메뉴 건너뛰기




Volumn 30, Issue 1, 2005, Pages 57-69

Molecular biology of the blood-brain barrier

Author keywords

Blood brain barrier (BBB); Drug delivery; Endothelium; Genomics; Proteomics

Indexed keywords

ANTIBODIES; BLOOD; BRAIN; CLONING; DRUG THERAPY; GENES;

EID: 26244456551     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/mb:30:1:057     Document Type: Review
Times cited : (194)

References (36)
  • 1
    • 0017689969 scopus 로고
    • Morphology of blood-brain interfaces
    • Brightman, M. W. (1977) Morphology of blood-brain interfaces. Exp. Eye Res. 25 Suppl., 1-25.
    • (1977) Exp. Eye Res. , vol.25 , Issue.SUPPL. , pp. 1-25
    • Brightman, M.W.1
  • 2
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • Oldendorf, W. H. (1971) Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221, 1629-1639.
    • (1971) Am. J. Physiol. , vol.221 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 3
    • 0344453556 scopus 로고    scopus 로고
    • A morphological approach to the analysis of blood-brain barrier transport function,n
    • (Paulson, O., Knudsen, G. M., and Moos, T., eds.), Munksgaard, Copenhagen
    • Pardridge, W. M. (1999) A morphological approach to the analysis of blood-brain barrier transport function, in Brain Barrier Systems (Paulson, O., Knudsen, G. M., and Moos, T., eds.), Munksgaard, Copenhagen, pp. 19-42.
    • (1999) Brain Barrier Systems , pp. 19-42
    • Pardridge, W.M.1
  • 4
    • 0019153446 scopus 로고
    • Permeability and vascularity of the developing brain: Cerebellum vs. cerebral cortex
    • Johanson, C. E. (1980) Permeability and vascularity of the developing brain: cerebellum vs. cerebral cortex. Brain Res. 190, 3-16.
    • (1980) Brain Res. , vol.190 , pp. 3-16
    • Johanson, C.E.1
  • 5
    • 0029043028 scopus 로고
    • Ultrastructural analysis of tryptophan hydroxylase immunoreactive nerve terminals in the rat cerebral cortex and hippocampus: Their associations with local blood vessels
    • Cohen, Z., Ehret, M., Maitre, M., and Hamel, E. (1995) Ultrastructural analysis of tryptophan hydroxylase immunoreactive nerve terminals in the rat cerebral cortex and hippocampus: their associations with local blood vessels. Neuroscience 66, 555-569.
    • (1995) Neuroscience , vol.66 , pp. 555-569
    • Cohen, Z.1    Ehret, M.2    Maitre, M.3    Hamel, E.4
  • 6
    • 0030174546 scopus 로고    scopus 로고
    • Ultrastructural relationships between noradrenergic nerve fibers and non-neuronal elements in the rat cerebral cortex
    • Paspalas, C. D. and Papadopoulos, G. C. (1996) Ultrastructural relationships between noradrenergic nerve fibers and non-neuronal elements in the rat cerebral cortex. GLIA 17, 133-146.
    • (1996) GLIA , vol.17 , pp. 133-146
    • Paspalas, C.D.1    Papadopoulos, G.C.2
  • 7
    • 0023269322 scopus 로고
    • Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?
    • Paulson, O. B. and Newman, E. A. (1987) Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science 237, 896-898.
    • (1987) Science , vol.237 , pp. 896-898
    • Paulson, O.B.1    Newman, E.A.2
  • 8
    • 0023263412 scopus 로고
    • Major localization of aminopeptidase M in rat brain microvessels
    • Solhonne, B., Gros, C., Pollard, H., and Schwartz, J. C. (1987) Major localization of aminopeptidase M in rat brain microvessels. Neuroscience 22, 225-232.
    • (1987) Neuroscience , vol.22 , pp. 225-232
    • Solhonne, B.1    Gros, C.2    Pollard, H.3    Schwartz, J.C.4
  • 9
    • 0028322161 scopus 로고
    • The 140-kDa protein of blood-brain barrier-associated pericytes is identical to aminopeptidase M
    • Kunz, J., Krause, D., Kremer, M., and Dermietzel, R. (1994) The 140-kDa protein of blood-brain barrier-associated pericytes is identical to aminopeptidase M. J. Neurochem. 62, 2375-2386.
    • (1994) J. Neurochem. , vol.62 , pp. 2375-2386
    • Kunz, J.1    Krause, D.2    Kremer, M.3    Dermietzel, R.4
  • 11
    • 0024576304 scopus 로고
    • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
    • Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. (1989) Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem. 37, 159-164.
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 159-164
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3    Gottesman, M.M.4    Pastan, I.5    Willingham, M.C.6
  • 12
    • 0025165341 scopus 로고
    • Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis
    • Raine, C. S., Lee, S. C., Scheinberg L. C., Duijvestin, A. M., and Cross, A. H. (1990) Adhesion molecules on endothelial cells in the central nervous system: an emerging area in the neuroimmunology of multiple sclerosis. Clin. Immunol. Immunopathol. 57, 173-187.
    • (1990) Clin. Immunol. Immunopathol. , vol.57 , pp. 173-187
    • Raine, C.S.1    Lee, S.C.2    Scheinberg, L.C.3    Duijvestin, A.M.4    Cross, A.H.5
  • 15
    • 0035940380 scopus 로고    scopus 로고
    • Brain-specific expression of an exogenous gene following intravenous administration
    • Shi, N., Zhang, Y., Boado, R. J., Zhu, C., and Pardridge, W. M. (2001) Brain-specific expression of an exogenous gene following intravenous administration. Proc. Natl. Acad. Sci. USA 98, 12754-12759.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12754-12759
    • Shi, N.1    Zhang, Y.2    Boado, R.J.3    Zhu, C.4    Pardridge, W.M.5
  • 16
    • 0034687846 scopus 로고    scopus 로고
    • Antisense imaging of gene expression in the brain in vivo
    • Shi, N., Boado, R. J., and Pardridge, W. M. (2000) Antisense imaging of gene expression in the brain in vivo. Proc. Natl. Acad. Sci. USA 97, 14709-14714.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14709-14714
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 17
    • 0032824986 scopus 로고    scopus 로고
    • Genetically engineered brain drug delivery vectors - Cloning, expression, and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein
    • Li, J. Y., Sugimura, K., Boado, R. J., Lee, H. J., Zhang, C., Dubel, S., and Pardridge, W. M. (1999) Genetically engineered brain drug delivery vectors - cloning, expression, and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein. Protein Engineering 12, 787-796.
    • (1999) Protein Engineering , vol.12 , pp. 787-796
    • Li, J.Y.1    Sugimura, K.2    Boado, R.J.3    Lee, H.J.4    Zhang, C.5    Dubel, S.6    Pardridge, W.M.7
  • 18
    • 0021841594 scopus 로고
    • Human blood-brain barrier insulin receptor
    • Pardridge, W. M., Eisenberg, J., and Yang, J. (1985) Human blood-brain barrier insulin receptor. J. Neurochem. 44, 1771-1778.
    • (1985) J. Neurochem. , vol.44 , pp. 1771-1778
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 20
    • 0021352278 scopus 로고
    • Capacity for energy metabolism in microvessels isolated from rat brain
    • Lasbennes, R. and Gayet, J. (1983) Capacity for energy metabolism in microvessels isolated from rat brain. Neurochem. Res. 9, 1-9.
    • (1983) Neurochem. Res. , vol.9 , pp. 1-9
    • Lasbennes, R.1    Gayet, J.2
  • 21
    • 0025885450 scopus 로고
    • A one-step procedure for isolation of poly A+ mRNA from isolated brain capillaries and endothelial cells in culture
    • Boado, R. J. and Pardridge, W. M. (1991) A one-step procedure for isolation of poly A+ mRNA from isolated brain capillaries and endothelial cells in culture. J. Neurochem. 57, 2136-2139.
    • (1991) J. Neurochem. , vol.57 , pp. 2136-2139
    • Boado, R.J.1    Pardridge, W.M.2
  • 22
    • 13044258426 scopus 로고    scopus 로고
    • Selective expression of the large neutral amino acid transporter (LAT) at the blood-brain barrier
    • Boado, R. J., Li, J. Y., Nagaya, M., Zhang, C., and Pardridge, W. M. (1999) Selective expression of the large neutral amino acid transporter (LAT) at the blood-brain barrier. Proc. Natl. Acad. Sci USA 96, 12079-12084.
    • (1999) Proc. Natl. Acad. Sci USA , vol.96 , pp. 12079-12084
    • Boado, R.J.1    Li, J.Y.2    Nagaya, M.3    Zhang, C.4    Pardridge, W.M.5
  • 23
    • 0021020420 scopus 로고
    • Brain metabolism: A perspective from the blood-brain barrier
    • Pardridge, W. M. (1983) Brain metabolism: a perspective from the blood-brain barrier. Physiol. Rev. 63, 1481-1535.
    • (1983) Physiol. Rev. , vol.63 , pp. 1481-1535
    • Pardridge, W.M.1
  • 24
    • 0036043194 scopus 로고    scopus 로고
    • Vascular proteomics and subtractive antibody expression cloning
    • Shusta, E. V., Boado, R. J., and Pardridge, W. M. (2002) Vascular proteomics and subtractive antibody expression cloning. Mol. Cell. Proteomics 1, 75-82.
    • (2002) Mol. Cell. Proteomics , vol.1 , pp. 75-82
    • Shusta, E.V.1    Boado, R.J.2    Pardridge, W.M.3
  • 25
    • 0031592820 scopus 로고    scopus 로고
    • Sequencing of cDNA encoding serum albumin and its extrahepatic synthesis in the Mongolian gerbil, Meriones unguiculatus
