-
1
-
-
62549162170
-
Genomics and cardiovascular drug development
-
Plump AS, Lum PY: Genomics and cardiovascular drug development. J. Am. Coll. Cardiol. 53, 1089-1100 (2009).
-
(2009)
J. Am. Coll. Cardiol.
, vol.53
, pp. 1089-1100
-
-
Plump, A.S.1
Lum, P.Y.2
-
2
-
-
77949913670
-
Secondary prevention strategies for coronary heart disease
-
Weiner SD, Rabbani LE: Secondary prevention strategies for coronary heart disease. J. Throm. Thrombolysis 29(1), 8-24 (2010).
-
(2010)
J. Throm. Thrombolysis
, vol.29
, Issue.1
, pp. 8-24
-
-
Weiner, S.D.1
Rabbani, L.E.2
-
3
-
-
39749191084
-
Heart disease and stroke statistics: 2008 update: A report from the American heart association statistics committee and stroke statistics subcommittee
-
Rosamond W, Flegal K, Furie K et al.: Heart disease and stroke statistics: 2008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117, e25-e146 (2008).
-
(2008)
Circulation
, vol.117
-
-
Rosamond, W.1
Flegal, K.2
Furie, K.3
-
4
-
-
60449094498
-
Heart disease and stroke statistics-2009 update: A report from the American heart association statistics committee and stroke statistics subcommittee
-
Lloyd-Jones D, Adams R, Carnethon M et al.: Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, 480-486 (2009).
-
(2009)
Circulation
, vol.119
, pp. 480-486
-
-
Lloyd-Jones, D.1
Adams, R.2
Carnethon, M.3
-
5
-
-
33644850953
-
Obesity and cardiovascular diseases: Pathophysiology, evaluation and effect of weight loss: An update of the 1997 American heart association statement on obesity and heart disease from the obesity committee of the council on nutrition, physical activity, and metabolism
-
Poirier P, Giles TD, Bray GA et al.: Obesity and cardiovascular diseases: Pathophysiology, evaluation and effect of weight loss: An update of the 1997 American Heart Association Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113, 898-918 (2006).
-
(2006)
Circulation
, vol.113
, pp. 898-918
-
-
Poirier, P.1
Giles, T.D.2
Bray, G.A.3
-
6
-
-
42649131079
-
Overweight and obesity: Key components of cradiometabolic risk
-
Aronne LJ, Isoldi KK: Overweight and obesity: Key components of cradiometabolic risk. Clin. Cornerstone 8, 29-37 (2007).
-
(2007)
Clin. Cornerstone
, vol.8
, pp. 29-37
-
-
Aronne, L.J.1
Isoldi, K.K.2
-
7
-
-
65549109680
-
Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss
-
Lavie CJ, Milani RV, Ventura HO: Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss. J. Am. Coll. Cardiol. 53, 1925-1932 (2009).
-
(2009)
J. Am. Coll. Cardiol.
, vol.53
, pp. 1925-1932
-
-
Lavie, C.J.1
Milani, R.V.2
Ventura, H.O.3
-
8
-
-
65349195631
-
The obesity, metabolic syndrome, and Type 2 diabetes mellitus pandemic: Part I: Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and Type 2 diabetes mellitus
-
Ginsberg HN, MacCallum PR: The obesity, metabolic syndrome, and Type 2 diabetes mellitus pandemic: Part I: Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and Type 2 diabetes mellitus. J. Cardiometab. Syndr. 4, 113-119 (2009).
-
(2009)
J. Cardiometab. Syndr.
, vol.4
, pp. 113-119
-
-
Ginsberg, H.N.1
MacCallum, P.R.2
-
9
-
-
33644533580
-
Diabetes mellitus-associated atherosclerosis: Mechanisms involved and potential for pharmacological invention
-
Calkin AC, Allen TJ: Diabetes mellitus-associated atherosclerosis: Mechanisms involved and potential for pharmacological invention. Am. J. Cardiovasc Drugs 61, 15-40 (2006).
-
(2006)
Am. J. Cardiovasc Drugs
, vol.61
, pp. 15-40
-
-
Calkin, A.C.1
Allen, T.J.2
-
10
-
-
33847063390
-
Multiple risk factors for cardiovascular disease and diabetes mellitus
-
Smith SC: Multiple risk factors for cardiovascular disease and diabetes mellitus. Am. J. Med. 120, S3-S11 (2007).
-
(2007)
Am. J. Med.
, vol.120
-
-
Smith, S.C.1
-
11
-
-
55849120862
-
Epidemiology of diabetes and diabetes-related complications
-
Deshpande AD, Harris-Hays M, Schootman M: Epidemiology of diabetes and diabetes-related complications. Phys. Ther. 88, 1254-1264 (2008).
-
(2008)
Phys. Ther.
, vol.88
, pp. 1254-1264
-
-
Deshpande, A.D.1
Harris-Hays, M.2
Schootman, M.3
-
13
-
-
33646432226
-
Overweight and obesity: Prevalence, consequences, and causes of a growing public health problem
-
Wyatt SB, Winters KP, Dubbert PM: Overweight and obesity: Prevalence, consequences, and causes of a growing public health problem. Am. J. Med. Sci. 331, 166-174 (2006).
-
(2006)
Am. J. Med. Sci.
, vol.331
, pp. 166-174
-
-
Wyatt, S.B.1
Winters, K.P.2
Dubbert, P.M.3
-
14
-
-
39649092297
-
Obesity, metabolic syndrome, and Type 2 diabetes: Inflammatory basis of glucose metabolic disorders
-
Pradhan A: Obesity, metabolic syndrome, and Type 2 diabetes: Inflammatory basis of glucose metabolic disorders. Nutr. Rev. 65, S152-S156 (2007).
-
(2007)
Nutr. Rev.
, vol.65
-
-
Pradhan, A.1
-
15
-
-
39749147110
-
Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and b-cell failure in Type 2 diabetes
-
Muoio DM, Newgard CB: Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and b-cell failure in Type 2 diabetes. Nat. Rev. Mol. Cell. Biol. 9, 193-205 (2008).
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 193-205
-
-
Muoio, D.M.1
Newgard, C.B.2
-
16
-
-
39749172476
-
The metabolic syndrome: Definitions, prevalence and mangement
-
Levesque J, Lamarche B: The metabolic syndrome: Definitions, prevalence and mangement. J. Nutrigenet. Nutrigenomics 1, 100-108 (2008).
-
(2008)
J. Nutrigenet. Nutrigenomics
, vol.1
, pp. 100-108
-
-
Levesque, J.1
Lamarche, B.2
-
18
-
-
34249289000
-
PPARa: Its role in the human metabolic syndrome
-
Azhar S, Kelley G: PPARa: Its role in the human metabolic syndrome. Future Lipidol. 2, 31-53 (2007).
-
(2007)
Future Lipidol.
, vol.2
, pp. 31-53
-
-
Azhar, S.1
Kelley, G.2
-
19
-
-
27444443876
-
Diagnosis and management of the metabolic syndrome: An American heart association/national heart, lung, and blood institute scientific statement
-
Grundy SM: Cleeman JI, Daniels SR et al.: Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112, 2735-2752 (2005).
-
(2005)
Circulation
, vol.112
, pp. 2735-2752
-
-
Grundy, S.M.1
Cleeman, J.I.2
Daniels, S.R.3
-
21
-
-
70350245011
-
Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung and Blood Institute; American Heart Association; World heart federation; international atherosclerosis society; and international association for the study of obesity
-
Alberti KG, Eckel RH, Grundy SM et al.: Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120, 1640-1645 (2009).
-
(2009)
Circulation
, vol.120
, pp. 1640-1645
-
-
Alberti, K.G.1
Eckel, R.H.2
Grundy, S.M.3
-
22
-
-
12344304272
-
Metabolic syndrome: Definition, pathophysiology, and mechanisms
-
Miranda PJ, DeFronzo RA, Califf RM: Metabolic syndrome: Definition, pathophysiology, and mechanisms. Am. Heart J. 149, 33-45 (2005).
-
(2005)
Am. Heart J.
, vol.149
, pp. 33-45
-
-
Miranda, P.J.1
DeFronzo, R.A.2
Califf, R.M.3
-
23
-
-
33645304589
-
Insulin resistance, the insulin resistance syndrome, and cardiovascular disease
-
Reaven GM: Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. Panminerva Med. 47, 201-210 (2005).
-
(2005)
Panminerva Med.
, vol.47
, pp. 201-210
-
-
Reaven, G.M.1
-
25
-
-
73249128357
-
The metabolic syndrome: Common origins of a multifactorial disorder
-
Bruce KD, Byrne CD: The metabolic syndrome: Common origins of a multifactorial disorder. Postgrad. Med. J. 85, 614-621 (2009).
-
(2009)
Postgrad. Med. J.
, vol.85
, pp. 614-621
-
-
Bruce, K.D.1
Byrne, C.D.2
-
26
-
-
74049154021
-
The metabolic syndrome: Definition, global impact, and pathophysiology
-
Potenza MV, Mechanick JI: The metabolic syndrome: Definition, global impact, and pathophysiology. Nutr. Clin. Pract. 24, 560-577 (2009).
-
(2009)
Nutr. Clin. Pract.
, vol.24
, pp. 560-577
-
-
Potenza, M.V.1
Mechanick, J.I.2
-
28
-
-
17844367331
-
Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome
-
Apridonidze T, Essah PA, Luorno MJ, Nestler JE: Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 90, 1929-1935 (2005).
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 1929-1935
-
-
Apridonidze, T.1
Essah, P.A.2
Luorno, M.J.3
Nestler, J.E.4
-
29
-
-
11844257549
-
Metabolic syndrome among HIV-infected patients: Prevalence, characteristics, and related factors
-
Jerico C, Knobel H, Montero M et al.: Metabolic syndrome among HIV-infected patients: Prevalence, characteristics, and related factors. Diabetes Care 28, 132-137 (2005).
-
(2005)
Diabetes Care
, vol.28
, pp. 132-137
-
-
Jerico, C.1
Knobel, H.2
Montero, M.3
-
31
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications: Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications: Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Metab. 15, 539-553 (1998).
-
(1998)
Diabet. Metab.
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
32
-
-
0032709705
-
Comment on the provisional report from the WHO consultation: European group for the study of insulin resistance (EGIR)
-
Balkau B, Charles MA: Comment on the provisional report from the WHO consultation: European Group for the Study of insulin Resistance (EGIR). Diabet. Med. 16, 442-443 (1999).
-
(1999)
Diabet. Med.
, vol.16
, pp. 442-443
-
-
Balkau, B.1
Charles, M.A.2
-
33
-
-
0035897696
-
Executive summary of the third report of the Nationnal Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III)
-
Executive summary of the third report of the Nationnal Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285, 2486-2497 (2001).
-
(2001)
JAMA
, vol.285
, pp. 2486-2497
-
-
-
34
-
-
0842277242
-
Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
-
Grudy SM, Brewer HB Jr, Cleeman JI et al.: Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109, 433-438 (2004).
-
(2004)
Circulation
, vol.109
, pp. 433-438
-
-
Grudy, S.M.1
Brewer Jr., H.B.2
Cleeman, J.I.3
-
35
-
-
27444443876
-
Diagnosis and management of the metabolic syndrome: An American heart association/national heart, lung, and blood institute scientific statement
-
Grundy SM, Cleeman JI, Daniels SR et al.: Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112, 2735-2752 (2005).
-
(2005)
Circulation
, vol.112
, pp. 2735-2752
-
-
Grundy, S.M.1
Cleeman, J.I.2
Daniels, S.R.3
-
36
-
-
0347853481
-
American College of Endocrinology position statement on the insulin resistance syndrome
-
Einhorn D, Reaven GM, Cobin RH et al.: American College of Endocrinology position statement on the insulin resistance syndrome. Endocr. Pract. 9, 237-252 (2003).
-
(2003)
Endocr. Pract.
