-
1
-
-
0024973841
-
The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo
-
Weigel, D., Jurgens, G., Kuttner, F., Seifert, E. & Jackle, H. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 57, 645-658 (1989).
-
(1989)
Cell
, vol.57
, pp. 645-658
-
-
Weigel, D.1
Jurgens, G.2
Kuttner, F.3
Seifert, E.4
Jackle, H.5
-
2
-
-
0036387193
-
Forkhead transcription factors: Key players in development and metabolism
-
Carlsson, P. & Mahlapuu, M. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250, 1-23 (2002).
-
(2002)
Dev. Biol
, vol.250
, pp. 1-23
-
-
Carlsson, P.1
Mahlapuu, M.2
-
3
-
-
0034661826
-
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
-
Furuyama, T., Nakazawa, T., Nakano, I. & Mori, N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349, 629-634 (2000).
-
(2000)
Biochem. J
, vol.349
, pp. 629-634
-
-
Furuyama, T.1
Nakazawa, T.2
Nakano, I.3
Mori, N.4
-
4
-
-
0027771804
-
-
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464 (1993).
-
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464 (1993).
-
-
-
-
5
-
-
0030657540
-
DAF-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin, K., Dorman, J. B., Rodan, A. & Kenyon, C. DAF-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322 (1997).
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
6
-
-
0030659557
-
-
Ogg, S. et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999 (1997). References 5 and 6 identified DAF-16 as a mediator of insulin signalling and lifespan.
-
Ogg, S. et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999 (1997). References 5 and 6 identified DAF-16 as a mediator of insulin signalling and lifespan.
-
-
-
-
7
-
-
0033560896
-
Direct control of the Forkhead transcription factor AFX by protein kinase B
-
Kops, G. J. et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634 (1999).
-
(1999)
Nature
, vol.398
, pp. 630-634
-
-
Kops, G.J.1
-
8
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
-
9
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
Biggs, W. H., Meisenhelder, J., Hunter, T., Cavenee, W. K. & Arden, K. C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl Acad. Sci. USA 96, 7421-7426 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 7421-7426
-
-
Biggs, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
10
-
-
0039425278
-
Negative regulation of the forkhead transcription factor FKHR by Akt
-
Tang, E. D., Nunez, G., Barr, F. G. & Guan, K. L. Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 16741-16746
-
-
Tang, E.D.1
Nunez, G.2
Barr, F.G.3
Guan, K.L.4
-
11
-
-
13044315956
-
Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
-
Takaishi, H. et al. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc. Natl Acad. Sci. USA 96, 11836-11841 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 11836-11841
-
-
Takaishi, H.1
-
12
-
-
0035034038
-
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
-
Brownawell, A. M., Kops, G. J., Macara, I. G. & Burgering, B. M. Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX. Mol. Cell Biol. 21, 3534-3546 (2001).
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 3534-3546
-
-
Brownawell, A.M.1
Kops, G.J.2
Macara, I.G.3
Burgering, B.M.4
-
13
-
-
0036629251
-
-
Burgering, B. M. & Kops, G. J. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 27, 352-360 (2002).
-
Burgering, B. M. & Kops, G. J. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 27, 352-360 (2002).
-
-
-
-
14
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman, D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300 (1956).
-
(1956)
J. Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
15
-
-
0034806293
-
Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells
-
Barthel, A. et al. Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells. Biochem. Biophys. Res. Commun. 285, 897-902 (2001).
-
(2001)
Biochem. Biophys. Res. Commun
, vol.285
, pp. 897-902
-
-
Barthel, A.1
-
16
-
-
0035185021
-
The forkhead transcription factor FOXO1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae, J., Kitamura, T., Silver, D. L. & Accili, D. The forkhead transcription factor FOXO1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J. Clin. Invest. 108, 1359-1367 (2001).
-
(2001)
J. Clin. Invest
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
17
-
-
33744515637
-
FOXO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
-
Zhang, W. et al. FOXO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281, 10105-10117 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10105-10117
-
-
Zhang, W.1
-
18
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
Nemoto, S. & Finkel, T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452 (2002).
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
19
-
-
0037136563
-
-
Kops, G. J. et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321 (2002). References 18 and 19 establish a role for FoxO in the control of oxidative stress in mammalian cells.
