메뉴 건너뛰기




Volumn 19, Issue 19, 2012, Pages 3070-3102

Drug-loaded nanocarriers: Passive targeting and crossing of biological barriers

Author keywords

Biological barriers; Drug delivery; Nanocarrier; Oral administration; Passive targeting; Pulmonary administration; Surface properties; Vascular endothelium

Indexed keywords

ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CYTARABINE; DAUNORUBICIN; DEXTRAN DERIVATIVE; DOXORUBICIN; ENKEPHALIN; EXCITATORY AMINO ACID TRANSPORTER; HEPARAN; IRINOTECAN; LIPOSOME; MACROGOL; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; NANOCARRIER; NANOPARTICLE; PENICILLAMINE; PLASMA PROTEIN; POLY(N ISOPROPYLACRYLAMIDE); POLYESTER; POLYGLACTIN; POLYSTYRENE; POLYVINYL ALCOHOL; POVIDONE; PROTEOGLYCAN; UNINDEXED DRUG; VASOPRESSIN;

EID: 84863672079     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712800784702     Document Type: Review
Times cited : (163)

References (356)
  • 2
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of siRNA therapeutics: Barriers and carriers
    • Wang, J.; Lu, Z.; Wientjes, M.G.; Au, J.L.S. Delivery of siRNA therapeutics: barriers and carriers. AAPS J., 2010, 12(4), 492-503.
    • (2010) AAPS J. , vol.12 , Issue.4 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.S.4
  • 3
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin, V. P. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov., 2005, 4(2), 145-160.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , Issue.2 , pp. 145-160
    • Torchilin, V.P.1
  • 4
    • 0032778659 scopus 로고    scopus 로고
    • Polymeric micelles-a new generation of colloidal drug carriers
    • Jones, M.C.; Leroux, J.C. Polymeric micelles-a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm., 1999, 48(2), 101-111.
    • (1999) Eur. J. Pharm. Biopharm. , vol.48 , Issue.2 , pp. 101-111
    • Jones, M.C.1    Leroux, J.C.2
  • 5
    • 77749283338 scopus 로고    scopus 로고
    • Design of stimuli-responsive dendrimers
    • Kojima, C. Design of stimuli-responsive dendrimers. Expert Opin. Drug Deliv., 2010, 7(3), 307-319.
    • (2010) Expert Opin. Drug Deliv. , vol.7 , Issue.3 , pp. 307-319
    • Kojima, C.1
  • 8
    • 84859510563 scopus 로고    scopus 로고
    • The journey of a drug carrier in the body: An anatomo-physiological perspective
    • doi: 10.1016/j.jconrel.2011.09.098
    • Bertrand, N.; Leroux, J.C. The journey of a drug carrier in the body: an anatomo-physiological perspective. J. Control. Release, 2011, doi: 10.1016/j.jconrel.2011.09.098.
    • (2011) J. Control. Release
    • Bertrand, N.1    Leroux, J.C.2
  • 9
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers' entry into the cell: Relevance to drug delivery
    • Hillaireau, H.; Couvreur, P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell. Mol. Life Sci., 2009, 66(17), 2873-2896.
    • (2009) Cell. Mol. Life Sci. , vol.66 , Issue.17 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 10
    • 79952782063 scopus 로고    scopus 로고
    • The delivery of biologically active (therapeutic) peptides and proteins into cells
    • Grdisa, M. The delivery of biologically active (therapeutic) peptides and proteins into cells. Curr. Med. Chem., 2011, 18(9), 1373-1379.
    • (2011) Curr. Med. Chem. , vol.18 , Issue.9 , pp. 1373-1379
    • Grdisa, M.1
  • 11
    • 57749193734 scopus 로고    scopus 로고
    • Targeted delivery of therapeutics to endothelium
    • Simone, E.; Ding, B.S.; Muzykantov, V. Targeted delivery of therapeutics to endothelium. Cell Tissue Res., 2009, 335(1), 283-300.
    • (2009) Cell Tissue Res. , vol.335 , Issue.1 , pp. 283-300
    • Simone, E.1    Ding, B.S.2    Muzykantov, V.3
  • 12
    • 33646384586 scopus 로고    scopus 로고
    • Parameters influencing the stealthiness of colloidal drug delivery systems
    • Vonarbourg, A.; Passirani, C.; Saulnier, P.; Benoit, J.P. Parameters influencing the stealthiness of colloidal drug delivery systems. Biomaterials, 2006, 27(24), 4356-4373.
    • (2006) Biomaterials , vol.27 , Issue.24 , pp. 4356-4373
    • Vonarbourg, A.1    Passirani, C.2    Saulnier, P.3    Benoit, J.P.4
  • 13
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens, D.E., 3rd; Peppas, N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm., 2006, 307(1), 93-102.
    • (2006) Int. J. Pharm. , vol.307 , Issue.1 , pp. 93-102
    • Owens III, D.E.1    Peppas, N.A.2
  • 14
    • 39749107963 scopus 로고    scopus 로고
    • Protein-nanoparticle interactions
    • Lynch, I.; Dawson, K.A. Protein-nanoparticle interactions. Nano Today, 2008, 3(1-2), 40-47.
    • (2008) Nano Today , vol.3 , Issue.1-2 , pp. 40-47
    • Lynch, I.1    Dawson, K.A.2
  • 15
    • 33847789142 scopus 로고    scopus 로고
    • Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
    • Cedervall, T.; Lynch, I.; Lindman, S.; Berggard, T.; Thulin, E.; Nilsson, H.; Dawson, K.A.; Linse, S. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc. Natl. Acad. Sci. U.S.A., 2007, 104(7), 2050-2055.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.7 , pp. 2050-2055
    • Cedervall, T.1    Lynch, I.2    Lindman, S.3    Berggard, T.4    Thulin, E.5    Nilsson, H.6    Dawson, K.A.7    Linse, S.8
  • 16
    • 0342424906 scopus 로고
    • Phagocytosis of polymer microspheres by macrophages
    • Tabata, Y.; Ikada, Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polym. Sci., 1990, 94, 107-141.
    • (1990) Adv. Polym. Sci. , vol.94 , pp. 107-141
    • Tabata, Y.1    Ikada, Y.2
  • 17
    • 9644272479 scopus 로고    scopus 로고
    • Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: Implications for rational design of nanoparticles
    • Ogawara, K.; Furumoto, K.; Nagayama, S.; Minato, K.; Higaki, K.; Kai, T.; Kimura, T. Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles. J. Control. Release, 2004, 100(3), 451-455.
    • (2004) J. Control. Release , vol.100 , Issue.3 , pp. 451-455
    • Ogawara, K.1    Furumoto, K.2    Nagayama, S.3    Minato, K.4    Higaki, K.5    Kai, T.6    Kimura, T.7
  • 18
    • 0033046220 scopus 로고    scopus 로고
    • Mechanisms of phagocytosis in macrophages
    • Aderem, A.; Underhill, D.M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol., 1999, 17, 593-623.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 593-623
    • Aderem, A.1    Underhill, D.M.2
  • 19
    • 34447551590 scopus 로고    scopus 로고
    • A murine scavenger receptor MARCO recognizes polystyrene nanoparticles
    • Kanno, S.; Furuyama, A.; Hirano, S. A murine scavenger receptor MARCO recognizes polystyrene nanoparticles. Toxicol. Sci., 2007, 97(2), 398-406.
    • (2007) Toxicol. Sci. , vol.97 , Issue.2 , pp. 398-406
    • Kanno, S.1    Furuyama, A.2    Hirano, S.3
  • 20
    • 55749091647 scopus 로고    scopus 로고
    • Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
    • Lundqvist, M.; Stigler, J.; Elia, G.; Lynch, I.; Cedervall, T.; Dawson, K.A. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc. Natl. Acad. Sci. U.S.A., 2008, 105(38), 14265-14270.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , Issue.38 , pp. 14265-14270
    • Lundqvist, M.1    Stigler, J.2    Elia, G.3    Lynch, I.4    Cedervall, T.5    Dawson, K.A.6
  • 26
    • 56749157999 scopus 로고    scopus 로고
    • Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles
    • Sant, S.; Poulin, S.; Hildgen, P. Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles. J. Biomed. Mater. Res. Part A, 2008, 87A(4), 885-895.
    • (2008) J. Biomed. Mater. Res. Part A , vol.87 A , Issue.4 , pp. 885-895
    • Sant, S.1    Poulin, S.2    Hildgen, P.3
  • 27
    • 0343191443 scopus 로고    scopus 로고
    • 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): Influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption
    • Gref, R.; Luck, M.; Quellec, P.; Marchand, M.; Dellacherie, E.; Harnisch, S.; Blunk, T.; Muller, R. H. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B Biointerfaces, 2000, 18(3-4), 301-313.
    • (2000) Colloids Surf. B Biointerfaces , vol.18 , Issue.3-4 , pp. 301-313
    • Gref, R.1    Luck, M.2    Quellec, P.3    Marchand, M.4    Dellacherie, E.5    Harnisch, S.6    Blunk, T.7    Muller, R.H.8
  • 28
    • 65749117793 scopus 로고    scopus 로고
    • Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
    • Aggarwal, P.; Hall, J.B.; McLeland, C.B.; Dobrovolskaia, M.A.; McNeil, S.E. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv. Drug Deliv. Rev., 2009, 61(6), 428-437.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , Issue.6 , pp. 428-437
    • Aggarwal, P.1    Hall, J.B.2    McLeland, C.B.3    Dobrovolskaia, M.A.4    McNeil, S.E.5
  • 29
    • 66449116301 scopus 로고    scopus 로고
    • Mediating tumor targeting efficiency of nanoparticles through design
    • Perrault, S.D.; Walkey, C.; Jennings, T.; Fischer, H.C.; Chan, W.C. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett., 2009, (5), 1909-1915.
    • (2009) Nano Lett. , Issue.5 , pp. 1909-1915
    • Perrault, S.D.1    Walkey, C.2    Jennings, T.3    Fischer, H.C.4    Chan, W.C.5
  • 30
    • 0034781649 scopus 로고    scopus 로고
    • Biodistribution of long-circulating PEG-grafted nanocapsules in mice: Effects of PEG chain length and density
    • Mosqueira, V.C.F.; Legrand, P.; Morgat, J.L.; Vert, M.; Mysiakine, E.; Gref, R.; Devissaguet, J.P.; Barratt, G. Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density. Pharm. Res., 2001, 18(10), 1411-1419.
    • (2001) Pharm. Res. , vol.18 , Issue.10 , pp. 1411-1419
    • Mosqueira, V.C.F.1    Legrand, P.2    Morgat, J.L.3    Vert, M.4    Mysiakine, E.5    Gref, R.6    Devissaguet, J.P.7    Barratt, G.8
  • 31
    • 66749179382 scopus 로고    scopus 로고
    • Tissue-and organ-selective biodistribution of NIR fluorescent quantum dots
    • Choi, H.S.; Ipe, B.I.; Misra, P.; Lee, J.H.; Bawendi, M.G.; Frangioni, J.V. Tissue-and organ-selective biodistribution of NIR fluorescent quantum dots. Nano Lett., 2009, 9(6), 2354-2359.
    • (2009) Nano Lett. , vol.9 , Issue.6 , pp. 2354-2359
    • Choi, H.S.1    Ipe, B.I.2    Misra, P.3    Lee, J.H.4    Bawendi, M.G.5    Frangioni, J.V.6
  • 32
    • 0031668265 scopus 로고    scopus 로고
    • Vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres
    • Neal, J.C.; Stolnik, S.; Schacht, E.; Kenawy, E.R.; Garnett, M.C.; Davis, S.S.; Illum, L. In vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres. J. Pharm. Sci., 1998, 87(10), 1242-1248.
    • (1998) J. Pharm. Sci. , vol.87 , Issue.10 , pp. 1242-1248
    • Neal, J.C.1    Stolnik, S.2    Schacht, E.3    Kenawy, E.R.4    Garnett, M.C.5    Davis, S.S.6    Illum, L.7
  • 33
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi, S.M.; Hunter, A.C.; Murray, J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev., 2001, 53(2), 283-318.
    • (2001) Pharmacol. Rev. , vol.53 , Issue.2 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 34
    • 0023659741 scopus 로고
    • Large unilamellar liposomes with low uptake into the reticuloendothelial system
    • Allen, T.M.; Chonn, A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett., 1987, 223(1), 42-46.
    • (1987) FEBS Lett. , vol.223 , Issue.1 , pp. 42-46
    • Allen, T.M.1    Chonn, A.2
  • 37
    • 0031939804 scopus 로고    scopus 로고
    • Influence of surface properties at biodegradable microsphere surfaces: Effects on plasma protein adsorption and phagocytosis
    • Lacasse, F.X.; Filion, M.C.; Phillips, N.C.; Escher, E.; McMullen, J.N.; Hildgen, P. Influence of surface properties at biodegradable microsphere surfaces: effects on plasma protein adsorption and phagocytosis. Pharm. Res., 1998, 15(2), 312-317.
    • (1998) Pharm. Res. , vol.15 , Issue.2 , pp. 312-317
    • Lacasse, F.X.1    Filion, M.C.2    Phillips, N.C.3    Escher, E.4    McMullen, J.N.5    Hildgen, P.6
  • 38
    • 0033853559 scopus 로고    scopus 로고
    • Cellular uptake of PEO surface-modified nanoparticles: Evaluation of nanoparticles made of PLA: PEO diblock and triblock copolymers
    • De Jaeghere, F.; Allemann, E.; Feijen, J.; Kissel, T.; Doelker, E.; Gurny, R. Cellular uptake of PEO surface-modified nanoparticles: evaluation of nanoparticles made of PLA: PEO diblock and triblock copolymers. J. Drug Target., 2000, 8(3), 143-153.
    • (2000) J. Drug Target. , vol.8 , Issue.3 , pp. 143-153
    • De Jaeghere, F.1    Allemann, E.2    Feijen, J.3    Kissel, T.4    Doelker, E.5    Gurny, R.6
  • 39
    • 0141927263 scopus 로고    scopus 로고
    • Stealth liposomes and long circulating nanoparticles: Critical issues in pharmacokinetics, opsonization and protein-binding properties
    • Moghimi, S.M.; Szebeni, J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog. Lipid Res., 2003, 42(6), 463-478.
    • (2003) Prog. Lipid Res. , vol.42 , Issue.6 , pp. 463-478
    • Moghimi, S.M.1    Szebeni, J.2
  • 40
    • 40849138014 scopus 로고    scopus 로고
    • Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
    • Ishida, T.; Kiwada, H. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int. J. Pharm., 2008, 354(1-2), 56-62.
    • (2008) Int. J. Pharm. , vol.354 , Issue.1-2 , pp. 56-62
    • Ishida, T.1    Kiwada, H.2
  • 41
    • 77954313055 scopus 로고    scopus 로고
    • Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting
    • Li, S.D.; Huang, L. Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. J. Control. Release, 2010, 145(3), 178-181.
    • (2010) J. Control. Release , vol.145 , Issue.3 , pp. 178-181
    • Li, S.D.1    Huang, L.2
  • 43
    • 33845639957 scopus 로고    scopus 로고
    • Methylation of the phosphate oxygen moiety of phospholipid- methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production
    • Moghimi, S.M.; Hamad, I.; Andresen, T.L.; Jorgensen, K.; Szebeni, J. Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production. FASEB J., 2006, 20(14), 2591-2593.
    • (2006) FASEB J. , vol.20 , Issue.14 , pp. 2591-2593
    • Moghimi, S.M.1    Hamad, I.2    Andresen, T.L.3    Jorgensen, K.4    Szebeni, J.5
  • 44
    • 0035889833 scopus 로고    scopus 로고
    • Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules
    • Mosqueira, V.C.F.; Legrand, P.; Gulik, A.; Bourdon, O.; Gref, R.; Labarre, D.; Barratt, G. Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules. Biomaterials, 2001, 22(22), 2967-2979.
    • (2001) Biomaterials , vol.22 , Issue.22 , pp. 2967-2979
    • Mosqueira, V.C.F.1    Legrand, P.2    Gulik, A.3    Bourdon, O.4    Gref, R.5    Labarre, D.6    Barratt, G.7
  • 45
    • 0037132508 scopus 로고    scopus 로고
    • PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance
    • Gbadamosi, J.K.; Hunter, A.C.; Moghimi, S.M. PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance. FEBS Lett., 2002, 532(3), 338-344.