, vol.9
, pp. 237-252
-
-
Einhorn, D.1
Reaven, G.M.2
Cobin, R.H.3
-
37
-
-
25144459980
-
The metabolic syndrome - A new worldwide definition
-
DOI 10.1016/S0140-6736(05)67402-8, PII S0140673605674028
-
Alberti KG, Zimmet P, Shaw J: The metabolic syndrome - a new worldwide definition. Lancet 366, 1059-1062 (2005). (Pubitemid 41338752)
-
(2005)
Lancet
, vol.366
, Issue.9491
, pp. 1059-1062
-
-
Alberti, K.G.M.M.1
Zimmet, P.2
Shaw, J.3
-
38
-
-
55849137212
-
Obesity and the metabolic syndrome in developing countries
-
Misra A, Khurana L: Obesity and the metabolic syndrome in developing countries. J. Clin. Endocrinol. Metab. 93, S9-S30 (2008).
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
-
-
Misra, A.1
Khurana, L.2
-
40
-
-
33845259380
-
Challenges associated with metabolic syndrome
-
Spinler SA: Challenges associated with metabolic syndrome. Pharmacotherapy 26, 209S-217S (2006).
-
(2006)
Pharmacotherapy
, vol.26
-
-
Spinler, S.A.1
-
41
-
-
37849002520
-
Epidemiology of paediatric metabolic syndrome and Type 2 diabetes mellitus
-
Epidemiology of paediatric metabolic syndrome and Type 2 diabetes mellitus. Diab. Vasc. Dis. Res. 4, 285-296 (2007).
-
(2007)
Diab. Vasc. Dis. Res.
, vol.4
, pp. 285-296
-
-
-
42
-
-
34548726311
-
The metabolic syndrome in children and adolescents - An IDF consensus report
-
Zimmet P, Alberti KG, Kaufman F et al.: The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr. Diabetes 8, 299-306 (2007).
-
(2007)
Pediatr. Diabetes
, vol.8
, pp. 299-306
-
-
Zimmet, P.1
Alberti, K.G.2
Kaufman, F.3
-
43
-
-
43649091349
-
Prevalence of the metabolic syndrome among US adolescents using the definition from the internatioanl diabetes federation
-
Ford ES, Li C, Zhao G, Pearson WS, Mokad AH: Prevalence of the metabolic syndrome among US adolescents using the definition from the Internatioanl Diabetes Federation. Diabetes Care 31, 587-589 (2008).
-
(2008)
Diabetes Care
, vol.31
, pp. 587-589
-
-
Ford, E.S.1
Li, C.2
Zhao, G.3
Pearson, W.S.4
Mokad, A.H.5
-
44
-
-
33644652183
-
Sorting out the roles of PPARa in energy metabolism and vascular homeostasis
-
Lefebvre P, Chinetti G, Fruchart JC, Staels B: Sorting out the roles of PPARa in energy metabolism and vascular homeostasis. J. Clin. Invest. 116, 571-580 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 571-580
-
-
Lefebvre, P.1
Chinetti, G.2
Fruchart, J.C.3
Staels, B.4
-
45
-
-
33644645013
-
PPARd: A dagger in the heart of the metabolic syndrome
-
Barish GD, Narkar VA, Evans RM: PPARd: A dagger in the heart of the metabolic syndrome. J. Clin. Invest. 116, 590-597 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 590-597
-
-
Barish, G.D.1
Narkar, V.A.2
Evans, R.M.3
-
47
-
-
32644460092
-
From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
-
Fiege JN, Gelman L, Michalik L, Desvergne B, Wahli W: From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog. Lipid Res. 45, 120-159 (2006).
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 120-159
-
-
Fiege, J.N.1
Gelman, L.2
Michalik, L.3
Desvergne, B.4
Wahli, W.5
-
49
-
-
50649097541
-
Fat and beyond: The diverse biology of PPARg
-
Tontonoz P, Spiegelman BM: Fat and beyond: The diverse biology of PPARg. Annu. Rev. Biochem. 77, 289-312 (2008).
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 289-312
-
-
Tontonoz, P.1
Spiegelman, B.M.2
-
50
-
-
76749137586
-
Peroxisome proliferator-activated receptor b/d (PPARb/d) acts as regulator of metabolism linked to multiple cellular functions
-
Wagner KD, Wagner N: Peroxisome proliferator-activated receptor b/d (PPARb/d) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol. Ther. 125, 423-435 (2010).
-
(2010)
Pharmacol. Ther.
, vol.125
, pp. 423-435
-
-
Wagner, K.D.1
Wagner, N.2
-
51
-
-
33644828263
-
Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes
-
DOI 10.1161/01.ATV.0000191663.12164.77, PII 0004360520060100000008
-
Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA: Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in Type 2 diabetes. Arterioscler. Thromb. Vasc. Biol. 26, 28-40 (2006). (Pubitemid 43732225)
-
(2006)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.26
, Issue.1
, pp. 28-40
-
-
Blaschke, F.1
Takata, Y.2
Caglayan, E.3
Law, R.E.4
Hsueh, W.A.5
-
52
-
-
47949094965
-
Integration of metabolism and inflammation by lipid-activated nuclear receptors
-
Bensinger SJ, Tontonoz P: Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454, 470-477 (2008).
-
(2008)
Nature
, vol.454
, pp. 470-477
-
-
Bensinger, S.J.1
Tontonoz, P.2
-
53
-
-
37349007681
-
PPARd as a therapeutic target in metabolic disease
-
Reilly SM, Lee C-H: PPARd as a therapeutic target in metabolic disease. FEBS Lett. 582, 26-31 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 26-31
-
-
Reilly, S.M.1
Lee, C.-H.2
-
54
-
-
67349155584
-
Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease
-
Robinson E, Grieve DJ: Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease. Pharmacol. Ther. 122, 246-263 (2009).
-
(2009)
Pharmacol. Ther.
, vol.122
, pp. 246-263
-
-
Robinson, E.1
Grieve, D.J.2
-
56
-
-
33846623798
-
Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
-
Brown JD, Plutzky J: Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 115, 518-533 (2007).
-
(2007)
Circulation
, vol.115
, pp. 518-533
-
-
Brown, J.D.1
Plutzky, J.2
-
57
-
-
40049109970
-
Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis
-
Hansen MK, Connolly TM: Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis. Curr. Opin. Investig. Drug. 9, 247-255 (2008).
-
(2008)
Curr. Opin. Investig. Drug.
, vol.9
, pp. 247-255
-
-
Hansen, M.K.1
Connolly, T.M.2
-
58
-
-
37549041988
-
Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome?
-
Barter PJ, Rye K-A: Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome? Arterioscler Thromb. Vasc. Biol. 28,39-46 (2008).
-
(2008)
Arterioscler Thromb. Vasc. Biol.
, vol.28
, pp. 39-46
-
-
Barter, P.J.1
Rye, K.-A.2
-
60
-
-
19244365650
-
Thiazolidinediones
-
Yki-Järvinen H: Thiazolidinediones. N. Engl. J. Med. 35, 1106-1118 (2004).
-
(2004)
N. Engl. J. Med.
, vol.35
, pp. 1106-1118
-
-
Yki-Järvinen, H.1
-
61
-
-
67449103220
-
Redefining the role of thiazolidinediones in the management of Type 2 diabetes
-
Barnett AH: Redefining the role of thiazolidinediones in the management of Type 2 diabetes. Vasc. Health Risk Manag. 5, 141-151 (2009).
-
(2009)
Vasc. Health Risk Manag.
, vol.5
, pp. 141-151
-
-
Barnett, A.H.1
-
62
-
-
33846443997
-
Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist
-
Sprecher DL, Massien C, Pearce G et al.: Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist. Arterioscler. Thromb. Vasc. Biol. 27, 359-365 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 359-365
-
-
Sprecher, D.L.1
Massien, C.2
Pearce, G.3
-
63
-
-
39649101196
-
Activation of peroxisome proliferator-activated receptor (PPAR) d promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
-
Risérus U, Sprecher D, Johnson T et al.: Activation of peroxisome proliferator-activated receptor (PPAR) d promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes 57, 332-339 (2008).
-
(2008)
Diabetes
, vol.57
, pp. 332-339
-
-
Risérus, U.1
Sprecher, D.2
Johnson, T.3
-
64
-
-
33747154772
-
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
-
Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ: Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126, 789-799 (2006).
-
(2006)
Cell
, vol.126
, pp. 789-799
-
-
Bookout, A.L.1
Jeong, Y.2
Downes, M.3
Yu, R.T.4
Evans, R.M.5
Mangelsdorf, D.J.6
-
65
-
-
33751533892
-
International union of pharmacology. LXI. Peroxisome proliferator- activated receptors
-
Michalik L, Auwerx J, Berger JP et al.: International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol. Rev. 58(4), 726-741 (2006).
-
(2006)
Pharmacol. Rev.
, vol.58
, Issue.4
, pp. 726-741
-
-
Michalik, L.1
Auwerx, J.2
Berger, J.P.3
-
66
-
-
33646776061
-
Peroxisome proliferator-activated receptor g as a drug target in the pathogenesis of insulin resistance
-
Guo L, Tabrizchi R: Peroxisome proliferator-activated receptor g as a drug target in the pathogenesis of insulin resistance. Pharmacol. Ther. 111, 145-173 (2006).
-
(2006)
Pharmacol. Ther.
, vol.111
, pp. 145-173
-
-
Guo, L.1
Tabrizchi, R.2
-
68
-
-
34547604561
-
Transcription coactivators for peroxisome proliferator-activated receptors
-
Yu S, Reddy JK: Transcription coactivators for peroxisome proliferator-activated receptors. Biochim. Biophys. Acta 1771, 936-951 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 936-951
-
-
Yu, S.1
Reddy, J.K.2
-
69
-
-
40049088000
-
PPARa: Mechansim of species differences and hepatocarcinogenesis of peroxisome proliferators
-
Gozalez FJ, Shah YM: PPARa: Mechansim of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 246, 2-8 (2008).
-
(2008)
Toxicology
, vol.246
, pp. 2-8
-
-
Gozalez, F.J.1
Shah, Y.M.2
-
70
-
-
77954987061
-
PPARa: Energy combustion, hypolipidemia, inflammation and cancer
-
Pyper SR, Viswakarma N, Yu S, Reddy JK: PPARa: Energy combustion, hypolipidemia, inflammation and cancer. Nucl. Recep. Signal. 8, 2002 (2010).
-
(2010)
Nucl. Recep. Signal.
, vol.8
, pp. 2002
-
-
Pyper, S.R.1
Viswakarma, N.2
Yu, S.3
Reddy, J.K.4
-
71
-
-
65349091310
-
PPARs and the cardiovascular system
-
Hamblin M, Chang L, Fan Y, Zhang J, Chen YE: PPARs and the cardiovascular system. Antioxid. Redox Signal. 11, 1-38 (2009).
-
(2009)
Antioxid. Redox Signal.
, vol.11
, pp. 1-38
-
-
Hamblin, M.1
Chang, L.2
Fan, Y.3
Zhang, J.4
Chen, Y.E.5
-
72
-
-
33748433528
-
Fibrate therapy in patients with metabolic syndrome and diabetes mellitus
-
Dayspring T, Pokrywka G: Fibrate therapy in patients with metabolic syndrome and diabetes mellitus. Curr. Atheroscler. Rep. 8, 356-364 (2006).
-
(2006)
Curr. Atheroscler. Rep.
, vol.8
, pp. 356-364
-
-
Dayspring, T.1
Pokrywka, G.2
-
73
-
-
67449108376
-
Peroxisome proliferator-activated receptor - A (PPARa): At the crossroads of obesity, diabetes and cardiovascular disease
-
Fruchart J-C: Peroxisome proliferator-activated receptor-a (PPARa): At the crossroads of obesity, diabetes and cardiovascular disease. Atherosclerosis 205, 1-8 (2009).
-
(2009)
Atherosclerosis
, vol.205
, pp. 1-8
-
-
Fruchart, J.-C.1
-
74
-
-
33746377553
-
Obesity-related derangements in metabolic regulation
-
Muoio DM, Newgard CB: Obesity-related derangements in metabolic regulation. Annu. Rev. Biocem. 75, 367-401 (2006).
-
(2006)
Annu Rev. Biocem.
