Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: In vivo evidence using the brain efflux index method

Journal of Neurochemistry

Volumn 73, Issue 3, 1999, Pages 1206-1211

  Hosoya, Ken Ichi ^a   Sugawara, Michiko ^a   Asaba, Hiroshi ^a   Terasaki, Tetsuya ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; D Aspartic acid; Efflux transport; L Aspartic acid; L Glutamic acid

Indexed keywords

ASPARTIC ACID; GLUTAMIC ACID;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN SLICE; CONTROLLED STUDY; IMAGE ANALYSIS; INTERSTITIAL FLUID; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY; TECHNIQUE; THIN LAYER CHROMATOGRAPHY;

ALGORITHMS; ANIMALS; ASPARTIC ACID; BLOOD-BRAIN BARRIER; BRAIN; GLUTAMIC ACID; KINETICS; MALE; MICROINJECTIONS; RATS; RATS, WISTAR; STEREOISOMERISM;

EID: 0032818545     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0731206.x     Document Type: Article

References (24)

1. Arriza J. L., Eliasof S., Kavanaugh M. P., and Amara S. G. (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 94, 4155-4160.
2. Benrabh H. and Lefauconnier J. M. (1996) Glutamate is transported across the rat blood-brain barrier by a sodium-independent system. Neurosci. Lett. 210, 9-12.
3. Comford E. M. (1985) The blood-brain barrier, a dynamic regulatory interface. Mol. Physiol. 7, 219-260.
4. Fairman W. A., Vandenberg R. J., Arriza J. L., Kavanaugh M. P., and Amara S. G. (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375, 599-603.
5. Fisher G. H., D'Aniello A., Vetere A., Padula L., Cusano G. P., Chavez M., Petrucelli L., and Man E. H. (1991) Free D-aspartate and D-alanine in normal and Alzheimer brain. Brain Res. Bull. 26, 983-985.
6. Fisher G. H., D'Aniello A., Vetere A., Cusano G. P., Chavez M., and Petrucelli L. (1992) Quantification of D-aspartate in normal and Alzheimer brains. Neurosci. Lett. 143, 215-218.
7. Hashimoto A., Nishikawa T., Oka T., Hayashi T., and Takahashi K. (1993) Widespread distribution of free D-aspartate in rat periphery. FEBS Lett. 331, 4-8.
8. Hutchison H. T., Eisenserg H., and Haber B. (1985) High-affinity transport of glutamate in rat brain microvessels. Exp. Neurol. 87, 260-269.
9. Imai K., Fukushima T., Santa T., Homma H., Hamase K., Sakai K., and Kato M. (1996) Analytical chemistry and biochemistry of D-amino acids. Biomed. Chromatogr. 10, 303-312.
10. Kakee A., Terasaki T., and Sugiyama Y. (1996) Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J. Pharmacol. Exp. Ther. 277, 1550-1559.
11. Kakee A., Terasaki T., and Sugiyama Y. (1997) Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: in vivo evidence by use of the brain efflux index method. J. Pharmacol. Exp. Ther. 283, 1018-1025.
12. Kanai K. (1997) Family of neutral and acidic amino acid transporters: molecular biology and medical implications. Curr. Opin. Cell Biol. 9, 565-572.
13. Kanai K. and Hediger M. A. (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360, 467-471.
14. Man E. H., Sandhouse M. E., Burg J., and Fisher G. H. (1983) Accumulation of D-aspartic acid with age in the human brain. Science 220, 1407-1408.
15. +. J. Cereb. Blood Flow Metab. 11, 398-406.
16. Pardridge W. M., Triguero D., Yang J., and Cancilla P. A. (1990) Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253, 884-891.
17. Pines G., Danbolt N. C., Bjorås M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., and Kanner B. I. (1992) Cloning and expression of a rat brain L-glutamate transporter. Nature 360, 464-467.
18. Schinkel A. H., Smit J. J. M., van Tellingen O., Beijnen J. H., Wagenaar E., van Deemter L., Mol C. A. A. M., van der Valk M. A., Robanus-Maandag E. C., te Riele H. P. J., Berns A. J. M., and Borst P. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77, 491-502.
19. +-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA 89, 10955-10959.
20. Swanson R. A., Liu J., Miller J. W., Rothstein J. D., Farrell K., Stein B. A., and Longuemare M. C. (1997) Neuronal regulation of glutamate transporter subtype expression in astrocytes. J. Neurosci. 17, 932-940.
21. Takasawa K., Terasaki T., Suzuki H., and Sugiyama Y. (1997) In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J. Pharmacol. Exp. Ther. 281, 369-375.
22. Tsuji A., Terasaki T., Takabatake Y., Tenda Y., Tamai I., Yamashima T., Moritani S., Tsuruo T., and Yamashita J. (1992) P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51, 1427-1437.
23. Yamaoka K., Tanigawara Y., Nakagawa T., and Uno T. (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiodyn. 4, 879-885.
24. Yang W. X., Terasaki T., Shiroki K., Ohka S., Aoki J., Tanabe S., Nomura T., Terada E., Sugiyama Y., and Nomoto A. (1997) Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor. Virology 229, 421-428.