID:21336567. http://dx.doi.org/10.1007/s11357-011-9216-6.
    • (2012) Age (Dordr) , vol.34 , pp. 169-179
    • Bellizzi, D.1    D'aquila, P.2    Montesanto, A.3    Corsonello, A.4    Mari, V.5    Mazzei, B.6
  • 33
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • PMID:6844925
    • Wilson VL, Jones PA. DNA methylation decreases in aging but not in immortal cells. Science 1983. 220:1055-1057. PMID:6844925. http://dx.doi.org/10.1126/science.6844925.2006.07.002.
    • (1983) Science , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 34
    • 4344685735 scopus 로고    scopus 로고
    • Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly
    • PMID:15327775
    • Sarraf SA, Stancheva I. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Mol Cell 2004. 15:595-605. PMID:15327775. http://dx.doi.org/10.1016/j.molcel.2004.06.043.
    • (2004) Mol Cell , vol.15 , pp. 595-605
    • Sarraf, S.A.1    Stancheva, I.2
  • 35
    • 0032845039 scopus 로고    scopus 로고
    • Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
    • PMID:10471500
    • Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet 1999. 23:62-66. PMID:10471500. http://dx.doi.org/10.1038/12664.
    • (1999) Nat Genet , vol.23 , pp. 62-66
    • Wade, P.A.1    Gegonne, A.2    Jones, P.L.3    Ballestar, E.4    Aubry, F.5    Wolffe, A.P.6
  • 36
    • 0033180082 scopus 로고    scopus 로고
    • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
    • PMID:10444591
    • Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 1999. 13:1924-1935. PMID:10444591. http://dx.doi.org/10.1101/gad.13.15.1924.
    • (1999) Genes Dev , vol.13 , pp. 1924-1935
    • Zhang, Y.1    Ng, H.H.2    Erdjument-Bromage, H.3    Tempst, P.4    Bird, A.5    Reinberg, D.6
  • 37
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • PMID:10615135
    • Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 2000. 24:88-91. PMID:10615135. http://dx.doi.org/10.1038/71750.
    • (2000) Nat Genet , vol.24 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3    Hughes-Davies, L.4    Kouzarides, T.5
  • 38
    • 0035873225 scopus 로고    scopus 로고
    • Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
    • PMID:11350943
    • Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 2001. 20:2536-2544. PMID:11350943. http://dx.doi.org/10.1093/emboj/20.10.2536.
    • (2001) EMBO J , vol.20 , pp. 2536-2544
    • Fuks, F.1    Burgers, W.A.2    Godin, N.3    Kasai, M.4    Kouzarides, T.5
  • 39
    • 0038412822 scopus 로고    scopus 로고
    • The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
    • PMID:12711675
    • Fuks F, Hurd PJ, Deplus R, Kouzarides T. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res 2003. 31:2305-2312. PMID:12711675. http://dx.doi.org/10.1093/nar/gkg332.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2305-2312
    • Fuks, F.1    Hurd, P.J.2    Deplus, R.3    Kouzarides, T.4
  • 40
    • 2142653519 scopus 로고    scopus 로고
    • DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
    • PMID:15120635
    • Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD. DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun 2004. 318:544-555. PMID:15120635. http://dx.doi.org/10.1016/j.bbrc.2004.04.058.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 544-555
    • Geiman, T.M.1    Sankpal, U.T.2    Robertson, A.K.3    Zhao, Y.4    Zhao, Y.5    Robertson, K.D.6
  • 41
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    • PMID:10888872
    • Rountree MR, Bachman KE, Baylin SB. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 2000. 25:269-277. PMID:10888872. http://dx.doi.org/10.1038/77023.
    • (2000) Nat Genet , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 42
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • PMID:10888886
    • Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 2000. 25:338-342. PMID:10888886. http://dx.doi.org/10.1038/77124.
    • (2000) Nat Genet , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 43
    • 15044362537 scopus 로고    scopus 로고
    • Epigenetic mechanism of rRNA gene silencing: Temporal order of NoRCmediated histone modification, chromatin remodeling and DNA methylation
    • PMID:15767661
    • Santoro R, Grummt I. Epigenetic mechanism of rRNA gene silencing: temporal order of NoRCmediated histone modification, chromatin remodeling and DNA methylation. Mol Cell Biol 2005. 25:2539-2546. PMID:15767661. http://dx.doi.org/10.1128/MCB.25.7.2539-46.2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 2539-2546
    • Santoro, R.1    Grummt, I.2
  • 44
    • 0036844024 scopus 로고    scopus 로고
    • The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
    • PMID:12368916
    • Santoro R, Li J, Grummt I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet 2002. 32:393-396. PMID:12368916. http://dx.doi.org/10.1038/ng1010.
    • (2002) Nat Genet , vol.32 , pp. 393-396
    • Santoro, R.1    Li, J.2    Grummt, I.3
  • 45
    • 73449105432 scopus 로고    scopus 로고
    • Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8
    • PMID:19434510
    • Wang CM, Tsai SN, Yew TW, Kwan YW, Ngai SM. Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8. Biogerontology 2010. 11:87-102. PMID:19434510. http://dx.doi.org/10.1007/s10522-009-9231-5.
