The entry of [D-penicillamine2,5]enkephalin into the central nervous system: Saturation kinetics and specificity

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1235-1240

  Thomas, Sarah A ^a,c   Abbruscato, Thomas J ^a   Hruby, Victor J ^b   Davis, Thomas P ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b University of Arizona   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; INSULIN; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; POLYLYSINE; ENKEPHALIN; TRITIUM;

ADOLESCENT; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS; ANIMAL; BRAIN; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

EID: 0030615087     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. ABBRUSCATO, T. J., WILLIAMS, S. A., HRUBY, V. J. AND DAVIS, T. P.: Blood-to-CNS entry and stability of biphalin, a unique double-enkephalin analogue, and its halogenated derivatives. J. Pharmacol. Exp. Ther. 276: 1049-1057, 1996.
2. ALABASTER, O., VONDERHAAR, B. K. AND SHAFIE, S. M.: Metabolic modification by insulin enhances methotrexate cytotoxicity in MCF-7 human breast cancer cells. Eur. J. Cancer Clin. Oncol. 17: 1223-1228, 1981.
3. AYRE, S. G.: New approaches to the delivery of drugs to the brain. Med. Hypotheses 29: 283-291, 1989.
4. AYRE. S. G., SKALETSKI, B. AND MOSNAIM, A. D.: Blood-brain barrier passage of azidodeoxythymidine in rats: Effect of insulin. Res. Commun. Chem. Pathol, Pharmacol. 63: 45-52, 1989.
5. BALDWIN, A. L. AND CHIEN, S.: Endothelial transport of anionized and cationized ferritin in the rabbit thoracic aorta and vasa vasorum. Arteriosclerosis 4: 372-382, 1984.
6. BANKS, W. A. AND KASTIN, A. J.: Saturable transport of peptides across the blood-brain barrier. Life Sci. 41: 1319-1338, 1987.
7. BASKIN, D. G., BREWITT, D. A., DAVIDSON, E., CORP, T., PACQUETTE, D. P., FIGLEWICZ, T. K., LEWELLEN, M. K., GRAHAM, M. K., WOODS, S. C. AND DORSA, D. M.: Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain. Diabetes 35: 246-249, 1986.
8. CHIKHALE, E. G., CHIKHALE, P. J. AND BORCHARDT, R. T.: Carrier-mediated transport of the antitumour agent acivicin across the blood-brain barrier. Biochem. Pharmacol. 49: 941-945, 1995.
9. DANON, D. AND SKUTELSKY, E.: Endothelial surface charge and its possible relationship to thrombogenesis. Ann. N. Y. Acad. Sci. 275: 47-63, 1976.
10. DAVSON, H. AND SEGAL, M. B.: Physiology of the CSF and Blood-Brain Barriers. CRC Press, London, 1995.
11. DUFFY, K. R., PARDRIDGE, W. M. AND ROSENFELD, R. G.: Human blood-brain barrier insulin-like growth factor receptor. Metabolism 37: 136-140, 1988.
12. FISHMAN, J. B., RUBIN, J. B., HANDRAHAN, J. V., CONNOR, J. R. AND FINE, R. E.: Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J. Neurosci. Res. 18: 299-304, 1987.
13. FREDERICKSON, R. C. A., SMITHWICK, E. L., SHUMAN, R. AND BEMIS, K. G.: Metkephamid, a systemically active analog of methionine enkephalin with potent opioid δ-receptor activity. Science (Wash. DC) 211: 603-605, 1981.
14. GALLIGAN, J. J., MOSBERG, H. L, HURST, R., HRUBY, V. J. AND BURKS, T. F.: Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids. J. Pharmacol. Exp. Ther. 229: 641-648, 1984.
15. GJEDDE, A.: Modulation of substrate transport to the brain. Acta Neurol. Scand. 67: 3-25, 1983.
16. GJEDDE, A.: Exchange diffusion of large neutral amino acids between blood and brain. In Peptide and Amino Acids Transport Mechanisms in the Central Nervous System, ed. by L. Rakic, D. J. Begley, H. Davson and B. V. Zlokovic, pp. 209-217, Macmillan Press, London, 1988.
17. GRIFFIN, D. E. AND GIFFELS, J.: Study of protein characteristics that influence entry into the cerebrospinal fluid of normal mice and mice with encephalitis. J. Clin. Invest. 70: 289-295, 1982.
18. HARDEBO, J. E. AND KÅHRSTRÖM, J.: Endothelial negative surface charge areas and blood-brain barrier function. Acta. Physiol. Scand. 125: 495-499, 1985.
19. KUMAGAI, A. K., EISENBERG, J. B. AND PARDRIDGE, W. M.: Absorptive-mediated endocytosis of cationized albumin and a β-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. J. Biol. Chem. 262: 15214-15219, 1987.
20. NAGY, Z., PETERS, H. AND HUTTNER, I.: Charge-related alterations of the cerebral endothelium. Lab. Investigations 49: 662-671, 1983.
21. PARDRIDGE, W. M., EISENBERG, J. AND YANG, J.: Human blood-brain barrier insulin receptor. J. Neurochem. 44: 1771-1778, 1985.
22. PODUSLO, J. F., CURRAN, G. L. AND BERG, C. T.: Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc. Natl. Acad. Sci. U.S.A. 91: 5705-5709, 1994.