    • (2002) FEBS Lett. , vol.532 , Issue.3 , pp. 338-344
    • Gbadamosi, J.K.1    Hunter, A.C.2    Moghimi, S.M.3
  • 46
    • 77952952638 scopus 로고    scopus 로고
    • Effect of polyethylene glycol (PEG) chain organization on the physicochemical properties of poly(D, L-lactide) (PLA) based nanoparticles
    • Essa, S.; Rabanel, J.M.; Hildgen, P. Effect of polyethylene glycol (PEG) chain organization on the physicochemical properties of poly(D, L-lactide) (PLA) based nanoparticles. Eur. J. Pharm. Biopharm., 2010, 75(2), 96-106.
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , Issue.2 , pp. 96-106
    • Essa, S.1    Rabanel, J.M.2    Hildgen, P.3
  • 47
    • 0031871655 scopus 로고    scopus 로고
    • Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate)
    • Passirani, C.; Barratt, G.; Devissaguet, J.P.; Labarre, D. Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate). Pharm. Res., 1998, 15(7), 1046-1050.
    • (1998) Pharm. Res. , vol.15 , Issue.7 , pp. 1046-1050
    • Passirani, C.1    Barratt, G.2    Devissaguet, J.P.3    Labarre, D.4
  • 48
    • 0035838774 scopus 로고    scopus 로고
    • Surface properties of polystyrene nanoparticles coated with dextrans and dextran-PEO copolymers. Effect of polymer architecture on protein adsorption
    • De Sousa Delgado, A.; Léonard, M.; Dellacherie, E. Surface properties of polystyrene nanoparticles coated with dextrans and dextran-PEO copolymers. Effect of polymer architecture on protein adsorption. Langmuir, 2001, 17(14), 4386-4391.
    • (2001) Langmuir , vol.17 , Issue.14 , pp. 4386-4391
    • De Sousa Delgado, A.1    Léonard, M.2    Dellacherie, E.3
  • 49
    • 44749084983 scopus 로고    scopus 로고
    • Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers
    • Shehata, T.; Ogawara, K.; Higaki, K.; Kimura, T. Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers. Int. J. Pharm., 2008, 359(1-2), 272-279.
    • (2008) Int. J. Pharm. , vol.359 , Issue.1-2 , pp. 272-279
    • Shehata, T.1    Ogawara, K.2    Higaki, K.3    Kimura, T.4
  • 50
    • 64149086416 scopus 로고    scopus 로고
    • Effect of poly(N-vinyl-pyrrolidone)-block-poly(D, L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles
    • Gaucher, G.; Asahina, K.; Wang, J.H.; Leroux, J.C., Effect of poly(N-vinyl-pyrrolidone)-block-poly(D, L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules, 2009, 10(2), 408-416.
    • (2009) Biomacromolecules , vol.10 , Issue.2 , pp. 408-416
    • Gaucher, G.1    Asahina, K.2    Wang, J.H.3    Leroux, J.C.4
  • 51
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly (d, l-lactide-co- glycolide) nanoparticles affects their physical properties and cellular uptake
    • Sahoo, S.K.; Panyam, J.; Prabha, S.; Labhasetwar, V. Residual polyvinyl alcohol associated with poly (d, l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J. Control. Release, 2002, 82(1), 105-114.
    • (2002) J. Control. Release , vol.82 , Issue.1 , pp. 105-114
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3    Labhasetwar, V.4
  • 52
    • 0032214525 scopus 로고    scopus 로고
    • Surface-modified biodegradable albumin nano-and microspheres. II: Effect of surface charges on in vitro phagocytosis and biodistribution in rats
    • Roser, M.; Fischer, D.; Kissel, T. Surface-modified biodegradable albumin nano-and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur. J. Pharm. Biopharm., 1998, 46(3), 255-263.
    • (1998) Eur. J. Pharm. Biopharm. , vol.46 , Issue.3 , pp. 255-263
    • Roser, M.1    Fischer, D.2    Kissel, T.3
  • 53
    • 1842832660 scopus 로고    scopus 로고
    • Influence of surface charge density on protein adsorption on polymeric nanoparticles: Analysis by two-dimensional electrophoresis
    • Gessner, A.; Lieske, A.; Paulke, B.R.; Muller, R.H. Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis. Eur. J. Pharm. Biopharm., 2002, 54(2), 165-170.
    • (2002) Eur. J. Pharm. Biopharm. , vol.54 , Issue.2 , pp. 165-170
    • Gessner, A.1    Lieske, A.2    Paulke, B.R.3    Muller, R.H.4
  • 55
    • 79957973266 scopus 로고    scopus 로고
    • Zwitteration as an alternative to PEGylation
    • Estephan, Z.G.; Schlenoff, P.S.; Schlenoff, J.B. Zwitteration as an alternative to PEGylation. Langmuir, 2011, 27(11), 6794-6800.
    • (2011) Langmuir , vol.27 , Issue.11 , pp. 6794-6800
    • Estephan, Z.G.1    Schlenoff, P.S.2    Schlenoff, J.B.3
  • 56
    • 56449122424 scopus 로고    scopus 로고
    • The influence of protein adsorption on nanoparticle association with cultured endothelial cells
    • Ehrenberg, M.S.; Friedman, A.E.; Finkelstein, J.N.; Oberdorster, G.; McGrath, J.L. The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials, 2009, 30(4), 603-610.
    • (2009) Biomaterials , vol.30 , Issue.4 , pp. 603-610
    • Ehrenberg, M.S.1    Friedman, A.E.2    Finkelstein, J.N.3    Oberdorster, G.4    McGrath, J.L.5
  • 57
    • 0026570605 scopus 로고
    • The role of surface charge and hydrophilic groups on liposome clearance in vivo
    • Gabizon, A.; Papahadjopoulos, D. The role of surface charge and hydrophilic groups on liposome clearance in vivo. Biochim. Biophys. Acta, 1992, 1103(1), 94-100.
    • (1992) Biochim. Biophys. Acta , vol.1103 , Issue.1 , pp. 94-100
    • Gabizon, A.1    Papahadjopoulos, D.2
  • 58
    • 0035834269 scopus 로고    scopus 로고
    • Long-circulating poly(ethylene glycol)-poly(D, L-lactide) block copolymer micelles with modulated surface charge
    • Yamamoto, Y.; Nagasaki, Y.; Kato, Y.; Sugiyama, Y.; Kataoka, K. Long-circulating poly(ethylene glycol)-poly(D, L-lactide) block copolymer micelles with modulated surface charge. J. Control. Release, 2001, 77(1-2), 27-38.
    • (2001) J. Control. Release , vol.77 , Issue.1-2 , pp. 27-38
    • Yamamoto, Y.1    Nagasaki, Y.2    Kato, Y.3    Sugiyama, Y.4    Kataoka, K.5
  • 59
    • 2042486365 scopus 로고    scopus 로고
    • Influence of PAMAM dendrimers on human red blood cells
    • Domanski, D.M.; Klajnert, B.; Bryszewska, M. Influence of PAMAM dendrimers on human red blood cells. Bioelectrochemistry, 2004, 63(1-2), 189-191.
    • (2004) Bioelectrochemistry , vol.63 , Issue.1-2 , pp. 189-191
    • Domanski, D.M.1    Klajnert, B.2    Bryszewska, M.3
  • 61
    • 78049338489 scopus 로고    scopus 로고
    • Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery
    • Huang, R.B.; Mocherla, S.; Heslinga, M.J.; Charoenphol, P.; Eniola-Adefeso, O. Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery. Mol. Membr. Biol., 2010, 27(7), 312-327.
    • (2010) Mol. Membr. Biol. , vol.27 , Issue.7 , pp. 312-327
    • Huang, R.B.1    Mocherla, S.2    Heslinga, M.J.3    Charoenphol, P.4    Eniola-Adefeso, O.5
  • 62
    • 28444496349 scopus 로고    scopus 로고
    • Vivo tumor targeting of tumor necrosis factor-[alpha]-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size
    • Fang, C.; Shi, B.; Pei, Y.Y.; Hong, M.H.; Wu, J.; Chen, H.Z. In vivo tumor targeting of tumor necrosis factor-[alpha]-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. Eur. J. Pharm. Sci., 2006, 27(1), 27-36.
    • (2006) Eur. J. Pharm. Sci. , vol.27 , Issue.1 , pp. 27-36
    • Fang, C.1    Shi, B.2    Pei, Y.Y.3    Hong, M.H.4    Wu, J.5    Chen, H.Z.6
  • 63
    • 0029984278 scopus 로고    scopus 로고
    • Mechanisms of phagocytosis
    • Allen, L.A.; Aderem, A. Mechanisms of phagocytosis. Curr. Opin. Immunol., 1996, 8(1), 36-40.
    • (1996) Curr. Opin. Immunol. , vol.8 , Issue.1 , pp. 36-40
    • Allen, L.A.1    Aderem, A.2
  • 64
    • 0031815720 scopus 로고    scopus 로고
    • Size of IgG-opsonized particles determines macrophage response during internalization
    • Koval, M.; Preiter, K.; Adles, C.; Stahl, P.D.; Steinberg, T.H. Size of IgG-opsonized particles determines macrophage response during internalization. Exp. Cell Res., 1998, 242(1), 265-273.
    • (1998) Exp. Cell Res. , vol.242 , Issue.1 , pp. 265-273
    • Koval, M.1    Preiter, K.2    Adles, C.3    Stahl, P.D.4    Steinberg, T.H.5
  • 65
    • 0026567096 scopus 로고
    • Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes
    • Liu, D.; Mori, A.; Huang, L. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim. Biophys. Acta, 1992, 1104(1), 95-101.
    • (1992) Biochim. Biophys. Acta , vol.1104 , Issue.1 , pp. 95-101
    • Liu, D.1    Mori, A.2    Huang, L.3
  • 66
    • 34547178393 scopus 로고    scopus 로고
    • Particle shape: A new design parameter for micro-and nanoscale drug delivery carriers
    • Champion, J.A.; Katare, Y.K.; Mitragotri, S. Particle shape: a new design parameter for micro-and nanoscale drug delivery carriers. J. Control. Release, 2007, 121(1-2), 3-9.
    • (2007) J. Control. Release , vol.121 , Issue.1-2 , pp. 3-9
    • Champion, J.A.1    Katare, Y.K.2    Mitragotri, S.3
  • 67
    • 78751508035 scopus 로고    scopus 로고
    • Shape-specific polymeric nanomedicine: Emerging opportunities and challenges
    • Tao, L.; Hu, W.; Liu, Y.; Huang, G.; Sumer, B.D.; Gao, J. Shape-specific polymeric nanomedicine: emerging opportunities and challenges. Exp. Biol. Med., 2011, 236(1), 20-29.
    • (2011) Exp. Biol. Med. , vol.236 , Issue.1 , pp. 20-29
    • Tao, L.1    Hu, W.2    Liu, Y.3    Huang, G.4    Sumer, B.D.5    Gao, J.6
  • 68
    • 57749207052 scopus 로고    scopus 로고
    • Intravascular delivery of particulate systems: Does geometry really matter?
    • Decuzzi, P.; Pasqualini, R.; Arap, W.; Ferrari, M. Intravascular delivery of particulate systems: does geometry really matter? Pharm. Res., 2009, 26(1), 235-243.
    • (2009) Pharm. Res. , vol.26 , Issue.1 , pp. 235-243
    • Decuzzi, P.1    Pasqualini, R.2    Arap, W.3    Ferrari, M.4
  • 69
    • 77951562117 scopus 로고    scopus 로고
    • Particle shape: A new design parameter for passive targeting in splenotropic drug delivery
    • Devarajan, P.V.; Jindal, A.B.; Patil, R.R.; Mulla, F.; Gaikwad, R.V.; Samad, A. Particle shape: a new design parameter for passive targeting in splenotropic drug delivery. J. Pharm. Sci., 2010, 99(6), 2576-2581.
    • (2010) J. Pharm. Sci. , vol.99 , Issue.6 , pp. 2576-2581
    • Devarajan, P.V.1    Jindal, A.B.2    Patil, R.R.3    Mulla, F.4    Gaikwad, R.V.5    Samad, A.6
  • 70
  • 72
    • 57749186709 scopus 로고    scopus 로고
    • Endothelial transcytosis in health and disease
    • Simionescu, M.; Popov, D.; Sima, A. Endothelial transcytosis in health and disease. Cell Tissue Res., 2009, 335(1), 27-40.
    • (2009) Cell Tissue Res. , vol.335 , Issue.1 , pp. 27-40
    • Simionescu, M.1    Popov, D.2    Sima, A.3
  • 73
    • 33646229178 scopus 로고    scopus 로고
    • Cell-cell channels
    • Baluška, F.; Volkmann, D.; Barlow, P.W., Eds.
    • Stan, R. V. In: Cell-Cell Channels, Baluška, F.; Volkmann, D.; Barlow, P.W., Eds. Landes Biosciences and Springer Science: Georgetown, 2006; pp. 251-266.
    • (2006) Landes Biosciences and Springer Science: Georgetown , pp. 251-266
    • Stan, R.V.1
  • 74
    • 77953278034 scopus 로고    scopus 로고
    • Morphological heterogeneity of endothelium
    • Tse, D.; Stan, R.V. Morphological heterogeneity of endothelium. Semin. Thromb. Hemost., 2010, 36(3), 236-245.
    • (2010) Semin. Thromb. Hemost. , vol.36 , Issue.3 , pp. 236-245
    • Tse, D.1    Stan, R.V.2
  • 75
    • 77956162919 scopus 로고    scopus 로고
    • Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability
    • Sarin, H. Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. J. Angiogenes. Res., 2010, 2(1), 14.
    • (2010) J. Angiogenes. Res. , vol.2 , Issue.1 , pp. 14
    • Sarin, H.1
  • 78
    • 2142763785 scopus 로고    scopus 로고
    • Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed
    • Rehm, M.; Zahler, S.; Lotsch, M.; Welsch, U.; Conzen, P.; Jacob, M.; Becker, B.F. Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed. Anesthesiology, 2004, 100(5), 1211-1223.
    • (2004) Anesthesiology , vol.100 , Issue.5 , pp. 1211-1223
    • Rehm, M.1    Zahler, S.2    Lotsch, M.3    Welsch, U.4    Conzen, P.5    Jacob, M.6    Becker, B.F.7
  • 80
    • 77954343077 scopus 로고    scopus 로고
    • Vascular permeability modulation at the cell, microvessel, or whole organ level: Towards closing gaps in our knowledge
    • Curry, F.R.; Adamson, R.H. Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovasc. Res., 2010, 87(2), 218-229.
    • (2010) Cardiovasc. Res. , vol.87 , Issue.2 , pp. 218-229
    • Curry, F.R.1    Adamson, R.H.2
  • 81
    • 35348904935 scopus 로고    scopus 로고
    • The structure and function of the endothelial glycocalyx layer
    • Weinbaum, S.; Tarbell, J.M.; Damiano, E.R. The structure and function of the endothelial glycocalyx layer. Annu. Rev. Biomed. Eng., 2007, 9, 121-167.
    • (2007) Annu. Rev. Biomed. Eng. , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 84
    • 0032475867 scopus 로고    scopus 로고
    • Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo
    • Mounkes, L.C.; Zhong, W.; Cipres-Palacin, G.; Heath, T.D.; Debs, R.J. Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J. Biol. Chem., 1998, 273(40), 26164-26170.
    • (1998) J. Biol. Chem. , vol.273 , Issue.40 , pp. 26164-26170
    • Mounkes, L.C.1    Zhong, W.2    Cipres-Palacin, G.3    Heath, T.D.4    Debs, R.J.5
  • 85
    • 0027242138 scopus 로고
    • Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue
    • Wu, N.Z.; Da, D.; Rudoll, T.L.; Needham, D.; Whorton, A.R.; Dewhirst, M.W. Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue. Cancer Res., 1993, 53(16), 3765-3770.
    • (1993) Cancer Res. , vol.53 , Issue.16 , pp. 3765-3770
    • Wu, N.Z.1    Da, D.2    Rudoll, T.L.3    Needham, D.4    Whorton, A.R.5    Dewhirst, M.W.6
  • 86
    • 79951820750 scopus 로고    scopus 로고
    • The effects of particle size, density and shape on margination of nanoparticles in microcirculation
    • Toy, R.; Hayden, E.; Shoup, C.; Baskaran, H.; Karathanasis, E. The effects of particle size, density and shape on margination of nanoparticles in microcirculation. Nanotechnology, 2011, 22(11), 115101.
