-
1
-
-
37249009271
-
Motif module map reveals enforcement of aging by continual NF-κB activity
-
DOI 10.1101/gad.1588507
-
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY (2007) Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev 21:3244-3257 (Pubitemid 350277752)
-
(2007)
Genes and Development
, vol.21
, Issue.24
, pp. 3244-3257
-
-
Adler, A.S.1
Sinha, S.2
Kawahara, T.L.A.3
Zhang, J.Y.4
Segal, E.5
Chang, H.Y.6
-
2
-
-
0242585476
-
Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
-
DOI 10.1126/science.1080418
-
Aguilaniu H, Gustafsson L, Rigoulet M, Nystrom T (2003) Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299:1751-1753 (Pubitemid 36337204)
-
(2003)
Science
, vol.299
, Issue.5613
, pp. 1751-1753
-
-
Aguilaniu, H.1
Gustafsson, L.2
Rigoulet, M.3
Nystrom, T.4
-
3
-
-
12944268979
-
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
-
DOI 10.1073/pnas.040577797
-
Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE et al (2000) Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97:2910-2915 (Pubitemid 30159271)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.6
, pp. 2910-2915
-
-
Ahlijanian, M.K.1
Barrezueta, N.X.2
Williams, R.D.3
Jakowski, A.4
Kowsz, K.P.5
McCarthy, S.6
Coskran, T.7
Carlo, A.8
Seymour, P.A.9
Burkhardt, J.E.10
Nelson, R.B.11
McNeish, J.D.12
-
4
-
-
0032510692
-
Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκb-dependent mechanism
-
DOI 10.1073/pnas.95.10.5795
-
Akama KT, Albanese C, Pestell RG, Van Eldik LJ (1998) Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc Natl Acad Sci USA 95:5795-5800 (Pubitemid 28224176)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.10
, pp. 5795-5800
-
-
Akama, K.T.1
Albanese, C.2
Pestell, R.G.3
Van Eldik, L.J.4
-
5
-
-
34249669270
-
Sirt1 regulates aging and resistance to oxidative stress in the heart
-
DOI 10.1161/01.RES.0000267723.65696.4a
-
Alcendor RR, Gao S, Zhai P et al (2007) Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100:1512-1521 (Pubitemid 46834764)
-
(2007)
Circulation Research
, vol.100
, Issue.10
, pp. 1512-1521
-
-
Alcendor, R.R.1
Gao, S.2
Zhai, P.3
Zablocki, D.4
Holle, E.5
Yu, X.6
Tian, B.7
Wagner, T.8
Vatner, S.F.9
Sadoshima, J.10
-
6
-
-
45749094496
-
Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites
-
Anantharaman V, Aravind L (2008) Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. Cell Cycle 7:1467-1472 (Pubitemid 351872586)
-
(2008)
Cell Cycle
, vol.7
, Issue.10
, pp. 1467-1472
-
-
Anantharaman, V.1
Aravind, L.2
-
7
-
-
0038329323
-
Nicatinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
DOI 10.1038/nature01578
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185 (Pubitemid 36569542)
-
(2003)
Nature
, vol.423
, Issue.6936
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
8
-
-
0037355004
-
+ gene is nonessential and has only minor effects on position-effect variegation
-
Astrom SU, Cline TW, Rine J (2003) The Drosophila melanogaster sir2(+) gene is nonessential and has only minor effects on position-effect variegation. Genetics 163:931-937 (Pubitemid 36417937)
-
(2003)
Genetics
, vol.163
, Issue.3
, pp. 931-937
-
-
Astrom, S.U.1
Cline, T.W.2
Rine, J.3
-
9
-
-
33744976074
-
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
-
DOI 10.1016/j.cell.2006.04.036, PII S0092867406006180
-
Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125:1165-1177 (Pubitemid 43866202)
-
(2006)
Cell
, vol.125
, Issue.6
, pp. 1165-1177
-
-
Berdichevsky, A.1
Viswanathan, M.2
Horvitz, H.R.3
Guarente, L.4
-
10
-
-
41949125454
-
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
-
Biacsi R, Kumari D, Usdin K (2008) SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome. PLoS Genet 4:e1000017
-
(2008)
PLoS Genet
, vol.4
-
-
Biacsi, R.1
Kumari, D.2
Usdin, K.3
-
11
-
-
77950968403
-
Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans
-
Bizat N, Peyrin JM, Haik S, Cochois V, Beaudry P, Laplanche JL, Neri C (2010) Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans. J Neurosci 30:5394-5403
-
(2010)
J Neurosci
, vol.30
, pp. 5394-5403
-
-
Bizat, N.1
Peyrin, J.M.2
Haik, S.3
Cochois, V.4
Beaudry, P.5
Laplanche, J.L.6
Neri, C.7
-
12
-
-
27844578650
-
Genetics of Parkinson's disease
-
Bonifati V (2005) Genetics of Parkinson's disease. Minerva Med 96:175-186 (Pubitemid 41641249)
-
(2005)
Minerva Medica
, vol.96
, Issue.3
, pp. 175-186
-
-
Bonifati, V.1
-
13
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
DOI 10.1111/j.1474-9726.2007.00335.x
-
Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J et al (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6:759-767 (Pubitemid 350131044)
-
(2007)
Aging Cell
, vol.6
, Issue.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
Van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
Gu, W.11
Guarente, L.12
-
14
-
-
0028841317
-
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
-
Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9:2888-2902
-
(1995)
Genes Dev
, vol.9
, pp. 2888-2902
-
-
Brachmann, C.B.1
Sherman, J.M.2
Devine, S.E.3
Cameron, E.E.4
Pillus, L.5
Boeke, J.D.6
-
15
-
-
27144475816
-
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors
-
DOI 10.1038/sj.leu.2403910, PII 2403910
-
Bradbury CA, Khanim FL, Hayden R, Bunce CM, White DA, Drayson MT, Craddock C, Turner BM (2005) Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 19: 1751-1759 (Pubitemid 41486152)
-
(2005)
Leukemia
, vol.19
, Issue.10
, pp. 1751-1759
-
-
Bradbury, C.A.1
Khanim, F.L.2
Hayden, R.3
Bunce, C.M.4
White, D.A.5
Drayson, M.T.6
Craddock, C.7
Turner, B.M.8
-
16
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
DOI 10.1126/science.1094637
-
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY et al (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015 (Pubitemid 38393275)
-
(2004)
Science
, vol.303
, Issue.5666
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsy, R.9
Cohen, H.Y.10
Hu, L.S.11
Cheng, H.-L.12
Jedrychowski, M.P.13
Gygi, S.P.14
Sinclair, D.A.15
Alt, F.W.16
Greenberg, M.E.17
-
17
-
-
70949092805
-
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
-
Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M et al (2009) Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PLoS One 4:e7897
-
(2009)
PLoS One
, vol.4
-
-
Bruzzone, S.1
Fruscione, F.2
Morando, S.3
Ferrando, T.4
Poggi, A.5
Garuti, A.6
D'urso, A.7
Selmo, M.8
Benvenuto, F.9
Cea, M.10
-
18
-
-
0031044789
-
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast
-
Bryk M, Banerjee M, Murphy M, Knudsen KE, Garfinkel DJ, Curcio MJ (1997) Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev 11:255-269 (Pubitemid 27081900)
-
(1997)
Genes and Development
, vol.11
, Issue.2
, pp. 255-269
-
-
Bryk, M.1
Banerjee, M.2
Murphy, M.3
Knudsen, K.E.4
Garfinkel, D.J.5
Curcio, M.J.6
-
19
-
-
77956382385
-
Sirtuin 1 regulation of developmental genes during differentiation of stem cells
-
Calvanese V, Lara E, Suarez-Alvarez B, Abu Dawud R, Vazquez-Chantada M, Martinez-Chantar ML, Embade N, Lopez-Nieva P, Horrillo A, Hmadcha A et al (2010) Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci USA 107: 13736-13741
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13736-13741
-
-
Calvanese, V.1
Lara, E.2
Suarez-Alvarez, B.3
Abu Dawud, R.4
Vazquez-Chantada, M.5
Martinez-Chantar, M.L.6
Embade, N.7
Lopez-Nieva, P.8
Horrillo, A.9
Hmadcha, A.10
-
20
-
-
0028876673
-
Genetic interactions and dosage effects of Polycomb group genes of Drosophila
-
Campbell RB, Sinclair DA, Couling M, Brock HW (1995) Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Mol Gen Genet 246:291-300
-
(1995)
Mol Gen Genet
, vol.246
, pp. 291-300
-
-
Campbell, R.B.1
Sinclair, D.A.2
Couling, M.3
Brock, H.W.4
-
21
-
-
33745520486
-
The sirtuins Hst3 and Hst4p preserve genome integrity by controlling histone H3 lysine 56 deacetylation
-
DOI 10.1016/j.cub.2006.06.023, PII S0960982206017490
-
Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A (2006) The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol 16:1280-1289 (Pubitemid 43977885)
-
(2006)
Current Biology
, vol.16
, Issue.13
, pp. 1280-1289
-
-
Celic, I.1
Masumoto, H.2
Griffith, W.P.3
Meluh, P.4
Cotter, R.J.5
Boeke, J.D.6
Verreault, A.7
-
22
-
-
34548208677
-
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
-
Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA (2007) Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 5:e201
-
(2007)
PLoS Biol
, vol.5
-
-
Chambers, S.M.1
Shaw, C.A.2
Gatza, C.3
Fisk, C.J.4
Donehower, L.A.5
Goodell, M.A.6
-
23
-
-
0037312934
-
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
-
DOI 10.1038/ng1077
-
Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet 33:197-202 (Pubitemid 36177074)
-
(2003)
Nature Genetics
, vol.33
, Issue.2
, pp. 197-202
-
-
Chen, W.Y.1
Zeng, X.2
Carter, M.G.3
Morrell, C.N.4
Chiu Yen, R.-W.5
Esteller, M.6
Watkins, D.N.7
Herman, J.G.8
Mankowski, J.L.9
Baylin, S.B.10
-
24
-
-
28844474597
-
SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
-
DOI 10.1074/jbc.M509329200
-
