-
1
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman D, (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
2
-
-
0031916984
-
The free radical theory of aging matures
-
Beckman KB, Ames BN, (1998) The free radical theory of aging matures. Physiol Rev 78: 547-581.
-
(1998)
Physiol Rev
, vol.78
, pp. 547-581
-
-
Beckman, K.B.1
Ames, B.N.2
-
3
-
-
0030038104
-
Replicative senescence: implications for in vivo aging and tumor suppression
-
Smith JR, Pereira-Smith OM, (1996) Replicative senescence: implications for in vivo aging and tumor suppression. Science 273: 63-67.
-
(1996)
Science
, vol.273
, pp. 63-67
-
-
Smith, J.R.1
Pereira-Smith, O.M.2
-
4
-
-
27144446633
-
The molecular and genetic control of leaf senescence and longevity in Arabidopsis
-
Lim PO, Nam HG, (2005) The molecular and genetic control of leaf senescence and longevity in Arabidopsis. Curr Top Dev Biol 67: 49-83.
-
(2005)
Curr Top Dev Biol
, vol.67
, pp. 49-83
-
-
Lim, P.O.1
Nam, H.G.2
-
5
-
-
0030759780
-
The heterochromatin loss model of aging
-
Villeponteau B, (1997) The heterochromatin loss model of aging. Exp Gerontol 32: 383-394.
-
(1997)
Exp Gerontol
, vol.32
, pp. 383-394
-
-
Villeponteau, B.1
-
6
-
-
0025787643
-
Telomere loss: mitotic clock or genetic time bomb?
-
Harley CB, (1991) Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256: 271-282.
-
(1991)
Mutat Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
7
-
-
13944249618
-
DNA repair, genome stability, and aging
-
Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, et al. (2005) DNA repair, genome stability, and aging. Cell 120: 497-512.
-
(2005)
Cell
, vol.120
, pp. 497-512
-
-
Lombard, D.B.1
Chua, K.F.2
Mostoslavsky, R.3
Franco, S.4
Gostissa, M.5
-
8
-
-
13944269223
-
The plasticity of aging: insights from long-lived mutants
-
Kenyon C, (2005) The plasticity of aging: insights from long-lived mutants. Cell 120: 449-460.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
9
-
-
34247140294
-
Role of insulin-like signalling in Drosophila lifespan
-
Giannakou ME, Partridge L, (2007) Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci 32: 180-188.
-
(2007)
Trends Biochem Sci
, vol.32
, pp. 180-188
-
-
Giannakou, M.E.1
Partridge, L.2
-
10
-
-
50649101095
-
Puzzles, promises and a cure for ageing
-
Vijg J, Campisi J, (2008) Puzzles, promises and a cure for ageing. Nature 454: 1065-1071.
-
(2008)
Nature
, vol.454
, pp. 1065-1071
-
-
Vijg, J.1
Campisi, J.2
-
11
-
-
43049162647
-
Aging by epigenetics-a consequence of chromatin damage?
-
Sedivy JM, Banumathy G, Adams PD, (2008) Aging by epigenetics-a consequence of chromatin damage? Exp Cell Res 314: 1909-1917.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1909-1917
-
-
Sedivy, J.M.1
Banumathy, G.2
Adams, P.D.3
-
12
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M, (2007) Cellular senescence in cancer and aging. Cell 130: 223-233.
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
13
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan JC, Ferreira M, Sedivy JM, Herbig U, (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128: 36-44.
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
14
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM, (2006) Cellular senescence in aging primates. Science 311: 1257.
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
15
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
Scaffidi P, Misteli T, (2006) Lamin A-dependent nuclear defects in human aging. Science 312: 1059-1063.