    • (2010) Biogerontology , vol.11 , pp. 87-102
    • Wang, C.M.1    Tsai, S.N.2    Yew, T.W.3    Kwan, Y.W.4    Ngai, S.M.5
  • 46
    • 0037131426 scopus 로고    scopus 로고
    • Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
    • PMID:12154089
    • Sarg B, Koutzamani E, Helliger W, Rundquist I, Lindner HH. Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J Biol Chem 2002. 277:39195-201.PMID:12154089. http://dx.doi.org/10.1074/jbc.M205166200.
    • (2002) J Biol Chem , vol.277 , pp. 39195-39201
    • Sarg, B.1    Koutzamani, E.2    Helliger, W.3    Rundquist, I.4    Lindner, H.H.5
  • 47
    • 66249109644 scopus 로고    scopus 로고
    • Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence
    • PMID:19462008
    • Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M. Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS One 2009. 4:5622. PMID:19462008. http://dx.doi.org/10.1371/journal.pone.0005622.
    • (2009) PLoS One , vol.4 , pp. 5622
    • Agherbi, H.1    Gaussmann-Wenger, A.2    Verthuy, C.3    Chasson, L.4    Serrano, M.5    Djabali, M.6
  • 48
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: The epigenetic language
    • PMID:17460165
    • Fraga MF, Agrelo R, Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann NY Acad Sci 2007. 1100:60-74. PMID:17460165. http://dx.doi.org/10.1196/annals.1395.005.
    • (2007) Ann NY Acad Sci , vol.1100 , pp. 60-74
    • Fraga, M.F.1    Agrelo, R.2    Esteller, M.3
  • 49
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: The targets and the marks
    • PMID:17559965
    • Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 2007. 23:413-418. PMID:17559965. http://dx.doi.org/10.1016/j.tig.2007.05.008.
    • (2007) Trends Genet , vol.23 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 50
    • 77953944814 scopus 로고    scopus 로고
    • Chromatin modifications: The driving force of senescence and aging?
    • PMID:20157508
    • Dimauro T, David G. Chromatin modifications: the driving force of senescence and aging? Aging (Albany NY) 2009. 1:182-190. PMID:20157508.
    • (2009) Aging (Albany NY) , vol.1 , pp. 182-190
    • Dimauro, T.1    David, G.2
  • 51
    • 66149094692 scopus 로고    scopus 로고
    • Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
    • PMID:19211682
    • Demontis F, Perrimon N. Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development 2009. 136:983-993. PMID:19211682. http://dx.doi.org/10.1242/dev.027466.
    • (2009) Development , vol.136 , pp. 983-993
    • Demontis, F.1    Perrimon, N.2
  • 52
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • PMID:18311132
    • Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol 2008. 10:452-459. PMID:18311132. http://dx.doi.org/10.1038/ncb1708.
    • (2008) Nat Cell Biol , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 53
    • 33748308794 scopus 로고    scopus 로고
    • JAK signaling globally counteracts heterochromatic gene silencing
    • PMID:16892059
    • Shi S, Calhoun HC, Xia F, Li J, Le L, Li WX. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet 2006. 38:1071-1076. PMID:16892059. http://dx.doi.org/10.1038/ng1860.
    • (2006) Nat Genet , vol.38 , pp. 1071-1076
    • Shi, S.1    Calhoun, H.C.2    Xia, F.3    Li, J.4    Le, L.5    Li, W.X.6
  • 54
    • 54049101441 scopus 로고    scopus 로고
    • Canonical and non-canonical JAK-STAT signaling
    • PMID:18848449
    • Li WX. Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol 2008. 18:545-551. PMID:18848449. http://dx.doi.org/10.1016/j.tcb.2008.08.008.
    • (2008) Trends Cell Biol , vol.18 , pp. 545-551
    • Li, W.X.1
  • 55
    • 44649178270 scopus 로고    scopus 로고
    • Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation
    • PMID:18549798
    • Shi M, Lin TH, Appell KC, Berg LJ. Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. Immunity 2008. 28:763-773. PMID:18549798. http://dx.doi.org/10.1016/j.immuni.2008.04.016.
    • (2008) Immunity , vol.28 , pp. 763-773
    • Shi, M.1    Lin, T.H.2    Appell, K.C.3    Berg, L.J.4
  • 56
    • 33845866637 scopus 로고    scopus 로고
    • H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability
    • PMID:17159999
    • Peng JC, Karpen GH. H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol 2007. 9:25-35. PMID:17159999. http://dx.doi.org/10.1038/ncb1514.
    • (2007) Nat Cell Biol , vol.9 , pp. 25-35
    • Peng, J.C.1    Karpen, G.H.2
  • 57
    • 63449109369 scopus 로고    scopus 로고
    • Heterochromatic genome stability requires regulators of histone H3 K9 methylation
    • PMID:19325889
    • Peng JC, Karpen GH. Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet 2009. 5:1000435. PMID:19325889. http://dx.doi.org/10.1371/journal.pgen.1000435.