-
Kops, G. J. et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321 (2002). References 18 and 19 establish a role for FoxO in the control of oxidative stress in mammalian cells.
-
-
-
-
20
-
-
0842347858
-
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a
-
Dansen, T. B. et al. Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. J. Lipid Res. 45, 81-88 (2004).
-
(2004)
J. Lipid Res
, vol.45
, pp. 81-88
-
-
Dansen, T.B.1
-
21
-
-
0036120725
-
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
-
Kops, G. J. et al. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell Biol. 22, 2025-2036 (2002).
-
(2002)
Mol. Cell Biol
, vol.22
, pp. 2025-2036
-
-
Kops, G.J.1
-
22
-
-
2342653278
-
Control of cyclin G2 mRNA expression by forkhead transcription factors: Novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead
-
Martinez-Gac, L., Marques, M., Garcia, Z., Campanero, M. R. & Carrera, A. C. Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell Biol. 24, 2181-2189 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 2181-2189
-
-
Martinez-Gac, L.1
Marques, M.2
Garcia, Z.3
Campanero, M.R.4
Carrera, A.C.5
-
24
-
-
0036839685
-
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D
-
Schmidt, M. et al. Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol. Cell Biol. 22, 7842-7852 (2002).
-
(2002)
Mol. Cell Biol
, vol.22
, pp. 7842-7852
-
-
Schmidt, M.1
-
25
-
-
26944461217
-
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
-
Puig, O. & Tjian, R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19, 2435-2446 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2435-2446
-
-
Puig, O.1
Tjian, R.2
-
26
-
-
0034609737
-
Expression of the proapoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers, P. F., Medema, R. H., Lammers, J. W., Koenderman, L. & Coffer, P. J. Expression of the proapoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10, 1201-1204 (2000).
-
(2000)
Curr. Biol
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
27
-
-
0037134491
-
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor
-
Tang, T. T. et al. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. J. Biol. Chem. 277, 14255-14265 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 14255-14265
-
-
Tang, T.T.1
-
28
-
-
0036787607
-
-
Nakae, J. et al. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nature Genet. 32, 245-253 (2002). Shows that aberrant FoxO regulation can cause diabetes in mice and thereby opposes normal insulin function.
-
Nakae, J. et al. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nature Genet. 32, 245-253 (2002). Shows that aberrant FoxO regulation can cause diabetes in mice and thereby opposes normal insulin function.
-
-
-
-
29
-
-
33745316089
-
Identification of a tumour suppressor network opposing nuclear Akt function
-
Trotman, L. C. et al. Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441, 523-527 (2006).
-
(2006)
Nature
, vol.441
, pp. 523-527
-
-
Trotman, L.C.1
-
30
-
-
33846295218
-
-
Paik, J. H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007). Provides in vivo evidence for a role of FoxO as a tumour suppressor.
-
Paik, J. H. et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128, 309-323 (2007). Provides in vivo evidence for a role of FoxO as a tumour suppressor.
-
-
-
-
31
-
-
33747588775
-
Mutations that increase the life span of C. elegans inhibit tumor growth
-
Pinkston, J. M., Garigan, D., Hansen, M. & Kenyon, C. Mutations that increase the life span of C. elegans inhibit tumor growth. Science 313, 971-975 (2006).
-
(2006)
Science
, vol.313
, pp. 971-975
-
-
Pinkston, J.M.1
Garigan, D.2
Hansen, M.3
Kenyon, C.4
-
32
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O. H. et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482 (2006).
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
-
33
-
-
33846419112
-
-
Tothova, Z. et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325-339 (2007). References 31-33 provide evidence for a role of PI3K signalling towards FoxO in the control of stem-cell fate.
-
Tothova, Z. et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325-339 (2007). References 31-33 provide evidence for a role of PI3K signalling towards FoxO in the control of stem-cell fate.
-
-
-
-
34
-
-
14844293962
-
The role of insulin and IGF-1 signaling in longevity
-
Katic, M. & Kahn, C. R. The role of insulin and IGF-1 signaling in longevity. Cell. Mol. Life Sci. 62, 320-343 (2005).
