Understanding biophysicochemical interactions at the nano-bio interface

Nature Materials

Volumn 8, Issue 7, 2009, Pages 543-557

  Nel, Andre E ^a   Mädler, Lutz ^b   Velegol, Darrell ^c   Xia, Tian ^a   Hoek, Eric M V ^d   Somasundaran, Ponisseril ^e   Klaessig, Fred ^f   Castranova, Vince ^g   Thompson, Mike ^h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BREMEN   (Germany)

^c The Pennsylvania State University   (United States)

^d University of California   (United States)

^e Columbia University ^*  (United States)

^f Pennsylvania Bio Nano Systems   (United States)

^g NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^h Thermo Fisher Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYTIC PROCESS; BIOINTERFACES; COLLOIDAL FORCES; ENERGY RELEASE; ENGINEERED NANOMATERIALS; INTRACELLULAR UPTAKE; NANO-MATERIALS; NANOMATERIAL; PHASE TRANSFORMATION; PREDICTIVE RELATIONSHIPS; RAPID GROWTH; SURFACE COATINGS;

CELL MEMBRANES; DISSOLUTION; METAL RECOVERY; NUCLEIC ACIDS; PHASE INTERFACES; SURFACE CHEMISTRY;

NANOSTRUCTURED MATERIALS;

BIOMATERIAL; NANOPARTICLE; PROTEIN;

BIOLOGICAL MODEL; CHEMISTRY; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PARTICLE SIZE; REVIEW;

BIOCOMPATIBLE MATERIALS; MODELS, BIOLOGICAL; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PROTEINS;

EID: 67649491055     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat2442     Document Type: Review

References (99)