    • (2009) PLoS Genet , vol.5 , pp. 1000435
    • Peng, J.C.1    Karpen, G.H.2
  • 58
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • PMID:15189148
    • Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004. 73:417-435. PMID:15189148. http://dx.doi.org/10.1146/annurev.biochem.73.011303.073651.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 59
    • 0030916153 scopus 로고    scopus 로고
    • Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
    • PMID:9150138
    • Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, et al. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 1997. 89:381-391. PMID:9150138. http://dx.doi.org/10.1016/S0092-8674(00)80219-6.
    • (1997) Cell , vol.89 , pp. 381-391
    • Kennedy, B.K.1    Gotta, M.2    Sinclair, D.A.3    Mills, K.4    McNabb, D.S.5    Murthy, M.6
  • 60
    • 0031459980 scopus 로고    scopus 로고
    • Extrachromosomal rDNA circles-a cause of aging in yeast
    • PMID:9428525
    • Sinclair DA, Guarente L. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 1997. 91:1033-1042. PMID:9428525. http://dx.doi.org/10.1016/S0092-8674(00)80493-6.
    • (1997) Cell , vol.91 , pp. 1033-1042
    • Sinclair, D.A.1    Guarente, L.2
  • 61
    • 0030820491 scopus 로고    scopus 로고
    • Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
    • PMID:9271578
    • Sinclair DA, Mills K, Guarente L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 1997. 277:1313-1316. PMID:9271578. http://dx.doi.org/10.1126/science.277.5330.1313.
    • (1997) Science , vol.277 , pp. 1313-1316
    • Sinclair, D.A.1    Mills, K.2    Guarente, L.3
  • 62
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • PMID:10521401
    • Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999. 13:2570-2580. PMID:10521401. http://dx.doi.org/10.1101/gad.13.19.2570.
    • (1999) Genes Dev , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 63
    • 34548150187 scopus 로고    scopus 로고
    • The role of nuclear architecture in genomic instability and ageing
    • PMID:17700626
    • Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol 2007. 8:692-702. PMID:17700626. http://dx.doi.org/10.1038/nrm2238.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 692-702
    • Oberdoerffer, P.1    Sinclair, D.A.2
  • 64
    • 33746228121 scopus 로고    scopus 로고
    • Sirtuins in aging and age-related disease
    • PMID:16873059
    • Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006. 126:257-68. PMID:16873059. http://dx.doi.org/10.1016/j.cell.2006.07.002.2005.03.019.
    • (2006) Cell , vol.126 , pp. 257-268
    • Longo, V.D.1    Kennedy, B.K.2
  • 65
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins- emerging roles in physiology, aging and calorie restriction
    • PMID:17079682
    • Haigis MC, Guarente LP. Mammalian sirtuins- emerging roles in physiology, aging and calorie restriction. Genes Dev 2006. 20:2913-21. PMID:17079682. http://dx.doi.org/10.1101/gad.1467506.
    • (2006) Genes Dev , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 66
    • 33748331132 scopus 로고    scopus 로고
    • Progressive loss of SIRT1 with cell cycle withdrawal
    • PMID:16939484
    • Sasaki T, Maier B, Bartke A, Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 2006. 5:413-5422. PMID:16939484. http://dx.doi.org/10.1111/j.1474-9726.2006.00235.x.
    • (2006) Aging Cell , vol.5 , pp. 413-5422
    • Sasaki, T.1    Maier, B.2    Bartke, A.3    Scrable, H.4
  • 67
    • 33748948208 scopus 로고    scopus 로고
    • DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
    • PMID:16940753
    • Sommer M, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA, et al. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 2006. 5:2005-2011. PMID:16940753. http://dx.doi.org/10.4161/cc.5.17.3194.
    • (2006) Cell Cycle , vol.5 , pp. 2005-2011
    • Sommer, M.1    Poliak, N.2    Upadhyay, S.3    Ratovitski, E.4    Nelkin, B.D.5    Donehower, L.A.6
  • 68
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • PMID:11242085
    • Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001. 410:227-230. PMID:11242085. http://dx.doi.org/10.1038/35065638.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 69
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • PMID:15254550
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004. 430:686-689. PMID:15254550. http://dx.doi.org/10.1038/nature02789.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 70
    • 8644224064 scopus 로고    scopus 로고
    • Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    • PMID:15520384
    • Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 2004. 101:15998-16003. PMID:15520384. http://dx.doi.org/10.1073/pnas.0404184101.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15998-16003
    • Rogina, B.1    Helfand, S.L.2
  • 71
    • 80053168829 scopus 로고    scopus 로고
    • Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    • PMID:21938067
    • Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011. 477:482-485. PMID:21938067. http://dx.doi.org/10.1038/nature10296.
    • (2011) Nature , vol.477 , pp. 482-485
    • Burnett, C.1    Valentini, S.2    Cabreiro, F.3    Goss, M.4    Somogyvári, M.5    Piper, M.D.6
  • 72
    • 0141480988 scopus 로고    scopus 로고
    • Ageing: A toast to long life
    • PMID:12968159
    • Finkel T. Ageing: a toast to long life. Nature 2003. 425:132-133. PMID:12968159. http://dx.doi.org/10.1038/425132a.
