Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 3, 2001, Pages 866-873

  Higuchi, Hajime ^a   Miyoshi, Hideyuki ^a   Bronk, Steven F ^a   Zhang, Hong ^b   Dean, Nicholas ^b   Gores, Gregory J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BILE ACID; CELL RECEPTOR; CYTOCHROME C; FAS ANTIGEN; GLYCOCHENODEOXYCHOLIC ACID; GREEN FLUORESCENT PROTEIN; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHOLESTASIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENZYME RELEASE; IMMUNOBLOTTING; LIVER CELL; LIVER INJURY; MALE; MITOCHONDRION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTASIS, INTRAHEPATIC; DETERGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; LIVER; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OLIGONUCLEOTIDES, ANTISENSE;

EID: 0035197731     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Ursodeoxycholate (UDCA) inhibits the mitechondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
2. Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions
3. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
4. Toxic bile salts induce rodent hepatecyte apoptesis via direct activation of Fas
5. GSH transport in mitochondria: Defense against TNF-induced oxidative stress and alcohol-induced defect
6. Mitochondria and apoptosis
7. Mechanism of cholestasis. 6. Bile acids in human livers with or without biliary obstruction
8. The biochemistry of apoptosis
9. Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: Implications for gene therapy
10. The bile acid glycochenodeoxycholate induced trail-receptor 2/DR5 expression and apoptosis
11. The enterohepatic circulation of bile acids in man
12. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C
13. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line
14. Bax directly induces release of cytochrome c from isolated mitochondria
15. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes
16. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis
17. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
18. Cholestasis confers resistance to the rat liver mitochondrial permeability transition
19. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
20. Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas
21. Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E
22. Cholestasis
23. The transforming growth factor beta(1)-inducible transcription factor TIEG1, mediates apoptosis through oxidative stress
24. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
25. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
26. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
27. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
28. Two CD95 (APO-1/Fas) signaling pathways
29. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
30. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
31. Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids
32. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
33. The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
34. Caspases: Enemies within
35. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
36. Proapoptotic BAX and BAK a requisite gateway to mitochondrial dysfunction and death
37. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition
38. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
39. Pharmacokinetics and pharmacodynamics of an anti-sense phosphorothioate oligonucleotide targeting Fas mRNA in mice
40. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis