Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat

European Journal of Neuroscience

Volumn 15, Issue 8, 2002, Pages 1317-1326

  Calvo, Pilar ^a   Gouritin, Bruno ^a   Villarroya, Henri ^b   Eclancher, Françoise ^c   Giannavola, Claudia ^a   Klein, Christophe ^b   Andreux, Jean P ^a   Couvreur, Patrick ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c CNRS   (France)

Author keywords

Brain delivery; Long circulating systems; Polycyanoacrylate

Indexed keywords

CARBON 14; CYANOACRYLATE DERIVATIVE; LUTROL F68; NANOPARTICLE; POLOXAMER; POLOXAMINE 908; POLOXAMINE 908 POLYHEXADECYLCYANOACRYLATE COPOLYMER; POLY[METHOXYPOLY(ETHYLENE GLYCOL)CYANOACRYLATE CO HEXADECYLCYANOACRYLATE]; POLYHEXADECYLCYANOACRYLATE; SYNPERONIC; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CELL INFILTRATION; CELL INTERACTION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; FLUORESCENCE; ISOTOPE LABELING; MACROPHAGE; MALE; NONHUMAN; ORGAN DISTRIBUTION; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RADIOACTIVITY; RAT; SPINAL CORD; WHITE MATTER;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; CENTRAL NERVOUS SYSTEM; CYANOACRYLATES; DRUG DELIVERY SYSTEMS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FLUORESCENT DYES; MACROPHAGES; MALE; METABOLIC CLEARANCE RATE; MICROSPHERES; NANOTECHNOLOGY; PARTICLE SIZE; PHAGOCYTOSIS; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, INBRED STRAINS; SPINAL CORD;

EID: 0036460265     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.01967.x     Document Type: Article

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