    • (2003) Nature , vol.425 , pp. 132-133
    • Finkel, T.1
  • 73
    • 27744511769 scopus 로고    scopus 로고
    • Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    • PMID:16293764
    • Kaeberlein M, Powers RW, 3rd, Steffen KK, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005. 310:1193-1196. PMID:16293764. http://dx.doi.org/10.1126/science.1115535.
    • (2005) Science , vol.310 , pp. 1193-1196
    • Kaeberlein, M.1    Powers, R.W.2    Steffen, K.K.3    Westman, E.A.4    Hu, D.5    Dang, N.6
  • 74
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • PMID:15374670
    • Barja G. Free radicals and aging. Trends Neurosci 2004. 27:595-600. PMID:15374670. http://dx.doi.org/10.1016/j.tins.2004.07.005.
    • (2004) Trends Neurosci , vol.27 , pp. 595-600
    • Barja, G.1
  • 75
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction and aging
    • PMID:8658196
    • Sohal RS, Weindruch R. Oxidative stress, caloric restriction and aging. Science 1996. 273:59-63. PMID:8658196. http://dx.doi.org/10.1126/science.273.5271.59.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 76
    • 0037130175 scopus 로고    scopus 로고
    • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    • PMID:12124627
    • Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002. 418:344-348. PMID:12124627. http://dx.doi.org/10.1038/nature00829.
    • (2002) Nature , vol.418 , pp. 344-348
    • Lin, S.J.1    Kaeberlein, M.2    Andalis, A.A.3    Sturtz, L.A.4    Defossez, P.A.5    Culotta, V.C.6
  • 77
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • PMID:12939617
    • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003. 425:191-196. PMID:12939617. http://dx.doi.org/10.1038/nature01960.
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 78
    • 13944253348 scopus 로고    scopus 로고
    • Calorie restriction- the SIR2 connection
    • PMID:15734680
    • Guarente L, Picard F. Calorie restriction- the SIR2 connection. Cell 2005. 120:473-482. PMID:15734680. http://dx.doi.org/10.1016/j.cell.2005.01.029.
    • (2005) Cell , vol.120 , pp. 473-482
    • Guarente, L.1    Picard, F.2
  • 79
    • 0038329323 scopus 로고    scopus 로고
    • Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
    • PMID:12736687
    • Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 2003. 423:181-185. PMID:12736687. http://dx.doi.org/10.1038/nature01578.
    • (2003) Nature , vol.423 , pp. 181-185
    • Anderson, R.M.1    Bitterman, K.J.2    Wood, J.G.3    Medvedik, O.4    Sinclair, D.A.5
  • 80
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • PMID:10693811
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000. 403:795-800. PMID:10693811. http://dx.doi.org/10.1038/35001622.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 81
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • PMID:11000115
    • Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000. 289:2126-2128. PMID:11000115. http://dx.doi.org/10.1126/science.289.5487.2126.
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1    Defossez, P.A.2    Guarente, L.3
  • 82
    • 24944559665 scopus 로고    scopus 로고
    • HST2 mediates SIR2-independent life-span extension by calorie restriction
    • PMID:16051752
    • Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, et al. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 2005. 309:1861-1864. PMID:16051752. http://dx.doi.org/10.1126/science.1113611.
    • (2005) Science , vol.309 , pp. 1861-1864
    • Lamming, D.W.1    Latorre-Esteves, M.2    Medvedik, O.3    Wong, S.N.4    Tsang, F.A.5    Wang, C.6
  • 83
    • 74049161289 scopus 로고    scopus 로고
    • Calorie restriction reduces rDNA recombination independently of rDNA silencing
    • PMID:19732046
    • Riesen M, Morgan A. Calorie restriction reduces rDNA recombination independently of rDNA silencing. Aging Cell 2009. 8:624-632. PMID:19732046. http://dx.doi.org/10.1111/j.1474-9726.2009.00514.x.
    • (2009) Aging Cell , vol.8 , pp. 624-632
    • Riesen, M.1    Morgan, A.2
  • 84
    • 33745131114 scopus 로고    scopus 로고
    • Comment on HST2 mediates SIR2-independent life-span extension by calorie restriction
    • PMID:16741098
    • Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, et al. Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science 2006. 312:1312. PMID:16741098. http://dx.doi.org/10.1126/science.1124608.
    • (2006) Science , vol.312 , pp. 1312
    • Kaeberlein, M.1    Steffen, K.K.2    Hu, D.3    Dang, N.4    Kerr, E.O.5    Tsuchiya, M.6
  • 85
    • 19344374925 scopus 로고    scopus 로고
    • Sir2-independent life span extension by calorie restriction in yeast
    • PMID:15328540
    • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2004. 2:296. PMID:15328540. http://dx.doi.org/10.1371/journal.pbio.0020296.