23. RUBIN, L. L., HALL, D. E., PORTER, S., BARBU, K., CANNON, C., HORNER, H. C., JANATPOUR. M., LIAW, C. W., MANNING, K., MORALES, J., TANNER, L. I., TOMASELLI, K. J. AND BARD, F.: A cell culture model of the blood-brain barrier. J. Cell Biol. 115: 1725-1735, 1991.
24. SCHILSKY, R. L., BAILEY, B. D. AND CHABNER, B. A.: Characteristics of membrane transport of methotrexate by cultured human breast cancer cells. Biochem. Pharmacol. 30: 1537-1542, 1981.
25. SEILER, M. W., VENKATACHALAM, M. A. AND COTRAN, R. S.: Glomerular epithelium: Structural alterations induced by polycations. Science 189: 390-392, 1975.
26. SHEN, W.-C. AND RYSER, H. J.-P.: Conjugation of poly-L-lysine to albumin and horseradish peroxidase: A novel method of enhancing the cellular uptake of proteins. Proc. Natl. Acad. Sci. U.S.A. 75: 1872-1876, 1978.
27. SHEN, W-C., WAN, J. AND EKRAMI, H.: Enhancement of polypeptide and protein absorption by macromolecular carriers via endocytosis and transcytosis. Adv. Drug Delivery Rev. 8: 93-113, 1992.
28. SHIMURA, T., TABATA, S., OHNISHI, T., TERASAKI, T. AND TSUJI, A.: Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier. J. Pharmacol. Exp. Ther. 258: 459-465, 1991.
29. SHOOK, J. E., PELTON, J. T., HRUBY, V. J. AND BURKS, T. F.: Peptide opioid antagonist separates peripheral and central opioid antitransit effects. J. Pharmacol. Exp. Ther. 243: 492-500, 1987.
30. SMITH, Q. R., TAKASATO, Y. AND RAPOPORT, S. I.: Kinetic analysis of L-leucine transport across the blood-brain barrier. Brain Res. 311: 167-170, 1984.
31. TAKADA, Y., GREIG, N. H., VISTICA, D. T., RAPOPORT, S. I. AND SMITH, Q. R.: Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier. Cancer Chemother. Pharmacol. 29: 89-94, 1991.
32. TAKASATO, Y., MOMMA, S. AND SMITH, Q. R.: Kinetic analysis of cerebrovascular isoleucine transport from saline and plasma. J. Neurochem. 45: 1013-1020, 1985.
33. TERASAKI, T., ICHIHIRAI, K., SATO, H., KANG, Y. S. AND TSUJI, A.: Absorptive-mediated endocytosis of a dynorphin-like analgesic peptide, E-2078, into the blood-brain barrier. J. Pharmacol. Exp. Ther. 251: 351-357, 1989.
34. VAN DEURS, B., VON BÜLOW, F. AND MØLLER, M.: Vesicular transport of cationized ferritin by the epithelium of the rat choroid plexus. J. Cell Biol. 89: 131-139, 1981.
35. VORBRODT, A. W.: Ultracytochemical characterization of anionic sites in the wall of brain capillaries. J. Neurocytol. 18: 359-368, 1989.
36. VORBRODT, A. W., DOBROGOWSKA, D. H., UENO, M. AND LOSSINSKY, A. S.: Immunocytochemical studies of protamine-induced blood-brain barrier opening to endogenous albumin. Acta Neuropathol. 89: 491-499, 1995.
37. WARD, S. J. AND TAKEMORI, A, E.: Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice. J. Pharmacol. Exp. Ther. 224: 525-530, 1983.
38. 5]enkephalin and two halogenated analogs after intravenous administration. J. Pharmacol. Exp. Ther. 259: 1109-1117, 1991.
39. WESTERGAARD, E.: Ultrastructural permeability properties of cerebral micro-vasculature under normal and experimental conditions after application of tracers. Adv. Neurol. 28: 55-104, 1980.
40. WESTERGREN, I. AND JOHANSSON, B. B.: Altering the blood-brain barrier in the rat by intracarotid artery infusion of polycations: A comparison between protamine, poly-L-lysine and poly-L-arginine. Acta Physiol. Scand. 149: 99-104, 1993.
41. WILLIAMS, M. G., EARHART, R. H., BAILEY, H. AND MCGOVERN, J. P.: Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture. Cancer Res. 50: 5475-5480, 1990.
42. WILLIAMS, S. A., ABBRUSCATO, T. J., HRUBY, V. J. AND DAVIS, T. P.: The passage of a delta-opioid receptor selective enkephalin, DPDPE, across the blood-brain and blood-cerebrospinal fluid barriers. J. Neurochem. 66: 1289-1299, 1996.
43. ZLOKOVIC B. V., BEGLEY, D. J., DJURICIC, B. M. AND MITROVIC, D. M.: Measurement of solute transport across the blood-brain barrier in the perfused guinea-pig brain: Method and application to N-methylaminoisobutyric acid. J. Neurochem. 46: 1444-1451, 1986.
44. ZLOKOVIC, B. V., HYMAN, S., MCCOMB, J. G., LIPOVAC, M. N., TANG, G. AND DAVSON H.: Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim. Biophys. Acta. 1025: 191-198, 1990.
45. ZLOKOVIC, B. V., LIPOVAC, M. N., BEGLEY, D. J., DAVSON, H. AND RAKIC, L.: Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea-pig brain. J. Neurochem. 51: 252-257, 1988.
46. ZLOKOVIC, B. V., MACKIC, J. B., DJURICIC B. M. AND DAVSON, H.: Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J. Neurochem. 53: 1333-1340, 1989.
47. ZLOKOVIC B. V., SEGAL, M. B., BEGLEY, D. J., DAVSON, H. AND RAKIC, L.: Permeability of the blood-cerebrospinal fluid and the blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 358: 191-199, 1985.