Intratumoral drug delivery with nanoparticulate carriers

Pharmaceutical Research

Volumn 28, Issue 8, 2011, Pages 1819-1830

  Holback, Hillary ^a   Yeo, Yoon ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

extracellular matrix; interstitial fluid pressure; intratumoral distribution; nanoparticles; solid tumors

Indexed keywords

ALBUMIN; ALPHAVBETA5 INTEGRIN; BRADYKININ RECEPTOR AGONIST; CETUXIMAB; COLLAGENASE; DEXAMETHASONE; DOXORUBICIN; ELASTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPOTHILONE B; FOLATE RECEPTOR; GLYCOSAMINOGLYCAN; HUMAN SERUM ALBUMIN; HYALURONIDASE; IMATINIB; IMMUNOLIPOSOME; LIPOSOME; MACROGOL; MICROCRYSTALLINE COLLAGEN; MONOCLONAL ANTIBODY DC101; NANOCARRIER; NICOTINAMIDE; PACLITAXEL; POLYSTYRENE; PROSTAGLANDIN E1; PROTEIN LYSINE 6 OXIDASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULOTROPIN ANTIBODY;

ABLATION THERAPY; ANAPLASTIC CARCINOMA; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CHEMOTHERAPY; CANCER INHIBITION; DRUG BINDING SITE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG RELEASE; DRUG TRANSPORT; EXPERIMENTAL DESIGN; EXTRACELLULAR MATRIX; HUMAN; LIPOMA; MATERIAL COATING; MICELLE; NONHUMAN; OSTEOSARCOMA; OVARY TUMOR; PARTICLE SIZE; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; RECTUM TUMOR; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; SURFACE CHARGE; THERMAL ABLATION THERAPY; THYROID CARCINOMA; TISSUE PRESSURE;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; NANOPARTICLES; NEOPLASMS;

EID: 79961172204     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0360-y     Document Type: Review

References (163)

1. SH Jang MG Wientjes D Lu JLS Au 2003 Drug delivery and transport to solid tumors Pharm Res. 20 9 1337 50 14567626 1:CAS:528:DC%2BD3sXnt1KitLc%3D (Pubitemid 37164040)
2. RK Jain T Stylianopoulos 2010 Delivering nanomedicine to solid tumors Nat Rev Clin Oncol. 7 11 653 64 20838415 1:CAS:528:DC%2BC3cXhtlCrsb7P
3. Y Matsumura H Maeda 1986 A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 46 6387 92 2946403 1:CAS:528: DyaL2sXnvVensA%3D%3D (Pubitemid 17221789)
4. MJ Paszek N Zahir KR Johnson JN Lakins GI Rozenberg A Gefen, et al. 2005 Tensional homeostasis and the malignant phenotype Cancer Cell. 8 3 241 54 16169468 1:CAS:528:DC%2BD2MXhtV2gt7vO (Pubitemid 41317594)
5. JS Young CE Lumsden AL Stalker 1950 The significance of the "tissue pressure" of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit J Pathol Bacteriol. 62 3 313 33 14784896 1:STN:280:DyaG3M%2FhsVCntA%3D%3D
6. RK Jain 2001 Delivery of molecular and cellular medicine to solid tumors Adv Drug Deliv Rev. 46 1-3 149 68 11259838 1:CAS:528:DC%2BD3MXitVOhsLw%3D
7. LT Baxter RK Jain 1989 Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection Microvas Res. 37 1 77 104 1:STN:280:DyaL1M7lvV2itg%3D%3D (Pubitemid 19045527)
8. RK Jain LT Baxter 1988 Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure Cancer Res. 48 24 Pt 1 7022 32 3191477 1:STN:280:DyaL1M%2FltFOmtQ%3D%3D (Pubitemid 19013976)
9. CG Willett Y Boucher E di Tomaso DG Duda LL Munn RT Tong, et al. 2004 Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer Nat Med. 10 2 145 7 14745444 1:CAS:528: DC%2BD2cXoslKmtQ%3D%3D (Pubitemid 38524883)
10. Y Boucher LT Baxter RK Jain 1990 Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy Cancer Res. 50 15 4478 84 2369726 1:STN:280:DyaK3czhsFKjsA%3D%3D (Pubitemid 20230379)
11. CH Heldin K Rubin K Pietras A Ostman 2004 High interstitial fluid pressure - An obstacle in cancer therapy Nat Rev Cancer. 4 10 806 13 15510161 1:CAS:528:DC%2BD2cXos1ymu7s%3D (Pubitemid 39331152)
12. AI Minchinton IF Tannock 2006 Drug penetration in solid tumours Nat Rev Cancer. 6 8 583 92 16862189 1:CAS:528:DC%2BD28XntFGlu7w%3D (Pubitemid 44140857)
13. HJ Kuh SH Jang MG Wientjes JR Weaver JLS Au 1999 Determinants of paclitaxel penetration and accumulation in human solid tumor J Pharmacol Exp Ther. 290 2 871 80 10411604 1:CAS:528:DyaK1MXkvVKnsbc%3D (Pubitemid 29344588)
14. J Lankelma H Dekker RF Luque S Luykx K Hoekman P van der Valk, et al. 1999 Doxorubicin gradients in human breast cancer Clin Cancer Res. 5 7 1703 7 10430072 1:CAS:528:DyaK1MXltVCqtr0%3D (Pubitemid 29334449)