    • (2004) PLoS Biol , vol.2 , pp. 296
    • Kaeberlein, M.1    Kirkland, K.T.2    Fields, S.3    Kennedy, B.K.4
  • 86
    • 43049169926 scopus 로고    scopus 로고
    • Epigenetic control of rDNA loci in response to intracellular energy status
    • PMID:18485871
    • Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, et al. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 2008. 133:627-639. PMID:18485871. http://dx.doi.org/10.1016/j.cell.2008.03.030.
    • (2008) Cell , vol.133 , pp. 627-639
    • Murayama, A.1    Ohmori, K.2    Fujimura, A.3    Minami, H.4    Yasuzawa-Tanaka, K.5    Kuroda, T.6
  • 87
    • 79952083769 scopus 로고    scopus 로고
    • P16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms
    • PMID:21390332
    • Li Y, Tollefsbol TO. p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms. PLoS One 2011. 6:17421. PMID:21390332. http://dx.doi.org/10.1371/journal.pone.0017421.
    • (2011) PLoS One , vol.6 , pp. 17421
    • Li, Y.1    Tollefsbol, T.O.2
  • 88
    • 33645768490 scopus 로고    scopus 로고
    • Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
    • PMID:16596166
    • Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2006. 2:40. PMID:16596166. http://dx.doi.org/10.1371/journal.pgen.0020040.
    • (2006) PLoS Genet , vol.2 , pp. 40
    • Pruitt, K.1    Zinn, R.L.2    Ohm, J.E.3    McGarvey, K.M.4    Kang, S.H.5    Watkins, D.N.6
  • 89
    • 69249235740 scopus 로고    scopus 로고
    • Calorie restriction and the exercise of chromatin
    • PMID:19608767
    • Vaquero A, Reinberg D. Calorie restriction and the exercise of chromatin. Genes Dev 2009. 23:1849-1869. PMID:19608767. http://dx.doi.org/10.1101/gad.1807009.
    • (2009) Genes Dev , vol.23 , pp. 1849-1869
    • Vaquero, A.1    Reinberg, D.2
  • 90
    • 83255186739 scopus 로고    scopus 로고
    • SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
    • PMID:21947282
    • Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, et al. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol 2011. 31:4720-4734. PMID:21947282. http://dx.doi.org/10.1128/MCB.06147-11.
    • (2011) Mol Cell Biol , vol.31 , pp. 4720-4734
    • Peng, L.1    Yuan, Z.2    Ling, H.3    Fukasawa, K.4    Robertson, K.5    Olashaw, N.6
  • 91
    • 77952305618 scopus 로고    scopus 로고
    • Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
    • PMID:20019239
    • Li Y, Liu L, Tollefsbol TO. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J 2010. 24:1442-1453.PMID:20019239. http://dx.doi.org/10.1096/fj.09-149328.
    • (2010) FASEB J , vol.24 , pp. 1442-1453
    • Li, Y.1    Liu, L.2    Tollefsbol, T.O.3
  • 92
    • 0027745794 scopus 로고
    • Effects of caloric restriction in animals on cellular function, oncogene expression and DNA methylation in vitro
    • PMID:7507563
    • Hass BS, Hart RW, Lu MH, Lyn-Cook BD. Effects of caloric restriction in animals on cellular function, oncogene expression and DNA methylation in vitro. Mutat Res 1993. 295:281-289. PMID:7507563.
    • (1993) Mutat Res , vol.295 , pp. 281-289
    • Hass, B.S.1    Hart, R.W.2    Lu, M.H.3    Lyn-Cook, B.D.4
  • 93
    • 78650273646 scopus 로고    scopus 로고
    • Epigenetic control of aging
    • PMID:20518699
    • Muñoz-Najar U, Sedivy JM. Epigenetic control of aging. Antioxid Redox Signal 2011. 14:241-259. PMID:20518699. http://dx.doi.org/10.1089/ars.2010.3250.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 241-259
    • Muñoz-Najar, U.1    Sedivy, J.M.2
  • 94
    • 79954838543 scopus 로고    scopus 로고
    • Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
    • PMID:21172419
    • Chouliaras L, van den Hove DL, Kenis G, Dela Cruz J, Lemmens MA, van Os J, et al. Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus. Brain Behav Immun 2011. 25:616-623. PMID:21172419. http://dx.doi.org/10.1016/j.bbi.2010.11.016.
    • (2011) Brain Behav Immun , vol.25 , pp. 616-623
    • Chouliaras, L.1    van den Hove, D.L.2    Kenis, G.3    Dela, C.J.4    Lemmens, M.A.5    van Os, J.6
  • 95
    • 22744450382 scopus 로고    scopus 로고
    • Toward a unified theory of caloric restriction and longevity regulation
    • PMID:15893363
    • Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mech Ageing Dev 2005. 126:987-1002. PMID:15893363. http://dx.doi.org/10.1016/j.mad.2005.03.019.
    • (2005) Mech Ageing Dev , vol.126 , pp. 987-1002
    • Sinclair, D.A.1
  • 96
    • 33847647624 scopus 로고    scopus 로고
    • SIRT1 promotes DNA repair activity and deacetylation of Ku70
    • PMID:17334224
    • Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, et al. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med 2007. 39:8-13. PMID:17334224.