, vol.75
, pp. 367-401
-
-
Muoio, D.M.1
Newgard, C.B.2
-
75
-
-
33746255676
-
Association of V227A PPARa polymorphism with altered serum biochemistry and alcohol drinking in Japanese men
-
Naito H, Yamanoshita O, Kamijima M et al.: Association of V227A PPARa polymorphism with altered serum biochemistry and alcohol drinking in Japanese men. Pharmacogenet. Genomics 16, 569-577 (2006).
-
(2006)
Pharmacogenet. Genomics
, vol.16
, pp. 569-577
-
-
Naito, H.1
Yamanoshita, O.2
Kamijima, M.3
-
76
-
-
41649120952
-
Single gene contributions: Genetic variants of proliferator-activated receptor (isoforms a, b/d and g) and mechanisms of dyslipidemias
-
Yong EL, Li J, Liu MH: Single gene contributions: Genetic variants of proliferator-activated receptor (isoforms a, b/d and g) and mechanisms of dyslipidemias: Curr. Opin. Lipidol. 19, 106-112 (2008).
-
(2008)
Curr. Opin. Lipidol.
, vol.19
, pp. 106-112
-
-
Yong, E.L.1
Li, J.2
Liu, M.H.3
-
77
-
-
43049115747
-
A natural polymorphism in the peroxisome prolifertaor-activated receptor - A hinge region attenuates transcription due to defective release of nuclear receptor coreprssor from chromatin
-
Liu MH, Li J, Shen P, Husna B, Tai ES, Yong EL: A natural polymorphism in the peroxisome prolifertaor-activated receptor-a hinge region attenuates transcription due to defective release of nuclear receptor coreprssor from chromatin. Mol. Endocrinol. 22, 1078-1092 (2008).
-
(2008)
Mol. Endocrinol.
, vol.22
, pp. 1078-1092
-
-
Liu, M.H.1
Li, J.2
Shen, P.3
Husna, B.4
Tai, E.S.5
Yong, E.L.6
-
78
-
-
33745889984
-
The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women
-
Chan E, Tan CS, Deurenberg-Yap M, Chia KS, Chew SK, Tai ES: The V227A polymorphism at the PPARA locus is associated with serum lipid concentrations and modulates the association between dietary polyunsaturated fatty acid intake and serum high density lipoprotein concentrations in Chinese women. Atherosclerosis 187, 309-315 (2006).
-
(2006)
Atherosclerosis
, vol.187
, pp. 309-315
-
-
Chan, E.1
Tan, C.S.2
Deurenberg-Yap, M.3
Chia, K.S.4
Chew, S.K.5
Tai, E.S.6
-
79
-
-
33846382723
-
Relationships between the functional PPARa Leu162Val polymorphism and obesity, Type 2 diabetes, dyslipidemia, and related quantitative traits in studies of 5799 middle-aged white people
-
Sparsø T, Hussain MS, Andersen G et al.: Relationships between the functional PPARa Leu162Val polymorphism and obesity, Type 2 diabetes, dyslipidemia, and related quantitative traits in studies of 5799 middle-aged white people. Mol. Genet. Metab. 90, 205-209 (2007).
-
(2007)
Mol. Genet. Metab.
, vol.90
, pp. 205-209
-
-
Sparsø, T.1
Hussain, M.S.2
Andersen, G.3
-
80
-
-
34548181877
-
Peroxisome proliferator-activated receptor a polymorphisms and postprandial lipemia in healthy men
-
Tanaka T, Ordovas JM, Delgado-Lista J et al.: Peroxisome proliferator-activated receptor a polymorphisms and postprandial lipemia in healthy men. J. Lipid Res. 48, 1402-1408 (2007).
-
(2007)
J. Lipid Res.
, vol.48
, pp. 1402-1408
-
-
Tanaka, T.1
Ordovas, J.M.2
Delgado-Lista, J.3
-
81
-
-
35448951738
-
PPARa L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
-
Uthurralt J, Gordish-Dressman H, Bradbury M et al.: PPARa L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males. BMC Med. Genet. 8, 55 (2007).
-
(2007)
BMC Med. Genet.
, vol.8
, pp. 55
-
-
Uthurralt, J.1
Gordish-Dressman, H.2
Bradbury, M.3
-
82
-
-
62749097983
-
Differences in transcription activation by the two allelic (L162V polymorphic) variants of PPARa after omega-3 fatty acid treatment
-
Rudkowska I, Verrault M, Barbier O, Vohl M-C: Differences in transcription activation by the two allelic (L162V polymorphic) variants of PPARa after omega-3 fatty acid treatment. PPAR Res. 369602 (2009).
-
(2009)
PPAR Res.
, pp. 369602
-
-
Rudkowska, I.1
Verrault, M.2
Barbier, O.3
Vohl, M.-C.4
-
83
-
-
62749204385
-
The L162V polymorphism of the peroxisome proliferator activated receptor a gene (PPAR) is not associated with Type 2 diabetes, BMI or body fat composition
-
Silbernagel G, Stefan N, Hoffmann MM et al.: The L162V polymorphism of the peroxisome proliferator activated receptor a gene (PPAR) is not associated with Type 2 diabetes, BMI or body fat composition. Exp. Clin. Endocrinol. Diabetes 117, 113-118 (2009).
-
(2009)
Exp. Clin. Endocrinol. Diabetes
, vol.117
, pp. 113-118
-
-
Silbernagel, G.1
Stefan, N.2
Hoffmann, M.M.3
-
84
-
-
28844489398
-
Association of common variation in the variation in the PPARa gene withincident myocardial infarction in individuals with Type 2 diabetes: A Go-DARTS study
-
Doney AS, Fischer B, Lee SP, Morris AD, Leese G, Palmer CN: Association of common variation in the variation in the PPARa gene withincident myocardial infarction in individuals with Type 2 diabetes: A Go-DARTS study. Nucl Recept 3, 4 (2005).
-
(2005)
Nucl Recept
, vol.3
, pp. 4
-
-
Doney, A.S.1
Fischer, B.2
Lee, S.P.3
Morris, A.D.4
Leese, G.5
Palmer, C.N.6
-
85
-
-
33845577985
-
The PPAR regulatory system in cardiac physiology and disease
-
Finck BN: The PPAR regulatory system in cardiac physiology and disease. Cardiovasc. Res. 73, 269-277 (2007).
-
(2007)
Cardiovasc. Res.
, vol.73
, pp. 269-277
-
-
Finck, B.N.1
-
86
-
-
34447321069
-
Roles of PPARs on regulating myocardial energy and lipid homeostasis
-
Yang Q, Li Y: Roles of PPARs on regulating myocardial energy and lipid homeostasis. J. Mol Med. 85,697-706 (2007).
-
(2007)
J. Mol Med.
, vol.85
, pp. 697-706
-
-
Yang, Q.1
Li, Y.2
-
87
-
-
44649151707
-
The PPAR trio: Regulators of mitochondrial energy metabolism in health and disease
-
Madarazo JA, Kelley DP: The PPAR trio: Regulators of mitochondrial energy metabolism in health and disease. J. Mol. Cell. Cardiol. 44, 968-975 (2008).
-
(2008)
J. Mol. Cell. Cardiol.
, vol.44
, pp. 968-975
-
-
Madarazo, J.A.1
Kelley, D.P.2
-
88
-
-
37649030647
-
Genetic manipulations of PPARs: Effects on obesity and metabolic disease
-
Barak Y, Kim S: Genetic manipulations of PPARs: Effects on obesity and metabolic disease: PPAR Res. 12781 (2007).
-
(2007)
PPAR Res.
, pp. 12781
-
-
Barak, Y.1
Kim, S.2
-
89
-
-
24144490615
-
Cardiac-specific overexpression of peroxisome proliferator-activated receptor - A causes insulin resistance in heart and liver
-
Park SY, Cho YR, Finck BM et al.: Cardiac-specific overexpression of peroxisome proliferator-activated receptor-a causes insulin resistance in heart and liver. Diabetes 54, 2514-2524 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 2514-2524
-
-
Park, S.Y.1
Cho, Y.R.2
Finck, B.M.3
-
90
-
-
33644662725
-
Chronic activation of PPARa is detrimental to cardiac recovery after ischemia
-
Sambandhan N, Morabito D, Wagg C, Finck BN, Kelly DP, Lopaschuk GD: Chronic activation of PPARa is detrimental to cardiac recovery after ischemia. Am. J. Physiol. Heart Circ. Physiol. 290, H87-H95 (2006).
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.290
-
-
Sambandhan, N.1
Morabito, D.2
Wagg, C.3
Finck, B.N.4
Kelly, D.P.5
Lopaschuk, G.D.6
-
91
-
-
33847110733
-
Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-a/PGC-1a gene regulatory pathway
-
Duncan JG, Fong JL, Mederiros DM, Finck BN, Kelley DP: Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-a/PGC-1a gene regulatory pathway. Circulation 115, 909-917 (2007).
-
(2007)
Circulation
, vol.115
, pp. 909-917
-
-
Duncan, J.G.1
Fong, J.L.2
Mederiros, D.M.3
Finck, B.N.4
Kelley, D.P.5
-
92
-
-
85056058295
-
Causes and characteristics of diabetic cardiomyopathy
-
Wang J, Song Y, Wang Q, Kralik PM, Epstein PN: Causes and characteristics of diabetic cardiomyopathy. Rev Diabt Stud. 3, 108-117 (2005).
-
(2005)
Rev Diabt Stud.
, vol.3
, pp. 108-117
-
-
Wang, J.1
Song, Y.2
Wang, Q.3
Kralik, P.M.4
Epstein, P.N.5
-
93
-
-
19344362320
-
PPAR - A activation required for decreased glucose uptake and increased susceptibility to injury during ischemia
-
Panagia M, Gibbons GF, Radda GK, Clarke K: PPAR-a activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 288, H2677-H2683 (2005).
-
(2005)
Am. J. Physiol. Heart Circ. Physiol.
, vol.288
-
-
Panagia, M.1
Gibbons, G.F.2
Radda, G.K.3
Clarke, K.4
-
94
-
-
33745712686
-
Deletion of peroxisome proliferator-activated receptor - A induces an alteration of cardiac functions
-
Loichot C, Jesel L, Tesse A et al.: Deletion of peroxisome proliferator-activated receptor-a induces an alteration of cardiac functions. Am. J. Physiol. Heart Circ. Physiol. 291, H161-H166 (2006).
-
(2006)
Am. J. Physiol. Heart Circ. Physiol.
, vol.291
-
-
Loichot, C.1
Jesel, L.2
Tesse, A.3
-
95
-
-
41749091835
-
Alterations in carbohydrate metabolism and its regulation in PPARa null mouse hearts
-
Gélinas R, Labarthe F, Bouchard B et al.: Alterations in carbohydrate metabolism and its regulation in PPARa null mouse hearts. Am. J. Physiol. Heart Circ. Physiol. 294, H1571-H1580 (2008).
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.294
-
-
Gélinas, R.1
Labarthe, F.2
Bouchard, B.3
-
96
-
-
41149087688
-
Cardiac hypertrophy is enhanced in PPARa-/- mice in response to chronic pressure overload
-
Sweets PJH, Teunissen BEJ, Willemsen PHM et al.: Cardiac hypertrophy is enhanced in PPARa-/- mice in response to chronic pressure overload. Cardiovas. Res. 78, 79-89 (2008).
-
(2008)
Cardiovas. Res.
, vol.78
, pp. 79-89
-
-
Sweets, P.J.H.1
Teunissen, B.E.J.2
Willemsen, P.H.M.3
-
97
-
-
13944283346
-
Peroxisome proliferator-activated receptors and cardiovascular remodeling
-
Schiffrin EL: Peroxisome proliferator-activated receptors and cardiovascular remodeling. Am. J. Physiol. Heart Circ. Physiol. 288, H1037-H1043 (2005).
-
(2005)
Am. J. Physiol. Heart Circ. Physiol.
, vol.288
-
-
Schiffrin, E.L.1
-
98
-
-
33646524699
-
Peroxisome proliferator-activated receptors and inflammation
-
Moraes L, Piqueras L, Bishop-Bailey D: Peroxisome proliferator-activated receptors and inflammation. Pharmacol. Ther. 110, 371-385 (2006).