15. ME Davis Z Chen DM Shin 2008 Nanoparticle therapeutics: an emerging treatment modality for cancer Nat Rev Drug Discov. 7 9 771 82 18758474 1:CAS:528:DC%2BD1cXhtVGgtL%2FJ
16. JM Fleming TC Miller M Quinones Z Xiao X Xu MJ Meyer, et al. 2010 The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo BMC Med. 8 27 20492690
17. K Park 2010 A new ligand for targeted drug delivery to tumor stromal cells J Control Release. 145 2 75 20576503 1:CAS:528:DC%2BC3cXnvFGrsbg%3D
18. RK Reed K Rubin 2010 Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix Cardiovasc Res. 87 2 211 7 20472565 1:CAS:528:DC%2BC3cXotlChtbo%3D
19. T Ushiki 2002 Collagen fibers, reticular fibers and elastic fibers. A comprehensive understanding from a morphological viewpoint Arch Histol Cytol. 65 2 109 26 12164335 (Pubitemid 34863263)
20. I Stamenkovic 2003 Extracellular matrix remodelling: the role of matrix metalloproteinases J Pathol. 200 4 448 64 12845612 1:CAS:528: DC%2BD3sXnvF2ns7g%3D (Pubitemid 36818245)
21. D Barkan JE Green AF Chambers 2010 Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth Eur J Cancer. 46 7 1181 8 20304630 1:CAS:528:DC%2BC3cXkvFKqtr4%3D
22. RV Iozzo 1998 Matrix proteoglycans: from molecular design to cellular function Annu Rev Biochem. 67 609 52 9759499 1:CAS:528:DyaK1cXlsFOmsbo%3D (Pubitemid 28411140)
23. J Koninger T Giese FF di Mola MN Wente I Esposito MG Bachem, et al. 2004 Pancreatic tumor cells influence the composition of the extracellular matrix Biochem Biophys Res Commun. 322 3 943 9 15336555 (Pubitemid 39164444)
24. M Comalada M Cardo J Xaus AF Valledor J Lloberas F Ventura, et al. 2003 Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation J Immunol. 170 9 4450 6 12707320 1:CAS:528: DC%2BD3sXjtVKgu74%3D (Pubitemid 36519949)
25. G Csordas M Santra CC Reed I Eichstetter DJ McQuillan D Gross, et al. 2000 Sustained down-regulation of the epidermal growth factor receptor by decorin - A mechanism for controlling tumor growth in vivo J Biol Chem. 275 42 32879 87 10913155 1:CAS:528:DC%2BD3cXnslOiu7g%3D
26. E Schonherr B Levkau L Schaefer H Kresse K Walsh 2001 Decorin-mediated signal transduction in endothelial cells - Involvement of Akt/protein kinase B in up-regulation of p21(WAF1/CIP1) but not p27(KIP1) J Biol Chem. 276 44 40687 92 11546775 1:CAS:528:DC%2BD3MXosVKhtb0%3D
27. Y Yamaguchi DM Mann E Ruoslahti 1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin Nature 346 6281 281 4 2374594 1:CAS:528:DyaK3cXkvFWqu7Y%3D
28. AD Theocharis DH Vynios N Papageorgakopoulou SS Skandalisa DA Theocharis 2003 Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma Int J Biochem Cell Biol. 35 3 376 90 12531251 1:CAS:528:DC%2BD3sXislyguw%3D%3D (Pubitemid 36084460)
29. CC Reed J Gauldie RV Iozzo 2002 Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin Oncogene. 21 23 3688 95 12032837 1:CAS:528:DC%2BD38Xks1Ojs70%3D (Pubitemid 34620532)
30. M Santra T Skorski B Calabretta EC Lattime RV Iozzo 1995 De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells Proc Natl Acad Sci USA. 92 15 7016 20 7624361 1:CAS:528:DyaK2MXntVSktLs%3D
31. BA Teicher Y Maehara Y Kakeji G Ara SR Keyes J Wong, et al. 1997 Reversal of in vivo drug resistance by the transforming growth factor-beta inhibitor decorin Int J Cancer. 71 1 49 58 9096665 1:CAS:528:DyaK2sXis1GrsrY%3D (Pubitemid 27158409)
32. ME Tsara AD Theocharis DA Theocharis 2002 Compositional and structural alterations of proteoglycans in human rectum carcinoma with special reference to versican and decorin Anticancer Res. 22 5 2893 8 12530013 1:CAS:528: DC%2BD3sXosl2itA%3D%3D (Pubitemid 36069330)
33. KR Levental H Yu L Kass JN Lakins M Egeblad JT Erler, et al. 2009 Matrix crosslinking forces tumor progression by enhancing integrin signaling Cell. 139 5 891 906 19931152 1:CAS:528:DC%2BC3cXksFWltQ%3D%3D
34. DT Butcher T Alliston VM Weaver 2009 A tense situation: forcing tumour progression Nat Rev Cancer. 9 2 108 22 19165226 1:CAS:528:DC%2BD1MXpsVeqtA%3D%3D
35. H Kresse E Schonherr 2001 Proteoglycans of the extracellular matrix and growth control J Cell Physiol. 189 3 266 74 11748584 1:CAS:528: DC%2BD3MXotFGqsbk%3D (Pubitemid 33063294)