    • (2007) Exp Mol Med , vol.39 , pp. 8-13
    • Jeong, J.1    Juhn, K.2    Lee, H.3    Kim, S.H.4    Min, B.H.5    Lee, K.M.6
  • 97
    • 12144286529 scopus 로고    scopus 로고
    • Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
    • PMID:15023334
    • Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, et al. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 2004. 13:627-638. PMID:15023334. http://dx.doi.org/10.1016/S1097-2765(04)00094-2.
    • (2004) Mol Cell , vol.13 , pp. 627-638
    • Cohen, H.Y.1    Lavu, S.2    Bitterman, K.J.3    Hekking, B.4    Imahiyerobo, T.A.5    Miller, C.6
  • 98
    • 34447646492 scopus 로고    scopus 로고
    • Longevity determined by developmental arrest genes in Caenorhabditis elegans
    • PMID:17521386
    • Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 2007. 6:525-533. PMID:17521386. http://dx.doi.org/10.1111/j.1474-9726.2007.00305.x.
    • (2007) Aging Cell , vol.6 , pp. 525-533
    • Chen, D.1    Pan, K.Z.2    Palter, J.E.3    Kapahi, P.4
  • 99
    • 34247140294 scopus 로고    scopus 로고
    • Role of insulin-like signalling in Drosophila lifespan
    • PMID:17412594
    • Giannakou ME, Partridge L. Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci 2007. 32:180-188. PMID:17412594. http://dx.doi.org/10.1016/j.tibs.2007.02.007.
    • (2007) Trends Biochem Sci , vol.32 , pp. 180-188
    • Giannakou, M.E.1    Partridge, L.2
  • 100
    • 78650352864 scopus 로고    scopus 로고
    • Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
    • PMID:21150328
    • Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal. Cell Cycle 2010. 9:4788-4794. PMID:21150328. http://dx.doi.org/10.4161/cc.9.24.14360.
    • (2010) Cell Cycle , vol.9 , pp. 4788-4794
    • Blagosklonny, M.V.1
  • 101
    • 43049180299 scopus 로고    scopus 로고
    • Ageing and the regulation of protein synthesis: A balancing act?
    • PMID:18346894
    • Tavernarakis N. Ageing and the regulation of protein synthesis: a balancing act? Trends Cell Biol 2008. 18:228-235. PMID:18346894. http://dx.doi.org/10.1016/j.tcb.2008.02.004.
    • (2008) Trends Cell Biol , vol.18 , pp. 228-235
    • Tavernarakis, N.1
  • 102
    • 77954855717 scopus 로고    scopus 로고
    • The role of insulin/IGFlike signaling in C. elegans longevity and aging
    • PMID:20354111
    • Kaletsky R, Murphy CT. The role of insulin/IGFlike signaling in C. elegans longevity and aging. Dis Model Mech 2010. 3:415-419. PMID:20354111. http://dx.doi.org/10.1242/dmm.001040.
    • (2010) Dis Model Mech , vol.3 , pp. 415-419
    • Kaletsky, R.1    Murphy, C.T.2
  • 103
    • 0242362732 scopus 로고    scopus 로고
    • JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
    • PMID:14602080
    • Wang MC, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 2003. 5:811-816. PMID:14602080. http://dx.doi.org/10.1016/S1534-5807(03)00323-X.
    • (2003) Dev Cell , vol.5 , pp. 811-816
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 104
    • 0035989388 scopus 로고    scopus 로고
    • Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster
    • PMID:12072463
    • Sun J, Folk D, Bradley TJ, Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 2002. 161:661-672. PMID:12072463.
    • (2002) Genetics , vol.161 , pp. 661-672
    • Sun, J.1    Folk, D.2    Bradley, T.J.3    Tower, J.4
  • 105
    • 2342548187 scopus 로고    scopus 로고
    • Effects of simultaneous overexpression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span
    • PMID:15130751
    • Sun J, Molitor J, Tower J. Effects of simultaneous overexpression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech Ageing Dev 2004. 125:341-349. PMID:15130751. http://dx.doi.org/10.1016/j.mad.2004.01.009.
    • (2004) Mech Ageing Dev , vol.125 , pp. 341-349
    • Sun, J.1    Molitor, J.2    Tower, J.3
  • 106
    • 0032908347 scopus 로고    scopus 로고
    • FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
    • PMID:9858546
    • Sun J, Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 1999. 19:216-228. PMID:9858546.
    • (1999) Mol Cell Biol , vol.19 , pp. 216-228
    • Sun, J.1    Tower, J.2
  • 107
    • 0037466652 scopus 로고    scopus 로고
    • DAF-16 target genes that control C. elegans lifespan and metabolism
    • PMID:12690206
    • Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans lifespan and metabolism. Science 2003. 300:644-647. PMID:12690206. http://dx.doi.org/10.1126/science.1083614.
