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Volumn 16, Issue 10, 2005, Pages 478-488

Transcriptional corepression by SHP: Molecular mechanisms and physiological consequences

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; PROTEIN; SMALL HETERODIMER PARTNER PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 27844509037     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2005.10.005     Document Type: Review
Times cited : (126)

References (77)
  • 1
    • 8844262660 scopus 로고    scopus 로고
    • Principles for modulation of the nuclear receptor superfamily
    • H. Gronemeyer Principles for modulation of the nuclear receptor superfamily Nat. Rev. Drug Discov. 3 2004 950 964
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 950-964
    • Gronemeyer, H.1
  • 2
    • 0043268895 scopus 로고    scopus 로고
    • DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation
    • E. Lalli, and P. Sassone-Corsi DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation Mol. Endocrinol. 17 2003 1445 1453
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1445-1453
    • Lalli, E.1    Sassone-Corsi, P.2
  • 3
    • 0030001371 scopus 로고    scopus 로고
    • An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
    • W. Seol An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors Science 272 1996 1336 1339
    • (1996) Science , vol.272 , pp. 1336-1339
    • Seol, W.1
  • 4
    • 0030712244 scopus 로고    scopus 로고
    • Novel receptor interaction and repression domains in the orphan receptor SHP
    • W. Seol Novel receptor interaction and repression domains in the orphan receptor SHP Mol. Cell. Biol. 17 1997 7126 7131
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7126-7131
    • Seol, W.1
  • 5
    • 0032951135 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERα and ERβ
    • L. Johansson The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERα and ERβ J. Biol. Chem. 274 1999 345 353
    • (1999) J. Biol. Chem. , vol.274 , pp. 345-353
    • Johansson, L.1
  • 6
    • 0342980409 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors
    • L. Johansson The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors Mol. Cell. Biol. 20 2000 1124 1133
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1124-1133
    • Johansson, L.1
  • 7
    • 20844456958 scopus 로고    scopus 로고
    • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
    • E.A. Ortlund Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP Nat. Struct. Mol. Biol. 12 2005 357 363
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 357-363
    • Ortlund, E.A.1
  • 8
    • 0037169541 scopus 로고    scopus 로고
    • Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner
    • Y.K. Lee, and D.D. Moore Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner J. Biol. Chem. 277 2002 2463 2467
    • (2002) J. Biol. Chem. , vol.277 , pp. 2463-2467
    • Lee, Y.K.1    Moore, D.D.2
  • 9
    • 0033986961 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: Two mechanisms for repression
    • Y.K. Lee The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression Mol. Cell. Biol. 20 2000 187 195
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 187-195
    • Lee, Y.K.1
  • 10
    • 0036716912 scopus 로고    scopus 로고
    • The small heterodimer partner interacts with the liver X receptor {α} and represses its transcriptional activity
    • C. Brendel The small heterodimer partner interacts with the liver X receptor {α} and represses its transcriptional activity Mol. Endocrinol. 16 2002 2065 2076
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2065-2076
    • Brendel, C.1
  • 11
    • 0037127246 scopus 로고    scopus 로고
    • Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms
    • S. Sanyal Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms J. Biol. Chem. 277 2002 1739 1748
    • (2002) J. Biol. Chem. , vol.277 , pp. 1739-1748
    • Sanyal, S.1
  • 12
    • 0037147304 scopus 로고    scopus 로고
    • Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
    • L.J. Borgius Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP J. Biol. Chem. 277 2002 49761 49766
    • (2002) J. Biol. Chem. , vol.277 , pp. 49761-49766
    • Borgius, L.J.1