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
16
-
-
33745016642
-
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
-
Shumaker DK, Dechat T, Kohlmaier A, Adam SA, Bozovsky MR, et al. (2006) Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A 103: 8703-8708.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8703-8708
-
-
Shumaker, D.K.1
Dechat, T.2
Kohlmaier, A.3
Adam, S.A.4
Bozovsky, M.R.5
-
17
-
-
28044460514
-
Age-related changes of nuclear architecture in Caenorhabditis elegans
-
Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, et al. (2005) Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A 102: 16690-16695.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16690-16695
-
-
Haithcock, E.1
Dayani, Y.2
Neufeld, E.3
Zahand, A.J.4
Feinstein, N.5
-
18
-
-
33845755946
-
Heterochromatin revisited
-
Grewal SI, Jia S, (2007) Heterochromatin revisited. Nat Rev Genet 8: 35-46.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 35-46
-
-
Grewal, S.I.1
Jia, S.2
-
19
-
-
79960073028
-
Unphosphorylated STAT and heterochromatin protect genome stability
-
Yan SJ, Lim SJ, Shi S, Dutta P, Li WX, (2010) Unphosphorylated STAT and heterochromatin protect genome stability. FASEB J.
-
(2010)
FASEB J
-
-
Yan, S.J.1
Lim, S.J.2
Shi, S.3
Dutta, P.4
Li, W.X.5
-
20
-
-
33845866637
-
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability
-
Peng JC, Karpen GH, (2007) H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol 9: 25-35.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 25-35
-
-
Peng, J.C.1
Karpen, G.H.2
-
21
-
-
0031459980
-
Extrachromosomal rDNA circles-a cause of aging in yeast
-
Sinclair DA, Guarente L, (1997) Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91: 1033-1042.
-
(1997)
Cell
, vol.91
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
22
-
-
0030820491
-
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
-
Sinclair DA, Mills K, Guarente L, (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277: 1313-1316.
-
(1997)
Science
, vol.277
, pp. 1313-1316
-
-
Sinclair, D.A.1
Mills, K.2
Guarente, L.3
-
23
-
-
0026632337
-
The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
-
Eissenberg JC, Morris GD, Reuter G, Hartnett T, (1992) The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics 131: 345-352.
-
(1992)
Genetics
, vol.131
, pp. 345-352
-
-
Eissenberg, J.C.1
Morris, G.D.2
Reuter, G.3
Hartnett, T.4
-
24
-
-
0036532235
-
Heterochromatin: new possibilities for the inheritance of structure
-
Grewal SI, Elgin SC, (2002) Heterochromatin: new possibilities for the inheritance of structure. Curr Opin Genet Dev 12: 178-187.
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 178-187
-
-
Grewal, S.I.1
Elgin, S.C.2
-
25
-
-
10044244766
-
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
-
Ebert A, Schotta G, Lein S, Kubicek S, Krauss V, et al. (2004) Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev 18: 2973-2983.
-
(2004)
Genes Dev
, vol.18
, pp. 2973-2983
-
-
Ebert, A.1
Schotta, G.2
Lein, S.3
Kubicek, S.4
Krauss, V.5
-
26
-
-
43149084600
-
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
-
Shi S, Larson K, Guo D, Lim SJ, Dutta P, et al. (2008) Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol 10: 489-496.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 489-496
-
-
Shi, S.1
Larson, K.2
Guo, D.3
Lim, S.J.4
Dutta, P.5
-
27
-
-
33748308794
-
JAK signaling globally counteracts heterochromatic gene silencing
-
Shi S, Calhoun HC, Xia F, Li J, Le L, et al. (2006) JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet 38: 1071-1076.
-
(2006)
Nat Genet
, vol.38
, pp. 1071-1076
-
-
Shi, S.1
Calhoun, H.C.2
Xia, F.3
Li, J.4
Le, L.5
-
28
-
-
33746826011
-
JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions
-
Arbouzova NI, Zeidler MP, (2006) JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions. Development 133: 2605-2616.