1. Nel, A., Xia, T., Madler, L. & Li, N. Toxic potential of materials at the nanolevel. Science 311, 622-627 (2006).
2. Oberdorster, G. et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part. Fibre Toxicol. 2, 8 (2005).
3. Vertegel, A. A., Siegel, R. W. & Dordick, J. S. Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme. Langmuir 20, 6800-6807 (2004).
4. Sigmund, W., Pyrgiotakis, G. & Daga, A. Chemical Processing of Ceramics (CRC, 2005).
5. Gilbert, B., Huang, F., Zhang, H., Waychunas, G. A. & Banfield, J. F. Nanoparticles: Strained and stiff. Science 305, 651-654 (2004).
6. Min, Y., Akbulut, M., Kristiansen, K., Golan, Y. & Israelachvili, J. The role of interparticle and external forces in nanoparticle assembly. Nature Mater. 7, 527-538 (2008).
7. Velegol, D. Assembling colloidal devices by controlling interparticle forces. J. Nanophoton. 1, 012502 (2007).
8. Baca, H. K. et al. Cell-directed assembly of lipid-silica nanostructures providing extended cell viability. Science 313, 337-341 (2006).
9. Dagastine, R. R. et al. Dynamic forces between two deformable oil droplets in water. Science 313, 210-213 (2006).
10. Kim, H. Y., Sofo, J. O., Velegol, D., Cole, M. W. & Lucas, A. A. Van der Waals dispersion forces between dielectric nanoclusters. Langmuir 23, 1735-1740 (2007).
11. Feick, J. D., Chukwumah, N., Noel, A. E. & Velegol, D. Altering surface charge nonuniformity on individual colloidal particles. Langmuir 20, 3090-3095 (2004).
12. Velegol, D. & Thwar, P. K. Analytical model for the effect of surface charge nonuniformity on colloidal interactions. Langmuir 17, 7687-7693 (2001).
13. Baca, H. K. et al. Cell-directed assembly of bio/nano interfaces: A new scheme for cell immobilization. Acc. Chem. Res. 40, 836-845 (2007).
14. Dobrovolskaia, M. A. & McNeil, S. E. Immunological properties of engineered nanomaterials. Nature Nanotech. 2, 469-478 (2007).
15. Swanson, J. A. Shaping cups into phagosomes and macropinosomes. Nature Rev. Mol. Cell Biol. 9, 639-649 (2008).
16. Chen, H., Langer, R. & Edwards, D. A. A film tension theory of phagocytosis. J. Colloid Interface Sci. 190, 118-133 (1997).
17. Cedervall, T. et al. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc. Natl Acad. Sci. USA 104, 2050-2055 (2007).
18. Linse, S. et al. Nucleation of protein fibrillation by nanoparticles. Proc. Natl Acad. Sci. USA 104, 8691-8696 (2007).
19. Lundqvist, M. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc. Natl Acad. Sci. USA 105, 14265-14270 (2008).
20. Owens, D. E. III & Peppas, N. A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 307, 93-102 (2006).
21. Xia, T. et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. Am. Chem. Soc. Nano 2, 2121-2134 (2008).
22. Rodriguez, C. E., Fukuto, J. M., Taguchi, K., Froines, J. & Cho, A. K. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Chem. Biol. Interact. 155, 97-110 (2005).
23. Decuzzi, P. & Ferrari, M. The role of specific and nonspecific interactions in receptor-mediated endocytosis of nanoparticles. Biomaterials 28, 2915-2922 (2007).
24. Gao, H., Shi, W. & Freund, L. B. Mechanics of receptor-mediated endocytosis. Proc. Natl Acad. Sci. USA 102, 9469-9474 (2005).
25. Chithrani, B. D. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6, 662-668 (2006).
26. Verma, A. et al. Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nature Mater. 7, 588-595 (2008).
27. Fernandez-Carneado, J., Kogan, M. J., Pujals, S. & Giralt, E. Amphipathic peptides and drug delivery. Biopolymers 76, 196-203 (2004).
28. Leroueil, P. R. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 8, 420-424 (2008).
29. Fleck, C. C. & Netz, R. R. Electrostatic colloid-membrane binding. Europhys. Lett. 67, 314-320 (2004).
30. Wong-Ekkabut, J. et al. Computer simulation study of fullerene translocation through lipid membranes. Nature Nanotech. 3, 363-368 (2008).
31. Vonarbourg, A., Passirani, C., Saulnier, P. & Benoit, J. P. Parameters influencing the stealthiness of colloidal drug delivery systems. Biomaterials 27, 4356-4373 (2006).
32. Hoek, E. M. & Agarwal, G. K. Extended DLVO interactions between spherical particles and rough surfaces. J. Colloid Interface Sci. 298, 50-58 (2006).
33. Chithrani, B. D. & Chan, W. C. Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett. 7, 1542-1550 (2007).
34. Qian, Z. M., Li, H., Sun, H. & Ho, K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev. 54, 561-587 (2002).
35. Gratton, S. E. et al. The effect of particle design on cellular internalization pathways. Proc. Natl Acad. Sci. USA 105, 11613-11618 (2008).
36. Poland, C. A. et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotech. 3, 423-428 (2008).
37. Ferrari, M. Nanogeometry: Beyond drug delivery. Nature Nanotech. 3, 131-132 (2008).
38. Rejman, J., Oberle, V., Zuhorn, I. S. & Hoekstra, D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377, 159-169 (2004).
39. Sieczkarski, S. B. & Whittaker, G. R. Dissecting virus entry via endocytosis. J. Gen. Virol. 83, 1535-1545 (2002).
40. Oberdorster, G., Oberdorster, E. & Oberdorster, J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113, 823-839 (2005).
41. Sager, T. M. et al. Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1, 118-129 (2007).
42. Jiang, J., Oberdorster, G. & Biswas, P. Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies. J. Nanopart. Res. 11, 77-89 (2008).
43. Moreau, J. W. et al. Extracellular proteins limit the dispersal of biogenic nanoparticles. Science 316, 1600-1603 (2007).
44. Buford, M. C., Hamilton, R. F. Jr & Holian, A. A comparison of dispersing media for various engineered carbon nanoparticles. Part. Fibre Toxicol. 4, 6 (2007).
45. Dutta, D. et al. Adsorbed proteins influence the biological activity and molecular targeting of nanomaterials. Toxicol. Sci. 100, 303-315 (2007).
46. Xia, T., Kovochich, M., Liong, M., Zink, J. I. & Nel, A. E. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. Am. Chem. Soc. Nano 2, 85-96 (2008).
47. Xia, T. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 6, 1794-1807 (2006).
48. Thomas, M. & Klibanov, A. M. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc. Natl Acad. Sci. USA 100, 9138-9143 (2003).
49. Kuschner, W. G. et al. Pulmonary responses to purified zinc oxide fume. J. Invest. Med. 43, 371-378 (1995).