    • (2011) Nanotechnology , vol.22 , Issue.11 , pp. 115101
    • Toy, R.1    Hayden, E.2    Shoup, C.3    Baskaran, H.4    Karathanasis, E.5
  • 87
    • 0037133155 scopus 로고    scopus 로고
    • Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: A pathway to overcome cell barriers to drug and gene delivery
    • McIntosh, D.P.; Tan, X.Y.; Oh, P.; Schnitzer, J.E. Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery. Proc. Natl. Acad. Sci. U.S.A., 2002, 99(4), 1996-2001.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , Issue.4 , pp. 1996-2001
    • McIntosh, D.P.1    Tan, X.Y.2    Oh, P.3    Schnitzer, J.E.4
  • 88
    • 73849141603 scopus 로고    scopus 로고
    • And dynamics of caveolae studied using nanoparticles in living endothelial cells
    • Wang, Z.J.; Tiruppathi, C.; Minshall, R.D.; Malik, A.B. Size and dynamics of caveolae studied using nanoparticles in living endothelial cells. ACS Nano, 2009, 3(12), 4110-4116.
    • (2009) ACS Nano , vol.3 , Issue.12 , pp. 4110-4116
    • Wang, Z.J.1    Tiruppathi, C.2    Minshall, R.D.3    Size, B.M.A.4
  • 89
    • 79960807949 scopus 로고    scopus 로고
    • Delivery of nanoparticle: Complexed drugs across the vascular endothelial barrier via caveolae
    • Wang, Z.; Tiruppathi, C.; Cho, J.; Minshall, R.D.; Malik, A.B. Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae. IUBMB Life, 2011, 63(8), 659-667.
    • (2011) IUBMB Life , vol.63 , Issue.8 , pp. 659-667
    • Wang, Z.1    Tiruppathi, C.2    Cho, J.3    Minshall, R.D.4    Malik, A.B.5
  • 90
    • 0035074497 scopus 로고    scopus 로고
    • The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle
    • Dvorak, A.M.; Feng, D. The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle. J. Histochem. Cytochem., 2001, 49(4), 419-432.
    • (2001) J. Histochem. Cytochem. , vol.49 , Issue.4 , pp. 419-432
    • Dvorak, A.M.1    Feng, D.2
  • 91
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis: Crossing cellular barriers
    • Tuma, P.L.; Hubbard, A.L. Transcytosis: crossing cellular barriers. Physiol. Rev., 2003, 83(3), 871-932.
    • (2003) Physiol. Rev. , vol.83 , Issue.3 , pp. 871-932
    • Tuma, P.L.1    Hubbard, A.L.2
  • 92
    • 52649119391 scopus 로고    scopus 로고
    • Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status
    • Desai, N.P.; Trieu, V.; Hwang, L.Y.; Wu, R.J.; Soon-Shiong, P.; Gradishar, W.J. Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status. Anticancer. Drugs, 2008, 19(9), 899-909.
    • (2008) Anticancer. Drugs , vol.19 , Issue.9 , pp. 899-909
    • Desai, N.P.1    Trieu, V.2    Hwang, L.Y.3    Wu, R.J.4    Soon-Shiong, P.5    Gradishar, W.J.6
  • 93
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain, R.K.; Stylianopoulos, T. Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol., 2010, 7(11), 653-664.
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , Issue.11 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 94
    • 79960025389 scopus 로고    scopus 로고
    • Role of tumor vascular architecture in drug delivery
    • Narang, A.S.; Varia, S. Role of tumor vascular architecture in drug delivery. Adv. Drug Deliv. Rev., 2011, 63(8), 640-658.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , Issue.8 , pp. 640-658
    • Narang, A.S.1    Varia, S.2
  • 95
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts, W.G.; Palade, G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci., 1995, 108(Pt 6), 2369-2379.
    • (1995) J. Cell Sci. , vol.108 , Issue.PART 6 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 96
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • Fang, J.; Nakamura, H.; Maeda, H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev., 2011, 63(3), 136-151.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , Issue.3 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 98
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts, W.G.; Palade, G.E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res., 1997, 57(4), 765-72.
    • (1997) Cancer Res. , vol.57 , Issue.4 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 100
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
    • Yuan, F.; Dellian, M.; Fukumura, D.; Leunig, M.; Berk, D.A.; Torchilin, V.P.; Jain, R.K. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res., 1995, 55(17), 3752-3756.
    • (1995) Cancer Res. , vol.55 , Issue.17 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3    Leunig, M.4    Berk, D.A.5    Torchilin, V.P.6    Jain, R.K.7
  • 101
    • 34447103275 scopus 로고    scopus 로고
    • Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery
    • Bouzin, C.; Feron, O. Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery. Drug Resist. Updat., 2007, 10(3), 109-120.
    • (2007) Drug Resist. Updat. , vol.10 , Issue.3 , pp. 109-120
    • Bouzin, C.1    Feron, O.2
  • 102
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y.; Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res., 1986, 46(12 Pt 1), 6387-6392.
    • (1986) Cancer Res. , vol.46 , Issue.12 PART 1 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 103
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
    • Maeda, H. Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug. Chem., 2010, 21(5), 797-802.
    • (2010) Bioconjug. Chem. , vol.21 , Issue.5 , pp. 797-802
    • Maeda, H.1
  • 104
    • 79953035086 scopus 로고    scopus 로고
    • PLGA nanoparticles containing various anticancer agents and tumor delivery by EPR effect
    • Acharya, S.; Sahoo, S.K. PLGA nanoparticles containing various anticancer agents and tumor delivery by EPR effect. Adv. Drug Deliv. Rev., 2011, 63(3), 170-183.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , Issue.3 , pp. 170-183
    • Acharya, S.1    Sahoo, S.K.2
  • 105
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon, A.; Catane, R.; Uziely, B.; Kaufman, B.; Safra, T.; Cohen, R.; Martin, F.; Huang, A.; Barenholz, Y. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res., 1994, 54(4), 987-992.
    • (1994) Cancer Res. , vol.54 , Issue.4 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3    Kaufman, B.4    Safra, T.5    Cohen, R.6    Martin, F.7    Huang, A.8    Barenholz, Y.9
  • 106
    • 0343923453 scopus 로고    scopus 로고
    • Long-circulating liposomes for drug delivery in cancer therapy: A review of biodistribution studies in tumor-bearing animals
    • Gabizon, A.; Goren, D.; Horowitz, A.T.; Tzemach, D.; Lossos, A.; Siegal, T. Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals. Adv. Drug Deliv. Rev., 1997, 24(2-3), 337-344.
    • (1997) Adv. Drug Deliv. Rev. , vol.24 , Issue.2-3 , pp. 337-344
    • Gabizon, A.1    Goren, D.2    Horowitz, A.T.3    Tzemach, D.4    Lossos, A.5    Siegal, T.6
  • 107
    • 79960925147 scopus 로고    scopus 로고
    • Targeted drug delivery to tumors: Myths, reality and possibility
    • Bae, Y.H.; Park, K. Targeted drug delivery to tumors: myths, reality and possibility. J. Control. Release, 2011, 153(3), 198-205.
    • (2011) J. Control. Release , vol.153 , Issue.3 , pp. 198-205
    • Bae, Y.H.1    Park, K.2
  • 108
    • 77349118467 scopus 로고    scopus 로고
    • Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: Analogy between angina pectoris and solid tumors and enhancement of the EPR effect
    • Maeda, H. Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect. J. Control. Release, 2010, 142(3), 296-298.
    • (2010) J. Control. Release , vol.142 , Issue.3 , pp. 296-298
    • Maeda, H.1
  • 109
    • 0038002438 scopus 로고    scopus 로고
    • Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    • Metselaar, J.M.; Wauben, M.H.M.; Wagenaar-Hilbers, J.P.A.; Boerman, O.C.; Storm, G. Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum., 2003, 48(7), 2059-2066.
    • (2003) Arthritis Rheum. , vol.48 , Issue.7 , pp. 2059-2066
    • Metselaar, J.M.1    Wauben, M.H.M.2    Wagenaar-Hilbers, J.P.A.3    Boerman, O.C.4    Storm, G.5
  • 110
    • 65649115761 scopus 로고    scopus 로고
    • Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate
    • Higaki, M.; Ishihara, T.; Kubota, T.; Choi, T. Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate. J. Pharmacol. Exp. Ther., 2009, 329(2), 412-417.
    • (2009) J. Pharmacol. Exp. Ther. , vol.329 , Issue.2 , pp. 412-417
    • Higaki, M.1    Ishihara, T.2    Kubota, T.3    Choi, T.4
  • 112
    • 0028304405 scopus 로고
    • Mirovascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft
    • Yuan, F.; Leunig, M.; Huang, S.K.; Berk, D.A.; Papahadjopoulos, D.; Jain, R.K. Mirovascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res., 1994, 54(13), 3352-3356.
    • (1994) Cancer Res. , vol.54 , Issue.13 , pp. 3352-3356
    • Yuan, F.1    Leunig, M.2    Huang, S.K.3    Berk, D.A.4    Papahadjopoulos, D.5    Jain, R.K.6
  • 113
    • 79961172204 scopus 로고    scopus 로고
    • Intratumoral drug delivery with nanoparticulate carriers
    • Holback, H.; Yeo, Y. Intratumoral drug delivery with nanoparticulate carriers. Pharm. Res., 2011, 28(8), 1819-1830.
    • (2011) Pharm. Res. , vol.28 , Issue.8 , pp. 1819-1830
    • Holback, H.1    Yeo, Y.2
  • 114
    • 0026786660 scopus 로고
    • Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: Implications for vascular collapse
    • Boucher, Y.; Jain, R.K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res., 1992, 52(18), 5110-5114.
    • (1992) Cancer Res. , vol.52 , Issue.18 , pp. 5110-5114
    • Boucher, Y.1    Jain, R.K.2
  • 115
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier, F.; Feron, O.; Preat, V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J. Control. Release, 2010, 148(2), 135-146.
    • (2010) J. Control. Release , vol.148 , Issue.2 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Preat, V.3
  • 116
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti, P.A.; Berk, D.A.; Swartz, M.A.; Grodzinsky, A.J.; Jain, R.K. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res., 2000, 60(9), 2497-2503.
    • (2000) Cancer Res. , vol.60 , Issue.9 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3    Grodzinsky, A.J.4    Jain, R.K.5
  • 117
    • 78649270513 scopus 로고    scopus 로고
    • Diffusion anisotropy in collagen gels and tumors: The effect of fiber network orientation
    • Stylianopoulos, T.; Diop-Frimpong, B.; Munn, L.L.; Jain, R.K. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophys. J., 2010, 99(10), 3119-3128.
    • (2010) Biophys. J. , vol.99 , Issue.10 , pp. 3119-3128
    • Stylianopoulos, T.1    Diop-Frimpong, B.2    Munn, L.L.3    Jain, R.K.4
  • 118
    • 77956562428 scopus 로고    scopus 로고
    • Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions
    • Stylianopoulos, T.; Poh, M.Z.; Insin, N.; Bawendi, M.G.; Fukumura, D.; Munn, L.L.; Jain, R.K. Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys. J., 2010, 99(5), 1342-1349.
    • (2010) Biophys. J. , vol.99 , Issue.5 , pp. 1342-1349
    • Stylianopoulos, T.1    Poh, M.Z.2    Insin, N.3    Bawendi, M.G.4    Fukumura, D.5    Munn, L.L.6    Jain, R.K.7
  • 119
    • 33644772618 scopus 로고    scopus 로고
    • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    • Dreher, M.R.; Liu, W.; Michelich, C.R.; Dewhirst, M.W.; Yuan, F.; Chilkoti, A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl. Cancer Inst., 2006, 98(5), 335-344.
    • (2006) J. Natl. Cancer Inst. , vol.98 , Issue.5 , pp. 335-344
    • Dreher, M.R.1    Liu, W.2    Michelich, C.R.3    Dewhirst, M.W.4    Yuan, F.5    Chilkoti, A.6
  • 120
    • 78549283951 scopus 로고    scopus 로고
    • Vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels
    • Lee, H.; Hoang, B.; Fonge, H.; Reilly, R.M.; Allen, C. In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels. Pharm. Res., 2010, 27(11), 2343-2355.
    • (2010) Pharm. Res. , vol.27 , Issue.11 , pp. 2343-2355
    • Lee, H.1    Hoang, B.2    Fonge, H.3    Reilly, R.M.4    Allen, C.5
  • 121
    • 80051516651 scopus 로고    scopus 로고
    • Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
    • Meng, H.; Xue, M.; Xia, T.; Ji, Z.; Tarn, D.Y.; Zink, J.I.; Nel, A.E. Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano, 2011, 5(5), 4131-4144.
    • (2011) ACS Nano , vol.5 , Issue.5 , pp. 4131-4144
    • Meng, H.1    Xue, M.2    Xia, T.3    Ji, Z.4    Tarn, D.Y.5    Zink, J.I.6    Nel, A.E.7
  • 122
    • 41549123975 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery: The need for precision in reporting particle size parameters
    • Gaumet, M.; Vargas, A.; Gurny, R.; Delie, F. Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur. J. Pharm. Biopharm., 2008, 69(1), 1-9.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.1 , pp. 1-9
    • Gaumet, M.1    Vargas, A.2    Gurny, R.3    Delie, F.4
  • 123
    • 0036897324 scopus 로고    scopus 로고
    • Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
    • Campbell, R.B.; Fukumura, D.; Brown, E.B.; Mazzola, L.M.; Izumi, Y.; Jain, R.K.; Torchilin, V.P.; Munn, L.L. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res., 2002, 62(23), 6831-6836.
    • (2002) Cancer Res. , vol.62 , Issue.23 , pp. 6831-6836
    • Campbell, R.B.1    Fukumura, D.2    Brown, E.B.3    Mazzola, L.M.4    Izumi, Y.5    Jain, R.K.6    Torchilin, V.P.7    Munn, L.L.8
  • 124
    • 0036829110 scopus 로고    scopus 로고
    • Increased exposure of anionic phospholipids on the surface of tumor blood vessels
    • Ran, S.; Downes, A.; Thorpe, P.E. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res., 2002, 62(21), 6132-6140.
    • (2002) Cancer Res. , vol.62 , Issue.21 , pp. 6132-6140
    • Ran, S.1    Downes, A.2    Thorpe, P.E.3
  • 125
    • 84858440742 scopus 로고    scopus 로고
    • Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor
    • doi: 10.1016/j.addr.2011.04.006
    • Li, Y.; Wang, J.; Wientjes, M.G.; Au, J.L.S. Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor. Adv. Drug Deliv. Rev., 2011, doi: 10.1016/j.addr.2011.04.006.
    • (2011) Adv. Drug Deliv. Rev.
    • Li, Y.1    Wang, J.2    Wientjes, M.G.3    Au, J.L.S.4
  • 127
    • 0037142255 scopus 로고    scopus 로고
    • Liposome clearance in mice: The effect of a separate and combined presence of surface charge and polymer coating
    • Levchenko, T.S.; Rammohan, R.; Lukyanov, A.N.; Whiteman, K.R.; Torchilin, V. P. Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating. Int. J. Pharm., 2002, 240(1-2), 95-102.
    • (2002) Int. J. Pharm. , vol.240 , Issue.1-2 , pp. 95-102
    • Levchenko, T.S.1    Rammohan, R.2    Lukyanov, A.N.3    Whiteman, K.R.4    Torchilin, V.P.5
  • 128
    • 77951523558 scopus 로고    scopus 로고
    • Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties
    • Ho, E.A.; Ramsay, E.; Ginj, M.; Anantha, M.; Bregman, I.; Sy, J.; Woo, J.; Osooly-Talesh, M.; Yapp, D.T.; Bally, M.B. Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties. J. Pharm. Sci., 2010, 99(6), 2839-2853.
    • (2010) J. Pharm. Sci. , vol.99 , Issue.6 , pp. 2839-2853
    • Ho, E.A.1    Ramsay, E.2    Ginj, M.3    Anantha, M.4    Bregman, I.5    Sy, J.6    Woo, J.7    Osooly-Talesh, M.8    Yapp, D.T.9    Bally, M.B.10
  • 129
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • He, C.; Hu, Y.; Yin, L.; Tang, C.; Yin, C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials, 2010, 31(13), 3657-3666.