-
(2005)
Cell. Mol. Life Sci
, vol.62
, pp. 320-343
-
-
Katic, M.1
Kahn, C.R.2
-
35
-
-
0034033586
-
Caloric restriction and aging: An update
-
Masoro, E. J. Caloric restriction and aging: an update. Exp. Gerontol. 35, 299-305 (2000).
-
(2000)
Exp. Gerontol
, vol.35
, pp. 299-305
-
-
Masoro, E.J.1
-
36
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer, E. L. & Brunet, A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24, 7410-7425 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
37
-
-
25444442080
-
Triple layer control: Phosphorylation, acetylation and ubiquitination of FOXO proteins
-
Vogt, P. K., Jiang, H. & Aoki, M. Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 4, 908-913 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 908-913
-
-
Vogt, P.K.1
Jiang, H.2
Aoki, M.3
-
38
-
-
33646934067
-
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
-
Lehtinen, M. K. et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987-1001 (2006).
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
-
39
-
-
0032522704
-
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
-
Graves, J. D. et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17, 2224-2234 (1998).
-
(1998)
EMBO J
, vol.17
, pp. 2224-2234
-
-
Graves, J.D.1
-
40
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson, S. T. & Johnson, T. E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11, 1975-1980 (2001).
-
(2001)
Curr. Biol
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
41
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
-
42
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers, M. A. et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802-4812 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
-
43
-
-
15444371989
-
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
-
Oh, S. W. et al. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl Acad. Sci. USA 102, 4494-4499 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4494-4499
-
-
Oh, S.W.1
-
44
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang, M. C., Bohmann, D. & Jasper, H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121, 115-125 (2005).
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
45
-
-
0242362732
-
-
Wang, M. C., Bohmann, D. & Jasper, H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5, 811-816 (2003). References 42-45 provide evidence that the lifespan of model organisms can be controlled through JNK-mediated stress signalling and JNK-mediated DAF-16 (FoxO) phosphorylation.
-
Wang, M. C., Bohmann, D. & Jasper, H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev. Cell 5, 811-816 (2003). References 42-45 provide evidence that the lifespan of model organisms can be controlled through JNK-mediated stress signalling and JNK-mediated DAF-16 (FoxO) phosphorylation.
-
-
-
-
46
-
-
22944479314
-
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
-
Sunayama, J., Tsuruta, F., Masuyama, N. & Gotoh, Y. JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J. Cell Biol. 170, 295-304 (2005).
-
(2005)
J. Cell Biol
, vol.170
, pp. 295-304
-
-
Sunayama, J.1
Tsuruta, F.2
Masuyama, N.3
Gotoh, Y.4
-
47
-
-
33750032892
-
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage
-
Huang, H., Regan, K. M., Lou, Z., Chen, J. & Tindall, D. J. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314, 294-297 (2006).
-
(2006)
Science
, vol.314
, pp. 294-297
-
-
Huang, H.1
Regan, K.M.2
Lou, Z.3
Chen, J.4
Tindall, D.J.5
-
48
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2 (SIRT1)
-
van der Horst, A. et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2 (SIRT1). J. Biol. Chem. 279, 28873-28879 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 28873-28879
-
-
van der Horst, A.1
-
49
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta, M. C. et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563 (2004).
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
-
50
-
-
0035826271
-
-
Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230 (2001). This study shows that sir-2 can extend lifespan in higher eukaryotes.
-
Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230 (2001). This study shows that sir-2 can extend lifespan in higher eukaryotes.
-
-
-
-
51
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku, H. et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl Acad. Sci. USA 101, 10042-10047 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
-
52
-
-
2342445654
-
Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation
-
Fukuoka, M. et al. Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int. J. Mol. Med. 12, 503-508 (2003).
-
(2003)
Int. J. Mol. Med
, vol.12
, pp. 503-508
-
-
Fukuoka, M.1
-
53
-
-
24744469490
-
SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
-
Kobayashi, Y. et al. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int. J. Mol. Med. 16, 237-243 (2005).
-
(2005)
Int. J. Mol. Med
, vol.16
, pp. 237-243
-
-
Kobayashi, Y.1
-
54
-
-
85047695408
-
Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells
-
Mahmud, D. L. et al. Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene 21, 1556-1562 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 1556-1562
-
-
Mahmud, D.L.1
-
55
-
-
24344499875
-
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription
-
Perrot, V. & Rechler, M. M. The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription. Mol. Endocrinol. 19, 2283-2298 (2005).
