SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts

PLoS ONE

Volumn 3, Issue 3, 2008, Pages

  Huang, Jing ^a,b   Gan, Qini ^a,b   Han, Limin ^a,b   Li, Jian ^a,b   Zhang, Hai ^a,b   Sun, Ying ^a,b   Zhang, Zongyu ^a,b   Tong, Tanjun ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HISTIDINE; INHIBITOR OF DIFFERENTIATION 1; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; RESVERATROL; RETINOBLASTOMA PROTEIN; S6 KINASE; SIRTUIN 1; TYROSINE; ANTINEOPLASTIC ANTIBIOTIC; SIRT1 PROTEIN, HUMAN; SIRTUIN;

ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DIPLOIDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FETUS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HETEROCHROMATIN; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; CELL CYCLE; DRUG ANTAGONISM; FIBROBLAST; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA;

ANTIBIOTICS, ANTINEOPLASTIC; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL AGING; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DIPLOIDY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SIROLIMUS; SIRTUINS;

EID: 45849137875     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001710     Document Type: Article

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