36. CC Park J Rembert K Chew D Moore K Kerlikowske 2009 High mammographic breast density is independent predictor of local but not distant recurrence after lumpectomy and radiotherapy for invasive breast cancer Int J Radiat Oncol Biol Phys. 73 1 75 9 18692323
37. L Kolacna J Bakesova F Varga E Kostakova L Planka A Necas, et al. 2007 Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix Physiol Res. 56 Suppl 1 S51 60 17552894 1:CAS:528:DC%2BD1cXitV2qsL8%3D
38. S Ramaswamy KN Ross ES Lander TR Golub 2003 A molecular signature of metastasis in primary solid tumors Nat Genet. 33 1 49 54 12469122 1:CAS:528:DC%2BD38XpvVeqs7w%3D (Pubitemid 36068681)
39. YM Feng BC Sun XQ Li L Zhang Y Niu CH Xiao, et al. 2007 Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients Breast Cancer Res Treat. 103 3 319 29 17123152 1:CAS:528:DC%2BD2sXmsVOju74%3D (Pubitemid 46944516)
40. A Calvo R Catena MS Noble D Carbott I Gil-Bazo O Gonzalez-Moreno, et al. 2008 Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis Oncogene. 27 40 5373 84 18504437 1:CAS:528:DC%2BD1cXhtV2qtr3I
41. PA Netti DA Berk MA Swartz AJ Grodzinsky RK Jain 2000 Role of extracellular matrix assembly in interstitial transport in solid tumors Cancer Res. 60 9 2497 503 10811131 1:CAS:528:DC%2BD3cXjtV2qtLo%3D (Pubitemid 30262444)
42. BJ Pfeiffer CL Franklin FH Hsieh RA Bank CL Phillips 2005 Alpha 2(I) collagen deficient oim mice have altered biomechanical integrity, collagen content, and collagen crosslinking of their thoracic aorta Matrix Biol. 24 7 451 8 16095890 1:CAS:528:DC%2BD2MXhtFWhtrnO (Pubitemid 41443272)
43. JT Erler VM Weaver 2009 Three-dimensional context regulation of metastasis Clin Exp Metastasis. 26 1 35 49 18814043
44. LM Postovit DE Abbott SL Payne WW Wheaton NV Margaryan R Sullivan, et al. 2008 Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration J Cell Biochem. 103 5 1369 78 17685448 1:CAS:528:DC%2BD1cXkslShsr0%3D (Pubitemid 351490707)
45. A Albinger-Hegyi SJ Stoeckli S Schmid M Storz G Iotzova NM Probst-Hensch, et al. 2010 Lysyl oxidase expression is an independent marker of prognosis and a predictor of lymph node metastasis in oral and oropharyngeal squamous cell carcinoma (OSCC) Int J Cancer. 126 11 2653 62 19816945 1:CAS:528: DC%2BC3cXjvFKlsrY%3D
46. JS Desgrosellier DA Cheresh 2010 Integrins in cancer: biological implications and therapeutic opportunities Nat Rev Cancer. 10 1 9 22 20029421 1:CAS:528:DC%2BD1MXhsF2hsLzI
47. DG Stupack XS Puente S Boutsaboualoy CM Storgard DA Cheresh 2001 Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins J Cell Biol. 155 3 459 70 11684710 1:CAS:528:DC%2BD3MXotVSrtro%3D (Pubitemid 34289336)
48. HB Zhao FP Ross SL Teitelbaum 2005 Unoccupied alpha(v)beta(3) integrin regulates osteoclast apoptosis by transmitting a positive death signal Mol Endocrinol. 19 3 771 80 15591537 1:CAS:528:DC%2BD2MXit1Sqsr4%3D (Pubitemid 40349447)
49. Y Sawada M Tamada BJ Dubin-Thaler O Cherniavskaya R Sakai S Tanaka, et al. 2006 Force sensing by mechanical extension of the Src family kinase substrate p130Cas Cell. 127 5 1015 26 17129785 1:CAS:528:DC%2BD28XhtlWktrzN (Pubitemid 44803062)
50. CK Miranti JS Brugge 2002 Sensing the environment: a historical perspective on integrin signal transduction Nat Cell Biol. 4 4 E83 90 11944041 1:CAS:528:DC%2BD38XivV2jtrc%3D
51. SW Han FR Khuri J Roman 2006 Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways Cancer Res. 66 1 315 23 16397245 1:CAS:528:DC%2BD28XhsFWnsQ%3D%3D (Pubitemid 43166038)
52. L Vellon JA Menendez R Lupu 2005 alpha(v)beta(3) integrin regulates Heregulin (HRG)-induced cell proliferation and survival in breast cancer Oncogene. 24 23 3759 73 15782133 1:CAS:528:DC%2BD2MXksVOjsr4%3D (Pubitemid 40826875)
53. U Bohme U Scheler 2007 Effective charge of bovine serum albumin determined by electrophoresis NMR Chem Phys Lett. 435 342 5 (Pubitemid 46176840)
54. PNM Lohle I Verhagen AW Teelken EH Blaauw KG Go 1992 The pathogenesis of cerebral gliomatous cysts Neurosurgery. 30 2 180 5 1312229 1:STN:280: DyaK387oslShuw%3D%3D