    • Yoshida, K., Seto-Ohshima, A., and Sinohara, H. (1997) Sequencing of cDNA encoding serum albumin and its extrahepatic synthesis in the Mongolian gerbil, Meriones unguiculatus. DNA Res. 4, 351-354.
    • (1997) DNA Res. , vol.4 , pp. 351-354
    • Yoshida, K.1    Seto-Ohshima, A.2    Sinohara, H.3
  • 26
    • 0028240140 scopus 로고
    • Measurement of blood-brain barrier GLUT1 glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay
    • Boado, R. J. and Pardridge, W. M. (1994) Measurement of blood-brain barrier GLUT1 glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay. J. Neurochem. 62, 2085-2090.
    • (1994) J. Neurochem. , vol.62 , pp. 2085-2090
    • Boado, R.J.1    Pardridge, W.M.2
  • 27
    • 0001253552 scopus 로고
    • Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5′-untranslated region
    • Boado, R. J. and Pardridge, W. M. (1990) Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5′-untranslated region. Mol. Cell. Neurosci. 1, 224-232.
    • (1990) Mol. Cell. Neurosci. , vol.1 , pp. 224-232
    • Boado, R.J.1    Pardridge, W.M.2
  • 28
    • 0034899721 scopus 로고    scopus 로고
    • Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2
    • Li, J. Y., Boado, R. J., and Pardridge, W. M. (2001) Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2. J. Cereb. Blood Flow Metabol. 21, 929-936.
    • (2001) J. Cereb. Blood Flow Metabol. , vol.21 , pp. 929-936
    • Li, J.Y.1    Boado, R.J.2    Pardridge, W.M.3
  • 29
    • 0032859340 scopus 로고    scopus 로고
    • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
    • Gao, B., Stieger, B., Noe, B., Fritschy, J. M., and Meier, P. J. (1999) Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J. Histochem. Cytochem. 47, 1255-1264.
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1255-1264
    • Gao, B.1    Stieger, B.2    Noe, B.3    Fritschy, J.M.4    Meier, P.J.5
  • 31
    • 0031665574 scopus 로고    scopus 로고
    • Upregulation of blood-brain barrier short form leptin receptor gene products in rats fed a high fat diet
    • Boado, R. J., Golden, P. L., Levin, N., and Pardridge, W. M. (1998) Upregulation of blood-brain barrier short form leptin receptor gene products in rats fed a high fat diet. J. Neurochem. 71, 1761-1764.
    • (1998) J. Neurochem. , vol.71 , pp. 1761-1764
    • Boado, R.J.1    Golden, P.L.2    Levin, N.3    Pardridge, W.M.4
  • 32
    • 0022966985 scopus 로고
    • Phenylalanine transport at the human blood-brain barrier. Studies in isolated human brain capillaries
    • Choi, T. and Pardridge, W. M. (1986) Phenylalanine transport at the human blood-brain barrier. Studies in isolated human brain capillaries. J. Biol. Chem. 261, 6536-6541.
    • (1986) J. Biol. Chem. , vol.261 , pp. 6536-6541
    • Choi, T.1    Pardridge, W.M.2
  • 33
    • 0034066471 scopus 로고    scopus 로고
    • Membrane proteins and proteomics: Un amour possible?
    • Santoni, V., Molloy, M., and Rabilloud, T. (2000) Membrane proteins and proteomics: un amour possible? Electrophoresis 21, 1054-1070.
    • (2000) Electrophoresis , vol.21 , pp. 1054-1070
    • Santoni, V.1    Molloy, M.2    Rabilloud, T.3
  • 34
    • 0022610066 scopus 로고
    • Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein
    • Pardridge, W. M., Yang, J., Eisenberg, J., and Mietus, L. J. (1986) Antibodies to blood-brain barrier bind selectively to brain capillary endothelial lateral membranes and to a 46K protein. J. Cereb. Blood Flow Metab. 6, 203-211.
    • (1986) J. Cereb. Blood Flow Metab. , vol.6 , pp. 203-211
    • Pardridge, W.M.1    Yang, J.2    Eisenberg, J.3    Mietus, L.J.4
  • 35
    • 0036295091 scopus 로고    scopus 로고
    • Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier
    • Shusta, E. V., Zhu, C., Boado, R. J., and Pardridge, W. M. (2002) Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier. J. Neuropathol. Exp. Neurol. 61, 597-604.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 597-604
    • Shusta, E.V.1    Zhu, C.2    Boado, R.J.3    Pardridge, W.M.4
  • 36
    • 0025329190 scopus 로고
    • Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier
    • Pardridge, W. M., Triguero, D., Yang, J., and Cancilla, P. A. (1990) Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253, 884-891.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 884-891
    • Pardridge, W.M.1    Triguero, D.2    Yang, J.3    Cancilla, P.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.