Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 410-415

  Tamai, Ikumi ^a   Sai, Yoshimichi ^a   Kobayashi, Hiroyuki ^a   Kamata, Makoto ^b   Wakamiya, Tateaki ^b,c   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DANSYLCADAVERINE; DYNORPHIN; EBIRATIDE; ETHYLENEDIAMINE; POLYLYSINE; PROTAMINE;

ADSORPTION; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; DOPAMINE UPTAKE; ENDOCYTOSIS; HYDROPHOBICITY; INTERNALIZATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TIGHT JUNCTION; TRANSPORT KINETICS;

ADSORPTION; ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARIES; CATTLE; CELLS, CULTURED; ENDOCYTOSIS; ENDOTHELIUM, VASCULAR; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030948209     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. AUDUS, K. L. AND BORCHARDT, R. T.: Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharm. Res. 3: 81-87, 1986.
2. BORCHARDT, R. T.: Assessment of transport barriers using cell and tissue culture systems. Drug Dev. Ind. Pharm. 16: 2595-2612, 1990.
3. BROADWELL, R. D. AND BANKS, W. A.: Cell biological perspective for the transcytosis of peptides and proteins trough the mammalian blood-brain fluid barriers. In The Blood-Brain Barrier: Cellular and Molecular Biology, ed. by W. M. Pardridge, pp.165-199, Raven Press, New York, NY, 1993.
4. FRANK, H. J. L. AND PARDRIDGE, W. M.: A direct in vivo demonstration of insulin binding to isolated brain microvessels. Diabetes 30: 757-761, 1981.
5. GUILLOT, F. L., AUDUS, K. L. AND RAUB, T. J.: Fluid-phase endocytosis by primary cultures of bovine brain microvessel endothelial cell monolayer. Microvasc. Res. 39: 1-14, 1990.
6. 125I-epidermal growth factor in BALB/3T3 cells. J. Biol. Chem. 257: 12139-12142, 1982.
7. HUGHES, C. C. W. AND RANTOS, P. L.: Uptake of leucine and alanine by cultured cerebral capillary endothelial cells. Brain Res. 480: 126-132, 1989.
8. HUNTER, W. M. AND GREENWOOD, F. C.: Preparation of iodine-131 labeled human growth hormone of high specific activity. Nature 194: 495-496, 1962.
9. KUMAGAI, A. K., EISENBERG, J. B. AND PARDRIDGE, W. M.: Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. J. Biol. Chem. 262: 15214-15219, 1987.
10. LOWRY, O. H., ROSEBROUGH, N. J. FARR, A. L. AND RANDALL, R. J.: Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
11. MERESSE, S., DEHOUCK, M. P., DELORME, P., BENSAID, M., TAUBER, J. P., DELBART, C., FRUCHART, J. C. AND CECCHELLI, R.: Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture. J. Neurochem, 53:1363-1371, 1989.
12. PARDRIDGE, W. M. AND MIETUS, L. J.: Enkephalin and blood-brain barrier: studies of binding and degradation in isolated brain microvessels. Endocrinology 109: 1138-1143, 1981.
13. PARDRIDGE, W. M., EISENBERG, J. AND YAMADA, T.: Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels. J. Neurochem. 44: 1178-1184, 1985.
14. PARDRIDGE, W. M., EISENBERG, J. AND YANG, J.: Human blood-brain barrier transferrin receptor. Metabolism 36: 892-895, 1987.
15. PARDRIDGE, W. M., TRIGUERO, D. AND BUCIAK, J. B.: Transport of histone thorough the blood-brain barrier. J. Pharmacol. Exp. Ther. 251: 821-826, 1989.
16. PARDRIDGE, W. M. AND BOADO, T. J.: Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein. FEBS Lett. 288: 30-32, 1991.
17. RAUB, T. J. AND AUDUS, K. L.: Adsorptive endocytosis and membrane recycling by cultured primary bovine brain microvessel endothelial cell monolayers. J. Cell Sci. 97: 127-138, 1990.
18. SHIMURA, T., TABATA, S., OHNISHI, T., TERASAKI, T. AND TSUJI, A.: Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier. J. Pharmacol. Exp. Ther. 258: 459-465, 1991.
19. SHIMURA, T., TABATA, S., TERASAKI, T., DEGUCHI, Y. AND TSUJI, A.: In vivo blood-brain barrier transport of a novel adrenocorticotropic hormone analogue, ebiratide, demonstrated by brain microdialysis and capillary depletion methods, J. Pharm. Pharmacol. 44: 583-588, 1992.
20. SMITH, K. R., KATO, A. AND BOROCHARDT, R. T.: Characterization of specific receptors for atrial natriuretic factor on cultured bovine brain capillary endothelial cells. Biochem. Biophys, Res. Commun. 157: 308-314, 1988.
21. TERASAKI, T., HIRAI, K., SATO, H., KANG, Y.-S. AND TSUJI, A.: Absorptive-mediated endocytosis of a dynorphin-like analgesic peptide. E-2078. into the blood-brain barrier. J. Pharmacol. Exp. Ther. 251: 351-357, 1989.
22. TERASAKI, T., DEGUCHI, Y., SATO, H., HIRAI, K. AND TSUJI, A.: In vivo transport of a dynorphin-like analgesic peptide, E-2078, through the blood-brain barrier: An application of brain microdialysis. Pharm. Res. 8: 815-820, 1991a.
23. TERASAKI, T., TAKAKUWA, S., MORITANI, S. AND TSUJI, A.: Transport of monocarboxylic acids at the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells, J. Pharmacol. Exp. Ther. 258:932-937, 1991b.
24. TERASAKI, T., TAKAKUWA, S., SAHEKI, A., MORITANI, S., SHIMURA, T., TABATA, S. AND TSUJI, A.: Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells. Pharm. Res. 9: 529-534, 1992.
25. TSUJI, A., TERASAKI, T., TAKABATAKE, Y., TENDA, Y., TAMAI, I., YAMASHIMA, T., MORITANI, S., TSURUO, T. AND YAMASHITA, J.: P-Glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51: 1427-1437, 1992.
26. TSUJI, A., TAMAI, I., SAKATA, A., TENDA, Y. AND TEKASAKI, T.: Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46: 1096-1099, 1993.
27. YAMAOKA, K., TANIGAWARA, Y., NAKAGAWA, T. AND UNO, T.: A pharmacokinetics analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4: 879-885, 1981.