The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription

Nature Genetics

Volumn 32, Issue 3, 2002, Pages 393-396

  Santoro, Raffaella ^a   Li, Junwei ^a   Grummt, Ingrid ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; GENE PRODUCT; HISTONE ACETYLTRANSFERASE; PROTEIN NORC; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; GENE SILENCING; GENE STRUCTURE; GENETIC TRANSCRIPTION; HETEROCHROMATIN; IMMUNOPRECIPITATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MODIFICATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

3T3 CELLS; ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL DIVISION; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA; DNA, RIBOSOMAL; GENE SILENCING; HETEROCHROMATIN; HISTONES; MICE; MODELS, GENETIC; PRECIPITIN TESTS; RNA, RIBOSOMAL; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0036844024     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1010     Document Type: Article

References (27)

1. Fyodorov, D.V. & Kadonaga, J.T. The many faces of chromatin remodeling: SWItching beyond transcription. Cell 106, 523-525 (2001).
2. Varga-Weisz, P. ATP-dependent chromatin remodeling factors: Nucleosome shufflers with many missions. Oncogene 20, 3076-3085 (2001).
3. Strohner, R. et al. NoRC - A novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO J. 20, 4892-4900 (2001).
4. Ito, T. et al. ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev. 13, 1529-1539 (1999).
5. LeRoy et al. Requirement of RSF and FACT for transcription of chromatin templates in vitro. Science 282, 1900-1904 (1998).
6. Bochar, D.A. et al. A family of chromatin remodeling factors related to Williams syndrome transcription factor. Proc. Natl Acad. Sci USA 97, 1038-1043 (2000).
7. Poot, R. et al. HuCHRAC, a human ISWI chromatin remodeling complex contains hACF1 and two novel histone-fold proteins. EMBO J. 19, 6141-6149 (2000).
8. Bozhenok, L., Wade, P.A. & Varga-Weisz, P. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J. 21, 2231-2241 (2002).
9. Xiao, H. et al. Dual functions of largest NURF subunit NURF301 in nucleosome sliding and transcription factor interactions. Mol. Cell 8, 531-543 (2001).
10. Conconi, A., Widmer, R.M., Koller, T. & Sogo, J.M. Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle. Cell 57, 753-761 (1989).
11. Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 6, 41-45 (2000).
12. Zhang, Y. & Reinberg, D. Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails. Genes Dev. 15, 2343-2360 (2001).
13. Lachner, M. et al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
14. Santoro, R. & Grummt, J. Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription. Mol. Cell 8, 719-725 (2001).
15. Chen, Z.J. & Pikaard, C.S. Epigenetic silencing of RNA polymerase I transcription: A role for DNA methylation and histone modification in nucleolar dominance. Genes Dev. 11, 2124-2136 (1997).
16. Rice, J.C. & Allis, C.D. Histone methylation versus histone acetylation: New insights into epigenetic regulation. Curr. Opin. Cell Biol. 13, 263-273 (2001).
17. Tamaru, H. & Selker, U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277-282 (2001).
18. Zhou, Y., Santoro, R. & Grummt, I. The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J. 21, 4632-4640 (2002).
19. Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L. & Kouzarides, T. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genet. 24, 88-91 (2000).
20. Robertson, K.D. et al. Dnmtl forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genet. 25, 338-342 (2000).
21. Rountree, M.R., Bachman, K.E. & Baylin, S.B. Dnmt1 binds HDAC2 and a new corepressor, DMAP1, to form a complex at replication foci. Nature Genet. 25, 269-277 (2000).
22. Längst, G., Blank, T.A., Becker, P.B. & Grummt, I. RNA polymerase I transcription on nucleosomal templates: The transcription termination factor TTF-1 induces chromatin remodeling and relieves transcriptional repression. EMBO J. 16, 760-768 (1997).
23. Goodmark, J.P., Fazzio, T.G., Estep, P.W., Church, G.M. & Tsukiyama, T. The Iswi2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell 103, 423-433 (2000).
24. Fazzio, T.G. et al. Widespread collaboration of Isw2 and SIN3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol. Cell. Biol. 21, 6450-6460 (2001).
25. Bozhenok, L., Wade, P.A. & Varga-Weisz, P. WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci. EMBO J. 21, 2231-2241 (2002).
26. Le Douarin, B. et al. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptor, is fused to B-raf in the oncogenic protein. EMBO J. 14, 2020-2033 (1995).
27. Schultz, D.C., Friedman., J.R. & Rauscher, FJ.III. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev. 15, 428-443 (2001).