  • 13
    • 12144286826 scopus 로고    scopus 로고
    • Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/NeuroD
    • J-Y. Kim Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/NeuroD Mol. Endocrinol. 18 2004 776 790
    • (2004) Mol. Endocrinol. , vol.18 , pp. 776-790
    • Kim, J.-Y.1
  • 14
    • 23044502910 scopus 로고    scopus 로고
    • Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP
    • K. Boulias Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP EMBO J. 24 2005 2624 2633
    • (2005) EMBO J. , vol.24 , pp. 2624-2633
    • Boulias, K.1
  • 15
    • 0035470833 scopus 로고    scopus 로고
    • Suppression of sterol 12α-hydroxylase transcription by the short heterodimer partner: Insights into the repression mechanism
    • A. del Castillo-Olivares, and G. Gil Suppression of sterol 12α-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism Nucleic Acids Res. 29 2001 4035 4042
    • (2001) Nucleic Acids Res. , vol.29 , pp. 4035-4042
    • Del Castillo-Olivares, A.1    Gil, G.2
  • 16
    • 0035984883 scopus 로고    scopus 로고
    • A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP
    • A. Bavner A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP EMBO Rep. 3 2002 478 484
    • (2002) EMBO Rep. , vol.3 , pp. 478-484
    • Bavner, A.1
  • 17
    • 2342447392 scopus 로고    scopus 로고
    • Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1
    • Y-Y. Park Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1 Mol. Endocrinol. 18 2004 1082 1095
    • (2004) Mol. Endocrinol. , vol.18 , pp. 1082-1095
    • Park, Y.-Y.1
  • 18
    • 1242337303 scopus 로고    scopus 로고
    • Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP)
    • Y. Bae Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP) DNA Cell Biol. 23 2004 81 91
    • (2004) DNA Cell Biol. , vol.23 , pp. 81-91
    • Bae, Y.1
  • 19
    • 4344601668 scopus 로고    scopus 로고
    • Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP
    • J. Kemper Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP Mol. Cell. Biol. 24 2004 7707 7719
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7707-7719
    • Kemper, J.1
  • 20
    • 11344263349 scopus 로고    scopus 로고
    • Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression
    • K. Boulias, and I. Talianidis Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression Nucleic Acids Res. 32 2004 6096 6103
    • (2004) Nucleic Acids Res. , vol.32 , pp. 6096-6103
    • Boulias, K.1    Talianidis, I.2
  • 21
    • 17644363708 scopus 로고    scopus 로고
    • SHP represses transcriptional activity via recruitment of histone deacetylases
    • J. Gobinet SHP represses transcriptional activity via recruitment of histone deacetylases Biochemistry 44 2005 6312 6320
    • (2005) Biochemistry , vol.44 , pp. 6312-6320
    • Gobinet, J.1
  • 22
    • 22144487356 scopus 로고    scopus 로고
    • Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner
    • Y. Li Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner Proc. Natl. Acad. Sci. U. S. A. 102 2005 9505 9510
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9505-9510
    • Li, Y.1
  • 23
    • 27244462253 scopus 로고    scopus 로고
    • Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT)
    • C. Klinge Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) Arch. Biochem. Biophys. 390 2001 64 70
    • (2001) Arch. Biochem. Biophys. , vol.390 , pp. 64-70
    • Klinge, C.1
  • 24
    • 9644272451 scopus 로고    scopus 로고
    • Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding
    • J-Y. Kim Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding Mol. Endocrinol. 18 2004 2880 2894
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2880-2894
    • Kim, J.-Y.1
  • 25
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • B. Goodwin A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis Mol. Cell 6 2000 517 526
    • (2000) Mol. Cell , vol.6 , pp. 517-526
    • Goodwin, B.1
  • 26
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • T.T. Lu Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Mol. Cell 6 2000 507 515
    • (2000) Mol. Cell , vol.6 , pp. 507-515
    • Lu, T.T.1
  • 27