    • (2010) Biomaterials , vol.31 , Issue.13 , pp. 3657-3666
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 130
    • 0031709640 scopus 로고    scopus 로고
    • Arterial uptake of biodegradable nanoparticles: Effect of surface modifications
    • Labhasetwar, V.; Song, C.; Humphrey, W.; Shebuski, R.; Levy, R.J. Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J. Pharm. Sci., 1998, 87(10), 1229-1234.
    • (1998) J. Pharm. Sci. , vol.87 , Issue.10 , pp. 1229-1234
    • Labhasetwar, V.1    Song, C.2    Humphrey, W.3    Shebuski, R.4    Levy, R.J.5
  • 132
    • 60849117221 scopus 로고    scopus 로고
    • The association of silicon microparticles with endothelial cells in drug delivery to the vasculature
    • Serda, R.E.; Gu, J.; Bhavane, R.C.; Liu, X.; Chiappini, C.; Decuzzi, P.; Ferrari, M. The association of silicon microparticles with endothelial cells in drug delivery to the vasculature. Biomaterials, 2009, 30(13), 2440-2448.
    • (2009) Biomaterials , vol.30 , Issue.13 , pp. 2440-2448
    • Serda, R.E.1    Gu, J.2    Bhavane, R.C.3    Liu, X.4    Chiappini, C.5    Decuzzi, P.6    Ferrari, M.7
  • 133
    • 33847633001 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice
    • Kommareddy, S.; Amiji, M. Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice. J. Pharm. Sci., 2007, 96(2), 397-407.
    • (2007) J. Pharm. Sci. , vol.96 , Issue.2 , pp. 397-407
    • Kommareddy, S.1    Amiji, M.2
  • 134
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control. Release, 2008, 126(3), 187-204.
    • (2008) J. Control. Release , vol.126 , Issue.3 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 135
    • 33751520245 scopus 로고    scopus 로고
    • Thermo-and pH-responsive polymers in drug delivery
    • Schmaljohann, D. Thermo-and pH-responsive polymers in drug delivery. Adv. Drug Deliv. Rev., 2006, 58(15), 1655-1670.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , Issue.15 , pp. 1655-1670
    • Schmaljohann, D.1
  • 136
    • 77955600995 scopus 로고    scopus 로고
    • Intravital microscopy in window chambers: A unique tool to study tumor angiogenesis and delivery of nanoparticles
    • Hak, S.; Reitan, N.K.; Haraldseth, O.; de Lange Davies, C. Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles. Angiogenesis, 2010, 13(2), 113-130.
    • (2010) Angiogenesis , vol.13 , Issue.2 , pp. 113-130
    • Hak, S.1    Reitan, N.K.2    Haraldseth, O.3    De Lange Davies, C.4
  • 137
    • 0035981024 scopus 로고    scopus 로고
    • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors
    • Needham, D.; Dewhirst, M.W. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv. Drug Deliv. Rev., 2001, 53(3), 285-305.
    • (2001) Adv. Drug Deliv. Rev. , vol.53 , Issue.3 , pp. 285-305
    • Needham, D.1    Dewhirst, M.W.2
  • 138
    • 34249316870 scopus 로고    scopus 로고
    • Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors
    • Dreher, M.R.; Liu, W.; Michelich, C.R.; Dewhirst, M.W.; Chilkoti, A. Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. Cancer Res., 2007, 67(9), 4418-4424.
    • (2007) Cancer Res. , vol.67 , Issue.9 , pp. 4418-4424
    • Dreher, M.R.1    Liu, W.2    Michelich, C.R.3    Dewhirst, M.W.4    Chilkoti, A.5
  • 140
    • 78649934086 scopus 로고    scopus 로고
    • PH-responsive nanoparticles for drug delivery
    • Gao, W.; Chan, J.M.; Farokhzad, O.C. pH-responsive nanoparticles for drug delivery. Mol. Pharm., 2010, 7(6), 1913-1920.
    • (2010) Mol. Pharm. , vol.7 , Issue.6 , pp. 1913-1920
    • Gao, W.1    Chan, J.M.2    Farokhzad, O.C.3
  • 141
    • 77955915567 scopus 로고    scopus 로고
    • Liposomes as 'smart' pharmaceutical nanocarriers
    • Sawant, R.R.; Torchilin, V.P. Liposomes as 'smart' pharmaceutical nanocarriers. Soft Matter, 2010, 6(17), 4026-4044.
    • (2010) Soft Matter , vol.6 , Issue.17 , pp. 4026-4044
    • Sawant, R.R.1    Torchilin, V.P.2
  • 142
    • 0035858327 scopus 로고    scopus 로고
    • N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles
    • Leroux, J.C.; Roux, E.; Le Garrec, D.; Hong, K.L.; Drummond, D.C. N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. J. Control. Release, 2001, 72(1-3), 71-84.
    • (2001) J. Control. Release , vol.72 , Issue.1-3 , pp. 71-84
    • Leroux, J.C.1    Roux, E.2    Le Garrec, D.3    Hong, K.L.4    Drummond, D.C.5
  • 143
    • 0037734332 scopus 로고    scopus 로고
    • On the characterization of pH-sensitive liposome/polymer complexes
    • Roux, E.; Lafleur, M.; Lataste, E.; Moreau, P.; Leroux, J.C. On the characterization of pH-sensitive liposome/polymer complexes. Biomacromolecules, 2003, 4(2), 240-248.
    • (2003) Biomacromolecules , vol.4 , Issue.2 , pp. 240-248
    • Roux, E.1    Lafleur, M.2    Lataste, E.3    Moreau, P.4    Leroux, J.C.5
  • 144
    • 0141921478 scopus 로고    scopus 로고
    • Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids
    • Shin, J.; Shum, P.; Thompson, D.H. Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. J. Control. Release, 2003, 91(1-2), 187-200.
    • (2003) J. Control. Release , vol.91 , Issue.1-2 , pp. 187-200
    • Shin, J.1    Shum, P.2    Thompson, D.H.3
  • 145
    • 67749143922 scopus 로고    scopus 로고
    • Expansile nanoparticles: Synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system
    • Griset, A.P.; Walpole, J.; Liu, R.; Gaffey, A.; Colson, Y.L.; Grinstaff, M.W. Expansile nanoparticles: synthesis, characterization, and in vivo efficacy of an acid-responsive polymeric drug delivery system. J. Am. Chem. Soc., 2009, 131(7), 2469-2471.
    • (2009) J. Am. Chem. Soc. , vol.131 , Issue.7 , pp. 2469-2471
    • Griset, A.P.1    Walpole, J.2    Liu, R.3    Gaffey, A.4    Colson, Y.L.5    Grinstaff, M.W.6
  • 146
    • 66049162476 scopus 로고    scopus 로고
    • Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging
    • Criscione, J.M.; Le, B.L.; Stern, E.; Brennan, M.; Rahner, C.; Papademetris, X.; Fahmy, T.M. Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and noninvasive imaging. Biomaterials, 2009, 30(23-24), 3946-3955.
    • (2009) Biomaterials , vol.30 , Issue.23-24 , pp. 3946-3955
    • Criscione, J.M.1    Le, B.L.2    Stern, E.3    Brennan, M.4    Rahner, C.5    Papademetris, X.6    Fahmy, T.M.7
  • 147
    • 77950461871 scopus 로고    scopus 로고
    • Serum-stable, long-circulating, pH-sensitive PEGylated liposomes
    • Bertrand, N.; Simard, P.; Leroux, J.C. Serum-stable, long-circulating, pH-sensitive PEGylated liposomes. Methods Mol. Biol., 2010, 605, 545-558.
    • (2010) Methods Mol. Biol. , vol.605 , pp. 545-558
    • Bertrand, N.1    Simard, P.2    Leroux, J.C.3
  • 148
    • 42949138711 scopus 로고    scopus 로고
    • Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal
    • Mok, H.; Park, J.W.; Park, T.G. Enhanced intracellular delivery of quantum dot and adenovirus nanoparticles triggered by acidic pH via surface charge reversal. Bioconjug. Chem., 2008, 19(4), 797-801.
    • (2008) Bioconjug. Chem. , vol.19 , Issue.4 , pp. 797-801
    • Mok, H.1    Park, J.W.2    Park, T.G.3
  • 149
    • 79959806796 scopus 로고    scopus 로고
    • Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia
    • Poon, Z.; Chang, D.; Zhao, X.; Hammond, P.T. Layer-by-layer nanoparticles with a pH-sheddable layer for in vivo targeting of tumor hypoxia. ACS Nano, 2011, 5(6), 4284-4292.
    • (2011) ACS Nano , vol.5 , Issue.6 , pp. 4284-4292
    • Poon, Z.1    Chang, D.2    Zhao, X.3    Hammond, P.T.4
  • 151
    • 79959963318 scopus 로고    scopus 로고
    • Extravasation of polymeric nanomedicines across tumor vasculature
    • Danquah, M.K.; Zhang, X.A.; Mahato, R.I. Extravasation of polymeric nanomedicines across tumor vasculature. Adv. Drug Deliv. Rev., 2011, 63(8), 623-639.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , Issue.8 , pp. 623-639
    • Danquah, M.K.1    Zhang, X.A.2    Mahato, R.I.3
  • 152
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger, G.; Yuan, F.; Dellian, M.; Jain, R.K. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med., 1997, 3(2), 177-182.
    • (1997) Nat. Med. , vol.3 , Issue.2 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 153
    • 77957737792 scopus 로고    scopus 로고
    • Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes
    • Kuai, R.; Yuan, W.; Qin, Y.; Chen, H.; Tang, J.; Yuan, M.; Zhang, Z.; He, Q. Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes. Mol. Pharm., 2010, 7(5), 1816-1826.
    • (2010) Mol. Pharm. , vol.7 , Issue.5 , pp. 1816-1826
    • Kuai, R.1    Yuan, W.2    Qin, Y.3    Chen, H.4    Tang, J.5    Yuan, M.6    Zhang, Z.7    He, Q.8
  • 154
    • 0344873301 scopus 로고    scopus 로고
    • Pharmaco attributes of dioleoylphosphatidylethanolamine/ cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers
    • Zhang, J.X.; Zalipsky, S.; Mullah, N.; Pechar, M.; Allen, T.M. Pharmaco attributes of dioleoylphosphatidylethanolamine/cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers. Pharmacol. Res., 2004, 49(2), 185-198.
    • (2004) Pharmacol. Res. , vol.49 , Issue.2 , pp. 185-198
    • Zhang, J.X.1    Zalipsky, S.2    Mullah, N.3    Pechar, M.4    Allen, T.M.5
  • 155
    • 33749682476 scopus 로고    scopus 로고
    • Protease-modulated cellular uptake of quantum dots
    • Zhang, Y.; So, M.K.; Rao, J. Protease-modulated cellular uptake of quantum dots. Nano Lett., 2006, 6(9), 1988-1992.
    • (2006) Nano Lett. , vol.6 , Issue.9 , pp. 1988-1992
    • Zhang, Y.1    So, M.K.2    Rao, J.3
  • 157
    • 61549102484 scopus 로고    scopus 로고
    • PEGylated and MMP-2 specifically dePEGylated quantum dots: Comparative evaluation of cellular uptake
    • Mok, H.; Bae, K.H.; Ahn, C.H.; Park, T.G. PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake. Langmuir, 2008, 25(3), 1645-1650.
    • (2008) Langmuir , vol.25 , Issue.3 , pp. 1645-1650
    • Mok, H.1    Bae, K.H.2    Ahn, C.H.3    Park, T.G.4
  • 159
    • 0030015598 scopus 로고    scopus 로고
    • Die blut-hirn-schranke: eine besonderheit des cerebralen mikrozirkulationssystems
    • Wolf, S.; Seehaus, B.; Minol, K.; Günter Gassen, H. Die blut-hirn-schranke: eine besonderheit des cerebralen mikrozirkulationssystems. Naturwissenschaften, 1996, 83(7), 302-311.
    • (1996) Naturwissenschaften , vol.83 , Issue.7 , pp. 302-311
    • Wolf, S.1    Seehaus, B.2    Minol, K.3    Günter Gassen, H.4
  • 160
    • 21244497743 scopus 로고    scopus 로고
    • New aspects of the blood-brain barrier transporters; Its physiological roles in the central nervous system
    • Ohtsuki, S. New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. Biol. Pharm. Bull., 2004, 27(10), 1489-1496.
    • (2004) Biol. Pharm. Bull. , vol.27 , Issue.10 , pp. 1489-1496
    • Ohtsuki, S.1
  • 161
    • 0025285170 scopus 로고
    • Immune function of the blood-brain barrier: Incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro
    • Risau, W.; Engelhardt, B.; Wekerle, H. Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro. J. Cell Biol., 1990, 110(5), 1757-1766.
    • (1990) J. Cell Biol. , vol.110 , Issue.5 , pp. 1757-1766
    • Risau, W.1    Engelhardt, B.2    Wekerle, H.3
  • 162
    • 0011099824 scopus 로고    scopus 로고
    • Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain
    • el-Bacha, R.S.; Minn, A. Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain. Cell. Mol. Biol., 1999, 45(1), 15-23.
    • (1999) Cell. Mol. Biol. , vol.45 , Issue.1 , pp. 15-23
    • El-Bacha, R.S.1    Minn, A.2
  • 163
    • 0034986361 scopus 로고    scopus 로고
    • Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier
    • Gilgun-Sherki, Y.; Melamed, E.; Offen, D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the
    • (2001) Neuropharmacology , vol.40 , Issue.8 , pp. 959-975
    • Gilgun-Sherki, Y.1    Melamed, E.2    Offen, D.3
  • 164
    • 12344323934 scopus 로고    scopus 로고
    • The blood-brain barrier and neurotherapeutics
    • Pardridge, W. M. The blood-brain barrier and neurotherapeutics. Neurorx, 2005, 2(1), 1-2.
    • (2005) Neurorx , vol.2 , Issue.1 , pp. 1-2
    • Pardridge, W.M.1
  • 165
    • 0036020288 scopus 로고    scopus 로고
    • Morpho-functional studies of the blood-brain barrier in streptozotocin-induced diabetic rats
    • Bouchard, P.; Ghitescu, L. D.; Bendayan, M. Morpho-functional studies of the blood-brain barrier in streptozotocin-induced diabetic rats. Diabetologia, 2002, 45(7), 1017-1025.
    • (2002) Diabetologia , vol.45 , Issue.7 , pp. 1017-1025
    • Bouchard, P.1    Ghitescu, L.D.2    Bendayan, M.3
  • 166
    • 0030890905 scopus 로고    scopus 로고
    • Central nervous system complications of diabetes mellitus-a perspective from the blood-brain barrier
    • Mooradian, A. D. Central nervous system complications of diabetes mellitus-a perspective from the blood-brain barrier. Brain Res. Rev., 1997, 23(3), 210-218.
    • (1997) Brain Res. Rev. , vol.23 , Issue.3 , pp. 210-218
    • Mooradian, A.D.1
  • 167
    • 0035576934 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
    • Huber, J.D.; Egleton, R.D.; Davis, T.P. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci., 2001, 24(12), 719-725.
    • (2001) Trends Neurosci. , vol.24 , Issue.12 , pp. 719-725
    • Huber, J.D.1    Egleton, R.D.2    Davis, T.P.3
  • 168
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
    • Butt, A.M.; Jones, H.C.; Abbott, N.J. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol., 1990, 429, 47-62.
    • (1990) J. Physiol. , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 169
    • 0031985061 scopus 로고    scopus 로고
    • Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier
    • Cornford, E.M.; Hyman, S.; Cornford, M.E.; Landaw, E.M.; Delgado-Escueta, A.V. Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier. J. Cereb. Blood Flow Metab., 1998, 18(1), 26-42.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , Issue.1 , pp. 26-42
    • Cornford, E.M.1    Hyman, S.2    Cornford, M.E.3    Landaw, E.M.4    Delgado-Escueta, A.V.5
  • 170
    • 0017487289 scopus 로고
    • The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
    • Oldendorf, W.H.; Cornford, M.E.; Brown, W.J. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann. Neurol., 1977, 1(5), 409-417.
