Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Bruzzone, Santina ^a   Fruscione, Floriana ^b   Morando, Sara ^a   Ferrando, Tiziana ^a   Poggi, Alessandro ^c   Garuti, Anna ^d   D'Urso, Agustina ^e   Selmo, Martina ^a   Benvenuto, Federica ^a   Cea, Michele ^a   Zoppoli, Gabriele ^d   Moran, Eva ^d   Soncini, Debora ^d   Ballestrero, Alberto ^d   Sordat, Bernard ^f   Patrone, Franco ^d   Mostoslavsky, Raul ^e   Uccelli, Antonio ^a   Nencioni, Alessio ^d  

^a UNIVERSITY OF GENOA   (Italy)

^b Advanced Biotechnology Center   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e HARVARD MEDICAL SCHOOL   (United States)

^f EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GAMMA INTERFERON; N [4 (1 BENZOYL 4 PIPERIDINYL)BUTYL] 3 (3 PYRIDINYL)ACRYLAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; ACRYLAMIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; CYTOKINE; N (4 (1 BENZOYLPIPERIDIN 4 YL)BUTYL) 3 (PYRIDIN 3 YL)ACRYLAMIDE; N-(4-(1-BENZOYLPIPERIDIN-4-YL)BUTYL)-3-(PYRIDIN-3-YL)ACRYLAMIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE, MOUSE; PIPERIDINE DERIVATIVE;

ALLERGIC ENCEPHALOMYELITIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; DISABILITY; DRUG EFFICACY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; T LYMPHOCYTE ACTIVATION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL MEMBRANE POTENTIAL; CELL PROLIFERATION; CHEMISTRY; FEMALE; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MYELIN SHEATH; T LYMPHOCYTE;

ACRYLAMIDES; ADENOSINE TRIPHOSPHATE; ANIMALS; AUTOPHAGY; CELL PROLIFERATION; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; INTERFERON-GAMMA; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MYELIN SHEATH; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PIPERIDINES; POLY(ADP-RIBOSE) POLYMERASES; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70949092805     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007897     Document Type: Article

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