-
(2006)
Development
, vol.133
, pp. 2605-2616
-
-
Arbouzova, N.I.1
Zeidler, M.P.2
-
29
-
-
0036899655
-
The Jak/STAT pathway in model organisms. Emerging roles in cell movement
-
Hou SX, Zheng Z, Chen X, Perrimon N, (2002) The Jak/STAT pathway in model organisms. Emerging roles in cell movement. Dev Cell 3: 765-778.
-
(2002)
Dev Cell
, vol.3
, pp. 765-778
-
-
Hou, S.X.1
Zheng, Z.2
Chen, X.3
Perrimon, N.4
-
30
-
-
54049101441
-
Canonical and non-canonical JAK-STAT signaling
-
Li WX, (2008) Canonical and non-canonical JAK-STAT signaling. Trends Cell Biol 18: 545-551.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 545-551
-
-
Li, W.X.1
-
31
-
-
23844503747
-
Drosophila longevity is not affected by heterochromatin-mediated gene silencing
-
Frankel S, Rogina B, (2005) Drosophila longevity is not affected by heterochromatin-mediated gene silencing. Aging Cell 4: 53-56.
-
(2005)
Aging Cell
, vol.4
, pp. 53-56
-
-
Frankel, S.1
Rogina, B.2
-
32
-
-
0026554701
-
A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster
-
Sinclair DA, Ruddell AA, Brock JK, Clegg NJ, Lloyd VK, et al. (1992) A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster. Genetics 130: 333-344.
-
(1992)
Genetics
, vol.130
, pp. 333-344
-
-
Sinclair, D.A.1
Ruddell, A.A.2
Brock, J.K.3
Clegg, N.J.4
Lloyd, V.K.5
-
33
-
-
34848905626
-
Evidence for Transgenerational Transmission of Epigenetic Tumor Susceptibility in Drosophila
-
doi:10.1371/journal.pgen.0030151
-
Xing Y, Shi S, Le L, Lee CA, Silver-Morse L, et al. (2007) Evidence for Transgenerational Transmission of Epigenetic Tumor Susceptibility in Drosophila. PLoS Genet 3: e151 doi:10.1371/journal.pgen.0030151.
-
(2007)
PLoS Genet
, vol.3
-
-
Xing, Y.1
Shi, S.2
Le, L.3
Lee, C.A.4
Silver-Morse, L.5
-
34
-
-
34247641746
-
Modifiers of epigenetic reprogramming show paternal effects in the mouse
-
Chong S, Vickaryous N, Ashe A, Zamudio N, Youngson N, et al. (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nat Genet 39: 614-622.
-
(2007)
Nat Genet
, vol.39
, pp. 614-622
-
-
Chong, S.1
Vickaryous, N.2
Ashe, A.3
Zamudio, N.4
Youngson, N.5
-
35
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, et al. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 808-814.
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.A.1
Schmeissner, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
-
36
-
-
66149094692
-
Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
-
Demontis F, Perrimon N, (2009) Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila. Development 136: 983-993.
-
(2009)
Development
, vol.136
, pp. 983-993
-
-
Demontis, F.1
Perrimon, N.2
-
37
-
-
79954626173
-
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
-
Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, et al. (2011) Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 472: 221-225.
-
(2011)
Nature
, vol.472
, pp. 221-225
-
-
Liu, G.H.1
Barkho, B.Z.2
Ruiz, S.3
Diep, D.4
Qu, J.5
-
38
-
-
77956520661
-
Elevated histone expression promotes life span extension
-
Feser J, Truong D, Das C, Carson JJ, Kieft J, et al. (2010) Elevated histone expression promotes life span extension. Molecular cell 39: 724-735.
-
(2010)
Molecular Cell
, vol.39
, pp. 724-735
-
-
Feser, J.1
Truong, D.2
Das, C.3
Carson, J.J.4
Kieft, J.5
-
39
-
-
78049317185
-
Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage
-
Manosalva I, Gonzalez A, (2010) Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage. Theriogenology 74: 1539-1547.