    • (1977) Ann. Neurol. , vol.1 , Issue.5 , pp. 409-417
    • Oldendorf, W.H.1    Cornford, M.E.2    Brown, W.J.3
  • 171
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell, R.D.; Zlokovic, B.V. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol., 2009, 118(1), 103-113.
    • (2009) Acta Neuropathol. , vol.118 , Issue.1 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 172
    • 0036605677 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein at the blood brain barrier
    • Bendayan, R.; Lee, G.; Bendayan, M. Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc. Res. Tech., 2002, 57(5), 365-380.
    • (2002) Microsc. Res. Tech. , vol.57 , Issue.5 , pp. 365-380
    • Bendayan, R.1    Lee, G.2    Bendayan, M.3
  • 173
    • 48949117586 scopus 로고    scopus 로고
    • Pericytes: Pluripotent cells of the blood brain barrier
    • Dore-Duffy, P. Pericytes: pluripotent cells of the blood brain barrier. Curr. Pharm. Des., 2008, 14(16), 1581-1593.
    • (2008) Curr. Pharm. Des. , vol.14 , Issue.16 , pp. 1581-1593
    • Dore-Duffy, P.1
  • 174
  • 175
    • 0027197053 scopus 로고
    • Cerebral pericytes-a second line of defense in controlling blood-brain barrier peptide metabolism
    • Krause, D.; Kunz, J.; Dermietzel, R. Cerebral pericytes-a second line of defense in controlling blood-brain barrier peptide metabolism. Adv. Exp. Med. Biol., 1993, 331, 149-152.
    • (1993) Adv. Exp. Med. Biol. , vol.331 , pp. 149-152
    • Krause, D.1    Kunz, J.2    Dermietzel, R.3
  • 176
    • 26244456551 scopus 로고    scopus 로고
    • Molecular biology of the blood-brain barrier
    • Pardridge, W.M. Molecular biology of the blood-brain barrier. Mol. Biotechnol., 2005, 30(1), 57-70.
    • (2005) Mol. Biotechnol. , vol.30 , Issue.1 , pp. 57-70
    • Pardridge, W.M.1
  • 177
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott, N.J.; Ronnback, L.; Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci., 2006, 7(1), 41-53.
    • (2006) Nat. Rev. Neurosci. , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 178
    • 0031775308 scopus 로고    scopus 로고
    • Astrocyte regulation of endothelial tissue plasminogen activator in a blood-brain barrier model
    • Tran, N.D.; Schreiber, S.S.; Fisher, M. Astrocyte regulation of endothelial tissue plasminogen activator in a blood-brain barrier model. J. Cereb. Blood Flow Metab., 1998, 18(12), 1316-1324.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , Issue.12 , pp. 1316-1324
    • Tran, N.D.1    Schreiber, S.S.2    Fisher, M.3
  • 180
    • 12344319635 scopus 로고    scopus 로고
    • Development of neuropeptide drugs that cross the blood-brain barrier
    • Egleton, R.D.; Davis, T.P. Development of neuropeptide drugs that cross the blood-brain barrier. Neurorx, 2005, 2(1), 44-53.
    • (2005) Neurorx , vol.2 , Issue.1 , pp. 44-53
    • Egleton, R.D.1    Davis, T.P.2
  • 181
    • 0030893316 scopus 로고    scopus 로고
    • Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: Comparison with morphine
    • Abbruscato, T.J.; Thomas, S.A.; Hruby, V.J.; Davis, T.P. Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine. J. Pharmacol. Exp. Ther., 1997, 280(1), 402-409.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , Issue.1 , pp. 402-409
    • Abbruscato, T.J.1    Thomas, S.A.2    Hruby, V.J.3    Davis, T.P.4
  • 183
    • 0033526185 scopus 로고    scopus 로고
    • Blood-brain barrier permeability to small and large molecules
    • Cornford, E.M.; Hyman, S. Blood-brain barrier permeability to small and large molecules. Adv. Drug Deliv. Rev., 1999, 36(2-3), 145-163.
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , Issue.2-3 , pp. 145-163
    • Cornford, E.M.1    Hyman, S.2
  • 184
    • 34547786737 scopus 로고    scopus 로고
    • The role of aquaporin-4 in cerebral water transport and edema 1
    • Bloch, O.; Manley, T.G. The role of aquaporin-4 in cerebral water transport and edema 1. Neurosurg. Focus, 2007, 22(5), E3.
    • (2007) Neurosurg. Focus , vol.22 , Issue.5
    • Bloch, O.1    Manley, T.G.2
  • 185
    • 37349087117 scopus 로고    scopus 로고
    • Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats
    • Badaut, J.; Brunet, J.F.; Petit, J.M.; Guerin, C.F.; Magistretti, P.J.; Regli, L. Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats. Brain Res., 2008, 1188, 17-24.
    • (2008) Brain Res. , vol.1188 , pp. 17-24
    • Badaut, J.1    Brunet, J.F.2    Petit, J.M.3    Guerin, C.F.4    Magistretti, P.J.5    Regli, L.6
  • 186
    • 35449002927 scopus 로고    scopus 로고
    • Aquaporins in the brain: From aqueduct to multi-duct"
    • Badaut, J.; Brunet, J.F.; Regli, L. Aquaporins in the brain: from aqueduct to "multi-duct". Metab. Brain Dis., 2007, 22(3-4), 251-263.
    • (2007) Metab. Brain Dis. , vol.22 , Issue.3-4 , pp. 251-263
    • Badaut, J.1    Brunet, J.F.2    Regli, L.3
  • 187
  • 188
    • 65649123363 scopus 로고    scopus 로고
    • Expression profiling of the solute carrier gene family in the mouse brain
    • Dahlin, A.; Royall, J.; Hohmann, J. G.; Wang, J. Expression profiling of the solute carrier gene family in the mouse brain. J. Pharmacol. Exp. Ther., 2009, 329(2), 558-570.
    • (2009) J. Pharmacol. Exp. Ther. , vol.329 , Issue.2 , pp. 558-570
    • Dahlin, A.1    Royall, J.2    Hohmann, J.G.3    Wang, J.4
  • 189
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • Pardridge, W.M. Blood-brain barrier delivery. Drug Discov. Today, 2007, 12(1-2), 54-61.
    • (2007) Drug Discov. Today , vol.12 , Issue.1-2 , pp. 54-61
    • Pardridge, W.M.1
  • 190
    • 0030742898 scopus 로고    scopus 로고
    • Brain and spinal cord distribution of biphalin: Correlation with opioid receptor density and mechanism of CNS entry
    • Abbruscato, T.J.; Thomas, S.A.; Hruby, V.J.; Davis, T.P. Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry. J. Neurochem., 1997, 69(3), 1236-1245.
    • (1997) J. Neurochem. , vol.69 , Issue.3 , pp. 1236-1245
    • Abbruscato, T.J.1    Thomas, S.A.2    Hruby, V.J.3    Davis, T.P.4
  • 191
    • 0024435745 scopus 로고
    • Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain
    • Zlokovic, B.V.; Mackic, J.B.; Djuricic, B.; Davson, H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J. Neurochem., 1989, 53(5), 1333-1340.
    • (1989) J. Neurochem. , vol.53 , Issue.5 , pp. 1333-1340
    • Zlokovic, B.V.1    MacKic, J.B.2    Djuricic, B.3    Davson, H.4
  • 193
    • 0030615087 scopus 로고    scopus 로고
    • The entry of [D-penicillamine2, 5]enkephalin into the central nervous system: Saturation kinetics and specificity
    • Thomas, S.A.; Abbruscato, T.J.; Hruby, V.J.; Davis, T.P. The entry of [D-penicillamine2, 5]enkephalin into the central nervous system: saturation kinetics and specificity. J. Pharmacol. Exp. Ther., 1997, 280(3), 1235-1240.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , Issue.3 , pp. 1235-1240
    • Thomas, S.A.1    Abbruscato, T.J.2    Hruby, V.J.3    Davis, T.P.4
  • 194
    • 1642454475 scopus 로고    scopus 로고
    • ABC transporters and the blood-brain barrier
    • Begley, D.J. ABC transporters and the blood-brain barrier. Curr. Pharm. Des., 2004, 10(12), 1295-1312.
    • (2004) Curr. Pharm. Des. , vol.10 , Issue.12 , pp. 1295-1312
    • Begley, D.J.1
  • 195
    • 33748896303 scopus 로고    scopus 로고
    • Expression and function of multidrug resistance transporters at the blood brain barriers
    • Scherrmann, J.M. Expression and function of multidrug resistance transporters at the blood brain barriers. Expert Opin. Drug Metab. Toxicol., 2005, 1(2), 233-246.
    • (2005) Expert Opin. Drug Metab. Toxicol. , vol.1 , Issue.2 , pp. 233-246
    • Scherrmann, J.M.1
  • 196
    • 12344262373 scopus 로고    scopus 로고
    • Blood-brain barrier active efflux transporters: ATP-binding cassette gene family
    • Löscher, W.; Potschka, H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. Neurorx, 2005, 2(1), 86-98.
    • (2005) Neurorx , vol.2 , Issue.1 , pp. 86-98
    • Löscher, W.1    Potschka, H.2
  • 197
    • 0032818545 scopus 로고    scopus 로고
    • Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid
    • Hosoya, K.; Sugawara, M.; Asaba, H.; Terasaki, T., Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid. J. Neurochem., 1999, 73(3), 1206-1211.
    • (1999) J. Neurochem. , vol.73 , Issue.3 , pp. 1206-1211
    • Hosoya, K.1    Sugawara, M.2    Asaba, H.3    Terasaki, T.4
  • 198
    • 0029035114 scopus 로고
    • Transport of small molecules through the blood-brain barrier: Biology and methodology
    • Pardridge, W.M. Transport of small molecules through the blood-brain barrier: biology and methodology. Adv. Drug Deliv. Rev., 1995, 15(1-3), 5-36.
    • (1995) Adv. Drug Deliv. Rev. , vol.15 , Issue.1-3 , pp. 5-36
    • Pardridge, W.M.1
  • 199
    • 0022481626 scopus 로고
    • Receptor-mediated endocytosis
    • Stahl, P.; Schwartz, A.L. Receptor-mediated endocytosis. J. Clin. Invest., 1986, 77(3), 657-662.
    • (1986) J. Clin. Invest. , vol.77 , Issue.3 , pp. 657-662
    • Stahl, P.1    Schwartz, A.L.2
  • 200
    • 0027535206 scopus 로고
    • Receptor-mediated endocytosis of transferrin at the blood-brain barrier
    • Roberts, R.L.; Fine, R.E.; Sandra, A. Receptor-mediated endocytosis of transferrin at the blood-brain barrier. J. Cell Sci., 1993, 104(Pt 2), 521-532.
    • (1993) J. Cell Sci. , vol.104 , Issue.PART 2 , pp. 521-532
    • Roberts, R.L.1    Fine, R.E.2    Sandra, A.3
  • 201
    • 0023636719 scopus 로고
    • Blood-brain barrier transcytosis of insulin in developing rabbits
    • Duffy, K.R.; Pardridge, W.M. Blood-brain barrier transcytosis of insulin in developing rabbits. Brain Res., 1987, 420(1), 32-38.
    • (1987) Brain Res. , vol.420 , Issue.1 , pp. 32-38
    • Duffy, K.R.1    Pardridge, W.M.2
  • 202
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • Banks, W.A.; Kastin, A.J.; Huang, W.; Jaspan, J.B.; Maness, L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides, 1996, 17(2), 305-311.
    • (1996) Peptides , vol.17 , Issue.2 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 203
    • 0023830889 scopus 로고
    • Human blood-brain barrier insulin-like growth factor receptor
    • Duffy, K.R.; Pardridge, W.M.; Rosenfeld, R.G. Human blood-brain barrier insulin-like growth factor receptor. Metabolism., 1988, 37(2), 136-140.
    • (1988) Metabolism. , vol.37 , Issue.2 , pp. 136-140
    • Duffy, K.R.1    Pardridge, W.M.2    Rosenfeld, R.G.3
  • 204
    • 0030948209 scopus 로고    scopus 로고
    • Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier
    • Tamai, I.; Sai, Y.; Kobayashi, H.; Kamata, M.; Wakamiya, T.; Tsuji, A. Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier. J. Pharmacol. Exp. Ther., 1997, 280(1), 410-415.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , Issue.1 , pp. 410-415
    • Tamai, I.1    Sai, Y.2    Kobayashi, H.3    Kamata, M.4    Wakamiya, T.5    Tsuji, A.6
  • 205
    • 57149110011 scopus 로고    scopus 로고
    • CNS delivery via adsorptive transcytosis
    • Herve, F.; Ghinea, N.; Scherrmann, J.M. CNS delivery via adsorptive transcytosis. AAPS J., 2008, 10(3), 455-472.
    • (2008) AAPS J. , vol.10 , Issue.3 , pp. 455-472
    • Herve, F.1    Ghinea, N.2    Scherrmann, J.M.3
  • 206
    • 0031695039 scopus 로고    scopus 로고
    • Blood-brain barrier permeation: Molecular parameters governing passive diffusion
    • Fischer, H.; Gottschlich, R.; Seelig, A. Blood-brain barrier permeation: molecular parameters governing passive diffusion. J. Membr. Biol., 1998, 165(3), 201-211.
    • (1998) J. Membr. Biol. , vol.165 , Issue.3 , pp. 201-211
    • Fischer, H.1    Gottschlich, R.2    Seelig, A.3
  • 207
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: bottleneck in brain drug development. Neurorx, 2005, 2(1), 3-14.
    • (2005) Neurorx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 208
    • 0035037852 scopus 로고    scopus 로고
    • Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: Role of envelope proteins and adsorptive endocytosis
    • Banks, W.A.; Freed, E.O.; Wolf, K.M.; Robinson, S.M.; Franko, M.; Kumar, V.B. Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis. J. Virol., 2001, 75(10), 4681-4691.
    • (2001) J. Virol. , vol.75 , Issue.10 , pp. 4681-4691
    • Banks, W.A.1    Freed, E.O.2    Wolf, K.M.3    Robinson, S.M.4    Franko, M.5    Kumar, V.B.6
  • 209
    • 63249115678 scopus 로고    scopus 로고
    • The blood-brain barrier in brain homeostasis and neurological diseases
    • Weiss, N.; Miller, F.; Cazaubon, S.; Couraud, P.O. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim. Biophys. Acta, 2009, 1788(4), 842-857.
    • (2009) Biochim. Biophys. Acta , vol.1788 , Issue.4 , pp. 842-857
    • Weiss, N.1    Miller, F.2    Cazaubon, S.3    Couraud, P.O.4
  • 210
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • 51
    • Pardridge, W.M. Blood-brain barrier drug targeting: the future of brain drug development. Mol. Interv., 2003, 3(2), 90-105, 51.
    • (2003) Mol. Interv. , vol.3 , Issue.2 , pp. 90-105
    • Pardridge, W.M.1
  • 211
    • 33750630071 scopus 로고    scopus 로고
    • Advances in strategies to improve drug delivery to brain tumors
    • Newton, H.B. Advances in strategies to improve drug delivery to brain tumors. Expert Rev. Neurother., 2006, 6(10), 1495-1509.
    • (2006) Expert Rev. Neurother. , vol.6 , Issue.10 , pp. 1495-1509
    • Newton, H.B.1
  • 215
    • 0034757615 scopus 로고    scopus 로고
    • Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: Contributions of energy depletion and membrane fluidization
    • Batrakova, E.V.; Li, S.; Vinogradov, S.V.; Alakhov, V.Y.; Miller, D.W.; Kabanov, A.V. Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization. J. Pharmacol. Exp. Ther., 2001, 299(2), 483-493.
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , Issue.2 , pp. 483-493
    • Batrakova, E.V.1    Li, S.2    Vinogradov, S.V.3    Alakhov, V.Y.4    Miller, D.W.5    Kabanov, A.V.6
  • 216
    • 1342308343 scopus 로고    scopus 로고
    • Second-line chemotherapy with the association of liposomal daunorubicin, carboplatin and etoposide in children with recurrent malignant brain tumors
    • Fiorillo, A.; Maggi, G.; Greco, N.; Migliorati, R.; D'Amico, A.; De Caro, M.D.; Sabbatino, M.S.; Buffardi, F. Second-line chemotherapy with the association of liposomal daunorubicin, carboplatin and etoposide in children with recurrent malignant brain tumors. J. Neurooncol., 2004, 66(1-2), 179-85.
