A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Nature Genetics

Volumn 41, Issue 8, 2009, Pages 891-898

  Murga, Matilde ^a   Bunting, Samuel ^b   Montãa, Maria F ^a   Soria, Rebeca ^a   Mulero, Francisca ^a   Cãamero, Marta ^a   Lee, Youngsoo ^c   McKinnon, Peter J ^c   Nussenzweig, Andre ^b   Fernandez Capetillo, Oscar ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b NATIONAL CANCER INSTITUTE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; DNA; PROTEIN P53;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA REPLICATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME DEFICIENCY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SECKEL SYNDROME; SENESCENCE;

ABNORMALITIES, MULTIPLE; AGING; ALLELES; ANIMALS; APOPTOSIS; BRAIN; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; MICE; NUCLEAR PROTEINS; PHENOTYPE; PROGERIA; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; STRESS, PHYSIOLOGICAL; SYNDROME; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 68149161607     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.420     Document Type: Article

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