-
(2005)
Mol. Endocrinol
, vol.19
, pp. 2283-2298
-
-
Perrot, V.1
Rechler, M.M.2
-
56
-
-
16344384026
-
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
-
Yang, Y., Hou, H., Haller, E. M., Nicosia, S. V. & Bai, W. Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 24, 1021-1032 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 1021-1032
-
-
Yang, Y.1
Hou, H.2
Haller, E.M.3
Nicosia, S.V.4
Bai, W.5
-
57
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
-
Frescas, D., Valenti, L. & Accili, D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J. Biol. Chem. 280, 20589-20595 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
58
-
-
23844485211
-
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
-
Matsuzaki, H. et al. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc. Natl Acad. Sci. USA 102, 11278-11283 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 11278-11283
-
-
Matsuzaki, H.1
-
59
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
-
Bordone, L. et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells. PLoS Biol. 4, e31 (2005).
-
(2005)
PLoS Biol
, vol.4
-
-
Bordone, L.1
-
60
-
-
24344509883
-
The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
-
Lemieux, M. E. et al. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals. Mech. Ageing Dev. 126, 1097-1105 (2005).
-
(2005)
Mech. Ageing Dev
, vol.126
, pp. 1097-1105
-
-
Lemieux, M.E.1
-
61
-
-
33744976074
-
-
Berdichevsky, A., Viswanathan, M., Horvitz, H. R. & Guarente, L. C. elegans SIR-2. 1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177 (2006).
-
Berdichevsky, A., Viswanathan, M., Horvitz, H. R. & Guarente, L. C. elegans SIR-2. 1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125, 1165-1177 (2006).
-
-
-
-
62
-
-
33746245679
-
-
Wang, Y. et al. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech. Ageing Dev. 127, 741-747 (2006).
-
Wang, Y. et al. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech. Ageing Dev. 127, 741-747 (2006).
-
-
-
-
63
-
-
27144468317
-
FoxO-dependent and -independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression
-
Gan, L. et al. FoxO-dependent and -independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression. Biochem. Biophys. Res. Commun. 337, 1092-1096 (2005).
-
(2005)
Biochem. Biophys. Res. Commun
, vol.337
, pp. 1092-1096
-
-
Gan, L.1
-
64
-
-
4143050290
-
-
Giannakou, M. E. & Partridge, L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 14, 408-412 (2004). This review discusses the first results obtained on the regulation of FoxO by acetylation and SIRT1.
-
Giannakou, M. E. & Partridge, L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 14, 408-412 (2004). This review discusses the first results obtained on the regulation of FoxO by acetylation and SIRT1.
-
-
-
-
65
-
-
18144411313
-
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
-
Nemoto, S., Fergusson, M. M. & Finkel, T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α. J. Biol. Chem. 280, 16456-16460 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 16456-16460
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
66
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers, J. T. et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118 (2005).
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
67
-
-
15444377466
-
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
-
Bouras, T. et al. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 280, 10264-10276 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 10264-10276
-
-
Bouras, T.1
-
68
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
-
Picard, F. et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ. Nature 429, 771-776 (2004).
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
-
69
-
-
13444252337
-
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
-
Huang, H. et al. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl Acad. Sci. USA 102, 1649-1654 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1649-1654
-
-
Huang, H.1
-
70
-
-
0141706357
-
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
-
Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K. & Fukamizu, A. Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc. Natl Acad. Sci. USA 100, 11285-11290 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 11285-11290
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Tanaka, K.4
Fukamizu, A.5
-
71
-
-
0038362751
-
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
-
Plas, D. R. & Thompson, C. B. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J. Biol. Chem. 278, 12361-12366 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 12361-12366
-
-
Plas, D.R.1
Thompson, C.B.2
-
72
-
-
11144357466
-
IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
-
Hu, M. C. et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117, 225-237 (2004).
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
-
73
-
-
0029024015
-
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
-
Pagano, M. et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269, 682-685 (1995).
-
(1995)
Science
, vol.269
, pp. 682-685
-
-
Pagano, M.1
-
74
-
-
0021004708
-
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
-
Reich, N. C., Oren, M. & Levine, A. J. Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol. Cell Biol. 3, 2143-2150 (1983).
