Feed-forward regulation of bile acid detoxification by CYP3A4: Studies in humanized transgenic mice

Journal of Biological Chemistry

Volumn 279, Issue 12, 2004, Pages 11336-11343

  Stedman, Catherine ^a   Robertson, Graham ^a   Coulter, Sally ^a   Liddle, Christopher ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHOLESTEROL; ENZYMES; GENE TRANSFER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; SURGERY;

BILE ACIDS; FEEDBACK REGULATION;

BIOCHEMISTRY;

5 BROMO 4 CHLORO 3 INDOLYL BETA DEXTRO GALACTOPYRANOSIDE; BETA GALACTOSIDASE; BILE ACID; CYTOCHROME P450 3A4; LITHOCHOLIC ACID; PREGNANE X RECEPTOR; PYRANOSIDE; UNCLASSIFIED DRUG;

ADAPTATION; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DETOXIFICATION; DNA FLANKING REGION; ENZYME ACTIVATION; ENZYME INDUCTION; FEEDBACK SYSTEM; GENE ACTIVATION; HOMEOSTASIS; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER INJURY; LIVER PARENCHYMA; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE;

ANIMALS; BASE SEQUENCE; CHOLESTASIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; HUMANS; LAC OPERON; LITHOCHOLIC ACID; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, TRANSGENIC; ORGAN SIZE;

ANIMALIA; MUS MUSCULUS;

EID: 1642483471     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310258200     Document Type: Article

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