55. Y Ding X Bian W Yao R Li D Ding Y Hu, et al. 2010 Surface-potential- regulated transmembrane and cytotoxicity of chitosan/gold hybrid nanospheres ACS Appl Mater Interfaces. 2 5 1456 65 20420367 1:CAS:528:DC%2BC3cXltFylurk%3D
56. B Asadishad M Vosoughi I Alamzadeh A Tavakoli 2010 Synthesis of folate-modified, polyethylene glycol-functionalized gold nanoparticles for targeted drug delivery J Dispers Sci Technol. 31 4 492 500 1:CAS:528: DC%2BC3cXksF2qsLk%3D
57. WS Cho M Cho J Jeong M Choi BS Han HS Shin, et al. 2010 Size-dependent tissue kinetics of PEG-coated gold nanoparticles Toxicol Appl Pharmacol. 245 1 116 23 20193702 1:CAS:528:DC%2BC3cXlsFahtrk%3D
58. D Pornpattananangkul S Olson S Aryal M Sartor CM Huang K Vecchio, et al. 2010 Stimuli-responsive liposome fusion mediated by gold nanoparticles ACS Nano. 4 4 1935 42 20235571 1:CAS:528:DC%2BC3cXjtlajsLs%3D
59. HJ Wang PQ Zhao XF Liang XQ Gong T Song RF Niu, et al. 2010 Folate-PEG coated cationic modified chitosan - Cholesterol liposomes for tumor-targeted drug delivery Biomaterials. 31 14 4129 38 20163853 1:CAS:528: DC%2BC3cXjtFKis7w%3D
60. M Mevel N Kamaly S Carmona MH Oliver MR Jorgensen C Crowther, et al. 2010 DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA J Control Release. 143 2 222 32 19969034 1:CAS:528: DC%2BC3cXjvFSlsLw%3D
61. S Barua K Rege 2010 The influence of mediators of intracellular trafficking on transgene expression efficacy of polymer-plasmid DNA complexes Biomaterials. 31 22 5894 902 20452664 1:CAS:528:DC%2BC3cXmtlKitLg%3D
62. J Contreras J Xie YJ Chen H Pei G Zhang CL Fraser, et al. 2010 Intracellular uptake and trafficking of difluoroboron dibenzoylmethane- polylactide nanoparticles in HeLa cells ACS Nano. 4 5 2735 47 20420413 1:CAS:528:DC%2BC3cXltFykt7Y%3D
63. J Ravindran HB Nair BY Sung S Prasad RR Tekmal BB Aggarwal 2010 Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential Biochem Pharmacol. 79 11 1640 7 20105430 1:CAS:528:DC%2BC3cXjvFKmt7o%3D
64. CC Michel FE Curry 1999 Microvascular permeability Physiol Rev. 79 3 703 61 10390517 1:CAS:528:DyaK1MXksFemtr0%3D (Pubitemid 29330172)
65. K Aukland RK Reed 1993 Interstitial-lymphatic mechanisms in the control of extracellular fluid volume Physiol Rev. 73 1 1 78 8419962 1:STN:280:DyaK3s7is1Cmsw%3D%3D (Pubitemid 23065433)
66. RA Clark JM Folkvord CE Hart MJ Murray JM McPherson 1989 Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices J Clin Invest. 84 3 1036 40 2760210 1:CAS:528: DyaK3cXhs1yitQ%3D%3D (Pubitemid 19228382)
67. D Gullberg A Tingstrom AC Thuresson L Olsson L Terracio TK Borg, et al. 1990 Beta 1 integrin-mediated collagen gel contraction is stimulated by PDGF Exp Cell Res. 186 2 264 72 2298242 1:CAS:528:DyaK3cXhtFarsLY%3D
68. R Montesano L Orci 1988 Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing Proc Natl Acad Sci USA. 85 13 4894 7 3164478 1:CAS:528:DyaL1cXkslWms74%3D
69. A Milosevic A Fyles D Hedley R Hill 2004 The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure Semin Radiat Oncol. 14 3 249 58 15254868 (Pubitemid 38903229)
70. SJ Lunt N Chaudary RP Hill 2009 The tumor microenvironment and metastatic disease Clin Exp Metastasis. 26 1 19 34 18543068
71. EK Rofstad EBM Ruud B Mathiesen K Galappathi 2010 Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue Clin Cancer Res. 16 3 936 45 20103667 1:CAS:528:DC%2BC3cXhs1aqs70%3D
72. BD Curti WJ Urba WG Alvord JE Janik JW Smith K Madara, et al. 1993 Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment Cancer Res. 53 10 Suppl 2204 7 8485703 1:STN:280:DyaK3s3ltFCgtQ%3D%3D (Pubitemid 23156799)
73. CG Lee M Heijn E di Tomaso G Griffon-Etienne M Ancukiewicz C Koike, et al. 2000 Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions Cancer Res. 60 19 5565 70 11034104 1:CAS:528:DC%2BD3cXns1ehtL4%3D
74. Aukland K. Interstitial fluid balance in experimental animals and man. In: Staub NC, Hogg JC, Hargens AR, editors. Advances in Microcirculation, Vol 13 Interstitial-Lymphatic Liquid and Solute Movement; Satellite Symposium, Victoria, British Columbia, Canada, July 20-24, 1986 X + 290p S Karger Ag: Basel, Switzerland; New York, New York, USA Illus:110-123; 1987.