50. Mercer, R. R. et al. Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model. Am. J. Physiol. Lung Cell Mol. Physiol. 294, L87-L97 (2008).
51. Shvedova, A. A. et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 289, L698-L708 (2005).
52. Monteiller, C. et al. The proinflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area. Occup. Environ. Med. 64, 609-615 (2007).
53. 2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 91, 227-236 (2006).
54. Shvedova, A. A. et al. Nanotechnology: Characterization, Dosing and Health Effects (Informa Healthcare, 2007).
55. Araujo, J. A. et al. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ. Res. 102, 589-596 (2008).
56. Li, N. et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect. 111, 455-460 (2003).
57. McNeil, S. E. Nanoparticle therapeutics: A personal perspective. WIREs Nanomed. Nanobiotechnol. 1, 264-271 (2009).
58. Mortensen, L. J., Oberdorster, G., Pentland, A. P. & Delouise, L. A. In vivo skin penetration of quantum dot nanoparticles in the murine model: The effect of UVR. Nano Lett. 8, 2779-2787 (2008).
59. Goodman, C. M., McCusker, C. D., Yilmaz, T. & Rotello, V. M. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug. Chem. 15, 897-900 (2004).
60. Hoet, P. H., Gilissen, L. & Nemery, B. Polyanions protect against the in vitro pulmonary toxicity of polycationic paint components associated with the Ardystil syndrome. Toxicol. Appl. Pharmacol. 175, 184-190 (2001).
61. 2 nanoparticles. Chem. Commun. 4815-4817 (2007).
62. 2) nanoparticles on fish cells in vitro. Ecotoxicology 17, 410-420 (2008).
63. Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T. & Schlager, J. J. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol. In Vitro 19, 975-983 (2005).
64. Navarro, E. et al. Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi. Ecotoxicology 17, 372-386 (2008).
65. Hauck, T. S., Ghazani, A. A. & Chan, W. C. Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small 4, 153-159 (2008).
66. Khan, J. A., Pillai, B., Das, T. K., Singh, Y. & Maiti, S. Molecular effects of uptake of gold nanoparticles in HeLa cells. ChemBioChem. 8, 1237-1240 (2007).
67. Kirchner, C. et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett. 5, 331-338 (2005).
68. Ovrevik, J., Lag, M., Schwarze, P. & Refsnes, M. p38 and SrcERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells. Toxicol. Sci. 81, 480-490 (2004).
69. Auffan, M. et al. Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli. Environ. Sci. Technol. 42, 6730-6735 (2008).
70. Jain, T. K., Morales, M. A., Sahoo, S. K., LesliePelecky, D. L. & Labhasetwar, V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharmacol. 2, 194-205 (2005).
71. Laurent, S. et al. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem. Rev. 108, 2064-2110 (2008).
72. Magrez, A. et al. Cellular toxicity of carbon-based nanomaterials. Nano Lett. 6, 1121-1125 (2006).
73. Carrero-Sanchez, J. C. et al. Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen. Nano Lett. 6, 1609-1616 (2006).
74. Kagan, V. E. et al. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron. Toxicol. Lett. 165, 88-100 (2006).
75. Lam, C. W., James, J. T., McCluskey, R. & Hunter, R. L. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 77, 126-134 (2004).
76. Sayes, C. M. et al. The differential cytotoxicity of water-soluble fullerenes. Nano Lett. 4, 1881-1887 (2004).
77. Tansey, W. et al. Synthesis and characterization of branched poly(L-glutamic acid) as a biodegradable drug carrier. J. Control Release 94, 39-51 (2004).
78. Guo, D. et al. In vitro cellular uptake and cytotoxic effect of functionalized nickel nanoparticles on leukemia cancer cells. J. Nanosci. Nanotech. 8, 2301-2307 (2008).
79. 3) nanoparticles in mouse skin epithelial cells. Carcinogenesis 29, 1920-1929 (2008).
80. Oesterling, E. et al. Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol. Lett. 178, 160-166 (2008).
81. Karlsson, H. L., Cronholm, P., Gustafsson, J. & Moller, L. Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes. Chem. Res. Toxicol. 21, 1726-1732 (2008).
82. Chen, Z. et al. Acute toxicological effects of copper nanoparticles in vivo. Toxicol. Lett. 163, 109-120 (2006).
83. Niemantsverdriet, J. W. Spectroscopy in Catalysis (Wiley-VCH, 2007).
84. Yu, X., Jin, L. & Zhou, Z. H. 3.88 Å structure of cytoplasmic polyhedrosis virus by cry-oelectron microscopy. Nature 453, 415-419 (2008).
85. Baumeister, W. A voyage to the inner space of cells. Protein Sci. 14, 257-269 (2005).
86. Carragher, B. et al. Rapid routine structure determination of macromolecular assemblies using electron microscopy: Current progress and further challenges. J. Synchrotron. Radiat. 11, 83-85 (2004).
87. Kaneko, K. et al. Structural and morphological characterization of cerium oxide nanocrystals prepared by hydrothermal synthesis. Nano Lett. 7, 421-425 (2007).
88. Porter, A. E. Direct imaging of single-walled carbon nanotubes in cells. Nature Nanotech. 2, 713-717 (2007).
89. Lucic, V. et al. Multiscale imaging of neurons grown in culture: from light microscopy to cryo-electron tomography. J. Struct. Biol. 160, 146-156 (2007).
90. Sartori, A. et al. Correlative microscopy: Bridging the gap between fluorescence light microscopy and cryo-electron tomography. J. Struct. Biol. 160, 135-145 (2007).
91. Steven, A. C. & Baumeister, W. The future is hybrid. J. Struct. Biol. 163, 186-195 (2008).
92. Heymann, J. A. et al. Site-specific 3D imaging of cells and tissues with a dual beam microscope. J. Struct. Biol. 155, 63-73 (2006).
93. Marko, M. Focused-ion-beam thinning of frozen-hydrated biological specimens for cryo-electron microscopy. Nature Methods 4, 215-217 (2007).
94. Stephens, D. J. & Allan, V. J. Light microscopy techniques for live cell imaging. Science 300, 82-86 (2003).
95. Qian, X. et al. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nature Biotechnol. 26, 83-90 (2008).
96. Keren, S. et al. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proc. Natl Acad. Sci. USA 105, 5844-5849 (2008).
97. Liu, Z. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nature Nanotech. 2, 47-52 (2007).
98. Kostarelos, K. The long and short of carbon nanotube toxicity. Nature Biotechnol. 26, 774-776 (2008).
99. Lacerda, L. et al. Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv. Mater. 20, 225-230 (2008).