High dose cyclosporin A and budesonide-liposome aerosols

International Journal of Pharmaceutics

Volumn 152, Issue 1, 1997, Pages 27-36

  Waldrep, J C ^a   Arppe, J ^b   Jansa, K A ^a   Knight, V ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Aerosol; Budesonide; Cyclosporin A; Liposome; Lung; Nebulizer

Indexed keywords

BUDESONIDE; CYCLOSPORIN A; LIPOSOME;

AEROSOL; ARTICLE; DRUG FORMULATION; INHALATIONAL DRUG ADMINISTRATION; NEBULIZER; PRIORITY JOURNAL;

EID: 0030918431     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04912-0     Document Type: Article

References (32)

1. Andersson, P. and Ryrfeldt, A., Biotransformation of the topical glucorticoids budesonide and beclomethasone 17a,21-dipropionate in human liver and lung homogenate. J. Pharm. Pharmacol., 36 (1984) 763-765.
2. Arnon, S., Grigg, J., Nikander, K. and Silverman, M., Delivery of micronized budesonide suspension by metered dose inhaler and jet nebulizer into a neonatal ventilator circuit. Pediatric Pulmonol., 13 (1992) 172-175.
3. Cameron, D., Clay, M. and Silverman, M., Evaluation of nebulizers for use in neonatal ventilator circuits. Critical Care Med., 18 (1990) 866-870.
4. Carstensen, J.T., Disperse Systems, In Theory Pharm. Sys. Heterogeneous Sys., Vol. II, Academic Press, New York, pp. 80.
5. Charles, B.G., Norris, R.L.G. and Ravenscroft, P.J., A Modified Assay for Cyclosporin A in Blood Using Solid Phase Extraction With High Performance Liquid Chromatography. Ther. Drug Monitor., 10 (1988) 97-100.
6. Dalby, R.N. and Tiano, S.L., Pitfalls and opportunities in the inertial sizing and output testing of nebulizers. Pharm. Technol., 17 (1993) 144-156.
7. Farr, S.J., Kellaway, I.W., Parry-Jones, D.R. and Woolfrey, S.G., 99m-Technetium as a Markers of Liposomal Deposition and Clearance in the Human Lung. Int. J. Pharm., 26 (1985) 303-316.
8. Gilbert, B.E., Six, H.R., Wilson, S.Z., Wyde, P.R. and Knight, V., Small particle aerosols of enviroxime-containing liposomes. Antiviral Res., 9 (1988) 355-65.
9. Grit, M. and Crommelin, D.J., The effect of aging on the physical stability of liposome dispersions. Chem. Phys. Lipids, 62 (1992) 113-22.
10. Hung, O.R., Whynot, S.C., Varnel, J.R., Shafer, S.L. and Mezel, M., Pharmacokinetics of inhaled liposome encapasulated Fentanyl. Anesthesiology, 83 (1995) 277-284.
11. Iacono, A.T., Keenan, R.J., Duncan, S.R., Smaldone, G.C., Dauber, J.H., Paradis, I.L., Ohori, N.P., Grgurich, W.F., Burckart, G.J., Zeevi, A., Delgado, E., O'Riordan, T.G., Zendarsky, M.M., Yousem, S.A. and Griffith, B.P., Aerosolized cyclosporine in lung recipients with refractory chronic rejection. Am. J. Resp. Crit. Care Med., 153 (1996) 1451-5.
12. Knight, V. and Waldrep, J.C., New Approaches in Aerosol Drug delivery for the Treatment of Asthma. In Kay, A.B. (Ed.), All. Allergic Dis., Blackwell Science, Oxford, 1996, pp. 726-737.
13. Lodrup-Carlsen, K.C., Nikander, K. and Carlsen, K.H., How much nebulized budesonide reaches infants and toddlers? Arch. Dis. Children, 67 (1992) 1077-1079.
14. McCallion, O.N.M. and Patel, M.J., Viscosity Effects on Nebulization of Aqueous Solutions. Int. J. Pharm., 130 (1996) 245-249.