75. M Hofmann E McCormack M Mujic M Rossberg A Bernd J Bereiter-Hahn, et al. 2009 Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model Neoplasia. 11 8 812 22 19649211 1:CAS:528:DC%2BD1MXoslKiurk%3D
76. Y Boucher JM Kirkwood D Opacic M Desantis RK Jain 1991 Interstitial hypertension in superficial metastatic melanomas in humans Cancer Res. 51 24 6691 4 1742743 1:STN:280:DyaK38%2Fns1Cjtw%3D%3D
77. R Gutmann M Leunig J Feyh AE Goetz K Messmer E Kastenbauer, et al. 1992 Interstitial hypertension in head and neck tumors in patients: correlation with tumor size Cancer Res. 52 7 1993 5 1551128 1:STN:280:DyaK383gtVChsw%3D%3D
78. SD Nathanson L Nelson 1994 Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma Ann Surg Oncol. 1 4 333 8 7850532 1:STN:280:DyaK2M7ltleqsQ%3D%3D
79. K Pietras K Rubin T Sjoblom E Buchdunger M Sjoquist CH Heldin, et al. 2002 Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy Cancer Res. 62 19 5476 84 12359756 1:CAS:528: DC%2BD38Xnsl2lsL4%3D
80. M Milosevic A Fyles D Hedley M Pintilie W Levin L Manchul, et al. 2001 Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor - oxygen measurements Cancer Res. 61 17 6400 5 11522633 1:CAS:528:DC%2BD3MXmsF2jsLs%3D (Pubitemid 32783245)
81. P Carmeliet RK Jain 2000 Angiogenesis in cancer and other diseases Nature. 407 6801 249 57 11001068 1:CAS:528:DC%2BD3cXmvVSls74%3D
82. AJ Leu DA Berk A Lymboussaki K Alitalo RK Jain 2000 Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation Cancer Res. 60 16 4324 7 10969769 1:CAS:528:DC%2BD3cXmsVaitbk%3D (Pubitemid 32103603)
83. A Klosowska-Wardega Y Hasumi M Burmakin A Ahgren L Stuhr I Moen, et al. 2009 Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma PLoS One. 4 12 e8149 19997591
84. RH Adams K Alitalo 2007 Molecular regulation of angiogenesis and lymphangiogenesis Nat Rev Mol Cell Biol. 8 6 464 78 17522591 1:CAS:528:DC%2BD2sXlsFOhsb4%3D (Pubitemid 46823443)
85. HF Dvorak LF Brown M Detmar AM Dvorak 1995 Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis Am J Pathol. 146 5 1029 39 7538264 1:CAS:528:DyaK2MXmt1Kkt7g%3D
86. K Pietras M Stumm M Hubert E Buchdunger K Rubin CH Heldin, et al. 2003 STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake Clin Cancer Res. 9 10 Pt 1 3779 87 14506171 1:CAS:528:DC%2BD3sXosVOks70%3D (Pubitemid 37169248)
87. A Ostman CH Heldin 2001 Involvement of platelet-derived growth factor in disease: development of specific antagonists Adv Cancer Res. 80 1 38 11034538 1:CAS:528:DC%2BD3cXot1Snu7o%3D (Pubitemid 33717320)
88. G Gabbiani 2003 The myofibroblast in wound healing and fibrocontractive diseases J Pathol. 200 4 500 3 12845617 1:STN:280:DC%2BD3szhsFOrtg%3D%3D (Pubitemid 36818250)
89. EK Rofstad JV Gaustad KG Brurberg B Mathiesen K Galappathi TG Simonsen 2009 Radiocurability is associated with interstitial fluid pressure in human tumor xenografts Neoplasia. 11 11 1243 51 19881960 1:CAS:528: DC%2BD1MXhtlarsr%2FN
90. EK Rofstad SH Tunheim B Mathiesen BA Graff EF Halsør K Nilsen, et al. 2002 Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts Cancer Res. 62 3 661 4 11830516 1:CAS:528:DC%2BD38Xht1Krtbw%3D (Pubitemid 34126937)
91. M Hofmann M Guschel A Bernd J Bereiter-Hahn R Kaufmann C Tandi, et al. 2006 Lowering of tumor interstitial fluid pressure reduces tumor cell proliferation in a xenograft tumor model Neoplasia. 8 2 89 95 16611401
92. M Hofmann M Schultz A Bernd J Bereiter-Hahn R Kaufmann S Kippenberger 2007 Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression J Biomech. 40 10 2324 9 17166501 (Pubitemid 46977402)
93. Y Boucher RK Jain 1992 Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse Cancer Res. 52 18 5110 4 1516068 1:STN:280:DyaK38zos1GitQ%3D%3D
94. RK Jain 1994 Barriers to drug delivery in solid tumors Sci Am. 271 1 58 65 8066425 1:STN:280:DyaK2czksFenuw%3D%3D
95. RK Jain 1987 Transport of molecules in the tumor interstitium: a review Cancer Res. 47 12 3039 51 3555767 1:CAS:528:DyaL2sXksFKlu7Y%3D (Pubitemid 17082621)
96. YW Cho SA Park TH Han DH Son JS Park SJ Oh, et al. 2007 In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles: mechanisms, key factors, and their implications Biomaterials. 28 6 1236 47 17126900 1:CAS:528:DC%2BD28Xht1Kiu7fE (Pubitemid 44816372)
97. KY Choi KH Min JH Na K Choi K Kim JH Park, et al. 2009 Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution J Mater Chem. 19 24 4102 7 1:CAS:528:DC%2BD1MXntVKit7w%3D