    • (2003) Science , vol.300 , pp. 644-647
    • Lee, S.S.1    Kennedy, S.2    Tolonen, A.C.3    Ruvkun, G.4
  • 108
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • PMID:12845331
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003. 424:277-283. PMID:12845331. http://dx.doi.org/10.1038/nature01789.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5    Ahringer, J.6
  • 109
    • 0041507039 scopus 로고    scopus 로고
    • Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
    • PMID:12882326
    • Walker GA, Lithgow GJ. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2003. 2:131-139. PMID:12882326. http://dx.doi.org/10.1046/j.1474-9728.2003.00045.x.
    • (2003) Aging Cell , vol.2 , pp. 131-139
    • Walker, G.A.1    Lithgow, G.J.2
  • 110
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • PMID:13332224
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956. 11:298-300. PMID:13332224.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 111
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • PMID:11089981
    • Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000. 408:239-247. PMID:11089981. http://dx.doi.org/10.1038/35041687.
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 113
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • PMID:15190254
    • Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, et al. Gene regulation and DNA damage in the ageing human brain. Nature 2004. 429:883-891. PMID:15190254. http://dx.doi.org/10.1038/nature02661.
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.Y.3    Li, C.4    Kohane, I.5    Chan, J.6
  • 114
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • PMID:14679299
    • Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003. 16:29-37.PMID:14679299. http://dx.doi.org/10.1152/physiolgenomics.00122.2003.
    • (2003) Physiol Genomics , vol.16 , pp. 29-37
    • van Remmen, H.1    Ikeno, Y.2    Hamilton, M.3    Pahlavani, M.4    Wolf, N.5    Thorpe, S.R.6
  • 115
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • PMID:12540856
    • Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 2003. 421:643-648. PMID:12540856. http://dx.doi.org/10.1038/nature01385.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6
  • 116
    • 68149161607 scopus 로고    scopus 로고
    • A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    • PMID:19620979
    • Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, et al. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 2009. 41:891-898. PMID:19620979. http://dx.doi.org/10.1038/ng.420.
    • (2009) Nat Genet , vol.41 , pp. 891-898
    • Murga, M.1    Bunting, S.2    Montaña, M.F.3    Soria, R.4    Mulero, F.5    Cañamero, M.6
  • 117
    • 68149180793 scopus 로고    scopus 로고
    • Life can be stressful without ATR
    • PMID:19639025
    • O'Driscoll M. Life can be stressful without ATR. Nat Genet 2009. 41:866-868. PMID:19639025. http://dx.doi.org/10.1038/ng0809-866.
    • (2009) Nat Genet , vol.41 , pp. 866-868
    • O'Driscoll, M.1
  • 118
    • 34249885603 scopus 로고    scopus 로고
    • Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
    • PMID:18371340
    • Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 2007. 1:113-126.PMID:18371340. http://dx.doi.org/10.1016/j.stem.2007.03.002.
    • (2007) Cell Stem Cell , vol.1 , pp. 113-126
    • Ruzankina, Y.1    Pinzon-Guzman, C.2    Asare, A.3    Ong, T.4    Pontano, L.5    Cotsarelis, G.6
  • 119
    • 79251540845 scopus 로고    scopus 로고
    • Unphosphorylated STAT and heterochromatin protect genome stability
    • PMID:20847228
    • Yan SJ, Lim SJ, Shi S, Dutta P, Li WX. Unphosphorylated STAT and heterochromatin protect genome stability. FASEB J 2011. 25:232-241. PMID:20847228. http://dx.doi.org/10.1096/fj.10-169367.
    • (2011) FASEB J , vol.25 , pp. 232-241
    • Yan, S.J.1    Lim, S.J.2    Shi, S.3    Dutta, P.4    Li, W.X.5
  • 120
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • PMID:1722017
    • Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res 1991. 256:271-282. PMID:1722017.
    • (1991) Mutat Res , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 121
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • PMID:2342578
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990. 345:458-460. PMID:2342578. http://dx.doi.org/10.1038/345458a0.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 122
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • PMID:15743671
    • Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005. 37:961-976. PMID:15743671. http://dx.doi.org/10.1016/j.biocel.2004.10.013.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 123
    • 28244469090 scopus 로고    scopus 로고
    • Regulation of growth arrest in senescence: Telomere damage is not the end of the story
    • PMID:16229875
    • Herbig U, Sedivy JM. Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev 2006. 127:16-24. PMID:16229875. http://dx.doi.org/10.1016/j.mad.2005.09.002.
    • (2006) Mech Ageing Dev , vol.127 , pp. 16-24
    • Herbig, U.1    Sedivy, J.M.2
  • 124
    • 0030177489 scopus 로고    scopus 로고
    • Telomeres, telomerase and aging: Origin of the theory
    • PMID:9415101
    • Olovnikov AM. Telomeres, telomerase and aging: origin of the theory. Exp Gerontol 1996. 31:443-448. PMID:9415101. http://dx.doi.org/10.1016/0531-5565(96)00005-8.