    • (2004) J. Neurooncol. , vol.66 , Issue.1-2 , pp. 179-185
    • Fiorillo, A.1    Maggi, G.2    Greco, N.3    Migliorati, R.4    D'Amico, A.5    De Caro, M.D.6    Sabbatino, M.S.7    Buffardi, F.8
  • 217
    • 0034764188 scopus 로고    scopus 로고
    • High concentration of daunorubicin and daunorubicinol in human malignant astrocytomas after systemic administration of liposomal daunorubicin
    • Albrecht, K.W.; de Witt Hamer, P.C.; Leenstra, S.; Bakker, P.J.; Beijnen, J.H.; Troost, D.; Kaaijk, P.; Bosch, A.D. High concentration of daunorubicin and daunorubicinol in human malignant astrocytomas after systemic administration of liposomal daunorubicin. J. Neurooncol., 2001, 53(3), 267-271.
    • (2001) J. Neurooncol. , vol.53 , Issue.3 , pp. 267-271
    • Albrecht, K.W.1    De Witt Hamer, P.C.2    Leenstra, S.3    Bakker, P.J.4    Beijnen, J.H.5    Troost, D.6    Kaaijk, P.7    Bosch, A.D.8
  • 219
    • 0033734065 scopus 로고    scopus 로고
    • High intratumoral accumulation of stealth liposomal doxorubicin (Caelyx) in glioblastomas and in metastatic brain tumors
    • Koukourakis, M.I.; Koukouraki, S.; Fezoulidis, I.; Kelekis, N.; Kyrias, G.; Archimandritis, S.; Karkavitsas, N. High intratumoral accumulation of stealth liposomal doxorubicin (Caelyx) in glioblastomas and in metastatic brain tumors. Br. J. Cancer, 2000, 83(10), 1281-1286.
    • (2000) Br. J. Cancer , vol.83 , Issue.10 , pp. 1281-1286
    • Koukourakis, M.I.1    Koukouraki, S.2    Fezoulidis, I.3    Kelekis, N.4    Kyrias, G.5    Archimandritis, S.6    Karkavitsas, N.7
  • 220
    • 0032988632 scopus 로고    scopus 로고
    • Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin
    • Zucchetti, M.; Boiardi, A.; Silvani, A.; Parisi, I.; Piccolrovazzi, S.; D'Incalci, M. Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin. Cancer Chemother. Pharmacol., 1999, 44(2), 173-176.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , Issue.2 , pp. 173-176
    • Zucchetti, M.1    Boiardi, A.2    Silvani, A.3    Parisi, I.4    Piccolrovazzi, S.5    D'Incalci, M.6
  • 222
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino, M.L.; Dosio, F.; Cattel, L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int. J. Nanomedicine, 2006, 1(3), 297-315.
    • (2006) Int. J. Nanomedicine , vol.1 , Issue.3 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 224
    • 33750099138 scopus 로고    scopus 로고
    • Review: Nanoparticles in drug delivery for the treatment of cancer
    • Arayne, M.S.; Sultana, N. Review: nanoparticles in drug delivery for the treatment of cancer. Pak J. Pharm. Sci., 2006, 19(3), 258-268.
    • (2006) Pak J. Pharm. Sci. , vol.19 , Issue.3 , pp. 258-268
    • Arayne, M.S.1    Sultana, N.2
  • 226
    • 0033427851 scopus 로고    scopus 로고
    • Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity
    • Olivier, J.C.; Fenart, L.; Chauvet, R.; Pariat, C.; Cecchelli, R.; Couet, W. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Pharm. Res., 1999, 16(12), 1836-1842.
    • (1999) Pharm. Res. , vol.16 , Issue.12 , pp. 1836-1842
    • Olivier, J.C.1    Fenart, L.2    Chauvet, R.3    Pariat, C.4    Cecchelli, R.5    Couet, W.6
  • 227
    • 0032712180 scopus 로고    scopus 로고
    • Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
    • Gulyaev, A.E.; Gelperina, S.E.; Skidan, I.N.; Antropov, A.S.; Kivman, G.Y.; Kreuter, J. Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm. Res., 1999, 16(10), 1564-1569.
    • (1999) Pharm. Res. , vol.16 , Issue.10 , pp. 1564-1569
    • Gulyaev, A.E.1    Gelperina, S.E.2    Skidan, I.N.3    Antropov, A.S.4    Kivman, G.Y.5    Kreuter, J.6
  • 228
    • 0036896915 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting
    • Brigger, I.; Morizet, J.; Aubert, G.; Chacun, H.; Terrier-Lacombe, M.J.; Couvreur, P.; Vassal, G. Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting. J. Pharmacol. Exp. Ther., 2002, 303(3), 928-936.
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , Issue.3 , pp. 928-936
    • Brigger, I.1    Morizet, J.2    Aubert, G.3    Chacun, H.4    Terrier-Lacombe, M.J.5    Couvreur, P.6    Vassal, G.7
  • 229
    • 0036460265 scopus 로고    scopus 로고
    • Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat
    • Calvo, P.; Gouritin, B.; Villarroya, H.; Eclancher, F.; Giannavola, C.; Klein, C.; Andreux, J.P.; Couvreur, P. Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat. Eur. J. Neurosci., 2002, 15(8), 1317-1326.
    • (2002) Eur. J. Neurosci. , vol.15 , Issue.8 , pp. 1317-1326
    • Calvo, P.1    Gouritin, B.2    Villarroya, H.3    Eclancher, F.4    Giannavola, C.5    Klein, C.6    Andreux, J.P.7    Couvreur, P.8
  • 232
    • 26944477353 scopus 로고    scopus 로고
    • Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier
    • Costantino, L.; Gandolfi, F.; Tosi, G.; Rivasi, F.; Vandelli, M.A.; Forni, F. Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier. J. Control. Release, 2005, 108(1), 84-96.
    • (2005) J. Control. Release , vol.108 , Issue.1 , pp. 84-96
    • Costantino, L.1    Gandolfi, F.2    Tosi, G.3    Rivasi, F.4    Vandelli, M.A.5    Forni, F.6
  • 233
  • 235
    • 0032909537 scopus 로고    scopus 로고
    • Body distribution of camptothecin solid lipid nanoparticles after oral administration
    • Yang, S.; Zhu, J.; Lu, Y.; Liang, B.; Yang, C. Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm. Res., 1999, 16(5), 751-757.
    • (1999) Pharm. Res. , vol.16 , Issue.5 , pp. 751-757
    • Yang, S.1    Zhu, J.2    Lu, Y.3    Liang, B.4    Yang, C.5
  • 236
    • 0032950389 scopus 로고    scopus 로고
    • Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
    • Yang, S.C.; Lu, L.F.; Cai, Y.; Zhu, J.B.; Liang, B.W.; Yang, C.Z. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release, 1999, 59(3), 299-307.
    • (1999) J. Control. Release , vol.59 , Issue.3 , pp. 299-307
    • Yang, S.C.1    Lu, L.F.2    Cai, Y.3    Zhu, J.B.4    Liang, B.W.5    Yang, C.Z.6
  • 237
    • 0032852207 scopus 로고    scopus 로고
    • Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN)
    • Zara, G.P.; Cavalli, R.; Fundaro, A.; Bargoni, A.; Caputo, O.; Gasco, M.R. Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN). Pharmacol. Res., 1999, 40(3), 281-286.
    • (1999) Pharmacol. Res. , vol.40 , Issue.3 , pp. 281-286
    • Zara, G.P.1    Cavalli, R.2    Fundaro, A.3    Bargoni, A.4    Caputo, O.5    Gasco, M.R.6
  • 238
    • 4544240398 scopus 로고    scopus 로고
    • Paclitaxel nanoparticles for the potential treatment of brain tumors
    • Koziara, J.M.; Lockman, P.R.; Allen, D.D.; Mumper, R.J. Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Release, 2004, 99(2), 259-269.
    • (2004) J. Control. Release , vol.99 , Issue.2 , pp. 259-269
    • Koziara, J.M.1    Lockman, P.R.2    Allen, D.D.3    Mumper, R.J.4
  • 239
  • 240
    • 2342424322 scopus 로고    scopus 로고
    • New technologies for drug delivery across the blood brain barrier
    • Kabanov, A.V.; Batrakova, E.V. New technologies for drug delivery across the blood brain barrier. Curr. Pharm. Des., 2004, 10(12), 1355-1363.
    • (2004) Curr. Pharm. Des. , vol.10 , Issue.12 , pp. 1355-1363
    • Kabanov, A.V.1    Batrakova, E.V.2
  • 241
    • 34247473017 scopus 로고    scopus 로고
    • Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate
    • Dhanikula, R.S.; Hildgen, P. Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate. Biomaterials, 2007, 28(20), 3140-3152.
    • (2007) Biomaterials , vol.28 , Issue.20 , pp. 3140-3152
    • Dhanikula, R.S.1    Hildgen, P.2
  • 242
    • 39749200864 scopus 로고    scopus 로고
    • Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: Enhanced efficacy and intratumoral transport capability
    • Dhanikula, R.S.; Argaw, A.; Bouchard, J.F.; Hildgen, P. Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: enhanced efficacy and intratumoral transport capability. Mol. Pharm., 2008, 5(1), 105-116.
    • (2008) Mol. Pharm. , vol.5 , Issue.1 , pp. 105-116
    • Dhanikula, R.S.1    Argaw, A.2    Bouchard, J.F.3    Hildgen, P.4
  • 243
    • 67649230473 scopus 로고    scopus 로고
    • On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model
    • Dhanikula, R.S.; Hammady, T.; Hildgen, P. On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model. J. Pharm. Sci., 2009, 98(10), 3748-3760.
    • (2009) J. Pharm. Sci. , vol.98 , Issue.10 , pp. 3748-3760
    • Dhanikula, R.S.1    Hammady, T.2    Hildgen, P.3
  • 244
    • 31544443297 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery
    • Dhanikula, R.S.; Hildgen, P. Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery. Bioconjug. Chem., 2006, 17(1), 29-41.
    • (2006) Bioconjug. Chem. , vol.17 , Issue.1 , pp. 29-41
    • Dhanikula, R.S.1    Hildgen, P.2
  • 246
    • 0035989704 scopus 로고    scopus 로고
    • Targeting approaches to oral drug delivery
    • Lambkin, I.; Pinilla, C. Targeting approaches to oral drug delivery. Expert Opin. Biol. Ther., 2002, 2(1), 67-73.
    • (2002) Expert Opin. Biol. Ther. , vol.2 , Issue.1 , pp. 67-73
    • Lambkin, I.1    Pinilla, C.2
  • 247
    • 77957736261 scopus 로고    scopus 로고
    • Physiological parameters for oral delivery and in vitro testing
    • Mudie, D.M.; Amidon, G.L.; Amidon, G.E. Physiological parameters for oral delivery and in vitro testing. Mol. Pharm., 2010, 7(5), 1388-1405.
    • (2010) Mol. Pharm. , vol.7 , Issue.5 , pp. 1388-1405
    • Mudie, D.M.1    Amidon, G.L.2    Amidon, G.E.3
  • 248
    • 79952450888 scopus 로고    scopus 로고
    • Intestinal delivery of non-viral gene therapeutics: Physiological barriers and preclinical models
    • O'Neill, M.J.; Bourre, L.; Melgar, S.; O'Driscoll, C.M. Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Drug Discov. Today, 2011, 16(5-6), 203-218.
    • (2011) Drug Discov. Today , vol.16 , Issue.5-6 , pp. 203-218
    • O'Neill, M.J.1    Bourre, L.2    Melgar, S.3    O'Driscoll, C.M.4
  • 249
    • 14544286414 scopus 로고    scopus 로고
    • Particle uptake by Peyer̀s patches: A pathway for drug and vaccine delivery
    • Shakweh, M.; Ponchel, G.; Fattal, E. Particle uptake by Peyer̀s patches: a pathway for drug and vaccine delivery. Expert Opin. Drug Deliv., 2004, 1(1), 141-163.
    • (2004) Expert Opin. Drug Deliv. , vol.1 , Issue.1 , pp. 141-163
    • Shakweh, M.1    Ponchel, G.2    Fattal, E.3
  • 252
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai, S.K.; Wang, Y.Y.; Hanes, J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv. Drug Deliv. Rev., 2009, 61(2), 158-171.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , Issue.2 , pp. 158-171
    • Lai, S.K.1    Wang, Y.Y.2    Hanes, J.3
  • 253
    • 60149089459 scopus 로고    scopus 로고
    • Barrier properties of mucus
    • Cone, R. A. Barrier properties of mucus. Adv. Drug Deliv. Rev., 2009, 61(2), 75-85.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , Issue.2 , pp. 75-85
    • Cone, R.A.1
  • 254
    • 0029787628 scopus 로고    scopus 로고
    • Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: Implications for microbial attachment and oral vaccine targeting
    • Frey, A.; Giannasca, K.T.; Weltzin, R.; Giannasca, P.J.; Reggio, H.; Lencer, W.I.; Neutra, M.R. Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J. Exp. Med., 1996, 184(3), 1045-1059
    • (1996) J. Exp. Med. , vol.184 , Issue.3 , pp. 1045-1059
    • Frey, A.1    Giannasca, K.T.2    Weltzin, R.3    Giannasca, P.J.4    Reggio, H.5    Lencer, W.I.6    Neutra, M.R.7
  • 255
    • 0027715358 scopus 로고
    • Breaking through the tigh junction barrier
    • Gumbiner, B.M. Breaking through the tigh junction barrier. J. Cell Biol., 1993, 123(6), 1631-1633.
    • (1993) J. Cell Biol. , vol.123 , Issue.6 , pp. 1631-1633
    • Gumbiner, B.M.1
  • 256
    • 34248654342 scopus 로고    scopus 로고
    • Progress in absorption enhancers based on tight junction
    • Kondoh, M.; Yagi, K. Progress in absorption enhancers based on tight junction. Expert Opin. Drug Deliv., 2007, 4(3), 275-286.
    • (2007) Expert Opin. Drug Deliv. , vol.4 , Issue.3 , pp. 275-286
    • Kondoh, M.1    Yagi, K.2
  • 258
    • 0036771081 scopus 로고    scopus 로고
    • A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro
    • Hugger, E.D.; Novak, B.L.; Burton, P.S.; Audus, K.L.; Borchardt, R.T. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J. Pharm. Sci., 2002, 91(9), 1991-2002.
    • (2002) J. Pharm. Sci. , vol.91 , Issue.9 , pp. 1991-2002
    • Hugger, E.D.1    Novak, B.L.2    Burton, P.S.3    Audus, K.L.4    Borchardt, R.T.5
  • 259
    • 33846419807 scopus 로고    scopus 로고
    • How can we best use structural information on P-glycoprotein to design inhibitors?
    • McDevitt, C.A.; Callaghan, R. How can we best use structural information on P-glycoprotein to design inhibitors? Pharmacol. Ther., 2007, 113(2), 429-441.
    • (2007) Pharmacol. Ther. , vol.113 , Issue.2 , pp. 429-441
    • McDevitt, C.A.1    Callaghan, R.2
  • 260
    • 58149164868 scopus 로고    scopus 로고
    • Vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption
    • del Amo, E.M.; Heikkinen, A.T.; Monkkonen, J. In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption. Eur. J. Pharm. Sci., 2009, 36(2-3), 200-211.
    • (2009) Eur. J. Pharm. Sci. , vol.36 , Issue.2-3 , pp. 200-211
    • Del Amo, E.M.1    Heikkinen, A.T.2    Monkkonen, J.3
  • 262
    • 35348970995 scopus 로고    scopus 로고
    • Role of nanotechnology in pharmaceutical product development
    • Devalapally, H.; Chakilam, A.; Amiji, M.M. Role of nanotechnology in pharmaceutical product development. J. Pharm. Sci., 2007, 96(10), 2547-2565.
    • (2007) J. Pharm. Sci. , vol.96 , Issue.10 , pp. 2547-2565
    • Devalapally, H.1    Chakilam, A.2    Amiji, M.M.3
  • 263
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro-and nanoparticulates: Neither exceptional nor unusual
    • Florence, A.T. The oral absorption of micro-and nanoparticulates: Neither exceptional nor unusual. Pharm. Res., 1997, 14(3), 259-266.
