Lamin A-dependent nuclear defects in human aging

Science

Volumn 312, Issue 5776, 2006, Pages 1059-1063

  Scaffidi, Paola ^a   Misteli, Tom ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DNA; HISTOLOGY; MOLECULAR BIOLOGY; MUTAGENESIS; PROTEINS;

HUTCHINSON GILFORD PROGERIA; NUCLEAR DEFECTS; NUCLEAR STRUCTURAL PROTEIN LAMIN A; PREMATURE AGING SYNDROMES;

HUMAN ENGINEERING;

HISTONE; LAMIN A;

AGING; CELL ORGANELLE; MUTATION; PROTEIN;

AGING; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; GENE MUTATION; HUMAN; HUMAN CELL; PREMATURE AGING; PRIORITY JOURNAL; PROGERIA; PROTEIN MODIFICATION; PROTEIN SYNTHESIS;

AGED, 80 AND OVER; AGING; CELL LINE; CELL NUCLEUS; DNA DAMAGE; EXONS; HISTONES; HUMANS; LAMIN TYPE A; PROGERIA; RNA SPLICING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33646745137     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1127168     Document Type: Article

References (16)

1. C. J. Hutchison, Nat. Rev. Mol. Cell Biol. 3, 848 (2002).
2. A. De Sandre-Giovannoli et al., Science 300, 2055 (2003); published online 17 April 2003 (10.1126/science.1084125).
3. M. Eriksson et al., Nature 423, 293 (2003).
4. R. D. Goldman et al., Proc. Natl. Acad. Sci. U.S.A. 101, 8963 (2004).
5. B. Liu et al., Nat. Med. 11, 780 (2005).
6. P. Scaffidi, T. Misteli, Nat. Med. 11, 440 (2005).
7. W. Andrew, Adv. Gerontol. Res. 18, 87 (1964).
8. E. Haithcock et al., Proc. Natl. Acad. Sci. U.S.A. 102, 16690 (2005).
9. Materials and methods are available as supporting material on Science Online.
10. U. Herbig, M. Ferreira, L. Condel, D. Carey, J. M. Sedivy, Science 311, 1257 (2006); published online 2 February 2006 (10.1126/science.1122446).
11. O. A. Sedelnikova et al., Nat. Cell Biol. 6, 168 (2004).
12. I. Varela et al., Nature 437, 564 (2005).
13. S. G. Young, L. G. Fong, S. Michaelis, J. Lipid Res. 46, 2531 (2005).
14. S. H. Yang et al., Proc. Natl. Acad. Sci. U.S.A. 102, 10291 (2005).
15. B. M. Machiels et al., J. Biol. Chem. 271, 9249 (1996).
16. We thank D. Donato for help with statistical analysis, C. Baker for design of specific primer pairs, M. Sinensky for advice on metabolic labeling of farnesylated lamin A, and K. Wilson and T. Jenuwein for providing reagents. Fluorescence imaging was performed at the NCI Fluorescence Imaging Facility. This research was supported by the Intramural Research Program of the NIH, NCI, Center for Cancer Research.