The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

Nucleic Acids Research

Volumn 31, Issue 9, 2003, Pages 2305-2312

  Fuks, François ^a,b   Hurd, Paul J ^a   Deplus, Rachel ^b   Kouzarides, Tony ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CELL EXTRACT; DNA METHYLTRANSFERASE; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; METHYL CPG BINDING PROTEIN 2; CARRIER PROTEIN; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; GLUTATHIONE TRANSFERASE; HETEROCHROMATIN SPECIFIC NONHISTONE CHROMOSOMAL PROTEIN HP 1; HETEROCHROMATIN-SPECIFIC NONHISTONE CHROMOSOMAL PROTEIN HP-1; HISTONE; HYBRID PROTEIN; MALTOSE BINDING PROTEIN; MALTOSE-BINDING PROTEIN; METHYLTRANSFERASE; NONHISTONE PROTEIN; REPRESSOR PROTEIN; SUV39H1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DATA ANALYSIS; DNA METHYLATION; DNA PURIFICATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MODIFICATION; ENZYME REPRESSION; ENZYME SPECIFICITY; GENE SILENCING; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; CELL LINE; GENETICS; HELA CELL; METABOLISM; PROTEIN BINDING; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALIA; MAMMALIA;

BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HELA CELLS; HISTONES; HUMANS; LYSINE; METHYLTRANSFERASES; PRECIPITIN TESTS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS;

EID: 0038412822     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg332     Document Type: Article

References (28)

1. Bird,A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev., 16, 6-21.
2. Bestor,T.H. (2000) The DNA methyltransferases of mammals. Hum. Mol. Genet., 9, 2395-2402.
3. Li,E., Bestor,T.H. and Jaenisch,R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, 915-926.
4. Okano,M., Bell,D.W., Haber,D.A. and Li,E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247-257.
5. Bird,A.P. and Wolffe,A.P. (1999) Methylation-induced repression - belts, braces and chromatin. Cell, 99, 451-454.
6. Bachman,K.E., Rountree,M.R. and Baylin,S.B. (2001) Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem., 276, 32282-32287.
7. Fuks,F., Burgers,W.A., Brehm,A., Hughes-Davies,L. and Kouzarides,T. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genet., 24, 88-91.
8. Fuks,F., Burgers,W.A., Godin,N., Kasai,M. and Kouzarides,T. (2001) Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J., 20, 2536-2544.
9. Robertson,K.D., Ait-Si-Ali,S., Yokochi,T., Wade,P.A., Jones,P.L. and Wolffe,A.P. (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genet., 25, 338-342.
10. Rountree,M.R., Bachman,K.E. and Baylin,S.B. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genet., 25, 269-277.
11. Tamaru,H. and Selker,E.U. (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature, 414, 277-283.
12. Jackson,J.P., Lindroth,A.M., Cao,X. and Jacobsen,S.E. (2002) Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature, 416, 556-560.
13. Fuks,F., Hurd,P.J., Wolf,D., Nan,X., Bird,A.P. and Kouzarides,T. (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem., 278, 4035-4040.
14. Bannister,A.J., Zegerman,P., Partridge,J.F., Miska,E.A., Thomas,J.O., Allshire,R.C. and Kouzarides,T. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature, 410, 120-124.
15. Nielsen,S.J., Schneider,R., Bauer,U.M., Bannister,A.J., Morrison,A., O'Carroll,D., Firestein,R., Cleary,M., Jenuwein,T., Herrera,R.E. and Kouzarides,T. (2001) Rb targets histone H3 methylation and HP1 to promoters. Nature, 412, 561-565.
16. Fatemi,M., Hermann,A., Pradhan,S. and Jeltsch,A. (2001) The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J. Mol. Biol., 309, 1189-1199.
17. Deplus,R., Brenner,C., Burgers,W.A., Putmans,P., Kouzarides,T., de Launoit,Y. and Fuks F. (2002) Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res., 30, 3831-3838.
18. Bannister,A.J. and Kouzarides,T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
19. Kouzarides,T. (2002) Histone methylation in transcriptional control. Curr. Opin. Genet. Dev., 12, 198-209.
20. Aagaard,L., Schmid,M., Warburton,P. and Jenuwein,T. (2000) Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. J. Cell Sci., 113, 817-829.
21. Peters,A.H., O'Carroll,D., Scherthan,H., Mechtler,K., Sauer,S., Schofer,C., Weipoltshammer,K., Pagani,M., Lachner,M., Kohlmaier,A., Opravil,S., Doyle,M., Sibilia,M. and Jenuwein,T. (2001) Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell, 107, 323-337.
22. Aagaard,L., Laible,G., Selenko,P., Schmid,M., Dorn,R., Schotta,G., Kuhfittig,S., Wolf,A., Lebersorger,A., Singh,P.B., Reuter,G. and Jenuwein,T. (1999) Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J., 18, 1923-1938.
23. Lachner,M., O'Carroll,D., Rea,S., Mechtler,K. and Jenuwein,T. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature, 410, 116-120.
24. Jeddeloh,J.A., Stokes,T.L. and Richards,E.J. (1999) Maintenance of genomic methylation requires a SWI2/SNF2-like protein. Nature Genet., 22, 94-97.
25. Dennis,K., Fan,T., Geiman,T., Yan,Q. and Muegge,K. (2001) Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev., 15, 2940-2944.
26. Briggs,S.D., Bryk,M., Strahl,B.D., Cheung,W.L., Davie,J.K., Dent,S.Y., Winston,F. and Allis,C.D. (2001) Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev., 15, 3286-3295.
27. Bryk,M., Briggs,S.D., Strahl,B.D., Curcio,M.J., Allis,C.D. and Winston,F. (2002) Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Curr. Biol., 12, 165-170.
28. Jenuwein,T. and Allis,C.D. (2001) Translating the histone code. Science, 293, 1074-1080.