-
(1983)
Mol. Cell Biol
, vol.3
, pp. 2143-2150
-
-
Reich, N.C.1
Oren, M.2
Levine, A.J.3
-
75
-
-
4544312844
-
Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins
-
Aoki, M., Jiang, H. & Vogt, P. K. Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins. Proc. Natl Acad. Sci. USA 101, 13613-13617 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 13613-13617
-
-
Aoki, M.1
Jiang, H.2
Vogt, P.K.3
-
76
-
-
0035916325
-
KIP1 through the ubiquitin E3 ligase SCF (SKP2)
-
KIP1 through the ubiquitin E3 ligase SCF (SKP2). Curr. Biol. 11, 263-267 (2001).
-
(2001)
Curr. Biol
, vol.11
, pp. 263-267
-
-
Mamillapalli, R.1
-
77
-
-
33749188883
-
-
van der Horst, A. et al. FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nature Cell Biol. 8, 1064-1073 (2006). Shows for the first time that FOXOs are subject to monoubiquitylation and regulation by USP7 (HAUSP).
-
van der Horst, A. et al. FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nature Cell Biol. 8, 1064-1073 (2006). Shows for the first time that FOXOs are subject to monoubiquitylation and regulation by USP7 (HAUSP).
-
-
-
-
78
-
-
18844382368
-
Functional interaction between β-catenin and FOXO in oxidative stress signaling
-
Essers, M. A. et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 308, 1181-1184 (2005).
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
-
79
-
-
2442429306
-
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
-
Tsuruta, F. et al. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 23, 1889-1899 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 1889-1899
-
-
Tsuruta, F.1
-
80
-
-
0034708832
-
2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307
-
2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J. Biol. Chem. 275, 9047-9054 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
81
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
el-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
el-Deiry, W.S.1
-
82
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano, K. & Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
83
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673-682 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
84
-
-
0037564169
-
Singlet oxygen-mediated damage to proteins and its consequences
-
Davies, M. J. Singlet oxygen-mediated damage to proteins and its consequences. Biochem. Biophys. Res. Commun. 305, 761-770 (2003).
-
(2003)
Biochem. Biophys. Res. Commun
, vol.305
, pp. 761-770
-
-
Davies, M.J.1
-
85
-
-
85047695800
-
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
-
Trinei, M. et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene 21, 3872-3878 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 3872-3878
-
-
Trinei, M.1
-
86
-
-
0035945676
-
Reciprocal down-regulation of p53 and SOD2 gene expression - implication in p53 mediated apoptosis
-
Drane, P., Bravard, A., Bouvard, V. & May, E. Reciprocal down-regulation of p53 and SOD2 gene expression - implication in p53 mediated apoptosis. Oncogene 20, 430-439 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 430-439
-
-
Drane, P.1
Bravard, A.2
Bouvard, V.3
May, E.4
-
87
-
-
0034662602
-
Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells
-
Pani, G. et al. Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells. Cancer Res. 60, 4654-4660 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 4654-4660
-
-
Pani, G.1
-
88
-
-
11144356558
-
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis
-
Hussain, S. P. et al. p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Res. 64, 2350-2356 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 2350-2356
-
-
Hussain, S.P.1
-
89
-
-
18144382261
-
p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
-
Zhao, Y. et al. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res. 65, 3745-3750 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 3745-3750
-
-
Zhao, Y.1
-
90
-
-
11244347171
-
Glycolytic enzymes can modulate cellular life span
-
Kondoh, H. et al. Glycolytic enzymes can modulate cellular life span. Cancer Res. 65, 177-185 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 177-185
-
-
Kondoh, H.1
-
91
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad, K. et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120 (2006).
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
-
92
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650-1653 (2006).
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
-
93
-
-
0037716990
-
Mitochondrial impairment in p53-deficient human cancer cells
-
Zhou, S., Kachhap, S. & Singh, K. K. Mitochondrial impairment in p53-deficient human cancer cells. Mutagenesis 18, 287-292 (2003).