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005a) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280:40364-40374 (Pubitemid 41779174)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.48
, pp. 40364-40374
-
-
Chen, J.1
Zhou, Y.2
Mueller-Steiner, S.3
Chen, L.-F.4
Kwon, H.5
Yi, S.6
Mucke, L.7
Gan, L.8
-
25
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
DOI 10.1016/j.cell.2005.08.011, PII S0092867405008159
-
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB (2005b) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123:437-448 (Pubitemid 41546674)
-
(2005)
Cell
, vol.123
, Issue.3
, pp. 437-448
-
-
Wen, Y.C.1
Wang, D.H.2
RayWhay, C.Y.3
Luo, J.4
Gu, W.5
Baylin, S.B.6
-
26
-
-
47549105301
-
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair
-
DOI 10.1016/j.cell.2008.06.035, PII S0092867408008222
-
Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK (2008) Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. Cell 134:231-243 (Pubitemid 352010334)
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 231-243
-
-
Chen, C.-C.1
Carson, J.J.2
Feser, J.3
Tamburini, B.4
Zabaronick, S.5
Linger, J.6
Tyler, J.K.7
-
27
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
DOI 10.1073/pnas.1934713100
-
Cheng H, Mostoslavsky R, Saito Si, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chuaa KF (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)- deficient mice. Proc Natl Acad Sci USA 100:10794-10799 (Pubitemid 37140107)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.19
, pp. 10794-10799
-
-
Cheng, H.-L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
28
-
-
27244435939
-
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
-
DOI 10.1016/j.cmet.2005.06.007, PII S1550413105001725
-
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N et al (2005) Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2:67-76 (Pubitemid 43239826)
-
(2005)
Cell Metabolism
, vol.2
, Issue.1
, pp. 67-76
-
-
Chua, K.F.1
Mostoslavsky, R.2
Lombard, D.B.3
Pang, W.W.4
Saito, S.5
Franco, S.6
Kaushal, D.7
Cheng, H.-L.8
Fischer, M.R.9
Stokes, N.10
Murphy, M.M.11
Appella, E.12
Alt, F.W.13
-
29
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
DOI 10.1126/science.1099196
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392 (Pubitemid 38938153)
-
(2004)
Science
, vol.305
, Issue.5682
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
De Cabo, R.9
Sinclair, D.A.10
-
30
-
-
33749365317
-
Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: Role of NF-κB inhibition
-
DOI 10.1152/ajpheart.00340.2006
-
Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z (2006) Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am J Physiol Heart Circ Physiol 291:H1694-H1699 (Pubitemid 44497674)
-
(2006)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.291
, Issue.4
-
-
Csiszar, A.1
Smith, K.2
Labinskyy, N.3
Orosz, Z.4
Rivera, A.5
Ungvari, Z.6
-
31
-
-
49249100288
-
Vasoprotective effects of resveratrol and SIRT1: Attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
-
Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R et al (2008) Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol 294:H2721-H2735
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Csiszar, A.1
Labinskyy, N.2
Podlutsky, A.3
Kaminski, P.M.4
Wolin, M.S.5
Zhang, C.6
Mukhopadhyay, P.7
Pacher, P.8
Hu, F.9
De Cabo, R.10
-
32
-
-
67650659852
-
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
-
Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R, Ungvari Z (2009) Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev 130: 518-527
-
(2009)
Mech Ageing Dev
, vol.130
, pp. 518-527
-
-
Csiszar, A.1
Labinskyy, N.2
Jimenez, R.3
Pinto, J.T.4
Ballabh, P.5
Losonczy, G.6
Pearson, K.J.7
De Cabo, R.8
Ungvari, Z.9
-
33
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo 1-mediated transcription through its deacetylase activity
-
DOI 10.1073/pnas.0400593101
-
Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A (2004) Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101:10042-10047 (Pubitemid 38891191)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.27
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
Nakajima, T.7
Fukamizu, A.8
-
34
-
-
67149099680
-
Histone H4 lysine 16 acetylation regulates cellular lifespan
-
Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459:802-807
-
(2009)
Nature
, vol.459
, pp. 802-807
-
-
Dang, W.1
Steffen, K.K.2
Perry, R.3
Dorsey, J.A.4
Johnson, F.B.5
Shilatifard, A.6
Kaeberlein, M.7
Kennedy, B.K.8
Berger, S.L.9
-
35
-
-
65549113750
-
CBP/p300-mediated acetylation of histone H3 on lysine 56
-
Das C, Lucia MS, Hansen KC, Tyler JK (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459:113-117
-
(2009)
Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
Lucia, M.S.2
Hansen, K.C.3
Tyler, J.K.4
-
36
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
-
Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA (2009) Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324:1289-1293
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
Chen, R.2
Alexander, M.S.3
Zhang, Q.4
Hogg, R.T.5
Gerard, R.D.6
Garcia, J.A.7
-
37
-
-
77955046461
-
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
-
Donmez G, Wang D, Cohen DE, Guarente L (2010) SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142:320-332
-
(2010)
Cell
, vol.142
, pp. 320-332
-
-
Donmez, G.1
Wang, D.2
Cohen, D.E.3
Guarente, L.4
-
38
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
DOI 10.1128/MCB.23.9.3173-3185.2003
-
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA (2003) Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 23:3173-3185 (Pubitemid 36459231)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.9
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.-S.4
Tainsky, M.A.5
-
39
-
-
34249001997
-
Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing
-
DOI 10.1038/sj.emboj.7601690, PII 7601690
-
Durand-Dubief M, Sinha I, Fagerstrom-Billai F, Bonilla C, Wright A, Grunstein M, Ekwall K (2007) Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. EMBO J 26:2477-2488 (Pubitemid 46788316)
-
(2007)
EMBO Journal
, vol.26
, Issue.10
, pp. 2477-2488
-
-
Durand-Dubief, M.1
Sinha, I.2
Fagerstrom-Billai, F.3
Bonilla, C.4
Wright, A.5
Grunstein, M.6
Ekwall, K.7
-
40
-
-
34948846000
-
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p
-
DOI 10.1101/gad.439307
-
Erjavec N, Larsson L, Grantham J, Nystrom T (2007) Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregationremodeling factor Hsp104p. Genes Dev 21:2410-2421 (Pubitemid 47529371)
-
(2007)
Genes and Development
, vol.21
, Issue.19
, pp. 2410-2421
-
-
Erjavec, N.1
Larsson, L.2
Grantham, J.3
Nystrom, T.4
-
41
-
-
27744596999
-
Sir2 blocks extreme life-span extension
-
DOI 10.1016/j.cell.2005.08.042, PII S009286740500913X
-
Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD (2005) Sir2 blocks extreme life-span extension. Cell 123:655-667 (Pubitemid 41608467)
-
(2005)
Cell
, vol.123
, Issue.4
, pp. 655-667
-
-
Fabrizio, P.1
Gattazzo, C.2
Battistella, L.3
Wei, M.4
Cheng, C.5
McGrew, K.6
Longo, V.D.7
-
42
-
-
77955501963
-
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
-
Fan W, Luo J (2010) SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell 39:247-258
-
(2010)
Mol Cell
, vol.39
, pp. 247-258
-
-
Fan, W.1
Luo, J.2
-
43
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel T, Deng CX, Mostoslavsky R (2009) Recent progress in the biology and physiology of sirtuins. Nature 30:587-591
-
(2009)
Nature
, vol.30
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
44
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C et al (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One 3:e2020
-
(2008)
PLoS One
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
Bhimavarapu, A.7
Luikenhuis, S.8
De Cabo, R.9
Fuchs, C.10
-
45
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K et al (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37:391-400
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
Bonaldi, T.7
Haydon, C.8
Ropero, S.9
Petrie, K.10
-
47
-
-
0032831937
-
+ gene is a SIR2 homologue with silencing and centromeric functions
-
Freeman-Cook LL, Sherman JM, Brachmann CB, Allshire RC, Boeke JD, Pillus L (1999) The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Mol Biol Cell 10:3171-3186 (Pubitemid 29489553)
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.10
, pp. 3171-3186
-
-
Freeman-Cook, L.L.1
Sherman, J.M.2
Brachmann, C.B.3
Allshire, R.C.4
Boeke, J.D.5
Pillus, L.6
-
48
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via sirt-dependent deacetylation promotes expression of glucogenetic genes
-
DOI 10.1074/jbc.M412357200
-
Frescas D, Valenti L, Accili D (2005) Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280:20589-20595 (Pubitemid 40776761)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
49
-
-
0030831573
-
Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA
-
DOI 10.1093/emboj/16.21.6495
-
Fritze CE, Verschueren K, Strich R, Easton Esposito R (1997) Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16:6495-6509 (Pubitemid 27483275)
-
(1997)
EMBO Journal
, vol.16
, Issue.21
, pp. 6495-6509