-
(2006)
Pharmacol. Ther.
, vol.110
, pp. 371-385
-
-
Moraes, L.1
Piqueras, L.2
Bishop-Bailey, D.3
-
99
-
-
34547597709
-
PPARa in atherosclerosis and inflammation
-
Zandbergen F, Plutzky J: PPARa in atherosclerosis and inflammation. Biochim. Biophys. Acta. 1771, 972-982 (2007).
-
(2007)
Biochim. Biophys. Acta.
, vol.1771
, pp. 972-982
-
-
Zandbergen, F.1
Plutzky, J.2
-
100
-
-
33846623798
-
Peroxisome proliferator-activated receptors as transcription nodal points and therapeutic targets
-
Brown JD, Plutzky J: Peroxisome proliferator-activated receptors as transcription nodal points and therapeutic targets. Circulation 115, 518-533 (2007).
-
(2007)
Circulation
, vol.115
, pp. 518-533
-
-
Brown, J.D.1
Plutzky, J.2
-
101
-
-
2442711384
-
Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells
-
Marx N, Duez H, Fruchart JC, Staels B: Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells. Circ. Res. 94, 1168-1178, (2004).
-
(2004)
Circ. Res.
, vol.94
, pp. 1168-1178
-
-
Marx, N.1
Duez, H.2
Fruchart, J.C.3
Staels, B.4
-
102
-
-
30844462540
-
Peroxisome proliferator-activated receptor controls cellular cholesterol trafficking in macrophages
-
DOI 10.1194/jlr.M500326-JLR200
-
Chinetti-Gbaguidi G, Rigamonti E, Helin L et al.: Peroxisome proliferator-activated a controls cellular cholesterol trafficking in macrophages. J. Lipid Res. 46, 2717-2725 (2005). (Pubitemid 43107484)
-
(2005)
Journal of Lipid Research
, vol.46
, Issue.12
, pp. 2717-2725
-
-
Chinetti-Gbaguidi, G.1
Rigamonti, E.2
Helin, L.3
Mutka, A.L.4
Lepore, M.5
Fruchart, J.C.6
Clavey, V.7
Ikonen, E.8
Lestavel, S.9
Staels, B.10
-
103
-
-
24144476576
-
PPARa, but not PPARg, activators decrease macrophage-lawn atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia
-
Hennuyer N, Tailleux A, Torpier G et al.: PPARa, but not PPARg, activators decrease macrophage-lawn atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia. Arterioscler. Thromb. Vasc. Biol. 25, 1897-1902 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1897-1902
-
-
Hennuyer, N.1
Tailleux, A.2
Torpier, G.3
-
104
-
-
85047693466
-
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARa, b/d, and g
-
Li AC, Binder CJ, Gutierrez A et al.: Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARa, b/d, and g. J. Clin. Invest. 114, 1564-1576 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1564-1576
-
-
Li, A.C.1
Binder, C.J.2
Gutierrez, A.3
-
105
-
-
34548693923
-
Macrophage expression of peroxisome proliferator-activated receptor - A reduces atherosclerosis in low-density lipoprotein-deficient mice
-
Babaev VR, Ishiguro H, Ding L et al.: Macrophage expression of peroxisome proliferator-activated receptor-a reduces atherosclerosis in low-density lipoprotein-deficient mice. Circulation 116, 1404-1412 (2007).
-
(2007)
Circulation
, vol.116
, pp. 1404-1412
-
-
Babaev, V.R.1
Ishiguro, H.2
Ding, L.3
-
106
-
-
33644645013
-
PPARd: A dagger in the heart of metabolic syndrome
-
Barish GD, Nakar V, Evans RM: PPARd: A dagger in the heart of metabolic syndrome. J. Clin. Invest. 116, 590-597 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 590-597
-
-
Barish, G.D.1
Nakar, V.2
Evans, R.M.3
-
107
-
-
43549085285
-
PPARb/d ligands as modulators of the inflammatory response
-
Kilgore KS, Billin A: PPARb/d ligands as modulators of the inflammatory response. Curr. Opin. Investig. Drugs 9, 463-469 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 463-469
-
-
Kilgore, K.S.1
Billin, A.2
-
108
-
-
70349111436
-
Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation
-
Bishop-baily D, Bystrom J: Emerging roles of peroxisome proliferator-activated receptor-b/d in inflammation. Pharmacol. Ther. 124, 141-150 (2009).
-
(2009)
Pharmacol. Ther.
, vol.124
, pp. 141-150
-
-
Bishop-baily, D.1
Bystrom, J.2
-
109
-
-
0035942162
-
A selective peroxisome proliferator-activated receptor d agonist promotes reverse cholesterol transport
-
Oliver WR, Shenk JL, Snaith MR et al.: A selective peroxisome proliferator-activated receptor d agonist promotes reverse cholesterol transport. Proc. Natl Acad. Sci. USA 98, 5305-5311.
-
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5305-5311
-
-
Oliver, W.R.1
Shenk, J.L.2
Snaith, M.R.3
-
110
-
-
22144492005
-
Effects of peroxisome proliferator-activated receptor a/d agonists on HDL-cholesterol in vervet monkeys
-
Wallace JM, Schwarz M, Coward P et al.: Effects of peroxisome proliferator-activated receptor a/d agonists on HDL-cholesterol in vervet monkeys. J. Lipid Res. 46, 1009-1016 (2005).
-
(2005)
J. Lipid Res.
, vol.46
, pp. 1009-1016
-
-
Wallace, J.M.1
Schwarz, M.2
Coward, P.3
-
111
-
-
41949138804
-
PPARd regulates multiple proinflammatory pathways to suppress atherosclerosis
-
Barish GD, Atkins AR, Downes M et al.: PPARd regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc. Natl Acad. Sci. USA 105, 4271-4276 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 4271-4276
-
-
Barish, G.D.1
Atkins, A.R.2
Downes, M.3
-
112
-
-
41949123156
-
PPARd-mediated anti-inflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
-
Tokata Y, Liu J, Fen Y et al.: PPARd-mediated anti-inflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc. Natl Acad, Sci. USA 105, 4277-4282 (2008).
-
(2008)
Proc. Natl Acad, Sci. USA
, vol.105
, pp. 4277-4282
-
-
Tokata, Y.1
Liu, J.2
Fen, Y.3
-
113
-
-
34547136480
-
New therapeutic target for metabolic syndrome
-
Takahashi S, Tanaka T, Sakai J: New therapeutic target for metabolic syndrome. Endocr. J. 54, 347-357 (2007).
-
(2007)
Endocr. J.
, vol.54
, pp. 347-357
-
-
Takahashi, S.1
Tanaka, T.2
Sakai, J.3
-
115
-
-
70349664475
-
Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor d
-
Ehrenborg E, Krook A: Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor d. Pharmacol.Rev. 61, 373-393 (2009).
-
(2009)
Pharmacol.Rev.
, vol.61
, pp. 373-393
-
-
Ehrenborg, E.1
Krook, A.2
-
116
-
-
22344449773
-
Reduced cholesterol absorption upon PPARd activation coincides with decreased intestinal expression of NPC1L1
-
van der Veen JN, Kruit JK, Havinga R et al.: Reduced cholesterol absorption upon PPARd activation coincides with decreased intestinal expression of NPC1L1. J. Lipid Res. 46, 526-534 (2005).
-
(2005)
J. Lipid Res.
, vol.46
, pp. 526-534
-
-
Van Der Veen, J.N.1
Kruit, J.K.2
Havinga, R.3
-
117
-
-
2442692690
-
Peroxisome proliferator b/d regulates very low density lipoprotein production and catabolism in mice on a western diet
-
Akiyama TE, Lambert G, Nicol CJ: Et al.: Peroxisome proliferator b/d regulates very low density lipoprotein production and catabolism in mice on a western diet. J. Biol. Chem. 279, 20874-20881 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20874-20881
-
-
Akiyama, T.E.1
Lambert, G.2
Nicol, C.J.3
-
118
-
-
33645802802
-
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor b(d)
-
Nadra K, Anghel SI, Joye E et al.: Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor b(d). Mol. Cell. Biol. 26, 3266-3281 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3266-3281
-
-
Nadra, K.1
Anghel, S.I.2
Joye, E.3
-
119
-
-
33644766913
-
PPARd regulates glucose metabolism and insulin sensitivity
-
Lee CH, Olson P, Hevener A et al.: PPARd regulates glucose metabolism and insulin sensitivity. Proc. Natl Acad. Sci. USA 103, 3444-3449 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 3444-3449
-
-
Lee, C.H.1
Olson, P.2
Hevener, A.3
-
120
-
-
44349112305
-
Adipocyte-derived TH2 cytokines and myeloid PPARd regulate macrophage polarization and insulin sensitivity
-
Kang K, Reilly SM, Karabacak V et al.: Adipocyte-derived TH2 cytokines and myeloid PPARd regulate macrophage polarization and insulin sensitivity. Cell Metab. 7, 485-495 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 485-495
-
-
Kang, K.1
Reilly, S.M.2
Karabacak, V.3
-
121
-
-
44349161098
-
Alternative M2 activation of Kupffer cells by PPARd ameliorates obesity- induced insulin resistance
-
Odegaard JI, Richardo-Gonzalez RR, Eagle AR et al.: Alternative M2 activation of Kupffer cells by PPARd ameliorates obesity- induced insulin resistance. Cell Metab. 7, 496-507 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 496-507
-
-
Odegaard, J.I.1
Richardo-Gonzalez, R.R.2
Eagle, A.R.3
-
122
-
-
44349102409
-
PPARd/b: The lobbyist switching macrophage allegiance in favor of metabolism
-
Desvergne B: PPARd/b: The lobbyist switching macrophage allegiance in favor of metabolism. Cell Metab. 7, 467-469 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 467-469
-
-
Desvergne, B.1
-
123
-
-
9144262378
-
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-d deletion pertubs myocardial fatty acid oxidation and leads to cardiomyopathy
-
Cheng L, Ding G, Qin Q et al.: Cardiomyocyte-restricted peroxisome proliferator-activated receptor-d deletion pertubs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat. Med. 10, 1245-1250 (2004).
-
(2004)
Nat. Med.
, vol.10
, pp. 1245-1250
-
-
Cheng, L.1
Ding, G.2
Qin, Q.3
-
124
-
-
69249212275
-
High-fat feeding in cardiomyocyte-restricted PPARd knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
-
Cheng LY, Qin Q, Liu J, Liu J, Lo WK, Brako LA, Yang Q: High-fat feeding in cardiomyocyte-restricted PPARd knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. J. Mol. Cell. Cardiol. 47, 536-543 (2009).
-
(2009)
J. Mol. Cell. Cardiol.
, vol.47
, pp. 536-543
-
-
Cheng, L.Y.1
Qin, Q.2
Liu, J.3
Liu, J.4
Lo, W.K.5
Brako, L.A.6
Yang, Q.7
-
125
-
-
36849068108
-
Nuclear receptors PPARb/d and PPARa direct distinct metabolic regulatory programs in the mouse heart
-
Burkat EM, Sambandam N, Han X et al.: Nuclear receptors PPARb/d and PPARa direct distinct metabolic regulatory programs in the mouse heart. J. Clin. Invest. 117, 3930-3939 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3930-3939
-
-
Burkat, E.M.1
Sambandam, N.2
Han, X.3
-
126
-
-
8844276054
-
Regulation of muscle fiber type and running endurance by PPARd
-
Wang YX, Zhang CL, Yu RT et al.: Regulation of muscle fiber type and running endurance by PPARd. PLoS Biol. 2, 1532-1539 (2004).
-
(2004)
PLoS Biol.
, vol.2
, pp. 1532-1539
-
-
Wang, Y.X.1
Zhang, C.L.2
Yu, R.T.3
-
127
-
-
36448944298
-
Lipids, lipoproteins, and peroxisome proliferator activated receptor d
-
Sprecher DL: Lipids, lipoproteins, and peroxisome proliferator activated receptor d. Am. J. Cardiol. 100(11A), N20-N24 (2007).
-
(2007)
Am. J. Cardiol.