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • T.A. Kerr Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis Dev. Cell 2 2002 713 720
    • (2002) Dev. Cell , vol.2 , pp. 713-720
    • Kerr, T.A.1
  • 28
    • 18444377348 scopus 로고    scopus 로고
    • Redundant pathways for negative feedback regulation of bile acid production
    • L. Wang Redundant pathways for negative feedback regulation of bile acid production Dev. Cell 2 2002 721 731
    • (2002) Dev. Cell , vol.2 , pp. 721-731
    • Wang, L.1
  • 29
    • 0242582371 scopus 로고    scopus 로고
    • Resistance of SHP-null mice to bile acid-induced liver damage
    • L. Wang Resistance of SHP-null mice to bile acid-induced liver damage J. Biol. Chem. 278 2003 44475 44481
    • (2003) J. Biol. Chem. , vol.278 , pp. 44475-44481
    • Wang, L.1
  • 30
    • 0035816609 scopus 로고    scopus 로고
    • The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor
    • Y. Luo The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor J. Biol. Chem. 276 2001 24767 24773
    • (2001) J. Biol. Chem. , vol.276 , pp. 24767-24773
    • Luo, Y.1
  • 31
    • 0037827787 scopus 로고    scopus 로고
    • Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    • F. Chen Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter J. Biol. Chem. 278 2003 19909 19916
    • (2003) J. Biol. Chem. , vol.278 , pp. 19909-19916
    • Chen, F.1
  • 32
    • 10844287785 scopus 로고    scopus 로고
    • FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade
    • H. Li FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade Am. J. Physiol. Gastrointest. Liver Physiol. 288 2005 G60 G66
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288
    • Li, H.1
  • 33
    • 3042828426 scopus 로고    scopus 로고
    • Bile acid-induced negative feedback regulation of the human ileal bile acid transporter
    • E. Neimark Bile acid-induced negative feedback regulation of the human ileal bile acid transporter Hepatology 40 2004 149 156
    • (2004) Hepatology , vol.40 , pp. 149-156
    • Neimark, E.1
  • 34
    • 5044229657 scopus 로고    scopus 로고
    • Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription
    • P. Delerive Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription Mol. Endocrinol. 18 2004 2378 2387
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2378-2387
    • Delerive, P.1
  • 35
    • 0035834771 scopus 로고    scopus 로고
    • Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): Roles of heaptocyte nuclear factor 4α in mediating bile acid repression
    • M. Zhang, and J.Y. Chiang Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4α in mediating bile acid repression J. Biol. Chem. 276 2001 41690 41699
    • (2001) J. Biol. Chem. , vol.276 , pp. 41690-41699
    • Zhang, M.1    Chiang, J.Y.2
  • 36
    • 0242380392 scopus 로고    scopus 로고
    • Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4[α] (HNF4[α])
    • W. Chen, and J.Y.L. Chiang Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4[α] (HNF4[α]) Gene 313 2003 71 82
    • (2003) Gene , vol.313 , pp. 71-82
    • Chen, W.1    Chiang, J.Y.L.2
  • 37
    • 0037371120 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 α: aa key mediator of the effect of bile acids on gene expression
    • D. Jung, and G. Kullak-Ublick Hepatocyte nuclear factor 1 α: a key mediator of the effect of bile acids on gene expression Hepatology 37 2003 622 631
    • (2003) Hepatology , vol.37 , pp. 622-631
    • Jung, D.1    Kullak-Ublick, G.2
  • 38
    • 8544256355 scopus 로고    scopus 로고
    • Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4
    • H. Hirokane Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4 J. Biol. Chem. 279 2004 45685 45692
    • (2004) J. Biol. Chem. , vol.279 , pp. 45685-45692
    • Hirokane, H.1
  • 39
    • 0030874825 scopus 로고    scopus 로고
    • Molecular genetics of human hypertension: Role of angiotensinogen
    • P. Corvol, and X. Jeunemaitre Molecular genetics of human hypertension: role of angiotensinogen Endocr. Rev. 18 1997 662 677
    • (1997) Endocr. Rev. , vol.18 , pp. 662-677
    • Corvol, P.1    Jeunemaitre, X.2
  • 40
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • K. Yamagata Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1 J. Biol. Chem. 279 2004 23158 23165
