FXR and PXR: Potential therapeutic targets in cholestasis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 130, Issue 3-5, 2012, Pages 147-158

  Jonker, Johan W ^a   Liddle, Christopher ^b   Downes, Michael ^c  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF SYDNEY   (Australia)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Cholestasis; FXR; Liver; Nuclear receptor; PXR; Review

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; 6 ETHYL CHENODEOXYCHOLIC ACID; CHENODEOXYCHOLIC ACID; CHENODEOXYCHOLIC ACID DERIVATIVE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; CYTOCHROME P450 3A; DEXAMETHASONE; FARNESOID X RECEPTOR; FEXARAMINE; GLUCOCORTICOID ANTAGONIST; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GUGGULSTERONE; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; LITHOCHOLIC ACID; PHYTOESTROGEN; PREGNANE X RECEPTOR; PREGNENOLONE; PROGESTERONE; RIFAMPICIN; SULFOTRANSFERASE; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ADJUVANT THERAPY; ALKALINE PHOSPHATASE BLOOD LEVEL; BILE ACID METABOLISM; BILE FLOW; BILE SECRETION; BINDING AFFINITY; CHOLESTASIS; CRYSTAL STRUCTURE; DISEASE COURSE; DNA BINDING; DOWN REGULATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG TOLERABILITY; ENZYME ACTIVITY; GENE CONTROL; HEPATITIS; HOMEOSTASIS; HUMAN; HYDROXYLATION; LIGAND BINDING; LIVER DISEASE; MONOTHERAPY; MORBIDITY; MORTALITY; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; PROTEIN EXPRESSION; PRURITUS; RECEPTOR BINDING; REVIEW; UPREGULATION;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTASIS; HUMANS; MICE; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID;

EID: 84861198882     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.06.012     Document Type: Review

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