, vol.100
, Issue.11 A
-
-
Sprecher, D.L.1
-
128
-
-
37349007681
-
PPARd as a therapeutic target in metabolic disease
-
Reilly SM, Lee C-H: PPARd as a therapeutic target in metabolic disease. FEBS. Lett. 582, 26-31 (2008).
-
(2008)
FEBS. Lett.
, vol.582
, pp. 26-31
-
-
Reilly, S.M.1
Lee, C.-H.2
-
129
-
-
33745819570
-
Association of the T+294C polymorphism in PPAR d with low HDL cholesterol and coronary heart disease risk in women
-
Aberle J, Hopfer I, Beil FU, Seedorf U: Association of the T+294C polymorphism in PPAR d with low HDL cholesterol and coronary heart disease risk in women. Int. J. Med. Sci. 3,108-111 (2006).
-
(2006)
Int. J. Med. Sci.
, vol.3
, pp. 108-111
-
-
Aberle, J.1
Hopfer, I.2
Beil, F.U.3
Seedorf, U.4
-
130
-
-
34247844401
-
Variation in the peroxisome proliferator-activated receptor d gene in relation to common metabolic traits in 7,495 middle-aged white people
-
Grarup N, Albrechtsen A, Ek J et al.: Variation in the peroxisome proliferator-activated receptor d gene in relation to common metabolic traits in 7,495 middle-aged white people. Diabetologia 50, 1201-1208 (2007).
-
(2007)
Diabetologia
, vol.50
, pp. 1201-1208
-
-
Grarup, N.1
Albrechtsen, A.2
Ek, J.3
-
131
-
-
34250797341
-
Peroxisome proliferator-activated receptor-d polymorphisms are associated with physical performance and plasma lipids: The HERITAGE family study
-
Hautala AJ, Leon AS, Skinner JS, Rao DC, Bouchard C, Rankinen T: Peroxisome proliferator-activated receptor-d polymorphisms are associated with physical performance and plasma lipids: The HERITAGE Family Study. Am. J. Physiol. Heart Circ. Physiol. 292, H2498-H2505 (2007).
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.292
-
-
Hautala, A.J.1
Leon, A.S.2
Skinner, J.S.3
Rao, D.C.4
Bouchard, C.5
Rankinen, T.6
-
132
-
-
33847256899
-
Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor d -87T>C polymorphism and dietary fat in French-Canadians
-
Robitaille J, Gaudet D, Pérusse L, Vohl MC: Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor d -87T>C polymorphism and dietary fat in French-Canadians. Int. Obes (Lond). 31, 411-417 (2007).
-
(2007)
Int. Obes (Lond).
, vol.31
, pp. 411-417
-
-
Robitaille, J.1
Gaudet, D.2
Pérusse, L.3
Vohl, M.C.4
-
133
-
-
42049105146
-
Variations in PPARD determine the change in body composition during lifestyle intervention: A whole-body magnetic resonance study
-
Thamer C, Machann J, Stefan N et al.: Variations in PPARD determine the change in body composition during lifestyle intervention: A whole-body magnetic resonance study. J. Clin. Endocrinol. Metab. 93, 1497-1500 (2008).
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, pp. 1497-1500
-
-
Thamer, C.1
Machann, J.2
Stefan, N.3
-
134
-
-
77951649533
-
Peroxisome proliferator-activated receptor-d genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: A genetic of diabetes audit and research tayside study
-
Burch LR, Donnelly LA, Doney ASF et al.: Peroxisome proliferator- activated receptor-d genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: A genetic of diabetes audit and research tayside study. J. Clin. Endocrinol. Metab. 95, 1830-1837 (2010).
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. 1830-1837
-
-
Burch, L.R.1
Donnelly, L.A.2
Doney, A.S.F.3
-
135
-
-
34249852535
-
Genetic variations in PPARD and and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
-
Stefan N, Thamer C, Staiger H et al.: Genetic variations in PPARD and and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J. Clin Endocrinol. Metab. 92, 1827-1833 (2007).
-
(2007)
J. Clin Endocrinol. Metab.
, vol.92
, pp. 1827-1833
-
-
Stefan, N.1
Thamer, C.2
Staiger, H.3
-
136
-
-
70350087550
-
Is there an interaction between PPARD T294C and PPARGC1A Gly482Ser polymorphisms and human endurance performance?
-
Eynon N, Meckel Y, Alves AJ et al.: Is there an interaction between PPARD T294C and PPARGC1A Gly482Ser polymorphisms and human endurance performance? Exp. Physiol. 94, 1147-1152 (2009).
-
(2009)
Exp. Physiol.
, vol.94
, pp. 1147-1152
-
-
Eynon, N.1
Meckel, Y.2
Alves, A.J.3
-
137
-
-
33845256051
-
Assocaition of peroxisome proliferator-activated receptor d +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor a 162V
-
Aberle J, Hopfer I, Beil FU, Seedorf U: Assocaition of peroxisome proliferator-activated receptor d +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor a 162V. Int. J. Obes. (Lond.). 30, 1709-1713 (2006).
-
(2006)
Int. J. Obes. (Lond.)
, vol.30
, pp. 1709-1713
-
-
Aberle, J.1
Hopfer, I.2
Beil, F.U.3
Seedorf, U.4
-
138
-
-
33644688988
-
Single nucleotide polymorphisms in the peroxisome prolifertaor-activated receptor d gene are associated with skeletal muscle glucose uptake
-
Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J: Single nucleotide polymorphisms in the peroxisome prolifertaor-activated receptor d gene are associated with skeletal muscle glucose uptake. Diabetes 54, 3587-3591 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 3587-3591
-
-
Vänttinen, M.1
Nuutila, P.2
Kuulasmaa, T.3
Pihlajamäki, J.4
-
139
-
-
1442301053
-
Genetic polymorphisms in peroxisome proliferator-activated receptor d associated with obesity
-
Shin HD, Park BL, Kim LH et al.: Genetic polymorphisms in peroxisome proliferator-activated receptor d associated with obesity. Diabetes 53, 847-851 (2004).
-
(2004)
Diabetes
, vol.53
, pp. 847-851
-
-
Shin, H.D.1
Park, B.L.2
Kim, L.H.3
-
140
-
-
33751251346
-
Peroxisome proliferator-activated receptor (PPAR) d genetic polymorphism and its association with insulin resistance index and fasting plasma gluose concentrations in Chinese subjects
-
Hu C, Jia W, Fan Q, Zhang R, Wang C, Lu J, Xiang K: Peroxisome proliferator-activated receptor (PPAR) d genetic polymorphism and its association with insulin resistance index and fasting plasma gluose concentrations in Chinese subjects. Diabet. Med. 23, 1307-1312 (2006).
-
(2006)
Diabet. Med.
, vol.23
, pp. 1307-1312
-
-
Hu, C.1
Jia, W.2
Fan, Q.3
Zhang, R.4
Wang, C.5
Lu, J.6
Xiang, K.7
-
141
-
-
33749074664
-
PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease
-
DOI 10.1016/j.neulet.2006.08.029, PII S030439400600838X
-
Holzapfel J, Heun R, Lütjohann D, Jessen F, Maier W, Kölsch H: PPARD haplotype influences cholesterol metabolism but is no risk factor for Alzheimer's disease. Neurosci. Lett. 408, 57-61 (2006). (Pubitemid 44466201)
-
(2006)
Neuroscience Letters
, vol.408
, Issue.1
, pp. 57-61
-
-
Holzapfel, J.1
Heun, R.2
Lutjohann, D.3
Jessen, F.4
Maier, W.5
Kolsch, H.6
-
142
-
-
8444233254
-
Nuclear receptors in Macrophage biology: At the crossroads of lipid metabolism and inflammation
-
Castriloo A, Tontonoz P: Nuclear receptors in Macrophage biology: At the crossroads of lipid metabolism and inflammation. Annu. Rev. Cell. Dev. Biol. 20, 455-480 (2004).
-
(2004)
Annu. Rev. Cell. Dev. Biol.
, vol.20
, pp. 455-480
-
-
Castriloo, A.1
Tontonoz, P.2
-
143
-
-
43549085285
-
PPARb/d ligands as modulators of the inflammatory response
-
Kilgore KS, Billin AN: PPARb/d ligands as modulators of the inflammatory response. Curr. Opin. Investig. Drugs 9, 463-469 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 463-469
-
-
Kilgore, K.S.1
Billin, A.N.2
-
144
-
-
38549127422
-
Suppression of proinflammatory adhesion molecules by PPAR-d in human vascular endothelial cells
-
Fan Y, Wang Z, Tang Z: Et al.: Suppression of proinflammatory adhesion molecules by PPAR-d in human vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 28, 315-321 (2008).
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 315-321
-
-
Fan, Y.1
Wang, Z.2
Tang, Z.3
-
145
-
-
68849112732
-
Activation of PPARb/d inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release
-
Piqueras L, Sanz MJ, Perretti M et al.: Activation of PPARb/d inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J. Leukoc. Biol. 86, 115-122 (2009).
-
(2009)
J. Leukoc. Biol.
, vol.86
, pp. 115-122
-
-
Piqueras, L.1
Sanz, M.J.2
Perretti, M.3
-
146
-
-
77952360473
-
Comparison of PPARd and PPARg in inhibiting the proinflammatory effects of C-reactive protein in endothelial cells
-
Epub ahead of print
-
Liang YJ, Liu YC, Chen CY et al.: Comparison of PPARd and PPARg in inhibiting the proinflammatory effects of C-reactive protein in endothelial cells. Int. J. Cardiol. (2009) (Epub ahead of print).
-
(2009)
Int. J. Cardiol.
-
-
Liang, Y.J.1
Liu, Y.C.2
Chen, C.Y.3
-
147
-
-
38549127422
-
Suppression adhesion molecules by PPAR-d in vascular human and endothelial cells
-
Fang Y, Wang Y, Tang Z et al.: Suppression adhesion molecules by PPAR-d in vascular human and endothelial cells. Arterioscler. Thromb. Vasc. Biol. 28 315-321 (2008)
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 315-321
-
-
Fang, Y.1
Wang, Y.2
Tang, Z.3
-
148
-
-
58549107793
-
PPAR d agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle
-
Lim HJ, Lee S, Park JH et al.: PPAR d agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Atherosclerosis 202, 446-454 (2009).
-
(2009)
Atherosclerosis
, vol.202
, pp. 446-454
-
-
Lim, H.J.1
Lee, S.2
Park, J.H.3
-
149
-
-
41149134486
-
Transforming growth factor-b1 is a molecular target for the peroxisome proliferator-activated receptor d
-
Kim HJ, Ham SA, Kim SU et al.: Transforming growth factor-b1 is a molecular target for the peroxisome proliferator-activated receptor d. Circ. Res. 102, 193-200 (2008).
-
(2008)
Circ. Res.
, vol.102
, pp. 193-200
-
-
Kim, H.J.1
Ham, S.A.2
Kim, S.U.3
-
150
-
-
1942422103
-
PPARs and LXRs: Atherosclerosis goes nuclear
-
Barish GD, Evans RM: PPARs and LXRs: Atherosclerosis goes nuclear: Trends Endocriol. Metab. 15, 158-1165 (2004).
-
(2004)
Trends Endocriol. Metab.
, vol.15
, pp. 158-1165
-
-
Barish, G.D.1
Evans, R.M.2
-
151
-
-
58149465391
-
PPAR-d in vascular pathophysiology
-
Wang N: PPAR-d in vascular pathophysiology: PPAR Res. 164163, 1-10 (2008).
-
(2008)
PPAR Res. 164163
, pp. 1-10
-
-
Wang, N.1
-
152
-
-
20444378931
-
The PPARd agonist GW0742X reduces atherosclerosis in LDLR (-/-) mice
-
Graham TL, Mookherjee C, Suckling KE, Palmer CN, Patel L: The PPARd agonist GW0742X reduces atherosclerosis in LDLR (-/-) mice. Atherosclerosis 181, 29-37 (2005).
-
(2005)
Atherosclerosis
, vol.181
, pp. 29-37
-
-
Graham, T.L.1
Mookherjee, C.2
Suckling, K.E.3
Palmer, C.N.4
Patel, L.5
-
153
-
-
33947573906
-
PPARb/d activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts
-
Zhang H, Pi R, Li R et al.: PPARb/d activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts. Arch. Biochem. Biophys. 460, 25-32 (2007).