    • (2004) J. Biol. Chem. , vol.279 , pp. 23158-23165
    • Yamagata, K.1
  • 41
    • 7344223257 scopus 로고    scopus 로고
    • Structure and expression of the orphan nuclear receptor SHP gene
    • H-K. Lee Structure and expression of the orphan nuclear receptor SHP gene J. Biol. Chem. 273 1998 14398 14402
    • (1998) J. Biol. Chem. , vol.273 , pp. 14398-14402
    • Lee, H.-K.1
  • 42
    • 10744227070 scopus 로고    scopus 로고
    • Control of pancreas and liver gene expression by HNF transcription factors
    • D.T. Odom Control of pancreas and liver gene expression by HNF transcription factors Science 303 2004 1378 1381
    • (2004) Science , vol.303 , pp. 1378-1381
    • Odom, D.T.1
  • 43
    • 0035512077 scopus 로고    scopus 로고
    • Loss of HNF-1α function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism
    • D.Q. Shih Loss of HNF-1α function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism Diabetes 50 2001 2472 2480
    • (2001) Diabetes , vol.50 , pp. 2472-2480
    • Shih, D.Q.1
  • 44
    • 12444293733 scopus 로고    scopus 로고
    • Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: Mutational analysis and association studies in multiple populations
    • C-C.C. Hung Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations Diabetes 52 2003 1288 1291
    • (2003) Diabetes , vol.52 , pp. 1288-1291
    • Hung, C-C.C.1
  • 45
    • 7644224183 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun
    • Y.H. Choi The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun J. Leukoc. Biol. 76 2004 1082 1088
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 1082-1088
    • Choi, Y.H.1
  • 46
    • 25444448223 scopus 로고    scopus 로고
    • A nuclear receptor atlas: Macrophage activation
    • G.D. Barish A nuclear receptor atlas: macrophage activation Mol. Endocrinol. 19 2005 2466 2477
    • (2005) Mol. Endocrinol. , vol.19 , pp. 2466-2477
    • Barish, G.D.1
  • 47
    • 0032230250 scopus 로고    scopus 로고
    • Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)
    • W. Seol Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner) Mol. Endocrinol. 12 1998 1551 1557
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1551-1557
    • Seol, W.1
  • 48
    • 0141815640 scopus 로고    scopus 로고
    • Estrogen receptor {α} regulates expression of the orphan receptor small heterodimer partner
    • K. Lai Estrogen receptor {α} regulates expression of the orphan receptor small heterodimer partner J. Biol. Chem. 278 2003 36418 36429
    • (2003) J. Biol. Chem. , vol.278 , pp. 36418-36429
    • Lai, K.1
  • 49
    • 0347286633 scopus 로고    scopus 로고
    • Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes
    • A. Kovacic Inhibition of aromatase transcription via promoter II by short heterodimer partner in human preadipocytes Mol. Endocrinol. 18 2004 252 259
    • (2004) Mol. Endocrinol. , vol.18 , pp. 252-259
    • Kovacic, A.1
  • 50
    • 23844485897 scopus 로고    scopus 로고
    • From the cover: Location analysis of estrogen receptor {α} target promoters reveals that FOXA1 defines a domain of the estrogen response
    • J. Laganiere From the cover: location analysis of estrogen receptor {α} target promoters reveals that FOXA1 defines a domain of the estrogen response Proc. Natl. Acad. Sci. U. S. A. 102 2005 11651 11656
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 11651-11656
    • Laganiere, J.1
  • 51
    • 0031021288 scopus 로고    scopus 로고
    • An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: Interaction with several nuclear receptors
    • N. Masuda An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors Biochim. Biophys. Acta 1350 1997 27 32
    • (1997) Biochim. Biophys. Acta , vol.1350 , pp. 27-32
    • Masuda, N.1
  • 52
    • 0042787016 scopus 로고    scopus 로고
    • The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity
    • J.C. Ourlin The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity Mol. Endocrinol. 17 2003 1693 1703
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1693-1703
    • Ourlin, J.C.1
  • 53
    • 0033597891 scopus 로고    scopus 로고
    • Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers
    • Y.K. Lee Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers J. Biol. Chem. 274 1999 20869 20873
    • (1999) J. Biol. Chem. , vol.274 , pp. 20869-20873
    • Lee, Y.K.1
  • 54
    • 15444372801 scopus 로고    scopus 로고
    • Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells
    • M.G. Yeo Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells Mol. Endocrinol. 19 2005 950 963
    • (2005) Mol. Endocrinol. , vol.19 , pp. 950-963
    • Yeo, M.G.1
  • 55
    • 0035823584 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP, as a novel coregulator of nuclear factor-kB in oxLDL-treated macrophage cell RAW 264.7
    • Kim, Y.S. et al. (2001) The orphan nuclear receptor SHP, as a novel coregulator of nuclear factor-kB in oxLDL-treated macrophage cell RAW 264.7. J. Biol. Chem. 276, 33736-40
    • (2001) J. Biol. Chem. , vol.276 , pp. 33736-33740
    • Kim, Y.S.1
  • 56
    • 0035947087 scopus 로고    scopus 로고
    • The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase- dehydrogenase
    • A. Kassam The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase- dehydrogenase Mol. Cell. Endocrinol. 176 2001 49 56
    • (2001) Mol. Cell. Endocrinol. , vol.176 , pp. 49-56
    • Kassam, A.1
  • 57
    • 0037059762 scopus 로고    scopus 로고
    • Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor γ transactivation
    • H. Nishizawa Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor γ transactivation J. Biol. Chem. 277 2002 1586 1592
    • (2002) J. Biol. Chem. , vol.277 , pp. 1586-1592
    • Nishizawa, H.1
  • 58
    • 10744228017 scopus 로고    scopus 로고
    • Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene
    • Y. Shimamoto Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene J. Biol. Chem. 279 2004 7770 7776
    • (2004) J. Biol. Chem. , vol.279 , pp. 7770-7776
    • Shimamoto, Y.1
  • 59
    • 0036177214 scopus 로고    scopus 로고
    • The agonist activity of tamoxifen is inhibited by the short heterodimer partner orphan nuclear receptor in human endometrial cancer cells
    • C. Klinge The agonist activity of tamoxifen is inhibited by the short heterodimer partner orphan nuclear receptor in human endometrial cancer cells Endocrinology 143 2002 853 867
    • (2002) Endocrinology , vol.143 , pp. 853-867
    • Klinge, C.1
  • 60
    • 4744342647 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor [γ] has an exceptionally broad specificity of DNA sequence recognition
    • M.A. Razzaque Estrogen receptor-related receptor [γ] has an exceptionally broad specificity of DNA sequence recognition Gene 340 2004 275 282
    • (2004) Gene , vol.340 , pp. 275-282
    • Razzaque, M.A.1
  • 61
    • 0035909840 scopus 로고    scopus 로고
    • Characterization of the interaction between androgen receptor and a new transcriptional inhibitor, SHP
    • J. Gobinet Characterization of the interaction between androgen receptor and a new transcriptional inhibitor, SHP Biochemistry 40 2001 15369 15377
    • (2001) Biochemistry , vol.40 , pp. 15369-15377
    • Gobinet, J.1
  • 62
    • 4344636100 scopus 로고    scopus 로고
    • Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue
    • K.R. Steffensen Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue EMBO Rep. 5 2004 613 619
    • (2004) EMBO Rep. , vol.5 , pp. 613-619
    • Steffensen, K.R.1
  • 63
    • 0037071854 scopus 로고    scopus 로고
    • On the mechanism of bile acid inhibition of rat sterol 12[α]-hydroxylase gene (CYP8B1) transcription: Roles of [α]-fetoprotein transcription factor and hepatocyte nuclear factor 4
    • Y. Yang On the mechanism of bile acid inhibition of rat sterol 12[α]-hydroxylase gene (CYP8B1) transcription: roles of [α]-fetoprotein transcription factor and hepatocyte nuclear factor 4 Biochim. Biophys. Acta 1583 2002 63 73
    • (2002) Biochim. Biophys. Acta , vol.1583 , pp. 63-73
    • Yang, Y.1
  • 64
    • 1942469288 scopus 로고    scopus 로고
    • The role of {α}1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: A known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis
    • A. del Castillo-Olivares The role of {α}1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis J. Biol. Chem. 279 2004 16813 16821
    • (2004) J. Biol. Chem. , vol.279 , pp. 16813-16821