-
-
Fritze, C.E.1
Verschueren, K.2
Strich, R.3
Esposito, R.E.4
-
50
-
-
0033600176
-
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (Sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
-
DOI 10.1006/bbrc.1999.0897
-
Frye RA (1999) Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun 260:273-279 (Pubitemid 29351819)
-
(1999)
Biochemical and Biophysical Research Communications
, vol.260
, Issue.1
, pp. 273-279
-
-
Frye, R.A.1
-
51
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
DOI 10.1006/bbrc.2000.3000
-
Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273:793-798 (Pubitemid 30599063)
-
(2000)
Biochemical and Biophysical Research Communications
, vol.273
, Issue.2
, pp. 793-798
-
-
Frye, R.A.1
-
52
-
-
34648816970
-
Cellular senescence and chromatin structure
-
DOI 10.1007/s00412-007-0115-7
-
Funayama R, Ishikawa F (2007) Cellular senescence and chromatin structure. Chromosoma 116:431-440 (Pubitemid 47456911)
-
(2007)
Chromosoma
, vol.116
, Issue.5
, pp. 431-440
-
-
Funayama, R.1
Ishikawa, F.2
-
53
-
-
6944253702
-
SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex
-
DOI 10.1016/j.cub.2004.09.060, PII S0960982204007742
-
Furuyama T, Banerjee R, Breen TR, Harte PJ (2004) SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex. Curr Biol 14:1812-1821 (Pubitemid 39408770)
-
(2004)
Current Biology
, vol.14
, Issue.20
, pp. 1812-1821
-
-
Furuyama, T.1
Banerjee, R.2
Breen, T.R.3
Harte, P.J.4
-
54
-
-
77956185062
-
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
-
Gao J, Wang WY, Mao YW, Graff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH (2010) A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 466:1105-1109
-
(2010)
Nature
, vol.466
, pp. 1105-1109
-
-
Gao, J.1
Wang, W.Y.2
Mao, Y.W.3
Graff, J.4
Guan, J.S.5
Pan, L.6
Mak, G.7
Kim, D.8
Su, S.C.9
Tsai, L.H.10
-
55
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
DOI 10.1038/75508
-
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25:115-119 (Pubitemid 30257049)
-
(2000)
Nature Genetics
, vol.25
, Issue.1
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
Desai-Mehta, A.4
Spring, K.5
Kozlov, S.6
Lavin, M.F.7
Gatti, R.A.8
Concannon, P.9
Khanna, K.10
-
56
-
-
47249153469
-
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila
-
DOI 10.1073/pnas.0803837105
-
Griswold AJ, Chang KT, Runko AP, Knight MA, Min KT (2008) Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci USA 105:8673-8678 (Pubitemid 351987739)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.25
, pp. 8673-8678
-
-
Griswold, A.J.1
Chang, K.T.2
Runko, A.P.3
Knight, M.A.4
Min, K.-T.5
-
57
-
-
39749087530
-
SIRT1 regulates apoptosis and nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
-
DOI 10.1016/j.stem.2008.01.002, PII S1934590908000039
-
Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE (2008) SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2:241-251 (Pubitemid 351298591)
-
(2008)
Cell Stem Cell
, vol.2
, Issue.3
, pp. 241-251
-
-
Han, M.-K.1
Song, E.-K.2
Guo, Y.3
Ou, X.4
Mantel, C.5
Broxmeyer, H.E.6
-
58
-
-
0028919756
-
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
-
Hecht A, Laroche T, Strahl-Bolsinger S, Gasser SM, Grunstein M (1995) Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80:583-592
-
(1995)
Cell
, vol.80
, pp. 583-592
-
-
Hecht, A.1
Laroche, T.2
Strahl-Bolsinger, S.3
Gasser, S.M.4
Grunstein, M.5
-
59
-
-
78650758398
-
Sirt1 improves healthy ageing and protects from metabolic syndromeassociated cancer
-
doi:10.1038
-
Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M (2010) Sirt1 improves healthy ageing and protects from metabolic syndromeassociated cancer. Nat Commun 1:3. doi:10.1038
-
(2010)
Nat Commun
, vol.1
, pp. 3
-
-
Herranz, D.1
Muñoz-Martin, M.2
Cañamero, M.3
Mulero, F.4
Martinez-Pastor, B.5
Fernandez-Capetillo, O.6
Serrano, M.7
-
60
-
-
34247570492
-
Strong expression of a longevity-related protein, SIRT1, in Bowen's disease
-
DOI 10.1007/s00403-006-0725-6
-
Hida Y, Kubo Y, Murao K, Arase S (2007) Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res 299:103-106 (Pubitemid 46669407)
-
(2007)
Archives of Dermatological Research
, vol.299
, Issue.2
, pp. 103-106
-
-
Hida, Y.1
Kubo, Y.2
Murao, K.3
Arase, S.4
-
61
-
-
0041829415
-
Proteomics-based identification of differentially expressed genes in human gliomas: Down-regulation of SIRT2 gene
-
DOI 10.1016/j.bbrc.2003.08.029
-
Hiratsuka M, Inoue T, Toda T, Kimura N, Shirayoshi Y, Kamitani H, Watanabe T, Ohama E, Tahimic CG, Kurimasa A et al (2003) Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun 309:558-566 (Pubitemid 37083288)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.309
, Issue.3
, pp. 558-566
-
-
Hiratsuka, M.1
Inoue, T.2
Toda, T.3
Kimura, N.4
Shirayoshi, Y.5
Kamitani, H.6
Watanabe, T.7
Ohama, E.8
Tahimic, C.G.T.9
Kurimasa, A.10
Oshimura, M.11
-
62
-
-
55749095213
-
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
-
Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y (2008) Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci USA 105:15599-15604
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15599-15604
-
-
Hisahara, S.1
Chiba, S.2
Matsumoto, H.3
Tanno, M.4
Yagi, H.5
Shimohama, S.6
Sato, M.7
Horio, Y.8
-
63
-
-
0036261650
-
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation
-
DOI 10.1128/MCB.22.12.4167-4180.2002
-
Hoppe GJ, Tanny JC, Rudner AD, Gerber SA, Danaie S, Gygi SP, Moazed D (2002) Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol 22:4167-4180 (Pubitemid 34556587)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.12
, pp. 4167-4180
-
-
Hoppe, G.J.1
Tanny, J.C.2
Rudner, A.D.3
Gerber, S.A.4
Danaie, S.5
Gygi, S.P.6
Moazed, D.7
-
64
-
-
45849137875
-
SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
-
Huang J, Gan Q, Han L, Li J, Zhang H, Sun Y, Zhang Z, Tong T (2008) SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One 3:e1710
-
(2008)
PLoS One
, vol.3
-
-
Huang, J.1
Gan, Q.2
Han, L.3
Li, J.4
Zhang, H.5
Sun, Y.6
Zhang, Z.7
Tong, T.8
-
65
-
-
34547100073
-
SIRT1 is significantly elevated in mouse and human prostate cancer
-
DOI 10.1158/0008-5472.CAN-07-0085
-
Huffman DM, GrizzleWE, BammanMM, Kim JS, Eltoum IA, Elgavish A, Nagy TR (2007) SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67:6612-6618 (Pubitemid 47105506)
-
(2007)
Cancer Research
, vol.67
, Issue.14
, pp. 6612-6618
-
-
Huffman, D.M.1
Grizzle, W.E.2
Bamman, M.M.3
Kim, J.-S.4
Eltoum, I.A.5
Elgavish, A.6
Nagy, T.R.7
-
66
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
DOI 10.1038/35001622
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800 (Pubitemid 30111843)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 795-800
-
-
Imai, S.-I.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
67
-
-
34248151365
-
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
-
Inoue T, Hiratsuka M, Osaki M, Oshimura M (2007) The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 6:1011-1018 (Pubitemid 46708571)
-
(2007)
Cell Cycle
, vol.6
, Issue.9
, pp. 1011-1018
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Oshimura, M.4
-
68
-
-
33847647624
-
SIRT1 promotes DNA repair activity and deacetylation of Ku70
-
Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH (2007) SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med 39:8-13 (Pubitemid 46356001)
-
(2007)
Experimental and Molecular Medicine
, vol.39
, Issue.1
, pp. 8-13
-
-
Jeong, J.1
Juhn, K.2
Lee, H.3
Kim, S.-H.4
Min, B.-H.5
Lee, K.-M.6
Cho, M.-H.7
Park, G.-H.8
Lee, K.-H.9
-
69
-
-
0036696982
-
Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast
-
Jiang J, Wawryn J, Shantha Kumara H, Jazwinski S (2002) Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. Exp Gerontol 37:1023
-
(2002)
Exp Gerontol
, vol.37
, pp. 1023
-
-
Jiang, J.1
Wawryn, J.2
Shantha Kumara, H.3
Jazwinski, S.4
-
70
-
-
34547397081
-
SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation
-
DOI 10.1016/j.cmet.2007.07.003, PII S155041310700191X
-
Jing E, Gesta S, Kahn CR (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 6:105-114 (Pubitemid 47163621)
-
(2007)
Cell Metabolism
, vol.6
, Issue.2
, pp. 105-114
-
-
Jing, E.1
Gesta, S.2
Kahn, C.R.3
-
71
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
DOI 10.1101/gad.13.19.2570
-
Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13:2570-2580 (Pubitemid 29489648)
-
(1999)
Genes and Development
, vol.13
, Issue.19
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
73
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi A, Weinert BT, Choudhary C, Jackson S (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329:1348-1353
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.4
-
74
-
-
77953244349
-
SIRT6 protects against pathological damage caused by diet-induced obesity
-
Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Scho N, Cohen HY (2010) SIRT6 protects against pathological damage caused by diet-induced obesity. Aging Cell 9: 162-173
-
(2010)
Aging Cell
, vol.9
, pp. 162-173
-
-
Kanfi, Y.1
Peshti, V.2
Gil, R.3
Naiman, S.4
Nahum, L.5
Levin, E.6
Kronfeld-Scho, N.7
Cohen, H.Y.8
