Neuron dysfunction is induced by prion protein with an insertional mutation via a fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans

Journal of Neuroscience

Volumn 30, Issue 15, 2010, Pages 5394-5403

  Bizat, Nicolas ^a,b   Peyrin, Jean Michel ^c,f   Haïk, Stephane ^d,e,f   Cochois, Véronique ^b   Beaudry, Patrick ^b   Laplanche, Jean Louis ^b   Néri, Christian ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INRA Institut National de la Recherche Agronomique   (France)

^d INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN; PROTEIN KINASE FYN; SIRTUIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELL MEMBRANE; ENZYME ACTIVATION; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; LONGEVITY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; TRANSGENICS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL DEATH; CELL MEMBRANE; CELLS, CULTURED; CEREBELLUM; ENDOPEPTIDASE K; HUMANS; MECHANORECEPTORS; MICE; MUTAGENESIS, INSERTIONAL; NEURONS; NEUROPROTECTIVE AGENTS; PRIONS; PROTO-ONCOGENE PROTEINS C-FYN; SIRTUINS; SRC-FAMILY KINASES; STILBENES; TOUCH;

EID: 77950968403     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5831-09.2010     Document Type: Article

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