Pharmaceutical use of mouse models humanized for the xenobiotic receptor

Drug Discovery Today

Volumn 7, Issue 9, 2002, Pages 509-515

  Xie, Wen ^a,c   Evans, Ronald M ^b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 3A; GLUCOCORTICOID; PHENOBARBITAL; RIFAMPICIN; XENOBIOTIC AGENT; CELL RECEPTOR; N DEMETHYLASE; PREGNANE X RECEPTOR; STEROID RECEPTOR; SXR RECEPTOR; UNSPECIFIC MONOOXYGENASE;

DRUG METABOLISM; DRUG SAFETY; ENZYME INDUCTION; HUMAN; LIVER CELL; MOLECULAR GENETICS; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SPECIES DIFFERENCE; ANIMAL; ANIMAL MODEL; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER; MOUSE; PHYSIOLOGY;

ANIMAL; ARYL HYDROCARBON HYDROXYLASES; DRUG DESIGN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMAN; LIVER; MICE; MODELS, ANIMAL; OXIDOREDUCTASES, N-DEMETHYLATING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; SUPPORT, NON-U.S. GOV'T; ANIMALS; CYTOCHROME P-450 CYP3A; HUMANS;

EID: 0036558204     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02251-1     Document Type: Review

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