-
75
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NFkappaB- dependent gene expression and organismal life span
-
Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY et al (2009) SIRT6 links histone H3 lysine 9 deacetylation to NFkappaB- dependent gene expression and organismal life span. Cell 136:62-74
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
McCord, R.A.7
Ongaigui, K.C.8
Boxer, L.D.9
Chang, H.Y.10
-
76
-
-
0024280881
-
Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast
-
Kayne PS, Kim UJ, Han M, Mullen JR, Yoshizaki F, Grunstein M (1988) Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55:27-39
-
(1988)
Cell
, vol.55
, pp. 27-39
-
-
Kayne, P.S.1
Kim, U.J.2
Han, M.3
Mullen, J.R.4
Yoshizaki, F.5
Grunstein, M.6
-
77
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
DOI 10.1038/sj.emboj.7601758, PII 7601758
-
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM et al (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J 26(13):3169-3179 (Pubitemid 47057498)
-
(2007)
EMBO Journal
, vol.26
, Issue.13
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.-H.13
-
78
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
DOI 10.1038/nature06500, PII NATURE06500
-
Kim JE, Chen J, Lou Z (2008) DBC1 is a negative regulator of SIRT1. Nature 451:583-586 (Pubitemid 351186264)
-
(2008)
Nature
, vol.451
, Issue.7178
, pp. 583-586
-
-
Kim, J.-E.1
Chen, J.2
Lou, Z.3
-
79
-
-
0019364691
-
Regulation of transcription in expressed and unexpressed mating type cassettes of yeast
-
DOI 10.1038/289239a0
-
Klar AJ, Strathern JN, Borach JR, Hicks JB (1981) Regulation of transcription in expressed and unexpressed mating type cassettes of yeast. Nature 289:239-244 (Pubitemid 11180670)
-
(1981)
Nature
, vol.289
, Issue.5795
, pp. 239-244
-
-
Klar, A.J.S.1
Strathern, J.N.2
Broach, J.R.3
Hicks, J.B.4
-
80
-
-
40149093701
-
Human immunodeficiency virus type 1 tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
-
DOI 10.1016/j.chom.2008.02.002, PII S193131280800053X
-
Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe 3: 158-167 (Pubitemid 351325758)
-
(2008)
Cell Host and Microbe
, vol.3
, Issue.3
, pp. 158-167
-
-
Kwon, H.-S.1
Brent, M.M.2
Getachew, R.3
Jayakumar, P.4
Chen, L.-F.5
Schnolzer, M.6
McBurney, M.W.7
Marmorstein, R.8
Greene, W.C.9
Ott, M.10
-
81
-
-
0033616716
-
Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
DOI 10.1073/pnas.96.7.3922
-
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999) Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc Natl Acad Sci USA 96:3922-3927 (Pubitemid 29169012)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.7
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
Gilbert, S.4
Pfeiffer, R.5
Jasionowski, M.6
Haass, C.7
Fahrenholz, F.8
-
82
-
-
24944559665
-
Cell biology: HST2 mediates SIR2-independent life-span extension by calorie restriction
-
DOI 10.1126/science.1113611
-
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309:1861-1864 (Pubitemid 41325097)
-
(2005)
Science
, vol.309
, Issue.5742
, pp. 1861-1864
-
-
Lamming, D.W.1
Latorre-Esteves, M.2
Medvedik, O.3
Wong, S.N.4
Tsang, F.A.5
Wang, C.6
Lin, S.-J.7
Sinclair, D.A.8
-
83
-
-
0034735990
-
Role of NAD(+) in the deacetylase activity of the SIR2- like proteins
-
Landry J, Slama JT, Sternglanz R (2000) Role of NAD(+) in the deacetylase activity of the SIR2- like proteins. Biochem Biophys Res Commun 278:685-690
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 685-690
-
-
Landry, J.1
Slama, J.T.2
Sternglanz, R.3
-
84
-
-
0033565609
-
Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
-
DOI 10.1016/S0960-9822(99)80339-X
-
Lee SE, Paques F, Sylvan J, Haber JE (1999) Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths. Curr Biol 9:767-770 (Pubitemid 29350858)
-
(1999)
Current Biology
, vol.9
, Issue.14
, pp. 767-770
-
-
Lee, S.E.1
Paques, F.2
Sylvan, J.3
Haber, J.E.4
-
85
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
DOI 10.1101/gad.1363206
-
Levine AJ, Feng Z, Mak TW, You H, Jin S (2006) Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 20:267-275 (Pubitemid 43200281)
-
(2006)
Genes and Development
, vol.20
, Issue.3
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
You, H.4
Jin, S.5
-
86
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
DOI 10.1016/j.molcel.2007.07.032, PII S109727650700620X
-
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 28:91-106 (Pubitemid 47531974)
-
(2007)
Molecular Cell
, vol.28
, Issue.1
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
87
-
-
43149118368
-
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
-
Li K, Casta A, Wang R, Lozada E, Fan W, Kane S, Ge Q, Gu W, Orren D, Luo J (2008a) Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem 283:7590-7598
-
(2008)
J Biol Chem
, vol.283
, pp. 7590-7598
-
-
Li, K.1
Casta, A.2
Wang, R.3
Lozada, E.4
Fan, W.5
Kane, S.6
Ge, Q.7
Gu, W.8
Orren, D.9
Luo, J.10
-
88
-
-
45549096918
-
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
-
DOI 10.1016/j.cmet.2008.05.004, PII S1550413108001484
-
Li Y, Xu W, McBurney MW, Longo VD (2008b) SirT1 inhibition reduces IGF-I/IRS-2/ Ras/ERK1/2 signaling and protects neurons. Cell Metab 8:38-48 (Pubitemid 351859225)
-
(2008)
Cell Metabolism
, vol.8
, Issue.1
, pp. 38-48
-
-
Li, Y.1
Xu, W.2
McBurney, M.W.3
Longo, V.D.4
-
89
-
-
0034611728
-
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
-
DOI 10.1038/35007091
-
Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613-617 (Pubitemid 30205060)
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 613-617
-
-
Lim, D.-S.1
Kim, S.-T.2
Xu, B.3
Maser, R.S.4
Lin, J.5
Petrini, J.H.J.6
Kastan, M.B.7
-
90
-
-
36549025835
-
Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: Health effects and costs
-
DOI 10.1016/S0140-6736(07)61699-7, PII S0140673607616997
-
Lim SS, Gaziano TA, Gakidou E, Reddy KS, Farzadfar F, Lozano R, Rodgers A (2007) Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: health effects and costs. Lancet 370:2054-2062 (Pubitemid 50007974)
-
(2007)
Lancet
, vol.370
, Issue.9604
, pp. 2054-2062
-
-
Lim, S.S.1
Gaziano, T.A.2
Gakidou, E.3
Reddy, K.S.4
Farzadfar, F.5
Lozano, R.6
Rodgers, A.7
-
91
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha
-
Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38:864-878
-
(2010)
Mol Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
Lee, Y.M.2
Chun, Y.S.3
Chen, J.4
Kim, J.E.5
Park, J.W.6
-
92
-
-
33645774382
-
Increased life span due to calorie restriction in respiratory-deficient yeast
-
author reply e34
-
Lin SJ, Guarente L (2006) Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2:e33, author reply e34
-
(2006)
PLoS Genet
, vol.2
-
-
Lin, S.J.1
Guarente, L.2
-
93
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-2128
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
94
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
DOI 10.1038/nature00829
-
Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418:344-348 (Pubitemid 34790687)
-
(2002)
Nature
, vol.418
, Issue.6895
, pp. 344-348
-
-
Lin, S.-J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.-A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
95
-
-
0347128279
-
Calorie restriction extends yeast life span by lowering the level of NADH
-
DOI 10.1101/gad.1164804
-
Lin SJ, Ford E, Haigis M, Liszt G, Guarente L (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18:12-16 (Pubitemid 38090683)
-
(2004)
Genes and Development
, vol.18
, Issue.1
, pp. 12-16
-
-
Lin, S.-J.1
Ford, E.2
Haigis, M.3
Liszt, G.4
Guarente, L.5
-
96
-
-
19344377042
-
Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation
-
DOI 10.1016/j.cell.2005.03.035, PII S0092867405003545
-
Liou GG, Tanny JC, Kruger RG, Walz T, Moazed D (2005) Assembly of the SIR complex and its regulation by O-acetyl-ADP-ribose, a product of NAD-dependent histone deacetylation. Cell 121:515-527 (Pubitemid 40720006)
-
(2005)
Cell
, vol.121
, Issue.4
, pp. 515-527
-
-
Liou, G.-G.1
Tanny, J.C.2
Kruger, R.G.3
Walz, T.4
Moazed, D.5
-
97
-
-
74549184412
-
The polarisome is required for segregation and retrograde transport of protein aggregates
-
Liu B, Larsson L, Caballero A, Hao X, Oling D, Grantham J, Nystrom T (2010) The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140:257-267
-
(2010)
Cell
, vol.140
, pp. 257-267
-
-
Liu, B.1
Larsson, L.2
Caballero, A.3
Hao, X.4
Oling, D.5
Grantham, J.6
Nystrom, T.7
-
98
-
-
34247477207
-
Hypoxia inducible factor-2alpha in cancer
-
Lofstedt T, Fredlund E, Holmquist-Mengelbier L, Pietras A, Ovenberger M, Poellinger L, Pahlman S (2007) Hypoxia inducible factor-2alpha in cancer. Cell Cycle 6:919-926
-
(2007)
Cell Cycle
, vol.6
, pp. 919-926
-
-
Lofstedt, T.1
Fredlund, E.2
Holmquist-Mengelbier, L.3
Pietras, A.4
Ovenberger, M.5
Poellinger, L.6
Pahlman, S.7
-
99
-
-
38349171766
-
SIRT6 in DNA repair, metabolism and ageing
-
Lombard DB, Schwer B, Alt FW, Mostoslavsky R (2008) SIRT6 in DNA repair, metabolism and ageing. J Intern Med 263:128-141
-
(2008)
J Intern Med
, vol.263
, pp. 128-141
-
-
Lombard, D.B.1
Schwer, B.2
Alt, F.W.3
Mostoslavsky, R.4
-