98. K Park J-H Kim YS Nam S Lee HY Nam K Kim, et al. 2007 Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles J Control Release. 122 3 305 314 17643545 1:CAS:528:DC%2BD2sXhtVKrsL3L (Pubitemid 47404663)
99. TA ElBayoumi VP Torchilin 2009 Tumor-targeted nanomedicines: enhanced antitumor efficacy in vivo of doxorubicin-loaded, long-circulating liposomes modified with cancer-specific monoclonal antibody Clin Cancer Res. 5 6 1973 80
100. E Gullotti Y Yeo 2009 Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery Mol Pharm. 6 4 1041 51 19366234 1:CAS:528:DC%2BD1MXlt12mt7s%3D
101. DB Kirpotin DC Drummond Y Shao MR Shalaby KL Hong UB Nielsen, et al. 2006 Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models Cancer Res. 66 13 6732 40 16818648 1:CAS:528:DC%2BD28XmsVamu7Y%3D (Pubitemid 44085631)
102. DW Bartlett H Su IJ Hildebrandt WA Weber ME Davis 2007 Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc Natl Acad Sci USA. 104 39 15549 54 17875985 1:CAS:528:DC%2BD2sXhtFajtbrI (Pubitemid 47502954)
103. X Zhang CG Koh B Yu S Liu L Piao G Marcucci, et al. 2009 Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model Pharm Res. 26 6 1516 24 19291371 1:CAS:528:DC%2BD1MXjt1Sqs7w%3D
104. T Nomura N Koreeda F Yamashita Y Takakura M Hashida 1998 Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors Pharm Res. 15 1 128 32 9487559 1:CAS:528:DyaK1cXosFSjug%3D%3D (Pubitemid 28080879)
105. LH Reddy RK Sharma RSR Murthy 2004 Enhanced tumour uptake of doxorubicin loaded Poly(butyl cyanoacrylate) nanoparticles in mice bearing Dalton's lymphoma tlimour J Drug Target. 12 7 443 51 15621669 1:CAS:528:DC%2BD2cXhtFSisLfK (Pubitemid 39562428)
106. Y Bae N Nishiyama S Fukushima H Koyama M Yasuhiro K Kataoka 2005 Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy Bioconjug Chem. 16 1 122 30 15656583 1:CAS:528:DC%2BD2cXhtFSlur3K (Pubitemid 40129685)
107. TT Goodman JY Chen K Matveev SH Pun 2008 Spatio-temporal modeling of nanoparticle delivery to multicellular tumor spheroids Biotechnol Bioeng. 101 2 388 99 18500767 1:CAS:528:DC%2BD1cXhtFChtbnO
108. H Lee H Fonge B Hoang RM Reilly C Allen 2010 The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles Mol Pharm. 7 4 1195 208 20476759 1:CAS:528: DC%2BC3cXmsFSnsrg%3D
109. MA Dobrovolskaia P Aggarwal JB Hall SE McNeil 2008 Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution Mol Pharm. 5 4 487 95 18510338 1:CAS:528:DC%2BD1cXmsVOhuro%3D
110. DE Owens NA Peppas 2006 Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int J Pharm. 307 1 93 102 16303268 1:CAS:528:DC%2BD2MXht12isrvM (Pubitemid 41773257)
111. J Wang M Sui W Fan 2010 Nanoparticles for tumor targeted therapies and their pharmacokinetics Curr Drug Metab. 11 2 129 41 20359289 1:CAS:528:DC%2BC3cXmvFaisbk%3D
112. RB Campbell D Fukumura EB Brown LM Mazzola Y Izumi RK Jain, et al. 2002 Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors Cancer Res. 62 23 6831 6 12460895 1:CAS:528:DC%2BD38XpsVahs78%3D (Pubitemid 35424069)
113. M Dellian F Yuan VS Trubetskoy VP Torchilin RK Jain 2000 Vascular permeability in a human tumour xenograft: molecular charge dependence Br J Cancer. 82 9 1513 8 10789717 1:CAS:528:DC%2BD3cXjsFaksr0%3D (Pubitemid 30204355)
114. B Kim G Han BJ Toley CK Kim VM Rotello NS Forbes 2010 Tuning payload delivery in tumour cylindroids using gold nanoparticles Nat Nanotechnol. 5 6 465 72 20383126 1:CAS:528:DC%2BC3cXmvFWlt70%3D
115. T Stylianopoulos MZ Poh N Insin MG Bawendi D Fukumura LL Munn, et al. 2010 Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions Biophys J. 99 5 1342 9 20816045 1:CAS:528: DC%2BC3cXhtFals7fO
116. O Lieleg RM Baumgärtel AR Bausch 2009 Selective filtering of particles by the extracellular matrix: an electrostatic bandpass Biophys J. 97 6 1569 77 19751661 1:CAS:528:DC%2BD1MXhsVCjsr%2FM
117. C Mamot DC Drummond CO Noble V Kallab ZX Guo KL Hong, et al. 2005 Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo Cancer Res. 65 24 11631 8 16357174 1:CAS:528:DC%2BD2MXhtlWiu7rK (Pubitemid 41821723)
118. A Gabizon AT Horowitz D Goren D Tzemach H Shmeeda S Zalipsky 2003 In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice Clin Cancer Res. 9 17 6551 9 14695160 1:CAS:528:DC%2BD3sXhtVSqurnF (Pubitemid 38031844)
119. OC Farokhzad J Cheng BA Teply I Sherifi S Jon PW Kantoff, et al. 2006 Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo Proc Natl Acad Sci USA. 103 16 6315 20 16606824 1:CAS:528:DC%2BD28XktFamsbk%3D