    • Del Castillo-Olivares, A.1
  • 65
    • 22944449688 scopus 로고    scopus 로고
    • A FXR-SHP regulatory cascade modulates TIMP-1 and MMPs expression in HSCs and promotes resolution of liver fibrosis
    • S. Fiorucci A FXR-SHP regulatory cascade modulates TIMP-1 and MMPs expression in HSCs and promotes resolution of liver fibrosis J. Pharmacol. Exp. Ther. 314 2005 584 595
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 584-595
    • Fiorucci, S.1
  • 66
    • 0034950514 scopus 로고    scopus 로고
    • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
    • L.A. Denson The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp Gastroenterology 121 2001 140 147
    • (2001) Gastroenterology , vol.121 , pp. 140-147
    • Denson, L.A.1
  • 67
    • 20044380329 scopus 로고    scopus 로고
    • Cytokine-independent repression of rodent Ntcp in obstructive cholestasis
    • A. Geier Cytokine-independent repression of rodent Ntcp in obstructive cholestasis Hepatology 41 2005 470 477
    • (2005) Hepatology , vol.41 , pp. 470-477
    • Geier, A.1
  • 68
    • 0042817910 scopus 로고    scopus 로고
    • Liver receptor homolog 1 controls the expression of carboxyl ester lipase
    • E. Fayard Liver receptor homolog 1 controls the expression of carboxyl ester lipase J. Biol. Chem. 278 2003 35725 35731
    • (2003) J. Biol. Chem. , vol.278 , pp. 35725-35731
    • Fayard, E.1
  • 69
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • M. Watanabe Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c J. Clin. Invest. 113 2004 1408 1418
    • (2004) J. Clin. Invest. , vol.113 , pp. 1408-1418
    • Watanabe, M.1
  • 70
    • 0038748298 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4{α} isoforms originated from the P1 promoter are expressed in human pancreatic {β}-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms
    • J. Eeckhoute Hepatocyte nuclear factor 4{α} isoforms originated from the P1 promoter are expressed in human pancreatic {β}-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms Endocrinology 144 2003 1686 1694
    • (2003) Endocrinology , vol.144 , pp. 1686-1694
    • Eeckhoute, J.1
  • 71
    • 17844385785 scopus 로고    scopus 로고
    • The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4a and suppressed by bile acids
    • K. Popowski The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4a and suppressed by bile acids Mol. Pharm. 67 2005 1629 1638
    • (2005) Mol. Pharm. , vol.67 , pp. 1629-1638
    • Popowski, K.1
  • 72
    • 0345531088 scopus 로고    scopus 로고
    • Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1
    • H-J. Kim Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1 Nucleic Acids Res. 31 2003 6860 6872
    • (2003) Nucleic Acids Res. , vol.31 , pp. 6860-6872
    • Kim, H.-J.1
  • 73
    • 0037340125 scopus 로고    scopus 로고
    • Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-{α}
    • B. Goodwin Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-{α} Mol. Endocrinol. 17 2003 386 394
    • (2003) Mol. Endocrinol. , vol.17 , pp. 386-394
    • Goodwin, B.1
  • 74
    • 12544256026 scopus 로고    scopus 로고
    • Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis
    • C. Frank Identification of pregnane X receptor binding sites in the regulatory regions of genes involved in bile acid homeostasis J. Mol. Biol. 346 2005 505 519
    • (2005) J. Mol. Biol. , vol.346 , pp. 505-519
    • Frank, C.1
  • 75
    • 3142653231 scopus 로고    scopus 로고
    • Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1
    • H-J. Kim Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1 J. Biol. Chem. 279 2004 28122 28131
    • (2004) J. Biol. Chem. , vol.279 , pp. 28122-28131
    • Kim, H.-J.1
  • 76
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • T. Inagaki Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis Cell Metab. 2 2005 217 225
    • (2005) Cell Metab. , vol.2 , pp. 217-225
    • Inagaki, T.1
  • 77
    • 27844551588 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes
    • L. Wang The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes Cell Metab. 2 2005 227 238
    • (2005) Cell Metab. , vol.2 , pp. 227-238
    • Wang, L.1


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