-
(2007)
Arch. Biochem. Biophys.
, vol.460
, pp. 25-32
-
-
Zhang, H.1
Pi, R.2
Li, R.3
-
154
-
-
33947715721
-
Peroxisome proliferator activated receptor-d upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-b
-
Brunelli L, Cieslik A, Alcorn JL et al.: Peroxisome proliferator activated receptor-d upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-b. Circ. Res. 100, e59-e71 (2007).
-
(2007)
Circ. Res.
, vol.100
-
-
Brunelli, L.1
Cieslik, A.2
Alcorn, J.L.3
-
155
-
-
33846443997
-
Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist
-
Sprecher DL, Massien C, Pearce G et al.: Triglyceride: High-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor d agonist. Arterioscler. Thromb. Vasc. Biol. 27, 359-365 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 359-365
-
-
Sprecher, D.L.1
Massien, C.2
Pearce, G.3
-
156
-
-
58849141318
-
Direct antiatherosclerotic effects of PPAR agonists
-
Jandeleit-Dahm KAM, Calkin A, Tikellis C, Thomas M: Direct antiatherosclerotic effects of PPAR agonists. Curr. Opin. Lipidol. 20, 24-29 (2009).
-
(2009)
Curr. Opin. Lipidol.
, vol.20
, pp. 24-29
-
-
Jandeleit-Dahm, K.A.M.1
Calkin, A.2
Tikellis, C.3
Thomas, M.4
-
157
-
-
34447618831
-
PPARs and their metabolic modulation: New mechanisms for transcription regulation?
-
Ahmed W, Ziouzenkova O, Brown J et al.: PPARs and their metabolic modulation: New mechanisms for transcription regulation? J. Intern. Med. 262, 184-198 (2007).
-
(2007)
J. Intern. Med.
, vol.262
, pp. 184-198
-
-
Ahmed, W.1
Ziouzenkova, O.2
Brown, J.3
-
158
-
-
33646776061
-
Peroxisome proliferator-activated receptor g as a drug target in the pathogenesis of insulin resistance
-
Guo L, Tabrizchi R: Peroxisome proliferator-activated receptor g as a drug target in the pathogenesis of insulin resistance. Pharmacol. Ther. 111, 145-173 (2006).
-
(2006)
Pharmacol. Ther.
, vol.111
, pp. 145-173
-
-
Guo, L.1
Tabrizchi, R.2
-
159
-
-
36048950218
-
Adipogenesis and lipotoxicity: Role of peroxisome proliferator-activated receptor g (PPARg) and PPARgcoactivator (PGC1)
-
Medina-Gomez G, Gray S, Vidal-Puig A: Adipogenesis and lipotoxicity: Role of peroxisome proliferator-activated receptor g (PPARg) and PPARgcoactivator (PGC1): Public Health Nutr. 10, 1132-1137 (2007).
-
(2007)
Public Health Nutr.
, vol.10
, pp. 1132-1137
-
-
Medina-Gomez, G.1
Gray, S.2
Vidal-Puig, A.3
-
160
-
-
20044380758
-
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform
-
Medina-Gomez G, Virtue S, Lelliott C et al.: The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform. Diabetes 54, 1706-1716 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 1706-1716
-
-
Medina-Gomez, G.1
Virtue, S.2
Lelliott, C.3
-
161
-
-
34247636362
-
PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
Medina-Gomez G, Gray SL, Yetukuri L et al.: PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet. 3, e64 (2009).
-
(2009)
PLoS Genet.
, vol.3
-
-
Medina-Gomez, G.1
Gray, S.L.2
Yetukuri, L.3
-
163
-
-
33646480204
-
Identification and regulation of novel PPAR-g splice variants in human THP-1 macrophages
-
Chen Y, Jimenez AR, Medh JD: Identification and regulation of novel PPAR-g splice variants in human THP-1 macrophages. Biochim. Biophys. Acta. 1759, 32-43 (2006).
-
(2006)
Biochim. Biophys. Acta.
, vol.1759
, pp. 32-43
-
-
Chen, Y.1
Jimenez, A.R.2
Medh, J.D.3
-
164
-
-
0036290825
-
Genetic analysis of four novel peroxisome proliferator activated receptor-g splice variants in monkey macrophages
-
Zhou J, Wilson KM, Medh JD: Genetic analysis of four novel peroxisome proliferator activated receptor-g splice variants in monkey macrophages. Biochem. Biophys. Res. Commun. 293, 274-283 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 274-283
-
-
Zhou, J.1
Wilson, K.M.2
Medh, J.D.3
-
165
-
-
53149090164
-
Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis
-
Fernandez AZ: Peroxisome proliferator-activated receptors in the modulation of the immune/inflammatory response in atherosclerosis. PPAR Res. 2008, 285842 (2008).
-
(2008)
PPAR Res.
, vol.2008
, pp. 285842
-
-
Fernandez, A.Z.1
-
168
-
-
40049109970
-
Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis
-
Hansen MK, Connolly TM: Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis. Curr. Opin. Investig. Drugs 9, 247-255 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 247-255
-
-
Hansen, M.K.1
Connolly, T.M.2
-
169
-
-
21544466158
-
A comparison of lipid and glycemic effects on serum lipoprotein particle concentrations and sizes in patients with Type 2 diabetes and dyslipidemia
-
Goldberg RB, Kendell DM, Deeg MA et al.: A comparison of lipid and glycemic effects on serum lipoprotein particle concentrations and sizes in patients with Type 2 diabetes and dyslipidemia. Diabetes Care. 28, 1547-1554 (2005).
-
(2005)
Diabetes Care.
, vol.28
, pp. 1547-1554
-
-
Goldberg, R.B.1
Kendell, D.M.2
Deeg, M.A.3
-
170
-
-
35148837113
-
Pioglitazone and rosiglitazone have different effects on serum lipoproparticle concentrations and sizes in patients with Type 2 diabetes and dyslipidemia
-
Deeg MA, Buse JB, Goldberg RB et al.: Pioglitazone and rosiglitazone have different effects on serum lipoproparticle concentrations and sizes in patients with Type 2 diabetes and dyslipidemia. Diabetes Care. 30, 2458-2464 (2007).
-
(2007)
Diabetes Care.
, vol.30
, pp. 2458-2464
-
-
Deeg, M.A.1
Buse, J.B.2
Goldberg, R.B.3
-
171
-
-
0037330414
-
PPARg agonists in the treatment of Type II diabetes: Is increased fatness commensurate with long-term efficacy? Int
-
Larsen TM, Toubro S, Astrup A: PPARg agonists in the treatment of Type II diabetes: Is increased fatness commensurate with long-term efficacy? Int. J. Obes. Relat. Metab. Disord. 27, 147-161 (2003).
-
(2003)
J. Obes. Relat. Metab. Disord.
, vol.27
, pp. 147-161
-
-
Larsen, T.M.1
Toubro, S.2
Astrup, A.3
-
172
-
-
33846829811
-
Abdominal obesity: Role in the pathophysiology of metabolic disease and cardiovascular risk
-
Bergman RN, Kim SP, Hsu IR et al.: Abdominal obesity: Role in the pathophysiology of metabolic disease and cardiovascular risk. Am. J. Med. 120, S3-S8 (2007).
-
(2007)
Am. J. Med.
, vol.120
-
-
Bergman, R.N.1
Kim, S.P.2
Hsu, I.R.3
-
173
-
-
13544258629
-
Peroxisome proliferator-activated receptor g: The more the merrier?
-
Argmann CA, Cock TA, Auwerx J: Peroxisome proliferator-activated receptor g: The more the merrier? Eur: J. Clin. Invest. 35, 82-92 (2005).
-
(2005)
Eur J. Clin. Invest.
, vol.35
, pp. 82-92
-
-
Argmann, C.A.1
Cock, T.A.2
Auwerx, J.3
-
174
-
-
77951221502
-
Does peroxisome proliferator-activated receptor-γ (PPARg) protect from hypertension directly through effects in the vasculature? J
-
Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD: Does peroxisome proliferator-activated receptor-γ (PPARg) protect from hypertension directly through effects in the vasculature? J. Biol. Chem. 285, 9311-9316 (2010).
-
(2010)
Biol. Chem.
, vol.285
, pp. 9311-9316
-
-
Ketsawatsomkron, P.1
Pelham, C.J.2
Groh, S.3
Keen, H.L.4
Faraci, F.M.5
Sigmund, C.D.6
-
175
-
-
33847350685
-
Hupotension, lipodystrophy, and insulin resistance in generalized PPARg-deficient mice rescued from embryonic lethality
-
Duan SZ, Ivashchenko CY, Whitesall SE et al.: Hupotension, lipodystrophy, and insulin resistance in generalized PPARg-deficient mice rescued from embryonic lethality. J. Clin. Invest. 117, 812-822 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 812-822
-
-
Duan, S.Z.1
Ivashchenko, C.Y.2
Whitesall, S.E.3
-
176
-
-
34247636362
-
PPAR γ 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
-
Medina-Gomez G, Gray SL, Yetukuri L et al.: PPAR γ 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genetics 3, e64 (2007).
-
(2007)
PLoS Genetics
, vol.3
-
-
Medina-Gomez, G.1
Gray, S.L.2
Yetukuri, L.3
-
178
-
-
77949397703
-
The association between the peroxisome proliferator-activated receptor-g2 (PPATG2) Pro12Ala gene variant and Type 2 diabetes mellitus: A HuGE review and meta analysis
-
Gouda HN, Sagoo GS, Harding AH, Yates J, Sandhu MS, Higgins JPT: The association between the peroxisome proliferator-activated receptor-g2 (PPATG2) Pro12Ala gene variant and Type 2 diabetes mellitus: A HuGE review and meta analysis. Am. J. Epidemiol. 171, 645-655 (2010).
-
(2010)
Am. J. Epidemiol.
, vol.171
, pp. 645-655
-
-
Gouda, H.N.1
Sagoo, G.S.2
Harding, A.H.3
Yates, J.4
Sandhu, M.S.5
Higgins, J.P.T.6
-
179
-
-
57849154811
-
The pro12Ala PPARγ2 variant determines meatbolism at the gene-enviroment interface
-
Heikkinen S, Argmann C, Fiege JN et al.: The pro12Ala PPARγ2 variant determines meatbolism at the gene-enviroment interface. Cell Metab. 9, 88-98 (2009).
-
(2009)
Cell Metab.
, vol.9
, pp. 88-98
-
-
Heikkinen, S.1
Argmann, C.2
Fiege, J.N.3
-
180
-
-
4043151601
-
Hypertension, and abnormal fat distribution but not insulin resistance in mice with P465L PPARg
-
Tsai YS, Kim HJ, Takahashi N et al.: Hypertension, and abnormal fat distribution but not insulin resistance in mice with P465L PPARg. J. Clin. Invest. 114, 240-249 (2004).
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 240-249
-
-
Tsai, Y.S.1
Kim, H.J.2
Takahashi, N.3
-
181
-
-
33751507112
-
Decreased brown adipocyte recruitment and thermogenic capacity in mice
-
Gray SL, Dalla Nora E, Backlund EC et al.: Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome prolifertaor-activated receptor (P465L PPARg) function. Endocrinology 147, 5708-5714 (2006).
-
(2006)
Endocrinology
, vol.147
, pp. 5708-5714
-
-
Gray, S.L.1
Dalla Nora, E.2
Backlund, E.C.3
-
182
-
-
33750856072
-
Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor γ function (P465L PPARγ) in mice
-
DOI 10.2337/db06-0389
-
Gray SL, Dalla Nora E, Grosse J et al.: Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor g function (P465L PPARg) in mice. Diabetes 55, 2669-2677 (2006). (Pubitemid 44923664)
-
(2006)
Diabetes
, vol.55
, Issue.10
, pp. 2669-2677
-
-
Gray, S.L.1
Dalla Nora, E.2
Grosse, J.3
Manieri, M.4
Stoeger, T.5
Medina-Gomez, G.6
Burling, K.7
Wattler, S.8
Russ, A.9
Yeo, G.S.H.10
Chatterjee, V.K.11
O'Rahilly, S.12
Voshol, P.J.13
Cinti, S.14
Vidal-Puig, A.15
-
183
-
-
42049101837
-
Interference with PPARg signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling
-
Beyer AM, Baumbach GL, Halabi CM et al.: Interference with PPARg signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51, 867-871 (2008).