100
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
DOI 10.1016/j.cell.2006.07.002, PII S0092867406008920
-
Longo VD, Kennedy BK (2006) Sirtuins in aging and age-related disease. Cell 126:257-268 (Pubitemid 44092970)
-
(2006)
Cell
, vol.126
, Issue.2
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
101
-
-
0031009829
-
Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast
-
DOI 10.1083/jcb.137.7.1581
-
Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB (1997) Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 137:1581-1588 (Pubitemid 27282238)
-
(1997)
Journal of Cell Biology
, vol.137
, Issue.7
, pp. 1581-1588
-
-
Longo, V.D.1
Ellerby, L.M.2
Bredesen, D.E.3
Valentine, J.S.4
Gralla, E.B.5
-
102
-
-
0029591894
-
Silencing and heritable domains of gene expression
-
Loo S, Rine J (1995) Silencing and heritable domains of gene expression. Annu Rev Cell Dev Biol 11:519-548
-
(1995)
Annu Rev Cell Dev Biol
, vol.11
, pp. 519-548
-
-
Loo, S.1
Rine, J.2
-
103
-
-
0035913911
-
Negative control of p53 by Sir2α promotes cell survival under stress
-
DOI 10.1016/S0092-8674(01)00524-4
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148 (Pubitemid 33035941)
-
(2001)
Cell
, vol.107
, Issue.2
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.-I.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
104
-
-
0037097940
-
Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast
-
DOI 10.1101/gad.988802
-
Luo K, Vega-Palas MA, Grunstein M (2002) Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast. Genes Dev 16:1528-1539 (Pubitemid 34686334)
-
(2002)
Genes and Development
, vol.16
, Issue.12
, pp. 1528-1539
-
-
Luo, K.1
Vega-Palas, M.A.2
Grunstein, M.3
-
105
-
-
34047099212
-
GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis
-
DOI 10.1002/jcb.21140
-
Ma W, Stafford LJ, Li D, Luo J, Li X, Ning G, Liu M (2007) GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. J Cell Biochem 100:1376-1386 (Pubitemid 46515572)
-
(2007)
Journal of Cellular Biochemistry
, vol.100
, Issue.6
, pp. 1376-1386
-
-
Ma, W.1
Stafford, L.J.2
Li, D.3
Luo, J.4
Li, X.5
Ning, G.6
Liu, M.7
-
106
-
-
33745496607
-
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4
-
DOI 10.1016/j.molcel.2006.06.006, PII S1097276506004114
-
Maas NL, Miller KM, DeFazio LG, Toczyski DP (2006) Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell 23:109-119 (Pubitemid 43963450)
-
(2006)
Molecular Cell
, vol.23
, Issue.1
, pp. 109-119
-
-
Maas, N.L.1
Miller, K.M.2
DeFazio, L.G.3
Toczyski, D.P.4
-
107
-
-
0033612287
-
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
-
DOI 10.1016/S0092-8674(00)80773-4
-
Martin SG, Laroche T, Suka N, Grunstein M, Gasser SM (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97:621-633 (Pubitemid 29256965)
-
(1999)
Cell
, vol.97
, Issue.5
, pp. 621-633
-
-
Martin, S.G.1
Laroche, T.2
Suka, N.3
Grunstein, M.4
Gasser, S.M.5
-
108
-
-
22444448143
-
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response
-
DOI 10.1038/nature03714
-
Masumoto H, Hawke D, Kobayashi R, Verreault A (2005) A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response. Nature 436:294-298 (Pubitemid 41021284)
-
(2005)
Nature
, vol.436
, Issue.7048
, pp. 294-298
-
-
Masumoto, H.1
Hawke, D.2
Kobayashi, R.3
Verreault, A.4
-
109
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
DOI 10.1073/pnas.0704329104
-
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Irani K (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 104:14855-14860 (Pubitemid 350003232)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.37
, pp. 14855-14860
-
-
Mattagajasingh, I.1
Kim, C.-S.2
Naqvi, A.3
Yamamori, T.4
Hoffman, T.A.5
Jung, S.-B.6
DeRicco, J.7
Kasuno, K.8
Irani, K.9
-
110
-
-
66049150672
-
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF (2009) SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging 1:109-121
-
(2009)
Aging
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
Michishita, E.2
Hong, T.3
Berber, E.4
Boxer, L.D.5
Kusumoto, R.6
Guan, S.7
Shi, X.8
Gozani, O.9
Burlingame, A.L.10
Bohr, V.A.11
Chua, K.F.12
-
111
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
DOI 10.1042/BJ20070140
-
Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404:1-13 (Pubitemid 46788079)
-
(2007)
Biochemical Journal
, vol.404
, Issue.1
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
112
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
DOI 10.1038/nature06736, PII NATURE06736
-
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC et al (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452:492-496 (Pubitemid 351450840)
-
(2008)
Nature
, vol.452
, Issue.7186
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
Cheung, P.7
Kusumoto, R.8
Kawahara, T.L.A.9
Barrett, J.C.10
Chang, H.Y.11
Bohr, V.A.12
Ried, T.13
Gozani, O.14
Chua, K.F.15
-
113
-
-
69249221533
-
Cell cycledependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
-
Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF (2009) Cell cycledependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle 8: 2664-2666
-
(2009)
Cell Cycle
, vol.8
, pp. 2664-2666
-
-
Michishita, E.1
McCord, R.A.2
Boxer, L.D.3
Barber, M.F.4
Hong, T.5
Gozani, O.6
Chua, K.F.7
-
114
-
-
0033612189
-
MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
-
DOI 10.1016/S0092-8674(00)80772-2
-
Mills KD, Sinclair DA, Guarente L (1999) MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97:609-620 (Pubitemid 29256964)
-
(1999)
Cell
, vol.97
, Issue.5
, pp. 609-620
-
-
Mills, K.D.1
Sinclair, D.A.2
Guarente, L.3
-
115
-
-
0030951007
-
Silent information regulator protein complexes in Saccharomyces cerevisiae: A SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3
-
DOI 10.1073/pnas.94.6.2186
-
Moazed D, Kistler A, Axelrod A, Rine J, Johnson AD (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc Natl Acad Sci USA 94:2186-2191 (Pubitemid 27136849)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.6
, pp. 2186-2191
-
-
Moazed, D.1
Kistler, A.2
Axelrod, A.3
Rine, J.4
Johnson, A.D.5
-
116
-
-
0004760134
-
Life span of individual yeast cells
-
Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183:1751-1752
-
(1959)
Nature
, vol.183
, pp. 1751-1752
-
-
Mortimer, R.K.1
Johnston, J.R.2
-
117
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
DOI 10.1016/j.cell.2005.11.044, PII S0092867406000493
-
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM et al (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124:315-329 (Pubitemid 43121980)
-
(2006)
Cell
, vol.124
, Issue.2
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.-L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
-
118
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
DOI 10.1016/S0092-8674(04)00126-6
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116:551-563 (Pubitemid 38264432)
-
(2004)
Cell
, vol.116
, Issue.4
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
119
-
-
33751560439
-
SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
-
DOI 10.1177/1087057106294710
-
Nayagam VM, Wang X, Tan YC, Poulsen A, Goh KC, Ng T, Wang H, Song HY, Ni B, Entzeroth M et al (2006) SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11:959-967 (Pubitemid 44847150)
-
(2006)
Journal of Biomolecular Screening
, vol.11
, Issue.8
, pp. 959-967
-
-
Nayagam, V.M.1
Wang, X.2
Yong, C.T.3
Poulsen, A.4
Kee, C.G.5
Ng, T.6
Wang, H.7
Hong, Y.S.8
Ni, B.9
Entzeroth, M.10
Stunkel, W.11
-
120
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
DOI 10.1126/science.1101731
-
Nemoto S, Fergusson MM, Finkel T (2004) Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306:2105-2108 (Pubitemid 40007664)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
121
-
-
0037291214
-
+-dependent tubulin deacetylase
-
DOI 10.1016/S1097-2765(03)00038-8
-
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E (2003) The human Sir2 ortholog, SIRT2, is an NAD(+)-dependent tubulin deacetylase. Mol Cell 11:437-444 (Pubitemid 36293837)
-
(2003)
Molecular Cell
, vol.11
, Issue.2
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
122
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P et al (2008) SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135:907-918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
Hartlerode, A.7
Stegmuller, J.8
Hafner, A.9
Loerch, P.10
-
123
-
-
34547599329
-
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
-
DOI 10.1126/science.1143780
-
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ et al (2007) Sirtuin 2 inhibitors rescue alpha-synucleinmediated toxicity in models of Parkinson's disease. Science 317:516-519 (Pubitemid 47196116)
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.-C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
124
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW et al (2005) SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 3:e41
-
(2005)
PLoS Biol
, vol.3
-
-
Pagans, S.1
Pedal, A.2
North, B.J.3
Kaehlcke, K.4
Marshall, B.L.5
Dorr, A.6
Hetzer-Egger, C.7
Henklein, P.8
Frye, R.9
McBurney, M.W.10
-
125
-
-
0037452619
-
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex
-
DOI 10.1073/pnas.0434064100
-
Parsons XH, Garcia SN, Pillus L, Kadonaga JT (2003) Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. Proc Natl Acad Sci USA 100: 1609-1614 (Pubitemid 36254495)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.4
, pp. 1609-1614
-
-
Parsons, X.H.1
Garcia, S.N.2
Pillus, L.3
Kadonaga, J.T.4
-
126
-
-
0035863153
-
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
-
DOI 10.1093/emboj/20.1.197
-
Perrod S, Cockell MM, Laroche T, Renauld H, Ducrest AL, Bonnard C, Gasser SM (2001) A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J 20:197-209 (Pubitemid 32099116)
-
(2001)
EMBO Journal
, vol.20
, Issue.1-2
, pp. 197-209
-
-
Perrod, S.1
Cockell, M.M.2
Laroche, T.3
Renauld, H.4
Ducrest, A.-L.5
Bonnard, C.6
Gasser, S.M.7
-
127
-
-
58149339917
-
Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
-
Pfister JA, Ma C, Morrison BE, D'Mello SR (2008) Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One 3:e4090
-
(2008)
PLoS One
, vol.3
-
-
Pfister, J.A.1
Ma, C.2
Morrison, B.E.3
D'mello, S.R.4
-
128
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
DOI 10.1073/pnas.0802917105
-
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschop MH (2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA 105:9793-9798 (Pubitemid 352031379)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.28
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
129
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
-
DOI 10.1038/nature02583
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429(6993):771-776 (Pubitemid 38833129)
-
(2004)
Nature
, vol.429
, Issue.6993
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
De Oliveira, R.M.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
130
-
-
0026536066
-
Generation of mice carrying a mutant apolipoprotein e gene inactivated by gene targeting in embryonic stem cells
-
Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA 89:4471-4475
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4471-4475
-
-
Piedrahita, J.A.1
Zhang, S.H.2
Hagaman, J.R.3
Oliver, P.M.4
Maeda, N.5
-
131
-
-
0026725757
-
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
-
Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL (1992) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71:343-353
-
(1992)
Cell
, vol.71
, pp. 343-353
-
-
Plump, A.S.1
Smith, J.D.2
Hayek, T.3
Aalto-Setala, K.4
Walsh, A.5
Verstuyft, J.G.6
Rubin, E.M.7
Breslow, J.L.8
-
132
-
-
47849088748
-
Emerging roles of SIRT1 in vascular endothelial homeostasis
-
Potente M, Dimmeler S (2008) Emerging roles of SIRT1 in vascular endothelial homeostasis. Cell Cycle 7:2117-2122 (Pubitemid 352036236)
-
(2008)
Cell Cycle
, vol.7
, Issue.14
, pp. 2117-2122
-
-
Potente, M.1
Dimmeler, S.2
-
133
-
-
35348980724
-
SIRT1 controls endothelial angiogenic functions during vascular growth
-
DOI 10.1101/gad.435107
-
Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW et al (2007) SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21:2644-2658 (Pubitemid 47607673)
-
(2007)
Genes and Development
, vol.21
, Issue.20
, pp. 2644-2658
-
-
Potente, M.1
Ghaeni, L.2
Baldessari, D.3
Mostoslavsky, R.4
Rossig, L.5
Dequiedt, F.6
Haendeler, J.7
Mione, M.8
Dejana, E.9
Alt, F.W.10
Zeiher, A.M.11
Dimmeler, S.12
-
134
-
-
42349085704
-
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
-
Prozorovski T, Schulze-Topphoff U, Glumm R, Baumgart J, Schroter F, Ninnemann O, Siegert E, Bendix I, Brustle O, Nitsch R et al (2008) Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol 10:385-394
-
(2008)
Nat Cell Biol
, vol.10
, pp. 385-394
-
-
Prozorovski, T.1
Schulze-Topphoff, U.2
Glumm, R.3
Baumgart, J.4
Schroter, F.5
Ninnemann, O.6
Siegert, E.7
Bendix, I.8
Brustle, O.9
Nitsch, R.10
-
135
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2:e40
-
(2006)
PLoS Genet
, vol.2
-
-
Pruitt, K.1
Zinn, R.L.2
Ohm, J.E.3
McGarvey, K.M.4
Kang, S.H.5
Watkins, D.N.6
Herman, J.G.7
Baylin, S.B.8
-
136
-
-
34347338702
-
Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
-
DOI 10.1128/MCB.02279-06
-
Qiang L, Wang H, Farmer SR (2007) Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 27:4698-4707 (Pubitemid 47016124)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.13
, pp. 4698-4707
-
-
Qiang, L.1
Wang, H.2
Farmer, S.R.3
-
137
-
-
77956644726
-
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
-
Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R (2010) SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab 4:78-87
-
(2010)
Cell Metab
, vol.4
, pp. 78-87
-
-
Ramadori, G.1
Fujikawa, T.2
Fukuda, M.3
Anderson, J.4
Morgan, D.A.5
Mostoslavsky, R.6
Stuart, R.C.7
Perello, M.8
Vianna, C.R.9
Nillni, E.A.10
Rahmouni, K.11
Coppari, R.12
-
138
-
-
74049161289
-
Calorie restriction reduces rDNA recombination independently of rDNA silencing
-
Riesen M, Morgan A (2009) Calorie restriction reduces rDNA recombination independently of rDNA silencing. Aging Cell 8:624-632
-
(2009)
Aging Cell
, vol.8
, pp. 624-632
-
-
Riesen, M.1
Morgan, A.2
-
139
-
-
0023340731
-
Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
-
Rine J, Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116:9-22
-
(1987)
Genetics
, vol.116
, pp. 9-22
-
-
Rine, J.1
Herskowitz, I.2
-
140
-
-
0037123765
-
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination
-
DOI 10.1016/S0092-8674(02)00732-8
-
Rosenberg MI, Parkhurst SM (2002) Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell 109:447-458 (Pubitemid 34564472)
-
(2002)
Cell
, vol.109
, Issue.4
, pp. 447-458
-
-
Rosenberg, M.I.1
Parkhurst, S.M.2
-
141
-
-
0036324497
-
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae
-
DOI 10.1091/mbc.E02-03-0175
-
Rusche LN, Kirchmaier AL, Rine J (2002) Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell 13:2207-2222 (Pubitemid 34831327)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.7
, pp. 2207-2222
-
-
Rusche, L.N.1
Kirchmaier, A.L.2
Rine, J.3
-
142
-
-
34247271282
-
+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
-
DOI 10.1101/gad.1527307
-
Scher MB, Vaquero A, Reinberg D (2007) SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 21:920-928 (Pubitemid 46625641)
-
(2007)
Genes and Development
, vol.21
, Issue.8
, pp. 920-928
-
-
Scher, M.B.1
Vaquero, A.2
Reinberg, D.3
-
143
-
-
77956677458
-
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
-
Schug TT, Xu Q, Gao H, Peres-da-Silva A, Draper DW, Fessler MB, Purushotham A, Li X (2010) Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol 30(19):4712-4721
-
(2010)
Mol Cell Biol
, vol.30
, Issue.19
, pp. 4712-4721
-
-
Schug, T.T.1
Xu, Q.2
Gao, H.3
Peres-Da-Silva, A.4
Draper, D.W.5
Fessler, M.B.6
Purushotham, A.7
Li, X.8
-
144
-
-
34748850786
-
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
-
DOI 10.1016/j.cmet.2007.08.011, PII S1550413107002562
-
Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M (2007) Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 6:280-293 (Pubitemid 47468090)
-
(2007)
Cell Metabolism
, vol.6
, Issue.4
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
145
-
-
0035545802
-
Putting the stress on senescence
-
DOI 10.1016/S0955-0674(00)00278-7
-
Serrano M, Blasco MA (2001) Putting the stress on senescence. Curr Opin Cell Biol 13:748-753 (Pubitemid 33042736)
-
(2001)
Current Opinion in Cell Biology
, vol.13
, Issue.6
, pp. 748-753
-
-
Serrano, M.1
Blasco, M.A.2
-
146
-
-
0038714132
-
Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast
-
DOI 10.1016/S0960-9822(03)00489-5
-
Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI (2003) Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Curr Biol 13:1240-1246 (Pubitemid 36872948)
-
(2003)
Current Biology
, vol.13
, Issue.14
, pp. 1240-1246
-
-
Shankaranarayana, G.D.1
Motamedi, M.R.2
Moazed, D.3
Grewal, S.I.S.4
-
147
-
-
66149115196
-
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines
-
Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M (2009) Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol Gastrointest Liver Physiol 296:G1047-G1053
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.296
-
-
Shen, Z.1
Ajmo, J.M.2
Rogers, C.Q.3
Liang, X.4
Le Murr, L.M.M.5
Peng, Y.6
You, M.7
-
148
-
-
0033574594
-
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
-
Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Charbonneau H, Deshaies RJ (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97:233-244 (Pubitemid 29194274)
-
(1999)
Cell
, vol.97
, Issue.2
, pp. 233-244
-
-
Shou, W.1
Seol, J.H.2
Shevchenko, A.3
Baskerville, C.4
Moazed, D.5
Susan Chen, Z.W.6
Jang, J.7
Shevchenko, A.8
Charbonneau, H.9
Deshaies, R.J.10
-
149
-
-
0031459980
-
Extrachromosomal rDNA circles - A cause of aging in yeast
-
DOI 10.1016/S0092-8674(00)80493-6
-
Sinclair DA, Guarente L (1997) Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91:1033-1042 (Pubitemid 28027835)
-
(1997)
Cell
, vol.91
, Issue.7
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
150
-
-
59649125761
-
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway
-
Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, Brechlin AM, Schambach A, Hinrichsen L, Meyer G et al (2009) NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med 15:151-158
-
(2009)
Nat Med
, vol.15
, pp. 151-158
-
-
Skokowa, J.1
Lan, D.2
Thakur, B.K.3
Wang, F.4
Gupta, K.5
Cario, G.6
Brechlin, A.M.7
Schambach, A.8
Hinrichsen, L.9
Meyer, G.10
-
151
-
-
0031056907
-
An unusual form of transcriptional silencing in yeast ribosomal DNA
-
Smith JS, Boeke JD (1997) An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 11:241-254 (Pubitemid 27081899)
-
(1997)
Genes and Development
, vol.11
, Issue.2
, pp. 241-254
-
-
Smith, J.S.1
Boeke, J.D.2
-
152
-
-
12944283150
-
+-dependent protein deacetylase activity in the Sir2 protein family
-
DOI 10.1073/pnas.97.12.6658
-
Smith JS, Brachmann CB, Celic I, Kenna MA, Muhammad S, Starai VJ, Avalos JL, Escalante- Semerena JC, Grubmeyer C, Wolberger C et al (2000) A phylogenetically conserved NAD+- dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci USA 97:6658-6663 (Pubitemid 30412770)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.12
, pp. 6658-6663
-
-
Smith, J.S.1
Brachmann, C.B.2
Celic, I.3
Kenna, M.A.4
Muhammad, S.5
Starai, V.J.6
Avalos, J.L.7
Escalante-Semerena, J.C.8
Grubmeyer, C.9
Wolberger, C.10
Boeke, J.D.11
-
153
-
-
34548615053
-
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
-
DOI 10.1111/j.1474-9726.2007.00326.x
-
Smith DL Jr, McClure JM, Matecic M, Smith JS (2007) Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins. Aging Cell 6: 649-662 (Pubitemid 47400047)
-
(2007)
Aging Cell
, vol.6
, Issue.5
, pp. 649-662
-
-
Smith Jr., D.L.1
McClure, J.M.2
Matecic, M.3
Smith, J.S.4
-
154
-
-
74049131893
-
Calorie restriction effects on silencing and recombination at the yeast rDNA
-
Smith DL Jr, Li C, Matecic M, Maqani N, Bryk M, Smith JS (2009) Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell 8:633-642
-
(2009)
Aging Cell
, vol.8
, pp. 633-642
-
-
Smith Jr., D.L.1
Li, C.2
Matecic, M.3
Maqani, N.4
Bryk, M.5
Smith, J.S.6
-
155
-
-
0033574603
-
Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity
-
Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, Moazed D (1999) Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97:245-256 (Pubitemid 29194275)
-
(1999)
Cell
, vol.97
, Issue.2
, pp. 245-256
-
-
Straight, A.F.1
Shou, W.2
Dowd, G.J.3
Turck, C.W.4
Deshaies, R.J.5
Johnson, A.D.6
Moazed, D.7
-
156
-
-
36549044009
-
Function of the SIRTI protein deacetylase in cancer
-
DOI 10.1002/biot.200700087
-
Stunkel W, Peh BK, Tan YC, Nayagam VM, Wang X, Salto-Tellez M, Ni B, Entzeroth M, Wood J (2007) Function of the SIRT1 protein deacetylase in cancer. Biotechnol J 2:1360-1368 (Pubitemid 350176266)
-
(2007)
Biotechnology Journal
, vol.2
, Issue.11
, pp. 1360-1368
-
-
Stunkel, W.1
Peh, B.K.2
Tan, Y.C.3
Nayagam, V.M.4
Wang, X.5
Salto-Tellez, M.6
Ni, B.H.7
Entzeroth, M.8
Wood, J.9
-
157
-
-
0037474507
-
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
-
DOI 10.1016/S0006-291X(02)03020-6
-
Takata T, Ishikawa F (2003) Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 301:250-257 (Pubitemid 36268876)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.301
, Issue.1
, pp. 250-257
-
-
Takata, T.1
Ishikawa, F.2
-
158
-
-
20344364883
-
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair
-
DOI 10.1128/MCB.25.12.4903-4913.2005
-
Tamburini BA, Tyler JK (2005) Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Mol Cell Biol 25: 4903-4913 (Pubitemid 40781092)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.12
, pp. 4903-4913
-
-
Tamburini, B.A.1
Tyler, J.K.2
-
159
-
-
34250365395
-
+-dependent histone deacetylase SIRT1
-
DOI 10.1074/jbc.M609554200
-
Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y (2007) Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem 282:6823-6832 (Pubitemid 47100909)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.9
, pp. 6823-6832
-
-
Tanno, M.1
Sakamoto, J.2
Miura, T.3
Shimamoto, K.4
Horio, Y.5
-
160
-
-
0035895275
-
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product
-
DOI 10.1073/pnas.031563798
-
Tanny JC, Moazed D (2001) Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci USA 98:415-420 (Pubitemid 32105055)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.2
, pp. 415-420
-
-
Tanny, J.C.1
Moazed, D.2
-
161
-
-
0033598942
-
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
-
Tanny JC, Dowd GJ, Huang J, Hilz H, Moazed D (1999) An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99:735-745 (Pubitemid 30017644)
-
(1999)
Cell
, vol.99
, Issue.7
, pp. 735-745
-
-
Tanny, J.C.1
Dowd, G.J.2
Huang, J.3
Hilz, H.4
Moazed, D.5
-
162
-
-
38049115760
-
Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56
-
Thaminy S, Newcomb B, Kim J, Gatbonton T, Foss E, Simon J, Bedalov A (2007) Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56. J Biol Chem 282: 37805-37814
-
(2007)
J Biol Chem
, vol.282
, pp. 37805-37814
-
-
Thaminy, S.1
Newcomb, B.2
Kim, J.3
Gatbonton, T.4
Foss, E.5
Simon, J.6
Bedalov, A.7
-
163
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
DOI 10.1038/35065638
-
Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-230 (Pubitemid 32216597)
-
(2001)
Nature
, vol.410
, Issue.6825
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
164
-
-
0030964526
-
Silencing factors participate in DNA repair and rscombination in Saccharomyces cersvisiae
-
DOI 10.1038/42288
-
Tsukamoto Y, Kato J, Ikeda H (1997) Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388:900-903 (Pubitemid 27377065)
-
(1997)
Nature
, vol.388
, Issue.6645
, pp. 900-903
-
-
Tsukamoto, Y.1
Kato, J.-I.2
Ikeda, H.3
-
165
-
-
64049090625
-
Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging
-
Vakhrusheva O, Braeuer D, Liu Z, Braun T, Bober E (2008a) Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging. J Physiol Pharmacol 59(suppl 9):201-212
-
(2008)
J Physiol Pharmacol
, vol.59
, Issue.SUPPL. 9
, pp. 201-212
-
-
Vakhrusheva, O.1
Braeuer, D.2
Liu, Z.3
Braun, T.4
Bober, E.5
-
166
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
DOI 10.1161/CIRCRESAHA.107.164558
-
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E (2008b) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 102:703-710 (Pubitemid 351457857)
-
(2008)
Circulation Research
, vol.102
, Issue.6
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
Braun, T.7
Bober, E.8
-
167
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
DOI 10.1038/nrm2190, PII NRM2190
-
van der Horst A, Burgering BM (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8:440-450 (Pubitemid 46809159)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.6
, pp. 440-450
-
-
Van Der Horst, A.1
Burgering, B.M.T.2
-
168
-
-
3142742707
-
SIRT1
-
DOI 10.1074/jbc.M401138200
-
van der Horst A, Tertoolen LG, De Vries-Smits LM, Frye RA, Medema RH, Burgering BM (2004) FOXO4 Is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1. J Biol Chem 279:28873-28879 (Pubitemid 38915754)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.28
, pp. 28873-28879
-
-
Van Der Horst, A.1
Tertoolen, L.G.J.2
De Vries-Smits, L.M.M.3
Frye, R.A.4
Medema, R.H.5
Burgering, B.M.T.6
-
169
-
-
59649117804
-
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
-
Van Gool F, Galli M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O (2009) Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med 15:206-210
-
(2009)
Nat Med
, vol.15
, pp. 206-210
-
-
Van Gool, F.1
Galli, M.2
Gueydan, C.3
Kruys, V.4
Prevot, P.P.5
Bedalov, A.6
Mostoslavsky, R.7
Alt, F.W.8
De Smedt, T.9
Leo, O.10
-
170
-
-
77649225958
-
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
-
van Loosdregt J, Vercoulen Y, Guichelaar T, Gent YY, Beekman JM, van Beekum O, Brenkman AB, Hijnen DJ, Mutis T, Kalkhoven E et al (2010) Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 115:965-974
-
(2010)
Blood
, vol.115
, pp. 965-974
-
-
Van Loosdregt, J.1
Vercoulen, Y.2
Guichelaar, T.3
Gent, Y.Y.4
Beekman, J.M.5
Van Beekum, O.6
Brenkman, A.B.7
Hijnen, D.J.8
Mutis, T.9
Kalkhoven, E.10
-
171
-
-
4944245398
-
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
-
DOI 10.1016/j.molcel.2004.08.031, PII S1097276504005180
-
Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16: 93-105 (Pubitemid 39330155)
-
(2004)
Molecular Cell
, vol.16
, Issue.1
, pp. 93-105
-
-
Vaquero, A.1
Scher, M.2
Lee, D.3
Erdjument-Bromage, H.4
Tempst, P.5
Reinberg, D.6
-
172
-
-
33646550204
-
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
-
DOI 10.1101/gad.1412706
-
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D (2006) SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev 20(10):1256-1261 (Pubitemid 43727586)
-
(2006)
Genes and Development
, vol.20
, Issue.10
, pp. 1256-1261
-
-
Vaquero, A.1
Scher, M.B.2
Dong, H.L.3
Sutton, A.4
Cheng, H.-L.5
Alt, F.W.6
Serrano, L.7
Sternglanz, R.8
Reinberg, D.9
-
173
-
-
0035913903
-
SIRT1 functions as an NAD-dependent p53 deacetylase
-
DOI 10.1016/S0092-8674(01)00527-X
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159 (Pubitemid 33035942)
-
(2001)
Cell
, vol.107
, Issue.2
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Eaton, E.N.3