120. M Juweid R Neumann C Paik MJ Perez-Bacete J Sato W van Osdol, et al. 1992 Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier Cancer Res. 52 19 5144 53 1327501 1:CAS:528:DyaK38XmtlWqtL0%3D
121. CP Graff KD Wittrup 2003 Theoretical analysis of antibody targeting of tumor spheroids Cancer Res. 63 6 1288 96 12649189 1:CAS:528:DC%2BD3sXit1Sgtbw%3D
122. CM Lo HB Wang M Dembo YL Wang 2000 Cell movement is guided by the rigidity of the substrate Biophys J. 79 1 144 52 10866943 1:CAS:528: DC%2BD3cXks1Klurc%3D (Pubitemid 30436733)
123. J Jiang JS Moore HF Edelhauser MR Prausnitz 2009 Intrascleral drug delivery to the eye using hollow microneedles Pharm Res. 26 2 395 403 18979189 1:CAS:528:DC%2BD1cXhtlWhtbvK
124. Y Zhang MK So JH Rao 2006 Protease-modulated cellular uptake of quantum dots Nano Lett. 6 9 1988 92 16968013 1:CAS:528:DC%2BD28XnsV2ht7w%3D (Pubitemid 44555242)
125. L Eikenes M Tari I Tufto OS Bruland CD Davies 2005 Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx (TM)) in human osteosarcoma xenografts Br J Cancer. 93 1 81 8 15942637 1:CAS:528:DC%2BD2MXlsl2it7s%3D (Pubitemid 41078799)
126. RS Kerbel B St Croix VA Florenes J Rak 1996 Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors Hum Cell. 9 4 257 64 9183656 1:STN:280:DyaK2szis1ygtw%3D%3D
127. B St Croix S Man RS Kerbel 1998 Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors Cancer Lett. 131 1 35 44 9839618 1:CAS:528:DyaK1cXmvFWhtbs%3D (Pubitemid 28467039)
128. G Baumgartner C Gomar-Höss L Sakr E Ulsperger C Wogritsch 1998 The impact of extracellular matrix on the chemoresistance of solid tumors - experimental and clinical results of hyaluronidase as additive to cytostatic chemotherapy Cancer Lett. 131 1 85 99 9839623 1:CAS:528:DyaK1cXmvFWhuro%3D (Pubitemid 28467044)
129. E Brown T McKee E diTomaso A Pluen B Seed Y Boucher, et al. 2003 Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation Nat Med. 9 6 796 800 12754503 1:CAS:528:DC%2BD3sXktFOnu7g%3D (Pubitemid 36749232)
130. K Novak 2003 Measuring the matrix Nat Rev Cancer. 3 394 1:CAS:528:DC%2BD3sXktFOnt78%3D
131. SJ Kuhn SK Finch DE Hallahan TD Giorgio 2006 Proteolytic surface functionalization enhances in vitro magnetic nanoparticle mobility through extracellular matrix Nano Lett. 6 2 306 12 16464055 1:CAS:528: DC%2BD28XmvVWisQ%3D%3D (Pubitemid 43382969)
132. TT Goodman PL Olive SH Pun 2007 Increased nanoparticle penetration in collagenase-treated multicellular spheroids Int J Nanomedicine. 2 2 265 74 17722554 1:CAS:528:DC%2BD2sXpsFGrsr0%3D (Pubitemid 47224508)
133. RK Jain 2008 Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer Nat Rev Cancer. 8 4 309 16 18337733 1:CAS:528:DC%2BD1cXjsFCmsL8%3D (Pubitemid 351430862)
134. RK Jain 2005 Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy Science. 307 5706 58 62 15637262 1:CAS:528:DC%2BD2MXnvFar (Pubitemid 40093472)
135. RT Tong Y Boucher SV Kozin F Winkler DJ Hicklin RK Jain 2004 Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors Cancer Res. 64 11 3731 6 15172975 1:CAS:528:DC%2BD2cXksVKgur8%3D (Pubitemid 38697278)
136. KH Altmann M Wartmann T O'Reilly 2000 Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity Biochim Biophys Acta. 1470 3 M79 91 10799747 1:CAS:528:DC%2BD3cXivVGlsro%3D
137. DM Bollag PA McQueney J Zhu O Hensens L Koupal J Liesch, et al. 1995 Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action Cancer Res. 55 11 2325 33 7757983 1:CAS:528: DyaK2MXlvFeqsr0%3D
138. K Pietras A Ostman M Sjoquist E Buchdunger RK Reed CH Heldin, et al. 2001 Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors Cancer Res. 61 7 2929 34 11306470 1:CAS:528:DC%2BD3MXivFGqsro%3D (Pubitemid 32691937)
139. I Lee Y Boucher RK Jain 1992 Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications Cancer Res. 52 11 3237 40 1534273 1:CAS:528:DyaK38Xks1ant78%3D
140. PEG Kristjansen Y Boucher RK Jain 1993 Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft Cancer Res. 53 20 4764 6 8402656 1:CAS:528:DyaK3sXms1akur8%3D (Pubitemid 23326161)
141. CA Kristensen M Nozue Y Boucher RK Jain 1996 Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts Br J Cancer. 74 4 533 6 8761366 1:CAS:528:DyaK28XlvVWjtrk%3D (Pubitemid 26279046)
142. F Curnis A Sacchi A Corti 2002 Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration J Clin Invest. 110 4 475 82 12189241 1:CAS:528:DC%2BD38XmsVSiurk%3D (Pubitemid 34919701)