-
(2008)
Hypertension
, vol.51
, pp. 867-871
-
-
Beyer, A.M.1
Baumbach, G.L.2
Halabi, C.M.3
-
184
-
-
2942670612
-
PPARg agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: Role of diacylglycerol kinase
-
Verrier E, Wang L, Wadham C et al.: PPARg agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: Role of diacylglycerol kinase. Circ. Res. 94, 1515-1522 (2004).
-
(2004)
Circ. Res.
, vol.94
, pp. 1515-1522
-
-
Verrier, E.1
Wang, L.2
Wadham, C.3
-
185
-
-
63849093637
-
PPARs: The vasculature, inflammation and hypertension
-
Duan SH, Usher M, Mortensen RM: PPARs: The vasculature, inflammation and hypertension. Curr. Opin. Nephrol. Hyper. 18, 128-133 (2009).
-
(2009)
Curr. Opin. Nephrol. Hyper.
, vol.18
, pp. 128-133
-
-
Duan, S.H.1
Usher, M.2
Mortensen, R.M.3
-
186
-
-
15444367174
-
Peroxisome proliferator-activated receptor-g ligands regulate endothelial membrane superoxide production
-
Hwang J, Kleinhenz DJ, Lassegue B, Griendling KK, Dikalov S, Hart CM: Peroxisome proliferator-activated receptor-g ligands regulate endothelial membrane superoxide production. Am. J. Physiol. Cell Physiol. 288, C899-C905 (2005).
-
(2005)
Am. J. Physiol. Cell Physiol.
, vol.288
-
-
Hwang, J.1
Kleinhenz, D.J.2
Lassegue, B.3
Griendling, K.K.4
Dikalov, S.5
Hart, C.M.6
-
187
-
-
34249297995
-
Expression of heme oxygenase-1 in human vascular cells is activated by peroxisome proliferator-activated receptors
-
Kronke G, Kadl A, Ikonomu E et al.: Expression of heme oxygenase-1 in human vascular cells is activated by peroxisome proliferator-activated receptors. Arterioscler. Thromb. Vasc. Biol. 27, 1276-1282 (2007).
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 1276-1282
-
-
Kronke, G.1
Kadl, A.2
Ikonomu, E.3
-
188
-
-
15044350740
-
New targets for PPARg in the vessel wall: Implications for restenosis
-
Bruemmer D, Blaschke F, Law RE: New targets for PPARg in the vessel wall: Implications for restenosis. Int. J. Obes. 29 (Suppl. 1), S26-S30 (2005).
-
(2005)
Int. J. Obes.
, vol.29
, Issue.SUPPL. 1
-
-
Bruemmer, D.1
Blaschke, F.2
Law, R.E.3
-
189
-
-
36049032363
-
Atherosclerosis and cardiovascular risk reduction with PPAR agonists
-
Kuusisto J, Andrulionyte L, Laakksko M: Atherosclerosis and cardiovascular risk reduction with PPAR agonists. Curr. Atheroscler. Rep. 9, 274-280 (2007).
-
(2007)
Curr. Atheroscler. Rep.
, vol.9
, pp. 274-280
-
-
Kuusisto, J.1
Andrulionyte, L.2
Laakksko, M.3
-
190
-
-
33847413743
-
Nitric oxide activation of peroxisome proliferator-activated receptor g through a p38 MAPK signaling pathway
-
Ptasinska A, Wang S, Zhang J, Wesley RA, Danner RL: Nitric oxide activation of peroxisome proliferator-activated receptor g through a p38 MAPK signaling pathway. FASEB J. 21, 950-961 (2007).
-
(2007)
FASEB J.
, vol.21
, pp. 950-961
-
-
Ptasinska, A.1
Wang, S.2
Zhang, J.3
Wesley, R.A.4
Danner, R.L.5
-
191
-
-
65649116367
-
Transcriptional control of vascular smooth muscle cell proliferation by peroxisome proliferator-activated receptor-g: Therapeutic implications for cardiovascular diseases
-
Gizard F, Bruemmer D: Transcriptional control of vascular smooth muscle cell proliferation by peroxisome proliferator-activated receptor-g: Therapeutic implications for cardiovascular diseases. PPAR Res. 429123 (2008).
-
(2008)
PPAR Res.
, pp. 429123
-
-
Gizard, F.1
Bruemmer, D.2
-
192
-
-
33846898816
-
Inflammation in diabetes mellitus: Role of peroxisome proliferator-activated receptor-agonists
-
Libby P, Plutzky J: Inflammation in diabetes mellitus: Role of peroxisome proliferator-activated receptor-agonists. Am. J. Cardiol. 99 (Suppl. 99), 27B-40B (2007).
-
(2007)
Am. J. Cardiol.
, vol.99
, Issue.SUPPL. 99
-
-
Libby, P.1
Plutzky, J.2
-
193
-
-
33846623798
-
Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
-
Brown JD, Plutzky J: Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 115, 518-533 (2007).
-
(2007)
Circulation
, vol.115
, pp. 518-533
-
-
Brown, J.D.1
Plutzky, J.2
-
194
-
-
34547492488
-
PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
-
Bouhlel MA, Derudas B, Rigamonti E et al.: PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. 6, 137-143 (2007).
-
(2007)
Cell Metab.
, vol.6
, pp. 137-143
-
-
Bouhlel, M.A.1
Derudas, B.2
Rigamonti, E.3
-
195
-
-
39549119096
-
Narrowing in on cardiovascular disease: The atheroprotective role of peroxisome proliferator-activated receptor γ
-
Gerry JM, Pascual G: Narrowing in on cardiovascular disease: The atheroprotective role of peroxisome proliferator-activated receptor γ. Trends Cardiovasc. Med. 18, 39-44 (2008).
-
(2008)
Trends Cardiovasc. Med.
, vol.18
, pp. 39-44
-
-
Gerry, J.M.1
Pascual, G.2
-
196
-
-
34250665046
-
IL-3 induces expression of CD36 in human monocytes through PPARg activation
-
Berry A, Balard P, Coste A et al.: IL-3 induces expression of CD36 in human monocytes through PPARg activation. Eur. J. Immunol. 37, 1642-1652 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 1642-1652
-
-
Berry, A.1
Balard, P.2
Coste, A.3
-
197
-
-
34347354309
-
Macrophage-specific PPARg controls alternative activation and improves insulin resistance
-
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH et al.: Macrophage-specific PPARg controls alternative activation and improves insulin resistance. Nature 447, 1116-1120 (2007).
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
-
198
-
-
28344449833
-
Macrophage activation switching: An asset for the resolution of inflammation
-
Porcheray F, Viaud S, Rimaniol AC et al.: Macrophage activation switching: An asset for the resolution of inflammation. Clin. Exp. Immunol. 142, 481-489 (2005).
-
(2005)
Clin. Exp. Immunol.
, vol.142
, pp. 481-489
-
-
Porcheray, F.1
Viaud, S.2
Rimaniol, A.C.3
-
199
-
-
33745957332
-
Improvement of glycemic control triglycerides and HDL cholesterol levels with muraglitazar a dual (a/g peroxisome proliferators activated receptor activator in patients with Type 2 diabetes inadequately controlled with metformin monotherapy: A double-blinded randomized pioglitazone-comoartaive study
-
Kendall DM, Rubin CJ, Mohideen P et al.: Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (a/g peroxisome proliferators activated receptor activator, in patients with Type 2 diabetes inadequately controlled with metformin monotherapy: A double-blinded, randomized, pioglitazone-comoartaive study. Diabetes Care 29, 1016-1023 (2005).
-
(2005)
Diabetes Care
, vol.29
, pp. 1016-1023
-
-
Kendall, D.M.1
Rubin, C.J.2
Mohideen, P.3
-
200
-
-
2542491213
-
Peroxisome proliferator activated receptor g in diabetes and metabolism
-
Rangwala SM, Lazar MA: Peroxisome proliferator activated receptor g in diabetes and metabolism. Trends Pharmacol. Sci. 25, 331-336 (2004).
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 331-336
-
-
Rangwala, S.M.1
Lazar, M.A.2
-
201
-
-
33646045898
-
Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
-
Balint BL, Nagy L: Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocr. Metab. Immune Disord. Drug Targets 6, 33-43 (2006).
-
(2006)
Endocr. Metab. Immune Disord. Drug Targets
, vol.6
, pp. 33-43
-
-
Balint, B.L.1
Nagy, L.2
-
202
-
-
34247155688
-
Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and Type 2 diabetes mellitus
-
Jay MA, Ren J: Peroxisome proliferator-activated receptor (PPAR) in metabolic syndrome and Type 2 diabetes mellitus. Curr. Diabetes Rev. 3, 33-39 (2007).
-
(2007)
Curr. Diabetes Rev.
, vol.3
, pp. 33-39
-
-
Jay, M.A.1
Ren, J.2
-
203
-
-
33846929465
-
Effects of peroxisome proliferator-activated receptors on lipoprotein metabolism and glucose control in Type 2 diabetes mellitus
-
Rosenson RS: Effects of peroxisome proliferator-activated receptors on lipoprotein metabolism and glucose control in Type 2 diabetes mellitus. Am. J. Cardiol. 99, 96B-104B (2007)
-
(2007)
Am. J. Cardiol.
, vol.99
-
-
Rosenson, R.S.1
-
204
-
-
42249113454
-
Fibrate therapy
-
Remick J, Weintraub H, Setton R, Offenbacher J, Fisher E, Schwartzbard A: Fibrate therapy. Cardiol. Rev. 16, 129-141 (2008).
-
(2008)
Cardiol. Rev.
, vol.16
, pp. 129-141
-
-
Remick, J.1
Weintraub, H.2
Setton, R.3
Offenbacher, J.4
Fisher, E.5
Schwartzbard, A.6
-
205
-
-
41149167048
-
Should we use PPAR agonists to reduce cardiovascular risk?
-
Robinson J: Should we use PPAR agonists to reduce cardiovascular risk? PPAR Res. 891425, (2008).
-
(2008)
PPAR Res.
, pp. 891425
-
-
Robinson, J.1
-
206
-
-
23944482211
-
Identification of a novel selective peroxisome proliferators-activated receptor a agonist, 2-methyl-2-(4-{3-{1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1, 2,4-triazol-3-yl]propyl}phenoxy)proppanoic acid (LY618674), that produces marked changes in serum lipids and apolipoprotein A-1 expression
-
Singh JP, Kauffman R, Bensch W et al.: Identification of a novel selective peroxisome proliferators-activated receptor a agonist, 2-methyl-2-(4-{3-{1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl] propyl}phenoxy)proppanoic acid (LY618674), that produces marked changes in serum lipids and apolipoprotein A-1 expression. Mol. Pharmacol. 68, 763-768 (2005).
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 763-768
-
-
Singh, J.P.1
Kauffman, R.2
Bensch, W.3
-
207
-
-
67651171418
-
The peroxisome proliferator-activated receptor-a (PPAR-a) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats
-
Linz W, Wohlfart P, Baader M et al.: The peroxisome proliferator- activated receptor-a (PPAR-a) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats. Acta Pharmacol. Sin. 30, 935-946 (2009).
-
(2009)
Acta Pharmacol. Sin.
, vol.30
, pp. 935-946
-
-
Linz, W.1
Wohlfart, P.2
Baader, M.3
-
208
-
-
33847366561
-
Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARa agonists. 1. Discovey of a novel series potent HDLC raising agents
-
Sierra ML, Benton V, Boullay A-B et al.: Substituted 2-[(4-aminomethyl) phenoxy]-2-methylpropionic acid PPARa agonists. 1. Discovey of a novel series potent HDLC raising agents. J. Med. Chem. 50, 685-695 (2007).
