JAK signaling globally counteracts heterochromatic gene silencing

Nature Genetics

Volumn 38, Issue 9, 2006, Pages 1071-1076

  Shi, Song ^a   Calhoun, Healani C ^a   Xia, Fan ^a   Li, Jinghong ^a   Le, Long ^a   Li, Willis X ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCHROMATIN PROTEIN 1; JANUS KINASE; STAT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; EPIGENETICS; FEMALE; GENE DISRUPTION; GENE MUTATION; GENE SILENCING; HEMATOPOIETIC SYSTEM TUMOR; HETEROCHROMATIN; MALE; NONHUMAN; POSITION EFFECT VARIEGATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR MODEL; TUMOR SUPPRESSOR GENE;

ANIMALS; BETA-GALACTOSIDASE; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE SILENCING; HETEROCHROMATIN; IMMUNOHISTOCHEMISTRY; JANUS KINASES; MUTATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER;

EID: 33748308794     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1860     Document Type: Article

References (28)

1. Bromberg, J.F. Activation of STAT proteins and growth control. Bioessays 23, 161-169 (2001).
2. Levy, D.E. & Darnell, J.E., Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3, 651-662 (2002).
3. Yu, H. & Jove, R. The STATs of cancer-new molecular targets come of age. Nat. Rev. Cancer 4, 97-105 (2004).
4. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
5. Hou, X.S., Melnick, M.B. & Perrimon, N. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell 84, 411-419 (1996).
6. Yan, R., Small, S., Desplan, C., Dearolf, C.R. & Darnell, J.E., Jr. Identification of a Stat gene that functions in Drosophila development. Cell 84, 421-430 (1996).
7. Hou, S.X., Zheng, Z., Chen, X. & Perrimon, N. The Jak/STAT pathway in model organisms. Emerging roles in cell movement. Dev. Cell 3, 765-778 (2002).
8. Agaisse, H. & Perrimon, N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol. Rev. 198, 72-82 (2004).
9. Li, J., Xia, F. & Li, W.X. Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev. Cell 5, 787-798 (2003).
10. Hanratty, W.P. & Dearolf, C.R. The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol. Gen. Genet. 238, 33-37 (1993).
11. Harrison, D.A., Binari, R., Nahreini, T.S., Gilman, M. & Perrimon, N. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J. 14, 2857-2865 (1995).
12. Luo, H., Hanratty, W.P. & Dearolf, C.R. An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects. EMBO J. 14, 1412-1420 (1995).
13. Muller, P., Kuttenkeuler, D., Gesellchen, V., Zeidler, M.P. & Boutros, M. Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature 436, 871-875 (2005).
14. Baeg, G.H., Zhou, R. & Perrimon, N. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev. 19, 1861-1870 (2005).
15. Bach, E.A., Vincent, S., Zeidler, M.P. & Perrimon, N. A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics 165, 1149-1166 (2003).
16. Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143-153 (2004).
17. Lund, A.H. & van Lohuizen, M. Epigenetics and cancer. Genes Dev. 18, 2315-2335 (2004).
18. Grewal, S.I. & Moazed, D. Heterochromatin and epigenetic control of gene expression. Science 301, 798-802 (2003).
19. Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl.), 245-254 (2003).
20. Grewal, S.I. & Elgin, S.C. Heterochromatin: new possibilities for the inheritance of structure. Curr. Opin. Genet. Dev. 12, 178-187 (2002).
21. Zinyk, D.L., McGonnigal, B.G. & Dearolf, C.R. Drosophila awdK-pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum-1 haematopoietic oncogene. Nat. Genet. 4, 195-201 (1993).
22. Betz, A., Lampen, N., Martinek, S., Young, M.W. & Darnell, J.E., Jr. A Drosophila PIAS homologue negatively regulates stat92E. Proc. Natl. Acad. Sci. USA 98, 9563-9568 (2001).
23. Badenhorst, P., Voas, M., Rebay, I. & Wu, C. Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 16, 3186-3198 (2002).
24. Lebestky, T., Jung, S.H. & Banerjee, U.A. Serrate-expressing signaling center controls Drosophila hematopoiesis. Genes Dev. 17, 348-353 (2003).
25. Gilbert, M.M., Weaver, B.K., Gergen, J.P. & Reich, N.C. A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation. Mech. Dev. 122, 939-948 (2005).
26. Dorer, D.R. & Henikoff, S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77, 993-1002 (1994).
27. Ronsseray, S., Boivin, A. & Anxolabehere, D. P-Element repression in Drosophila melanogaster by variegating clusters of P-lacZ-white transgenes. Genetics 159, 1631-1642 (2001).
28. Li, Y., Danzer, J.R., Alvarez, P., Belmont, A.S. & Wallrath, L.L. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Development 130, 1817-1824 (2003).