143. F Curnis A Sacchi L Borgna F Magni A Gasparri A Corti 2000 Enhancement of tumor necrosis factor a antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13) Nat Biotechnol. 18 11 1185 90 11062439 1:CAS:528:DC%2BD3cXotVSltrY%3D
144. K Rubin M Sjoquist AM Gustafsson B Isaksson G Salvessen RK Reed 2000 Lowering of tumoral interstitial fluid pressure by prostaglandin E-1 is paralleled by an increased uptake of Cr-51-EDTA Int J Cancer. 86 5 636 43 10797284 1:CAS:528:DC%2BD3cXjslSls7c%3D (Pubitemid 30249873)
145. AV Salnikov VV Iversen M Koisti C Sundberg L Johansson LB Stuhr, et al. 2003 Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy FASEB J. 17 12 1756 8 12958200 1:CAS:528: DC%2BD3sXntlSktrs%3D
146. DF Emerich RL Dean P Snodgrass D Lafreniere M Agostino T Wiens, et al. 2001 Bradykinin modulation of tumor vasculature: II. Activation of nitric oxide and phospholipase A(2)/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors J Pharmacol Exp Ther. 296 2 632 41 11160652 1:CAS:528:DC%2BD3MXosleiug%3D%3D (Pubitemid 32112494)
147. E Lammerts P Roswall C Sundberg PJ Gotwals VE Koteliansky RK Reed, et al. 2002 Interference with TGF-beta 1 and -beta 3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma Int J Cancer. 102 5 453 62 12432546 1:CAS:528:DC%2BD38XovVOks7c%3D (Pubitemid 35315998)
148. C Brekken CD Davies 1998 Hyaluronidase reduces the interstitial fluid pressure in solid tumours in a non-linear concentration-dependent manner Cancer Lett. 131 1 65 70 9839621 1:CAS:528:DyaK1cXmvFWhur8%3D (Pubitemid 28467042)
149. SH Jang MG Wientjes JLS Au 2001 Determinants of paclitaxel uptake, accumulation and retention in solid tumors Invest New Drugs. 19 2 113 23 11392446 1:CAS:528:DC%2BD3MXktF2quro%3D (Pubitemid 32423717)
150. JH Zheng CT Chen JLS Au MG Wientjes 2001 Time- and concentration- dependent penetration of doxorubicin in prostate tumors AAPS PharmSci. 3 2 E15 11741266 1:CAS:528:DC%2BD3MXmslOlt7g%3D
151. SH Jang MG Wientjes JLS Au 2001 Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule J Pharmacol Exp Ther. 296 3 1035 42 11181938 1:CAS:528:DC%2BD3MXhtlOksLs%3D (Pubitemid 32187379)
152. Z Lu M Tsai D Lu J Wang MG Wientjes JLS Au 2008 Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer J Pharmacol Exp Ther. 327 3 673 82 18780831 1:CAS:528:DC%2BD1cXhsVCjtLrJ
153. G Griffon-Etienne Y Boucher C Brekken HD Suit RK Jain 1999 Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications Cancer Res. 59 15 3776 82 10446995 1:CAS:528:DyaK1MXltFCns78%3D (Pubitemid 29381886)
154. SJ Kuhn DE Hallahan TD Giorgio 2006 Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system Ann Biomed Eng. 34 1 51 8 16477503
155. M Ahmed SN Goldberg 2004 Combination radiofrequency thermal ablation and adjuvant IV liposomal doxorubicin increases tissue coagulation and intratumoural drug accumulation Int J Hyperthermia. 20 7 781 802 15675672 1:CAS:528:DC%2BD2cXhtVahtr7I (Pubitemid 39496856)
156. SN Goldberg PF Saldinger GS Gazelle JC Huertas KE Stuart T Jacobs, et al. 2001 Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intratumoral doxorubicin injection in a rat breast tumor model Radiology. 220 2 420 7 11477246 1:STN:280:DC%2BD3MvivFSnuw%3D%3D (Pubitemid 32667179)
157. SN Goldberg GD Girnan AN Lukyanov M Ahmed WL Monsky GS Gazelle, et al. 2002 Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model Radiology. 222 3 797 804 11867804 (Pubitemid 34215233)
158. WL Monsky JB Kruskal AN Lukyanov GD Girnun M Ahmed GS Gazelle, et al. 2002 Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model Radiology. 224 3 823 9 12202721 1:CAS:528:DC%2BD38Xnt1arurk%3D (Pubitemid 34919820)
159. A Zhang X Mi G Yang LX Xu 2009 Numerical study of thermally targeted liposomal drug delivery in tumor J Heat Transfer. 131 043209
160. DC Drummond O Meyer K Hong DB Kirpotin D Papahadjopoulos 1999 Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors Pharmacol Rev. 51 4 691 744 10581328 1:CAS:528:DC%2BD3cXnslChsLg%3D
161. H Lee B Hoang H Fonge R Reilly C Allen 2010 In vitro distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels Pharm Res. 27 11 2343 55 20195708 1:CAS:528:DC%2BC3cXis1ersrg%3D
162. Y Geng P Dalhaimer S Cai R Tsai M Tewari T Minko, et al. 2007 Shape effects of filaments versus spherical particles in flow and drug delivery Nat Nanotechnol. 2 4 249 55 18654271 1:CAS:528:DC%2BD1cXktVGgsbs%3D (Pubitemid 46739812)
163. ME Fox FC Szoka JMJ Fréchet 2009 Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture Acc Chem Res. 42 8 1141 51 19555070 1:CAS:528:DC%2BD1MXnslSkt7o%3D