    • (1996) Exp Gerontol , vol.31 , pp. 443-448
    • Olovnikov, A.M.1
  • 125
    • 0032055730 scopus 로고    scopus 로고
    • Mechanisms of silencing in Saccharomyces cerevisiae
    • PMID:9610415
    • Lustig AJ. Mechanisms of silencing in Saccharomyces cerevisiae. Curr Opin Genet Dev 1998. 8:233-239. PMID:9610415. http://dx.doi.org/10.1016/S0959-437X(98)80146-9.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 233-239
    • Lustig, A.J.1
  • 126
    • 0027443405 scopus 로고
    • Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast
    • PMID:8221892
    • Chien CT, Buck S, Sternglanz R, Shore D. Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell 1993. 75:531-541. PMID:8221892. http://dx.doi.org/10.1016/0092-8674(93)90387-6.
    • (1993) Cell , vol.75 , pp. 531-541
    • Chien, C.T.1    Buck, S.2    Sternglanz, R.3    Shore, D.4
  • 127
    • 0029048189 scopus 로고
    • The carboxy termini of Sir4 and Rap1 affect Sir3 localization: Evidence for a multicomponent complex required for yeast telomeric silencing
    • PMID:7744964
    • Cockell M, Palladino F, Laroche T, Kyrion G, Liu C, Lustig AJ, et al. The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol 1995. 129:909-924. PMID:7744964. http://dx.doi.org/10.1083/jcb.129.4.909.
    • (1995) J Cell Biol , vol.129 , pp. 909-924
    • Cockell, M.1    Palladino, F.2    Laroche, T.3    Kyrion, G.4    Liu, C.5    Lustig, A.J.6
  • 128
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • PMID:9560153
    • Lee HW, Blasco MA, Gottlieb GJ, Horner JW, 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998. 392:569-574. PMID:9560153. http://dx.doi.org/10.1038/33345.
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.W.1    Blasco, M.A.2    Gottlieb, G.J.3    Horner, J.W.4    Greider, C.W.5    Depinho, R.A.6
  • 129
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response and cancer in aging telomerase-deficient mice
    • PMID:10089885
    • Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response and cancer in aging telomerase-deficient mice. Cell 1999. 96:701-712. PMID:10089885. http://dx.doi.org/10.1016/S0092-8674(00)80580-2.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3    Blasco, M.4    Gottlieb, G.J.5    Greider, C.6
  • 130
    • 33846590977 scopus 로고    scopus 로고
    • Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
    • PMID:17237781
    • Benetti R, García-Cao M, Blasco MA. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 2007. 39:243-250. PMID:17237781. http://dx.doi.org/10.1038/ng1952.
    • (2007) Nat Genet , vol.39 , pp. 243-250
    • Benetti, R.1    García-Cao, M.2    Blasco, M.A.3
  • 131
    • 34548827379 scopus 로고    scopus 로고
    • Suv4-20 h deficiency results in telomere elongation and derepression of telomere recombination
    • PMID:17846168
    • Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T, et al. Suv4-20 h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol 2007. 178:925-936. PMID:17846168. http://dx.doi.org/10.1083/jcb.200703081.
    • (2007) J Cell Biol , vol.178 , pp. 925-936
    • Benetti, R.1    Gonzalo, S.2    Jaco, I.3    Schotta, G.4    Klatt, P.5    Jenuwein, T.6
  • 132
    • 33645702660 scopus 로고    scopus 로고
    • DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    • PMID:16565708
    • Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 2006. 8:416-424. PMID:16565708. http://dx.doi.org/10.1038/ncb1386.
    • (2006) Nat Cell Biol , vol.8 , pp. 416-424
    • Gonzalo, S.1    Jaco, I.2    Fraga, M.F.3    Chen, T.4    Li, E.5    Esteller, M.6
  • 133
    • 79851493300 scopus 로고    scopus 로고
    • Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16(ink4a)
    • PMID:21248468
    • Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16(ink4a). Cell Cycle 2011. 10:457-468. PMID:21248468. http://dx.doi.org/10.4161/cc.10.3.14707.
    • (2011) Cell Cycle , vol.10 , pp. 457-468
    • Kosar, M.1    Bartkova, J.2    Hubackova, S.3    Hodny, Z.4    Lukas, J.5    Bartek, J.6
  • 134
    • 23244461708 scopus 로고    scopus 로고
    • Oncogene-induced senescence as an initial barrier in lymphoma development
    • PMID:16079837
    • Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005. 436:660-665. PMID:16079837. http://dx.doi.org/10.1038/nature03841.
    • (2005) Nature , vol.436 , pp. 660-665
    • Braig, M.1    Lee, S.2    Loddenkemper, C.3    Rudolph, C.4    Peters, A.H.5    Schlegelberger, B.6
  • 135
    • 0036829090 scopus 로고    scopus 로고
    • Cancer and aging: A model for the cancer promoting effects of the aging stroma
    • PMID:12200035
    • Krtolica A, Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 2002. 34:1401-1414. PMID:12200035. http://dx.doi.org/10.1016/S1357-2725(02)00053-5.
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 1401-1414
    • Krtolica, A.1    Campisi, J.2
  • 136
  • 137
    • 1542781658 scopus 로고    scopus 로고
    • Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
    • PMID:14702099
    • Pelicci PG. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J Clin Invest 2004. 113:4-7. PMID:14702099.
    • (2004) J Clin Invest , vol.113 , pp. 4-7
    • Pelicci, P.G.1

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.