-
(2003)
Mutagenesis
, vol.18
, pp. 287-292
-
-
Zhou, S.1
Kachhap, S.2
Singh, K.K.3
-
94
-
-
15844382488
-
-
Maiyar, A. C., Huang, A. J., Phu, P. T., Cha, H. H. & Firestone, G. L. p53 stimulates promoter activity of the sgk. serum/glucocorticoid- inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J. Biol. Chem. 271, 12414-12422 (1996).
-
Maiyar, A. C., Huang, A. J., Phu, P. T., Cha, H. H. & Firestone, G. L. p53 stimulates promoter activity of the sgk. serum/glucocorticoid- inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J. Biol. Chem. 271, 12414-12422 (1996).
-
-
-
-
95
-
-
4644279286
-
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1
-
You, H. et al. p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc. Natl Acad. Sci. USA 101, 14057-14062 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 14057-14062
-
-
You, H.1
-
96
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic, V. et al. Regulation of PTEN transcription by p53. Mol. Cell 8, 317-325 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
-
97
-
-
18344380088
-
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas
-
Singh, B. et al. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev. 16, 984-993 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 984-993
-
-
Singh, B.1
-
98
-
-
0033119428
-
Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells
-
Fukazawa, T. et al. Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells. Oncogene 18, 2189-2199 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 2189-2199
-
-
Fukazawa, T.1
-
99
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane, J., Le, H. V., Shen, L., Anderson, S. A. & Massague, J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117, 211-223 (2004).
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massague, J.5
-
100
-
-
0037134040
-
-
Tran, H. et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530-534 (2002).
-
Tran, H. et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530-534 (2002).
-
-
-
-
101
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
-
Kastan, M. B. et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
-
(1992)
Cell
, vol.71
, pp. 587-597
-
-
Kastan, M.B.1
-
102
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
Nemoto, S., Fergusson, M. M. & Finkel, T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306, 2105-2108 (2004).
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
103
-
-
12644278836
-
Conformation-dependent phosphorylation of p53
-
Adler, V. et al. Conformation-dependent phosphorylation of p53. Proc. Natl Acad. Sci. USA 94, 1686-1691 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 1686-1691
-
-
Adler, V.1
-
104
-
-
0035913911
-
Negative control of p53 by Sir2α promotes cell survival under stress
-
Luo, J. et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (2001).
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
105
-
-
0035913903
-
-
Vaziri, H. et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001). References 104 and 105 demonstrate a role for SIRT1 in the regulation of p53.
-
Vaziri, H. et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001). References 104 and 105 demonstrate a role for SIRT1 in the regulation of p53.
-
-
-
-
106
-
-
0037061508
-
-
Li, M. et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653 (2002). Identifies USP7 (HAUSP) as a deubiquitylating enzyme for p53.
-
Li, M. et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 416, 648-653 (2002). Identifies USP7 (HAUSP) as a deubiquitylating enzyme for p53.
-
-
-
-
107
-
-
0348134742
-
Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2
-
Li, M. et al. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302, 1972-1975 (2003).
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
-
108
-
-
0034745050
-
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
-
Buschmann, T. et al. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell Biol. 21, 2743-2754 (2001).
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 2743-2754
-
-
Buschmann, T.1
-
109
-
-
0032167915
-
MEKK1/JNK signaling stabilizes and activates p53
-
Fuchs, S. Y., Adler, V., Pincus, M. R. & Ronai, Z. MEKK1/JNK signaling stabilizes and activates p53. Proc. Natl Acad. Sci. USA 95, 10541-10546 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 10541-10546
-
-
Fuchs, S.Y.1
Adler, V.2
Pincus, M.R.3
Ronai, Z.4
-
110
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner, S. D. et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53 (2002).
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
111
-
-
0037112844
-
-
Garcia-Cao, I. et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235 (2002). References 110 and 111 describe a role for p53 in the trade-off between cancer and lifespan.
-
Garcia-Cao, I. et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J. 21, 6225-6235 (2002). References 110 and 111 describe a role for p53 in the trade-off between cancer and lifespan.
-
-
-
-
112
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
van Heemst, D. et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40, 11-15 (2005).
-
(2005)
Exp. Gerontol
, vol.40
, pp. 11-15
-
-
van Heemst, D.1
-
113
-
-
28544444366
-
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
-
Ford, J., Jiang, M. & Milner, J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 65, 10457-10463 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
114
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt, K. et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2, e40 (2006).