Imai, S.-I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
174
-
-
77953386141
-
Local IGF-1 isoform protects cardiomyiocytes from hypertrophic and oxidative stresses via Sirt1 activity
-
Vinciguerra M, Santini MP, Claycomb WC, Ladurner AG, Rosenthal N (2009) Local IGF-1 isoform protects cardiomyiocytes from hypertrophic and oxidative stresses via Sirt1 activity. Aging 10:43-62
-
(2009)
Aging
, vol.10
, pp. 43-62
-
-
Vinciguerra, M.1
Santini, M.P.2
Claycomb, W.C.3
Ladurner, A.G.4
Rosenthal, N.5
-
175
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
DOI 10.1016/j.mad.2005.09.005, PII S0047637405002216
-
Wang Y, Tissenbaum HA (2006) Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev 127:48-56 (Pubitemid 41713513)
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, Issue.1
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
176
-
-
17144416530
-
Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells
-
Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005) Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res 65:3299-3306 (Pubitemid 40524614)
-
(2005)
Cancer Research
, vol.65
, Issue.8
, pp. 3299-3306
-
-
Wang, V.1
Davis, D.A.2
Haque, M.3
Huang, L.E.4
Yarchoan, R.5
-
177
-
-
33746245679
-
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO
-
DOI 10.1016/j.mad.2006.05.005, PII S0047637406001448
-
Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA (2006) C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev 127:741-747 (Pubitemid 44188819)
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, Issue.9
, pp. 741-747
-
-
Wang, Y.1
Oh, S.W.2
Deplancke, B.3
Luo, J.4
Walhout, A.J.M.5
Tissenbaum, H.A.6
-
178
-
-
34447626095
-
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
DOI 10.1111/j.1474-9726.2007.00304.x
-
Wang F, Nguyen M, Qin FX, Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6:505-514 (Pubitemid 47087055)
-
(2007)
Aging Cell
, vol.6
, Issue.4
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.-F.3
Tong, Q.4
-
179
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B et al (2008) Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14:312-323
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
Kim, S.7
Xu, X.8
Zheng, Y.9
Chilton, B.10
-
180
-
-
0001221508
-
On respiratory impairment in cancer cells
-
arburg O (1956) On respiratory impairment in cancer cells. Science 124:269-270
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
-
181
-
-
40249114794
-
Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
-
DOI 10.1016/j.neuron.2008.02.024, PII S0896627308001785
-
Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marie I, Maurin T, Wang L, Figueroa H, Herman M et al (2008) Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron 57:680-690 (Pubitemid 351335351)
-
(2008)
Neuron
, vol.57
, Issue.5
, pp. 680-690
-
-
Wen, Y.1
Yu, W.H.2
Maloney, B.3
Bailey, J.4
Ma, J.5
Marie, I.6
Maurin, T.7
Wang, L.8
Figueroa, H.9
Herman, M.10
Krishnamurthy, P.11
Liu, L.12
Planel, E.13
Lau, L.-F.14
Lahiri, D.K.15
Duff, K.16
-
182
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI (2009) Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323:1063-1066
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens Jr., S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
183
-
-
67650070795
-
HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line
-
Wirth M, Paap F, Fischle W, Wenzel D, Agafonov DE, Samatov TR, Wisniewski JR, Jedrusik- Bode M (2009) HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line. Mol Cell Biol 29:3700-3709
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3700-3709
-
-
Wirth, M.1
Paap, F.2
Fischle, W.3
Wenzel, D.4
Agafonov, D.E.5
Samatov, T.R.6
Wisniewski, J.R.7
Jedrusik- Bode, M.8
-
184
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
Wong PC, Pardo CA, Borchelt DR, LeeMK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14:1105-1116
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
Pardo, C.A.2
Borchelt, D.R.3
Leemk Copeland, N.G.4
Jenkins, N.A.5
Sisodia, S.S.6
Cleveland, D.W.7
Price, D.L.8
-
186
-
-
33847060910
-
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging
-
Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I (2007) Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol 292:L567-L576
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Yang, S.R.1
Wright, J.2
Bauter, M.3
Seweryniak, K.4
Kode, A.5
Rahman, I.6
-
187
-
-
69249229772
-
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
-
Yang B, Zwaans BM, Eckersdorff M, Lombard DB (2009) The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle 8:2662-2663
-
(2009)
Cell Cycle
, vol.8
, pp. 2662-2663
-
-
Yang, B.1
Zwaans, B.M.2
Eckersdorff, M.3
Lombard, D.B.4
-
188
-
-
3242719545
-
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
-
DOI 10.1038/sj.emboj.7600244
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23(12):2369-2380 (Pubitemid 38954844)
-
(2004)
EMBO Journal
, vol.23
, Issue.12
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
189
-
-
61749095297
-
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
-
Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM (2009) SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 29:1363-1374
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1363-1374
-
-
Yoshizaki, T.1
Milne, J.C.2
Imamura, T.3
Schenk, S.4
Sonoda, N.5
Babendure, J.L.6
Lu, J.C.7
Smith, J.J.8
Jirousek, M.R.9
Olefsky, J.M.10
-
190
-
-
77349087078
-
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
-
Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C et al (2010) SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 298:E419-E428
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Yoshizaki, T.1
Schenk, S.2
Imamura, T.3
Babendure, J.L.4
Sonoda, N.5
Bae, E.J.6
Oh, D.Y.7
Lu, M.8
Milne, J.C.9
Westphal, C.10
-
191
-
-
34250897968
-
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
-
DOI 10.1016/j.molcel.2007.05.029, PII S1097276507003309
-
Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 27:149-162 (Pubitemid 46991383)
-
(2007)
Molecular Cell
, vol.27
, Issue.1
, pp. 149-162
-
-
Yuan, Z.1
Zhang, X.2
Sengupta, N.3
Lane, W.S.4
Seto, E.5
-
192
-
-
65349096174
-
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
-
Yuan J, Minter-Dykhouse K, Lou Z (2009a) A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol 185:203-211
-
(2009)
J Cell Biol
, vol.185
, pp. 203-211
-
-
Yuan, J.1
Minter-Dykhouse, K.2
Lou, Z.3
-
193
-
-
66749102871
-
Histone H3-K56 acetylation is important for genomic stability in mammals
-
Yuan J, Pu M, Zhang Z, Lou Z (2009b) Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle 8:1747-1753
-
(2009)
Cell Cycle
, vol.8
, pp. 1747-1753
-
-
Yuan, J.1
Pu, M.2
Zhang, Z.3
Lou, Z.4
-
194
-
-
54149103338
-
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
-
Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC (2008) Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 80:191-199
-
(2008)
Cardiovasc Res
, vol.80
, pp. 191-199
-
-
Zhang, Q.J.1
Wang, Z.2
Chen, H.Z.3
Zhou, S.4
Zheng, W.5
Liu, G.6
Wei, Y.S.7
Cai, H.8
Liu, D.P.9
Liang, C.C.10
-
195
-
-
70349440053
-
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
-
Zhang J, Lee SM, Shannon S, Gao B, Chen W, Chen A, Divekar R, McBurney MW, Braley-Mullen H, Zaghouani H et al (2009) The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest 119:3048-3058
-
(2009)
J Clin Invest
, vol.119
, pp. 3048-3058
-
-
Zhang, J.1
Lee, S.M.2
Shannon, S.3
Gao, B.4
Chen, W.5
Chen, A.6
Divekar, R.7
McBurney, M.W.8
Braley-Mullen, H.9
Zaghouani, H.10
-
196
-
-
0034713393
-
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
-
DOI 10.1038/35013083
-
Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA et al (2000) Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405:473-477 (Pubitemid 30367425)
-
(2000)
Nature
, vol.405
, Issue.6785
, pp. 473-477
-
-
Zhao, S.1
Wong, Y.-C.2
Yuan, S.-S.F.3
Lin, Y.-T.4
Hsu, H.-C.5
Lin, S.-C.J.6
Gerbino, E.7
Song, M.-H.8
Zdzlenlcka, M.Z.9
Gatti, R.A.10
Shay, J.W.11
Ziv, Y.12
Shilch, Y.13
Lee, E.Y.-H.P.14
-
197
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
DOI 10.1038/nature06515, PII NATURE06515
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (2008) Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451:587-590 (Pubitemid 351186268)
-
(2008)
Nature
, vol.451
, Issue.7178
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.-P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
-
198
-
-
74549142287
-
The histone deacetylase SIRT6 regulates glucose homeostasis via Hif1alpha
-
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R (2010) The histone deacetylase SIRT6 regulates glucose homeostasis via Hif1alpha. Cell 140:280-293
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
D'urso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
Guimaraes, A.7
Marinelli, B.8
Wikstrom, J.D.9
Nir, T.10
Clish, C.B.11
Vaitheesvaran, B.12
Iliopoulos, O.13
Kurland, I.14
Dor, Y.15
Weissleder, R.16
Shirihai, O.S.17
Ellisen, L.W.18
Espinosa, J.M.19
Mostoslavsky, R.20
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