Bioadhesive polysaccharide in protein delivery system: Chitosan nanoparticles improve the intestinal absorption of insulin in vivo

International Journal of Pharmaceutics

Volumn 249, Issue 1-2, 2002, Pages 139-147

  Pan, Yan ^a   Li, Ying Jian ^a   Zhao, Hui Ying ^a   Zheng, Jun Min ^a   Xu, Hui ^a   Wei, Gang ^a   Hao, Jin Song ^b   Cui, Fu De ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Chitosan nanoparticles; Insulin; Oral administration; Relative pharmacological bioavailability

Indexed keywords

ALLOXAN; ANION; CHITOSAN; INSULIN; NANOPARTICLE; POLYSACCHARIDE; TRIPOLYPHOSPHATE; ADHESIVE AGENT; CHITIN; DRUG DERIVATIVE;

ANEMOMETRY; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG RELEASE; GELATION; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; INTESTINE ABSORPTION; MALE; NONHUMAN; PARTICLE SIZE; PH; PHOTON CORRECTION SPECTROMETRY; PRIORITY JOURNAL; RAT; SPECTROMETRY; ZETA POTENTIAL; ANIMAL; DRUG EFFECT; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; PHYSIOLOGY; WISTAR RAT;

ADHESIVES; ANIMALS; BLOOD GLUCOSE; CHITIN; CHITOSAN; DRUG DELIVERY SYSTEMS; INSULIN; INTESTINAL ABSORPTION; MALE; NANOTECHNOLOGY; POLYSACCHARIDES; RATS; RATS, WISTAR;

EID: 0037027876     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00486-6     Document Type: Article

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