-
(2006)
PLoS Genet
, vol.2
-
-
Pruitt, K.1
-
115
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg, B. et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66, 4368-4377 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
-
116
-
-
33646835771
-
HAUSP as a therapeutic target for hematopoietic tumors
-
Cheon, K. W. & Baek, K. H. HAUSP as a therapeutic target for hematopoietic tumors . Int. J. Oncol. 28, 1209-1215 (2006).
-
(2006)
Int. J. Oncol
, vol.28
, pp. 1209-1215
-
-
Cheon, K.W.1
Baek, K.H.2
-
117
-
-
33645240086
-
The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways
-
Masuya, D. et al. The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways. J. Pathol. 208, 724-732 (2006).
-
(2006)
J. Pathol
, vol.208
, pp. 724-732
-
-
Masuya, D.1
-
118
-
-
0041302157
-
-
Bennett, B. L., Satoh, Y. & Lewis, A. J. JNK: a new therapeutic target for diabetes. Curr. Opin. Pharmacol. 3, 420-425 (2003).
-
Bennett, B. L., Satoh, Y. & Lewis, A. J. JNK: a new therapeutic target for diabetes. Curr. Opin. Pharmacol. 3, 420-425 (2003).
-
-
-
-
119
-
-
23944466208
-
Context-specific inhibition of JNKs: Overcoming the dilemma of protection and damage
-
Waetzig, V. & Herdegen, T. Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage. Trends Pharmacol. Sci. 26, 455-461 (2005).
-
(2005)
Trends Pharmacol. Sci
, vol.26
, pp. 455-461
-
-
Waetzig, V.1
Herdegen, T.2
-
120
-
-
4444287774
-
-
Vlahopoulos, S. & Zoumpourlis, V. C. JNK: a key modulator of intracellular signaling. Biochemistry (Mosc.) 69, 844-854 (2004).
-
Vlahopoulos, S. & Zoumpourlis, V. C. JNK: a key modulator of intracellular signaling. Biochemistry (Mosc.) 69, 844-854 (2004).
-
-
-
-
121
-
-
28244475950
-
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
-
Wang, Y. & Tissenbaum, H. A. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 127, 48-56 (2006).
-
(2006)
Mech. Ageing Dev
, vol.127
, pp. 48-56
-
-
Wang, Y.1
Tissenbaum, H.A.2
-
122
-
-
33744471133
-
Aging in mouse and human systems: A comparative study
-
Demetrius, L. Aging in mouse and human systems: a comparative study. Ann. NY Acad. Sci. 1067, 66-82 (2006).
-
(2006)
Ann. NY Acad. Sci
, vol.1067
, pp. 66-82
-
-
Demetrius, L.1
-
123
-
-
32444435024
-
Caloric restriction and aging: Controversial issues
-
Masoro, E. J. Caloric restriction and aging: controversial issues. J. Gerontol. A Biol. Sci. Med. Sci. 61, 14-19 (2006).
-
(2006)
J. Gerontol. A Biol. Sci. Med. Sci
, vol.61
, pp. 14-19
-
-
Masoro, E.J.1
-
124
-
-
23644446635
-
Why dietary restriction substantially increases longevity in animal models but won't in humans
-
Phelan, J. P. & Rose, M. R. Why dietary restriction substantially increases longevity in animal models but won't in humans. Ageing Res. Rev. 4, 339-350 (2005).
-
(2005)
Ageing Res. Rev
, vol.4
, pp. 339-350
-
-
Phelan, J.P.1
Rose, M.R.2
-
125
-
-
28244466940
-
Caloric restriction in humans: Potential pitfalls and health concerns
-
Dirks, A. J. & Leeuwenburgh, C. Caloric restriction in humans: potential pitfalls and health concerns. Mech. Ageing Dev. 127, 1-7 (2006).
-
(2006)
Mech. Ageing Dev
, vol.127
, pp. 1-7
-
-
Dirks, A.J.1
Leeuwenburgh, C.2
-
127
-
-
33846208251
-
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
-
Asada, S. et al. Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal. 19, 519-527 (2007).
-
(2007)
Cell Signal
, vol.19
, pp. 519-527
-
-
Asada, S.1
|