15. McCallion, O.N.M., Taylor, K.M.G., Bridges, P.A., Thomas, M. and Taylor, A.J., Jet Nebulizers for Pulmonary Drug Delivery. Int. J. Pharm., 130 (1996a) 1-11.
16. McCallion, O.N.M., Taylor, K.M.G., Thomas, M. and Taylor, A.J., Nebulization of Fluids of Different Physicochemical Properties with Air-Jet and Ultrasonic Nebulizers. Pharm. Res., 12 (1995) 1682-1688.
17. McCallion, O.N.M., Taylor, K.M.G., Thomas, M. and Taylor, A.J., The Influence of Surface Tension on Aerosols Produced by Medical Nebulizers. Int. J. Pharm., 129 (1996b) 123-136.
18. McCallion, O.N.M., Taylor, K.M.G., Thomas, M. and Taylor, A.J., Nebulization of Monodisperse Latex Sphere Suspensions in Air-Jet and Ultrasonic Nebulizers. Int. J. Pharm., 133 (1996c) 203-214.
19. Nikander, K., Drug delivery systems. J. Aer. Med., 7 (1994) S19-S24.
20. Niven, R.W. and Schreier, H., Nebulization of liposomes. I. Effects of lipid composition. Pharm. Res., 1 (1990) 1127-33.
21. O'Riordan, T.G., Iacono, A., Keenan, R.J., Duncan, S.R., Burckart, G.J., Griffith, B.P. and Smaldone, G.C., Delivery and distribution of aerosolized cyclosporine in lung allograft recipients. Am. J. Resp. Crit. Care Med., 151 (1995) 516-21.
22. O'Riordan, T.G., Waldrep, J.C., Abraham, W.M., Mao, Y., Sabater, J.R., Sieiczak, M. and Knight, V., Delivery of Nebulized Budesonide Liposomes to the Respiratory Tract of Allergic Sheep. J. Aer. Med., in press (1997).
23. Schreier, H., Gonzalez-Rothi, R.J. and Stecenko, A.A., Pulmonary Delivery of Liposomes. J. Control. Rel., 24 (1993) 209-223.
24. Smaldone, G.C., Fuhrer, J., Steigbigel, R.T. and McPeck, M., Factors Determining Pulmonary Deposition of Aerosolized Pentamidine in Patients with Human Immunodeficiency Virus Infection. Am. Rev. Resp. Dis., 143 (1991) 727-737.
25. Taylor, K.G.M. and Farr, S.J., Liposomes for delivery to the respiratory tract. Drug Dev. Indust. Pharm., 19 (1993) 123-142.
26. Taylor, K.M.G., Taylor, G., Kellaway, I.W. and Stevens, J., The Stability of Liposomes to Nebulization. Int. J. Pharm., 58 (1990) 57-61.
27. Thomas, D.A., Myers, M.A., Wichert, B., Schreier, H. and Gonzalez-Rothi, R.J., Acute effects of liposome aerosol inhalation on pulmonary function in healthy human volunteers. Chest, 99 (1991) 1268-70.
28. Vidgren, M., Waldrep, J.C., Arppe, J., Black, M., Rodarte, J.A., Cole, W. and Knight, V., A study of 99m Technetium-labeled beclomethasone dipropionate dilauroylphosphatidylcholine liposome aerosol in normal volunteers. Int. J. Pharm., 115 (1994) 209-216.
29. Waldrep, J.C., Gilbert, B.E., Knight, C.M., Black, M.B., Scherer, P., Knight, V. and Eschenbacher, W., Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Chest, 111 (1997) 316-323.
30. Waldrep, J.C., Keyhani, K., Black, M. and Knight, V., Operating characteristics of 18 different continuous-flow jet nebulizers with beclomethasone dipropionate liposome aerosol. Chest, 105 (1994a) 106-10.
31. Waldrep, J.C., Scherer, P.W., Hess, G.D., Black, M. and Knight, V., Nebulized Glucocorticoids in Liposomes: Aerosol Characteristics and Human Dose Estimates. J. Aer. Med., 7 (1994b).
32. Waldrep, J.C., Scherer, P.W., Keyhani, K. and Knight, V., Cyclosporin A Liposome Aerosol: Particle Size and Calculated Respiratory Deposition. Int. J. Pharm., 97 (1993) 205-212.