    • (1997) Pharm. Res. , vol.14 , Issue.3 , pp. 259-266
    • Florence, A.T.1
  • 265
    • 0029053808 scopus 로고
    • Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence
    • Florence, A.T.; Hillery, A.M.; Hussain, N.; Jani, P.U. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. J. Drug Target., 1995, 3(1), 65-70.
    • (1995) J. Drug Target. , vol.3 , Issue.1 , pp. 65-70
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 266
    • 34548049483 scopus 로고    scopus 로고
    • Nanosizing-Oral formulation development and biopharmaceutical evaluation
    • Kesisoglou, F.; Panmai, S.; Wu, Y.H. Nanosizing-Oral formulation development and biopharmaceutical evaluation. Adv. Drug Deliv. Rev., 2007, 59(7), 631-644.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.7 , pp. 631-644
    • Kesisoglou, F.1    Panmai, S.2    Wu, Y.H.3
  • 267
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of nanoparticles
    • Li, S.D.; Huang, L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm., 2008, 5(4), 496-504.
    • (2008) Mol. Pharm. , vol.5 , Issue.4 , pp. 496-504
    • Li, S.D.1    Huang, L.2
  • 269
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles
    • Bravo-Osuna, I.; Vauthier, C.; Farabollini, A.; Palmieri, G. F.; Ponchel, G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials, 2007, 28(13), 2233-2243.
    • (2007) Biomaterials , vol.28 , Issue.13 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 270
    • 33745001611 scopus 로고    scopus 로고
    • Thiomers: Preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system
    • Bernkop-Schnürch, A.; Weithaler, A.; Albrecht, K.; Greimel, A. Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system. Int. J. Pharm., 2006, 317(1), 76-81.
    • (2006) Int. J. Pharm. , vol.317 , Issue.1 , pp. 76-81
    • Bernkop-Schnürch, A.1    Weithaler, A.2    Albrecht, K.3    Greimel, A.4
  • 271
    • 4444331868 scopus 로고    scopus 로고
    • Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels
    • Bromberg, L.; Temchenko, M.; Alakhov, V.; Hatton, T.A. Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels. Int. J. Pharm., 2004, 282(1-2), 45-60.
    • (2004) Int. J. Pharm. , vol.282 , Issue.1-2 , pp. 45-60
    • Bromberg, L.1    Temchenko, M.2    Alakhov, V.3    Hatton, T.A.4
  • 272
    • 0034872426 scopus 로고    scopus 로고
    • Size-dependent bioadhesion of micro-and nanoparticulate carriers to the inflamed colonic mucosa
    • Lamprecht, A.; Schafer, U.; Lehr, C.M. Size-dependent bioadhesion of micro-and nanoparticulate carriers to the inflamed colonic mucosa. Pharm. Res., 2001, 18(6), 788-793.
    • (2001) Pharm. Res. , vol.18 , Issue.6 , pp. 788-793
    • Lamprecht, A.1    Schafer, U.2    Lehr, C.M.3
  • 273
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: The effect of mucus on particle adsorption and transport
    • Behrens, I.; Pena, A.I.V.; Alonso, M.J.; Kissel, T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res., 2002, 19(8), 1185-1193.
    • (2002) Pharm. Res. , vol.19 , Issue.8 , pp. 1185-1193
    • Behrens, I.1    Pena, A.I.V.2    Alonso, M.J.3    Kissel, T.4
  • 274
    • 77954385916 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: Oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection
    • Sonaje, K.; Lin, K.J.; Wey, S.P.; Lin, C.K.; Yeh, T.H.; Nguyen, H.N.; Hsua, C.W.; Yen, T.C.; Juang, J.H.; Sung, H.W. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection. Biomaterials, 2010, 31(26), 6849-6858.
    • (2010) Biomaterials , vol.31 , Issue.26 , pp. 6849-6858
    • Sonaje, K.1    Lin, K.J.2    Wey, S.P.3    Lin, C.K.4    Yeh, T.H.5    Nguyen, H.N.6    Hsua, C.W.7    Yen, T.C.8    Juang, J.H.9    Biodistribution, W.S.H.10
  • 276
    • 0034601281 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake?
    • Jung, T.; Kamm, W.; Breitenbach, A.; Kaiserling, E.; Xiao, J.X.; Kissel, T. Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm., 2000, 50(1), 147-160.
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , Issue.1 , pp. 147-160
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Kaiserling, E.4    Xiao, J.X.5    Kissel, T.6
  • 277
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
    • des Rieux, A.; Fievez, V.; Garinot, M.; Schneider, Y.J.; Préat, V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control. Release, 2006, 116(1), 1-27.
    • (2006) J. Control. Release , vol.116 , Issue.1 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.J.4    Préat, V.5
  • 278
    • 20744454954 scopus 로고    scopus 로고
    • Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium
    • des Rieux, A.; Ragnarsson, E.G.; Gullberg, E.; Preat, V.; Schneider, Y.J.; Artursson, P. Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium. Eur. J. Pharm. Sci., 2005, 25(4-5), 455-465.
    • (2005) Eur. J. Pharm. Sci. , vol.25 , Issue.4-5 , pp. 455-465
    • Des Rieux, A.1    Ragnarsson, E.G.2    Gullberg, E.3    Preat, V.4    Schneider, Y.J.5    Artursson, P.6
  • 279
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai, M.P.; Labhasetwar, V.; Amidon, G.L.; Levy, R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res., 1996, 13(12), 1838-1845.
    • (1996) Pharm. Res. , vol.13 , Issue.12 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 280
    • 3242717735 scopus 로고    scopus 로고
    • Transport of PLA-PEG particles across the nasal mucosa: Effect of particle size and PEG coating density
    • Vila, A.; Gill, H.; McCallion, O.; Alonso, M.J. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J. Control. Release, 2004, 98(2), 231-244.
    • (2004) J. Control. Release , vol.98 , Issue.2 , pp. 231-244
    • Vila, A.1    Gill, H.2    McCallion, O.3    Alonso, M.J.4
  • 281
    • 0037462992 scopus 로고    scopus 로고
    • PEGylated nanoparticles for biological and pharmaceutical applications
    • Otsuka, H.; Nagasaki, Y.; Kataoka, K. PEGylated nanoparticles for biological and pharmaceutical applications. Adv. Drug Deliv. Rev., 2003, 55(3), 403-419.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , Issue.3 , pp. 403-419
    • Otsuka, H.1    Nagasaki, Y.2    Kataoka, K.3
  • 282
    • 77957120419 scopus 로고    scopus 로고
    • Vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems
    • Semete, B.; Booysen, L.; Lemmer, Y.; Kalombo, L.; Katata, L.; Verschoor, J.; Swai, H.S. In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine, 2010, 6(5), 662-671.
    • (2010) Nanomedicine , vol.6 , Issue.5 , pp. 662-671
    • Semete, B.1    Booysen, L.2    Lemmer, Y.3    Kalombo, L.4    Katata, L.5    Verschoor, J.6    Swai, H.S.7
  • 284
    • 33745386420 scopus 로고    scopus 로고
    • Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules
    • Peltier, S.; Oger, J.M.; Lagarce, F.; Couet, W.; Benoit, J.P., Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules. Pharm. Res., 2006, 23(6), 1243-1250.
    • (2006) Pharm. Res. , vol.23 , Issue.6 , pp. 1243-1250
    • Peltier, S.1    Oger, J.M.2    Lagarce, F.3    Couet, W.4    Benoit, J.P.5
  • 285
    • 70350617685 scopus 로고    scopus 로고
    • Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis
    • Roger, E.; Lagarce, F.; Garcion, E.; Benoit, J.P. Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. J. Control. Release, 2009, 140(2), 174-181.
    • (2009) J. Control. Release , vol.140 , Issue.2 , pp. 174-181
    • Roger, E.1    Lagarce, F.2    Garcion, E.3    Benoit, J.P.4
  • 286
    • 0030467140 scopus 로고    scopus 로고
    • Bioadhesion of lectin-latex conjugates to rat intestinal mucosa
    • Irache, J.M.; Durrer, C.; Duchêne, D.; Ponchel, G. Bioadhesion of lectin-latex conjugates to rat intestinal mucosa. Pharm. Res., 1996, 13(11), 1716-1719.
    • (1996) Pharm. Res. , vol.13 , Issue.11 , pp. 1716-1719
    • Irache, J.M.1    Durrer, C.2    Duchêne, D.3    Ponchel, G.4
  • 287
    • 34548828056 scopus 로고    scopus 로고
    • Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin
    • Yin, Y.; Chen, D.; Qiao, M.; Lu, Z.; Hu, H. Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin. J. Control. Release, 2006, 116(3), 337-345.
    • (2006) J. Control. Release , vol.116 , Issue.3 , pp. 337-345
    • Yin, Y.1    Chen, D.2    Qiao, M.3    Lu, Z.4    Hu, H.5
  • 288
    • 23144456860 scopus 로고    scopus 로고
    • Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model
    • Umamaheshwari, R.B.; Ramteke, S.; Jain, N.K. Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model. AAPS PharmSciTech, 2004, 5(2) 60-68.
    • (2004) AAPS PharmSciTech , vol.5 , Issue.2 , pp. 60-68
    • Umamaheshwari, R.B.1    Ramteke, S.2    Jain, N.K.3
  • 289
    • 0035940089 scopus 로고    scopus 로고
    • Exploiting M cells for drug and vaccine delivery
    • Clark, M.A.; Jepson, M.A.; Hirst, B.H. Exploiting M cells for drug and vaccine delivery. Adv. Drug Deliv. Rev., 2001, 50(1-2), 81-106.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , Issue.1-2 , pp. 81-106
    • Clark, M.A.1    Jepson, M.A.2    Hirst, B.H.3
  • 290
    • 77953807454 scopus 로고    scopus 로고
    • Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells
    • Primard, C.; Rochereau, N.; Luciani, E.; Genin, C.; Delair, T.; Paul, S.; Verrier, B. Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells. Biomaterials, 2010, 31(23), 6060-6068.
    • (2010) Biomaterials , vol.31 , Issue.23 , pp. 6060-6068
    • Primard, C.1    Rochereau, N.2    Luciani, E.3    Genin, C.4    Delair, T.5    Paul, S.6    Verrier, B.7
  • 291
    • 0037027876 scopus 로고    scopus 로고
    • Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo
    • Pan, Y.; Li, Y.J.; Zhao, H.Y.; Zheng, J.M.; Xu, H.; Wei, G.; Hao, J.S.; Cui, F.D. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm., 2002, 249(1-2), 139-147.
    • (2002) Int. J. Pharm. , vol.249 , Issue.1-2 , pp. 139-147
    • Pan, Y.1    Li, Y.J.2    Zhao, H.Y.3    Zheng, J.M.4    Xu, H.5    Wei, G.6    Hao, J.S.7    Cui, F.D.8
  • 293
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
    • Tobio, M.; Sanchez, A.; Vila, A.; Soriano, I.I.; Evora, C.; Vila-Jato, J.L.; Alonso, M.J. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf. B Biointerfaces, 2000, 18(3-4), 315-323.
    • (2000) Colloids Surf. B Biointerfaces , vol.18 , Issue.3-4 , pp. 315-323
    • Tobio, M.1    Sanchez, A.2    Vila, A.3    Soriano, I.I.4    Evora, C.5    Vila-Jato, J.L.6    Alonso, M.J.7
  • 295
    • 79951702169 scopus 로고    scopus 로고
    • Nanocarriers for transmucosal vaccine delivery
    • Jain, S.; Khomane, K.; Jain, A.K.; Dani, P. Nanocarriers for transmucosal vaccine delivery. Curr. Nanosci., 2011, 7(2), 160-177.
    • (2011) Curr. Nanosci. , vol.7 , Issue.2 , pp. 160-177
    • Jain, S.1    Khomane, K.2    Jain, A.K.3    Dani, P.4
  • 296
    • 33750501785 scopus 로고    scopus 로고
    • Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
    • Zhang, N.; Ping, Q.; Huang, G.; Xu, W.; Cheng, Y.; Han, X. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm., 2006, 327(1-2), 153-159.
    • (2006) Int. J. Pharm. , vol.327 , Issue.1-2 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6
  • 297
    • 43449084030 scopus 로고    scopus 로고
    • Polymeric micelles in oral chemotherapy
    • Bromberg, L. Polymeric micelles in oral chemotherapy. J. Control. Release, 2008, 128(2), 99-112.
    • (2008) J. Control. Release , vol.128 , Issue.2 , pp. 99-112
    • Bromberg, L.1
  • 299
    • 1842684452 scopus 로고    scopus 로고
    • Principles of transmucosal delivery of therapeutic agents
    • Blanchette, J.; Kavimandan, N.; Peppas, N.A. Principles of transmucosal delivery of therapeutic agents. Biomed. Pharmacother., 2004, 58(3), 142-151.
    • (2004) Biomed. Pharmacother. , vol.58 , Issue.3 , pp. 142-151
    • Blanchette, J.1    Kavimandan, N.2    Peppas, N.A.3
  • 300
    • 73649133678 scopus 로고    scopus 로고
    • Overcoming the barriers in micellar drug delivery: Loading efficiency. vivo stability, and micelle-cell interaction
    • Kim, S.; Shi, Y.; Kim, J.Y.; Park, K.; Cheng, J.X. Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction. Expert Opin. Drug Deliv., 2010, 7(1), 49-62.
    • (2010) Expert Opin. Drug Deliv. , vol.7 , Issue.1 , pp. 49-62
    • Kim, S.1    Shi, Y.2    Kim, J.Y.3    Park, K.4    Cheng, J.X.5
  • 301
    • 77950521540 scopus 로고    scopus 로고
    • Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes
    • Gaucher, G.; Marchessault, R.H.; Leroux, J.C. Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes. J. Control. Release, 2010, 143(1), 2-12.
    • (2010) J. Control. Release , vol.143 , Issue.1 , pp. 2-12
    • Gaucher, G.1    Marchessault, R.H.2    Leroux, J.C.3
  • 302
    • 33344463203 scopus 로고    scopus 로고
    • Intestinal uptake and biodistribution of novel polymeric micelles after oral administration
    • Mathot, F.; van Beijsterveldt, L.; Préat, V.; Brewster, M.; Ariën, A. Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. J. Control. Release, 2006, 111(1-2), 47-55.
    • (2006) J. Control. Release , vol.111 , Issue.1-2 , pp. 47-55
    • Mathot, F.1    Van Beijsterveldt, L.2    Préat, V.3    Brewster, M.4    Ariën, A.5
  • 303
    • 14644418493 scopus 로고    scopus 로고
    • Cellular evaluation of oral chemotherapy carriers
    • Blanchette, J.; Peppas, N.A. Cellular evaluation of oral chemotherapy carriers. J. Biomed. Mater. Res. Part A, 2005, 72(4), 381-388.
    • (2005) J. Biomed. Mater. Res. Part A , vol.72 , Issue.4 , pp. 381-388
    • Blanchette, J.1    Peppas, N.A.2
  • 304
    • 35848959714 scopus 로고    scopus 로고
    • Alginate/chitosan nanoparticles are effective for oral insulin delivery
    • Sarmento, B.; Ribeiro, A.; Veiga, F.; Sampaio, P.; Neufeld, R.; Ferreira, D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm. Res., 2007, 24(12), 2198-2206.
    • (2007) Pharm. Res. , vol.24 , Issue.12 , pp. 2198-2206
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3    Sampaio, P.4    Neufeld, R.5    Ferreira, D.6
  • 305
    • 77957264181 scopus 로고    scopus 로고
    • Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles
    • Woitiski, C.B.; Neufeld, R.J.; Veiga, F.; Carvalho, R.A.; Figueiredo, I.V. Pharmacological effect of orally delivered insulin facilitated by multilayered stable nanoparticles. Eur. J. Pharm. Sci., 2010, 41(3-4), 556-563.
    • (2010) Eur. J. Pharm. Sci. , vol.41 , Issue.3-4 , pp. 556-563
    • Woitiski, C.B.1    Neufeld, R.J.2    Veiga, F.3    Carvalho, R.A.4    Figueiredo, I.V.5
  • 306
    • 77958606883 scopus 로고    scopus 로고
    • Improvement of intestinal absorption of poorly absorbable drugs by polyamidoamine (PAMAM) dendrimers as novel absorption enhancers
    • Yamamoto, A. Improvement of intestinal absorption of poorly absorbable drugs by polyamidoamine (PAMAM) dendrimers as novel absorption enhancers. Yakugaku Zasshi, 2010, 130(9), 1123-1127.
