Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 23, 2006, Pages 8703-8708

  Shumaker, Dale K ^a   Dechat, Thomas ^a   Kohlmaier, Alexander ^a,b   Adam, Stephen A ^a   Bozovsky, Matthew R ^a   Erdos, Michael R ^c   Eriksson, Maria ^d   Goldman, Anne E ^a   Khuon, Satya ^a   Collins, Francis S ^c   Jenuwein, Thomas ^b   Goldman, Robert D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Heterochromatin; Histone methylation; Progeria

Indexed keywords

ANTIGEN; CREST ANTIGEN; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1ALPHA; HISTONE H3; HISTONE H3 TRIMETHYLATED ON LYSINE 27; LAMIN A; METHYLTRANSFERASE; METHYLTRANSFERASE EZH2; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CELL STRAIN HEK293; DOWN REGULATION; EPIGENETICS; FEMALE; HETEROCHROMATIN; HUMAN; HUMAN CELL; METHYLATION; PATHOGENESIS; PRIORITY JOURNAL; PROGERIA; PROTEIN EXPRESSION; UPREGULATION; X CHROMOSOME;

AGING, PREMATURE; CELL NUCLEUS; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HELA CELLS; HETEROCHROMATIN; HISTONES; HUMANS; LAMIN TYPE A; MUTATION; PROGERIA; RECOMBINANT FUSION PROTEINS; RNA, UNTRANSLATED; UP-REGULATION;

EID: 33745016642     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0602569103     Document Type: Article

References (34)

1. Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R. & Collins, F. S. (2004) Proc. Natl. Acad. Sci. USA 101, 8963-8968.
2. Hutchinson, J. (1886) Medicochir. Trans. 69, 473-477.
3. Gilford, M. (1904) Practitioner 73, 188-217.
4. Stables, G. I. & Morley, W. N. (1994) J. R. Soc. Med. 87, 243-244.
5. de Sandre-Giovannoli, A., Bernard, R., Cau, P., Navarro, C., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Munnich, A., Le Merrer, M. & Levy, N. (2003) Science 300, 2055.
6. Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al (2003) Nature 423, 293-298.
7. Goldman, R. D., Gruenbaum, Y., Moir, R. D., Shumaker, D. K. & Spann, T. P. (2002) Genes Dev. 16, 533-547.
8. Strelkov, S. V., Schumacher, J., Burkhard, P., Aebi, U. & Herrmann, H. (2004) J. Mol Biol. 343, 1067-1080.
9. Stuurman, N., Heins, S. & Aebi, U. (1998) J. Struct. Biol. 122, 42-66.
10. Shumaker, D. K., Kuczmarski, E. R. & Goldman, R. D. (2003) Curr. Opin. Cell Biol. 15, 358-366.
11. Gruenbaum, Y., Margalit, A., Goldman, R. D., Shumaker, D. K. & Wilson, K. L. (2005) Nat. Rev. Mol. Cell Biol. 6, 21-31.
12. Hegele, R. (2005) Clin. Genet. 68, 31-34.
13. Sarma, K. & Reinberg, D. (2005) Nat. Rev. Mol. Cell Biol. 6, 139-149.
14. Sims, R. J., 3rd, Nishioka, K. & Reinberg, D. (2003) Trends Genet. 19, 629-639.
15. Clemson, C. M., Chow, J. C., Brown, C. J. & Lawrence, J. B. (1998) J. Cell Biol. 142, 13-23.
16. Wutz, A. & Jaenisch, R. (2000) Mol. Cell 5, 695-705.
17. Kohlmaier, A., Savarese, F., Lachner, M., Martens, J., Jenuwein, T. & Wutz, A. (2004) PloS Biol. 2, E171.
18. Capell, B. C., Erdos, M. R., Madigan, J. P., Fiordalisi, J. J., Varga, R., Conneely, K. N., Gordon, L. B., Der, C. J., Cox, A. D. & Collins, F. S. (2005) Proc. Natl. Acad. Sci. USA 102, 12879-12884.
19. Scaffidi, P. & Misteli, T. (2005) Nat. Med. 11, 440-445.
20. Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S. & Zhang, Y. (2002) Science 298, 1039-1043.
21. Peters, A. H., Kubicek, S., Mechtler, K., O'Sullivan, R. J., Derijck, A. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) Mol. Cell 12, 1577-1589.
22. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. (2001) Nature 410, 116-120.
23. Van Hooser, A. A., Mancini, M. A., Allis, C. D., Sullivan, K. F. & Brinkley, B. R. (1999) FASEB J. 13, Suppl. 2, S216-S220.
24. Peters, A. H., O'Carroll, D., Scherthan, H., Mechtler, K., Sauer, S., Schofer, C., Weipoltshammer, K., Pagani, M., Lachner, M., Kohlmaier, A., et al. (2001) Cell 107, 323-337.
25. Rizzi, N., Denegri, M., Chiodi, I., Corioni, M., Valgardsdottir, R., Cobianchi, F., Riva, S. & Biamonti, G. (2004) Mol. Biol. Cell 15, 543-551.
26. Grady, D. L., Ratliff, R. L., Robinson, D. L., McCanlies, E. C., Meyne, J. & Moyzis, R. K. (1992) Proc. Natl. Acad. Sci. USA 89, 1695-1699.
27. Schotta, G., Lachner, M., Sarma, K., Ebert, A., Sengupta, R., Reuter, G., Reinberg, D. & Jenuwein, T. (2004) Genes Dev. 18, 1251-1262.
28. McClintock, D., Gordon, L. B. & Djabali, K. (2006) Proc. Natl. Acad. Sci. USA 103, 2154-2159.
29. Young, S. G., Fong, L. G. & Michaelis, S. (2005) J. Lipid Res. 46, 2531-2558.
30. Rougeulle, C., Chaumeil, J., Sarma, K., Allis, C. D., Reinberg, D., Avner, P. & Heard, E. (2004) Mol. Cell. Biol. 24, 5475-5484.
31. Jolly, C., Metz, A., Govin, J., Vigneron, M., Turner, B. M., Khochbin, S. & Vourc'h, C. (2004) J. Cell Biol. 164, 25-33.
32. Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I. & Lindner, H. H. (2002) J. Biol. Chem. 277, 39195-39201.
33. Laemmli, U. K. (1970) Nature 227, 680-685.
34. Jolly, C., Mongelard, F., Robert-Nicoud, M. & Vourc'h, C. (1997) J. Histochem. Cytochem. 45, 1585-1592.