-
(2010)
Theriogenology
, vol.74
, pp. 1539-1547
-
-
Manosalva, I.1
Gonzalez, A.2
-
40
-
-
4444283219
-
cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
-
Sun FL, Haynes K, Simpson CL, Lee SD, Collins L, et al. (2004) cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol 24: 8210-8220.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8210-8220
-
-
Sun, F.L.1
Haynes, K.2
Simpson, C.L.3
Lee, S.D.4
Collins, L.5
-
41
-
-
0028286165
-
Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
-
Dorer DR, Henikoff S, (1994) Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell 77: 993-1002.
-
(1994)
Cell
, vol.77
, pp. 993-1002
-
-
Dorer, D.R.1
Henikoff, S.2
-
42
-
-
53549088060
-
Epigenetic regulation of retrotransposons within the nucleolus of Drosophila
-
Eickbush DG, Ye J, Zhang X, Burke WD, Eickbush TH, (2008) Epigenetic regulation of retrotransposons within the nucleolus of Drosophila. Mol Cell Biol 28: 6452-6461.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6452-6461
-
-
Eickbush, D.G.1
Ye, J.2
Zhang, X.3
Burke, W.D.4
Eickbush, T.H.5
-
43
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang MC, Bohmann D, Jasper H, (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125.
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
44
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, et al. (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
-
45
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, et al. (2007) Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6: 111-119.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
-
46
-
-
34247569105
-
Lifespan regulation by evolutionarily conserved genes essential for viability
-
doi:10.1371/journal.pgen.0030056
-
Curran SP, Ruvkun G, (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3: e56 doi:10.1371/journal.pgen.0030056.
-
(2007)
PLoS Genet
, vol.3
-
-
Curran, S.P.1
Ruvkun, G.2
-
47
-
-
34447646492
-
Longevity determined by developmental arrest genes in Caenorhabditis elegans
-
Chen D, Pan KZ, Palter JE, Kapahi P, (2007) Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell 6: 525-533.
-
(2007)
Aging Cell
, vol.6
, pp. 525-533
-
-
Chen, D.1
Pan, K.Z.2
Palter, J.E.3
Kapahi, P.4
-
48
-
-
43049180299
-
Ageing and the regulation of protein synthesis: a balancing act?
-
Tavernarakis N, (2008) Ageing and the regulation of protein synthesis: a balancing act? Trends Cell Biol 18: 228-235.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 228-235
-
-
Tavernarakis, N.1
-
49
-
-
41949089130
-
Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4
-
Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, et al. (2008) Yeast life span extension by depletion of 60 s ribosomal subunits is mediated by Gcn4. Cell 133: 292-302.
-
(2008)
Cell
, vol.133
, pp. 292-302
-
-
Steffen, K.K.1
MacKay, V.L.2
Kerr, E.O.3
Tsuchiya, M.4
Hu, D.5
-
50
-
-
43049169926
-
Epigenetic control of rDNA loci in response to intracellular energy status
-
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, et al. (2008) Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133: 627-639.
-
(2008)
Cell
, vol.133
, pp. 627-639
-
-
Murayama, A.1
Ohmori, K.2
Fujimura, A.3
Minami, H.4
Yasuzawa-Tanaka, K.5
-
51
-
-
0036499971
-
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing
-
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, et al. (2002) Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. Embo J 21: 1121-1131.
-
(2002)
Embo J
, vol.21
, pp. 1121-1131
-
-
Schotta, G.1
Ebert, A.2
Krauss, V.3
Fischer, A.4
Hoffmann, J.5
-
52
-
-
0037847397
-
Effects of tethering HP1 to euchromatic regions of the Drosophila genome
-
Li Y, Danzer JR, Alvarez P, Belmont AS, Wallrath LL, (2003) Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Development 130: 1817-1824.
-
(2003)
Development
, vol.130
, pp. 1817-1824
-
-
Li, Y.1
Danzer, J.R.2
Alvarez, P.3
Belmont, A.S.4
Wallrath, L.L.5
|