    • (2010) Yakugaku Zasshi , vol.130 , Issue.9 , pp. 1123-1127
    • Yamamoto, A.1
  • 307
    • 0142042448 scopus 로고    scopus 로고
    • Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity
    • Jevprasesphant, R.; Penny, J.; Attwood, D.; McKeown, N.B.; D'Emanuele, A. Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharm. Res., 2003, 20(10), 1543-1550.
    • (2003) Pharm. Res. , vol.20 , Issue.10 , pp. 1543-1550
    • Jevprasesphant, R.1    Penny, J.2    Attwood, D.3    McKeown, N.B.4    D'Emanuele, A.5
  • 308
    • 34848910473 scopus 로고    scopus 로고
    • Polypropylene imine dendrimer mediated solubility enhancement: Effect of pH and functional groups of hydrophobes
    • Gupta, U.; Agashe, H.B.; Jain, N.K. Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes. J. Pharm. Pharm. Sci., 2007, 10(3), 358-367.
    • (2007) J. Pharm. Pharm. Sci. , vol.10 , Issue.3 , pp. 358-367
    • Gupta, U.1    Agashe, H.B.2    Jain, N.K.3
  • 309
    • 28744439003 scopus 로고    scopus 로고
    • Supramolecular structures from dendrons and dendrimers
    • Al-Jamal, K.T.; Ramaswamy, C.; Florence, A.T. Supramolecular structures from dendrons and dendrimers. Adv. Drug Deliv. Rev., 2005, 57(15), 2238-2270.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , Issue.15 , pp. 2238-2270
    • Al-Jamal, K.T.1    Ramaswamy, C.2    Florence, A.T.3
  • 312
    • 67649970063 scopus 로고    scopus 로고
    • Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases
    • Smola, M.; Vandamme, T.; Sokolowski, A. Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. Int. J. Nanomedicine, 2008, 3(1), 1-19.
    • (2008) Int. J. Nanomedicine , vol.3 , Issue.1 , pp. 1-19
    • Smola, M.1    Vandamme, T.2    Sokolowski, A.3
  • 313
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware, L.B.; Matthay, M.A. The acute respiratory distress syndrome. N. Engl. J. Med., 2000, 342(18), 1334-1349.
    • (2000) N. Engl. J. Med. , vol.342 , Issue.18 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 314
    • 0022406105 scopus 로고
    • Aerosol deposition considerations in inhalation therapy
    • Newman, S.P. Aerosol deposition considerations in inhalation therapy. Chest, 1985, 88(2), S152-S160.
    • (1985) Chest , vol.88 , Issue.2
    • Newman, S.P.1
  • 315
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles, M.R.; Boucher, R.C. Mucus clearance as a primary innate defense mechanism for mammalian airways. J. Clin. Invest., 2002, 109(5), 571-577.
    • (2002) J. Clin. Invest. , vol.109 , Issue.5 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 317
    • 77949915977 scopus 로고    scopus 로고
    • Nanodelivery in airway diseases: Challenges and therapeutic applications
    • Roy, I.; Vij, N. Nanodelivery in airway diseases: challenges and therapeutic applications. Nanomedicine, 2010, 6(2), 237-244.
    • (2010) Nanomedicine , vol.6 , Issue.2 , pp. 237-244
    • Roy, I.1    Vij, N.2
  • 318
    • 1642502969 scopus 로고    scopus 로고
    • Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer
    • Geiser, M.; Schurch, S.; Gehr, P. Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer. J. Appl. Physiol., 2003, 94(5), 1793-1801.
    • (2003) J. Appl. Physiol. , vol.94 , Issue.5 , pp. 1793-1801
    • Geiser, M.1    Schurch, S.2    Gehr, P.3
  • 319
    • 57049085726 scopus 로고    scopus 로고
    • Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that slip" through the human mucus barrier
    • Wang, Y.Y.; Lai, S.K.; Suk, J.S.; Pace, A.; Cone, R.; Hanes, J. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angew. Chem. Int. Ed. Engl., 2008, 47(50), 9726-9729.
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , Issue.50 , pp. 9726-9729
    • Wang, Y.Y.1    Lai, S.K.2    Suk, J.S.3    Pace, A.4    Cone, R.5    Hanes, J.6
  • 320
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • Patton, J. S. Mechanisms of macromolecule absorption by the lungs. Adv. Drug Deliv. Rev., 1996, 19(1), 3-36.
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , Issue.1 , pp. 3-36
    • Patton, J.S.1
  • 322
    • 33144476650 scopus 로고    scopus 로고
    • The influence of hydrogen peroxide and histamine on lung permeability and translocation of iridium nanoparticles in the isolated perfused rat lung
    • Meiring, J.; Borm, P.; Bagate, K.; Semmler, M.; Seitz, J.; Takenaka, S.; Kreyling, W. The influence of hydrogen peroxide and histamine on lung permeability and translocation of iridium nanoparticles in the isolated perfused rat lung. Part. Fibre Toxicol., 2005, 2(1), 3.
    • (2005) Part. Fibre Toxicol. , vol.2 , Issue.1 , pp. 3
    • Meiring, J.1    Borm, P.2    Bagate, K.3    Semmler, M.4    Seitz, J.5    Takenaka, S.6    Kreyling, W.7
  • 324
    • 67349092075 scopus 로고    scopus 로고
    • Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes
    • Furuyama, A.; Kanno, S.; Kobayashi, T.; Hirano, S. Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes. Arch. Toxicol., 2009, 83(5), 429-437.
    • (2009) Arch. Toxicol. , vol.83 , Issue.5 , pp. 429-437
    • Furuyama, A.1    Kanno, S.2    Kobayashi, T.3    Hirano, S.4
  • 326
    • 33646523609 scopus 로고    scopus 로고
    • Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: Effect of lipopolysaccharide
    • Chen, J.M.; Tan, M.G.; Nemmar, A.; Song, W.M.; Dong, M.; Zhang, G.L.; Li, Y. Quantification of extrapulmonary translocation of intratracheal-instilled particles in vivo in rats: Effect of lipopolysaccharide. Toxicology, 2006, 222(3), 195-201.
    • (2006) Toxicology , vol.222 , Issue.3 , pp. 195-201
    • Chen, J.M.1    Tan, M.G.2    Nemmar, A.3    Song, W.M.4    Dong, M.5    Zhang, G.L.6    Li, Y.7
  • 328
    • 79951727259 scopus 로고    scopus 로고
    • Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: Implications for health effects of air-pollution particles
    • Yacobi, N.; Fazllolahi, F.; Kim, Y.; Sipos, A.; Borok, Z.; Kim, K.J.; Crandall, E. Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Quality, Atmosphere & Health, 2011, 4(1), 65-78.
    • (2011) Air Quality Atmosphere & Health , vol.4 , Issue.1 , pp. 65-78
    • Yacobi, N.1    Fazllolahi, F.2    Kim, Y.3    Sipos, A.4    Borok, Z.5    Kim, K.J.6    Crandall, E.7
  • 330
    • 1842869151 scopus 로고    scopus 로고
    • Evidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillaries
    • Kato, T.; Yashiro, T.; Murata, Y.; Herbert, D.; Oshikawa, K.; Bando, M.; Ohno, S.; Sugiyama, Y. Evidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillaries. Cell Tissue Res., 2003, 311(1), 47-51.
    • (2003) Cell Tissue Res. , vol.311 , Issue.1 , pp. 47-51
    • Kato, T.1    Yashiro, T.2    Murata, Y.3    Herbert, D.4    Oshikawa, K.5    Bando, M.6    Ohno, S.7    Sugiyama, Y.8
  • 331
    • 0031904113 scopus 로고    scopus 로고
    • Recent advances in pulmonary drug delivery using large, porous inhaled particles
    • Edwards, D.A.; Ben-Jebria, A.; Langer, R. Recent advances in pulmonary drug delivery using large, porous inhaled particles. J. Appl. Physiol., 1998, 85(2), 379-385.
    • (1998) J. Appl. Physiol. , vol.85 , Issue.2 , pp. 379-385
    • Edwards, D.A.1    Ben-Jebria, A.2    Langer, R.3
  • 332
    • 20644449754 scopus 로고    scopus 로고
    • Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles
    • Oberdorster, G.; Oberdorster, E.; Oberdorster, J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect., 2005, 113(7), 823-839.
    • (2005) Environ. Health Perspect. , vol.113 , Issue.7 , pp. 823-839
    • Oberdorster, G.1    Oberdorster, E.2    Oberdorster, J.3
  • 334
    • 0030966556 scopus 로고    scopus 로고
    • Preparation and subsequent degradation of poly(L-lactic acid) microspheres suitable for aerosolisation: A physico-chemical study
    • ElBaseir, M.M.; Phipps, M.A.; Kellaway, I.W. Preparation and subsequent degradation of poly(L-lactic acid) microspheres suitable for aerosolisation: a physico-chemical study. Int. J. Pharm., 1997, 151(2), 145-153.
    • (1997) Int. J. Pharm. , vol.151 , Issue.2 , pp. 145-153
    • Elbaseir, M.M.1    Phipps, M.A.2    Kellaway, I.W.3
  • 336
    • 0030200977 scopus 로고    scopus 로고
    • The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation
    • French, D.L.; Edwards, D.A.; Niven, R.W. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation. J. Aerosol Sci., 1996, 27(5), 769-783.
    • (1996) J. Aerosol Sci. , vol.27 , Issue.5 , pp. 769-783
    • French, D.L.1    Edwards, D.A.2    Niven, R.W.3
  • 338
    • 0035884016 scopus 로고    scopus 로고
    • Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines
    • Brown, D.M.; Wilson, M.R.; MacNee, W.; Stone, V.; Donaldson, K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol., 2001, 175(3), 191-199.
    • (2001) Toxicol. Appl. Pharmacol. , vol.175 , Issue.3 , pp. 191-199
    • Brown, D.M.1    Wilson, M.R.2    MacNee, W.3    Stone, V.4    Donaldson, K.5
  • 340
  • 341
    • 0025847707 scopus 로고
    • Acute effects of liposome aerosol inhalation on pulmonary function in healthy human volunteers
    • Thomas, D.A.; Myers, M.A.; Wichert, B.; Schreier, H.; Gonzalezrothi, R.J. Acute effects of liposome aerosol inhalation on pulmonary function in healthy human volunteers. Chest, 1991, 99(5), 1268-1270.
    • (1991) Chest , vol.99 , Issue.5 , pp. 1268-1270
    • Thomas, D.A.1    Myers, M.A.2    Wichert, B.3    Schreier, H.4    Gonzalezrothi, R.J.5
  • 343
    • 0030918431 scopus 로고    scopus 로고
    • High dose cyclosporin A and budesonide-liposome aerosols
    • Waldrep, J.C.; Arppe, J.; Jansa, K.A.; Knight, V. High dose cyclosporin A and budesonide-liposome aerosols. Int. J. Pharm., 1997, 152(1), 27-36.
    • (1997) Int. J. Pharm. , vol.152 , Issue.1 , pp. 27-36
    • Waldrep, J.C.1    Arppe, J.2    Jansa, K.A.3    Knight, V.4
  • 344
    • 0031029186 scopus 로고    scopus 로고
    • Pulmonary delivery of beclomethasone liposome aerosol in volunteers-Tolerance and safety
    • Waldrep, J. C.; Gilbert, B. E.; Knight, C. M.; Black, M. B.; Scherer, P. W.; Knight, V.; Eschenbacher, W., Pulmonary delivery of beclomethasone liposome aerosol in volunteers-Tolerance and safety. Chest 1997, 111 (2), 316-323.
    • (1997) Chest , vol.111 , Issue.2 , pp. 316-323
    • Waldrep, J.C.1    Gilbert, B.E.2    Knight, C.M.3    Black, M.B.4    Scherer, P.W.5    Knight, V.6    Eschenbacher, W.7
  • 345
    • 0025245057 scopus 로고
    • Nebulization of liposomes. I. effects of lipid composition
    • Niven, R.W.; Schreier, H. Nebulization of liposomes. I. effects of lipid composition. Pharm. Res., 1990, 7(11), 1127-1133.
    • (1990) Pharm. Res. , vol.7 , Issue.11 , pp. 1127-1133
    • Niven, R.W.1    Schreier, H.2
  • 346
    • 0027234994 scopus 로고
    • Liposomes for drug delivery to the respiratory tract
    • Taylor, K.M.G.; Farr, S.J. Liposomes for drug delivery to the respiratory tract. Drug Dev. Ind. Pharm., 1993, 19(1-2), 123-142.
    • (1993) Drug Dev. Ind. Pharm. , vol.19 , Issue.1-2 , pp. 123-142
    • Taylor, K.M.G.1    Farr, S.J.2
  • 347
    • 0030573076 scopus 로고    scopus 로고
    • The stability of liposomes to ultrasonic nebulisation
    • Leung, K.K.M.; Bridges, P.A.; Taylor, K.M.G. The stability of liposomes to ultrasonic nebulisation. Int. J. Pharm., 1996, 145(1-2), 95-102.
    • (1996) Int. J. Pharm. , vol.145 , Issue.1-2 , pp. 95-102
    • Leung, K.K.M.1    Bridges, P.A.2    Taylor, K.M.G.3
  • 348
    • 33845388144 scopus 로고    scopus 로고
    • Micellar nanocarriers: Pharmaceutical perspectives
    • Torchilin, V. Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res., 2007, 24(1), 1-16.
    • (2007) Pharm. Res. , vol.24 , Issue.1 , pp. 1-16
    • Torchilin, V.1
  • 349
    • 77956036859 scopus 로고    scopus 로고
    • U.S. Poly(ethylene glycol) in drug delivery: Pros and cons as well as potential alternatives
    • Knop, K.; Hoogenboom, R.; Fischer, D.; Schubert, U.S. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew. Chem. Int. Ed. Engl., 2010, 49(36), 6288-308.
    • (2010) Angew. Chem. Int. Ed. Engl. , vol.49 , Issue.36 , pp. 6288-6308
    • Knop, K.1    Hoogenboom, R.2    Fischer, D.3    Schubert4
  • 350
    • 33847781099 scopus 로고    scopus 로고
    • Probing the interactions of proteins and nanoparticles
    • Klein, J. Probing the interactions of proteins and nanoparticles. Proc. Natl. Acad. Sci. U.S.A., 2007, 104(7), 2029-2030.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.7 , pp. 2029-2030
    • Klein, J.1
  • 351
    • 33645459798 scopus 로고    scopus 로고
    • Surface tailoring for controlled protein adsorption: Effect of topography at the nanometer scale and chemistry
    • Roach, P.; Farrar, D.; Perry, C.C. Surface tailoring for controlled protein adsorption: effect of topography at the nanometer scale and chemistry. J. Am. Chem. Soc., 2006, 128(12), 3939-3945.
    • (2006) J. Am. Chem. Soc. , vol.128 , Issue.12 , pp. 3939-3945
    • Roach, P.1    Farrar, D.2    Perry, C.C.3
  • 352
    • 78650606928 scopus 로고    scopus 로고
    • Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation
    • Deng, Z.J.; Liang, M.; Monteiro, M.; Toth, I.; Minchin, R.F. Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation. Nat Nanotechnol., 2011, 6(1), 39-44.
    • (2011) Nat Nanotechnol. , vol.6 , Issue.1 , pp. 39-44
    • Deng, Z.J.1    Liang, M.2    Monteiro, M.3    Toth, I.4    Minchin, R.F.5
  • 353
    • 72949109743 scopus 로고    scopus 로고
    • Positively-charged porous polysaccharide nanoparticles loaded with anionic molecules behave as 'stealth' cationic nanocarriers
    • Paillard, A.; Passirani, C.; Saulnier, P.; Kroubi, M.; Garcion, E.; Benoit, J.P.; Betbeder, D. Positively-charged, porous, polysaccharide nanoparticles loaded with anionic molecules behave as 'stealth' cationic nanocarriers. Pharm. Res., 2010, 27(1), 126-133.
    • (2010) Pharm. Res. , vol.27 , Issue.1 , pp. 126-133
    • Paillard, A.1    Passirani, C.2    Saulnier, P.3    Kroubi, M.4    Garcion, E.5    Benoit, J.P.6    Betbeder, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.