-
(2007)
J. Med. Chem.
, vol.50
, pp. 685-695
-
-
Sierra, M.L.1
Benton, V.2
Boullay, A.-B.3
-
209
-
-
14044262919
-
PPAR ligands: Potential therapies for metabolic syndrome
-
Akiyama TE, Meinke PT, Berger JP: PPAR ligands: Potential therapies for metabolic syndrome. Curr. Diab. Rep. 5, 45-52 (2005).
-
(2005)
Curr. Diab. Rep.
, vol.5
, pp. 45-52
-
-
Akiyama, T.E.1
Meinke, P.T.2
Berger, J.P.3
-
210
-
-
59149084957
-
Peroxisome proliferators-activated receptor g agonists as insulin sensitizers: From the discovery to recent progress
-
Cho N, Momose Y: Peroxisome proliferators-activated receptor g agonists as insulin sensitizers: From the discovery to recent progress. Curr. Top. Med. Chem. 8, 1483-1507 (2008).
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, pp. 1483-1507
-
-
Cho, N.1
Momose, Y.2
-
211
-
-
31344450173
-
Pioglitazone: A review of of its use in Type 2 diabetes mellitus
-
Waugh J, Keating GM, Plosker GL et al.: Pioglitazone: A review of of its use in Type 2 diabetes mellitus. Drugs 66, 410-418 (2006).
-
(2006)
Drugs
, vol.66
, pp. 410-418
-
-
Waugh, J.1
Keating, G.M.2
Plosker, G.L.3
-
212
-
-
34250213233
-
Evolution of paeroxisome proliferator-activated receptor agonists
-
Chang F, Jaber LA, Berlie HD, O'Connell MB: Evolution of paeroxisome proliferator-activated receptor agonists. Ann. Pharmacother. 41, 973-983 (2007).
-
(2007)
Ann. Pharmacother.
, vol.41
, pp. 973-983
-
-
Chang, F.1
Jaber, L.A.2
Berlie, H.D.3
O'Connell, M.B.4
-
213
-
-
10744221639
-
Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Diabetes Association
-
Nesto RW, Bell D, Bonow RO et al.: Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Diabetes Association. Diabetes Care 27, 256-263 (2004).
-
(2004)
Diabetes Care
, vol.27
, pp. 256-263
-
-
Nesto, R.W.1
Bell, D.2
Bonow, R.O.3
-
214
-
-
1942470630
-
Thiazolidinedione-induced congestive heart failure
-
Cheng AYY, Fantus IG: Thiazolidinedione-induced congestive heart failure. Ann. Pharmacother. 38, 817-820 (2004).
-
(2004)
Ann. Pharmacother.
, vol.38
, pp. 817-820
-
-
Cheng, A.Y.Y.1
Fantus, I.G.2
-
215
-
-
24944588417
-
Leukopenia and thrombocytopenia caused by thiazolidinediones
-
Digman C, Klein AK, Pittas AG: Leukopenia and thrombocytopenia caused by thiazolidinediones. Ann. Intern. Med. 143, 465-466 (2005).
-
(2005)
Ann. Intern. Med.
, vol.143
, pp. 465-466
-
-
Digman, C.1
Klein, A.K.2
Pittas, A.G.3
-
216
-
-
34247348110
-
Diabetes drugs tied to fractures in women
-
Hampton T: Diabetes drugs tied to fractures in women. JAMA 297, 1645 (2007).
-
(2007)
JAMA
, vol.297
, pp. 1645
-
-
Hampton, T.1
-
217
-
-
23844470219
-
Pharmacological profile of a novel, non-TZD PPARg agonist
-
Chen X, Osborne MC, Rybczynski PJ et al.: Pharmacological profile of a novel, non-TZD PPARg agonist. Diabetes Obes. Metab. 7, 536-546 (2005).
-
(2005)
Diabetes Obes. Metab.
, vol.7
, pp. 536-546
-
-
Chen, X.1
Osborne, M.C.2
Rybczynski, P.J.3
-
218
-
-
35748941359
-
On behalf of the consortium of the French Ministry of Research and Technology: S 26948: A new specific peroxisome proliferators-activated receptor g modulator with potent antidiabetes and antiatherogenic effects
-
Carmona MC, Louche K, Lefebvre B et al.: On behalf of the consortium of the French Ministry of Research and Technology: S 26948: A new specific peroxisome proliferators-activated receptor g modulator with potent antidiabetes and antiatherogenic effects. Diabetes 56, 2797-2808 (2007).
-
(2007)
Diabetes
, vol.56
, pp. 2797-2808
-
-
Carmona, M.C.1
Louche, K.2
Lefebvre, B.3
-
219
-
-
24144444526
-
Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects
-
Calkin AC, Forbes JM, Smith CM et al.: Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects. Arterioscler. Thromb. Vasc. Biol. 25, 1903-1909 (2005).
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1903-1909
-
-
Calkin, A.C.1
Forbes, J.M.2
Smith, C.M.3
-
220
-
-
2442626743
-
Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients witout diabetes
-
Sidhu JS, Kaposzta Z, Markus HS, Kaski JC: Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients witout diabetes. Arterioscler. Thromb. Vasc. Biol. 24, 930-934 (2004).
-
(2004)
Arterioscler. Thromb. Vasc. Biol.
, vol.24
, pp. 930-934
-
-
Sidhu, J.S.1
Kaposzta, Z.2
Markus, H.S.3
Kaski, J.C.4
-
221
-
-
33644853793
-
Peroxisome proliferators-activated receptor-g activation with pioglitazone improves endothelium dependent dialation in nondiabetic patients with major cardiovascular risk factors
-
Campia U, Matuskey LA, Panza JA: Peroxisome proliferators-activated receptor-g activation with pioglitazone improves endothelium dependent dialation in nondiabetic patients with major cardiovascular risk factors. Circulation 113, 867-875 (2006).
-
(2006)
Circulation
, vol.113
, pp. 867-875
-
-
Campia, U.1
Matuskey, L.A.2
Panza, J.A.3
-
222
-
-
33646695436
-
Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: Data from a randomized placebo-controlled trial
-
Meisner F, Walcher D, Gizard F et al.: Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: Data from a randomized placebo-controlled trial. Arterioscler. Thromb. Vasc. Biol. 26, 845-850 (2006).
-
(2006)
Arterioscler. Thromb. Vasc. Biol.
, vol.26
, pp. 845-850
-
-
Meisner, F.1
Walcher, D.2
Gizard, F.3
-
223
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infraction and death from cardiovascular causes
-
Nissen SE, Wolski K: Effect of rosiglitazone on the risk of myocardial infraction and death from cardiovascular causes. N. Engl. J. Med. 356, 2457-2471 (2007).
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
224
-
-
34548303246
-
The rosiglitazone story-lessons from an FDA adviosry committee meeting
-
Rosen CJ: The rosiglitazone story-lessons from an FDA Adviosry Committee Meeting. N. Engl. J. Med. 357, 844-846 (2007).
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 844-846
-
-
Rosen, C.J.1
-
225
-
-
35648969638
-
Does rosiglitazone increase cardiovascular outcomes?
-
Dogrell SA: Does rosiglitazone increase cardiovascular outcomes? Expert Opin. Pharmacother. 8, 2665-2669 (2007).
-
(2007)
Expert Opin. Pharmacother.
, vol.8
, pp. 2665-2669
-
-
Dogrell, S.A.1
-
226
-
-
65349195631
-
The obesity, metabolic syndrome, and Type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and Type 2 diabetes mellitus
-
Ginsberg HN, MacCallum PR: The obesity, metabolic syndrome, and Type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and Type 2 diabetes mellitus. J. Cardiometab. Syndr. 4, 113-119 (2009).
-
(2009)
J. Cardiometab. Syndr.
, vol.4
, pp. 113-119
-
-
Ginsberg, H.N.1
MacCallum, P.R.2
-
227
-
-
26844431513
-
Dual and pan-peroxisome proliferators-activated receptors (PPAR) co-agonism: The benzafibrate lessons
-
Tenenbaum A, Motro M, Fisman EZ: Dual and pan-peroxisome proliferators-activated receptors (PPAR) co-agonism: The benzafibrate lessons. Cardiovasc. Diabetol. 14 4, 14, (2005).
-
(2005)
Cardiovasc. Diabetol.
, vol.14
, Issue.4
, pp. 14
-
-
Tenenbaum, A.1
Motro, M.2
Fisman, E.Z.3
-
228
-
-
34547661569
-
Safety issues and prospects for future generations of PPAR modulators
-
Rubenstrunk A, Hanf R, Hun DW, Fruchart JC, Stales B: Safety issues and prospects for future generations of PPAR modulators. Biochim. Biophys. Acta 1771, 1065-1081 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1065-1081
-
-
Rubenstrunk, A.1
Hanf, R.2
Hun, D.W.3
Fruchart, J.C.4
Stales, B.5
-
229
-
-
34547625616
-
The next generation of PPAR drugs: Do we have the tools to find them?
-
Sharer BG, Billin AN: The next generation of PPAR drugs: Do we have the tools to find them? Biochim. Biophys. Acta 1771, 1082-1093 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1082-1093
-
-
Sharer, B.G.1
Billin, A.N.2
-
230
-
-
28144451163
-
Effect of muraglitizar on death and major adverse cardiovascular events in patients with Type 2 diabetes mellitus
-
Nissen SE, Wolski K, Topol EJ: Effect of muraglitizar on death and major adverse cardiovascular events in patients with Type 2 diabetes mellitus. JAMA 294, 2581-2586 (2005).
-
(2005)
JAMA
, vol.294
, pp. 2581-2586
-
-
Nissen, S.E.1
Wolski, K.2
Topol, E.J.3
-
231
-
-
34948839833
-
On behalf of the Gallant 6 Study Group: A double-blind, randomized trial of tesaglitazar versus pioglitazone in patients with Type 2 diabetes mellitus
-
Bay H, McElhattan J, Bryzinski BS; On behalf of the Gallant 6 Study Group: A double-blind, randomized trial of tesaglitazar versus pioglitazone in patients with Type 2 diabetes mellitus. Diab. Vasc. Dis. Res. 4, 181-193 (2007).
-
(2007)
Diab. Vasc. Dis. Res.
, vol.4
, pp. 181-193
-
-
Bay, H.1
McElhattan, J.2
Bryzinski, B.S.3
-
232
-
-
24944505598
-
Tesaglitazar, a novel dual peroxisome proliferator-activated receptor a/g agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population
-
Fagerberg B, Edwards S, Halmos T et al.: Tesaglitazar, a novel dual peroxisome proliferator-activated receptor a/g agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population. Diabetologia 48, 1716-1725 (2005).
-
(2005)
Diabetologia
, vol.48
, pp. 1716-1725
-
-
Fagerberg, B.1
Edwards, S.2
Halmos, T.3
-
233
-
-
33947110940
-
Safety considerations with fibrate therapy
-
Davidson MH, Armani A, McKenney JM, Jacobson TA: Safety considerations with fibrate therapy. Am. J. Cardiol. 99 (Suppl. 1), S3-S18 (2007).
-
(2007)
Am. J. Cardiol.
, vol.99
, Issue.SUPPL. 1
-
-
Davidson, M.H.1
Armani, A.2
McKenney, J.M.3
Jacobson, T.A.4
-
234
-
-
47249146946
-
PPAR modulators and PPAR pan agonists for metabolic diseases: The next generation of drugs targeting peroxisome proliferator-activated receptors?
-
Feldman PL, Lambert MH, Henke BR: PPAR modulators and PPAR pan agonists for metabolic diseases: The next generation of drugs targeting peroxisome proliferator-activated receptors? Curr. Top. Med. Chem. 8, 728-749 (2008).
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, pp. 728-749
-
-
Feldman, P.L.1
Lambert, M.H.2
Henke, B.R.3
-
235
-
-
33646045898
-
Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
-
Balint BL, Nagy L: Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocr. Metab. Immune Disord. Drug Targets 6, 33-43 (2006).
-
(2006)
Endocr. Metab. Immune Disord. Drug Targets
, vol.6
, pp. 33-43
-
-
Balint, B.L.1
Nagy, L.2
-
236
-
-
42449158652
-
Selective estrogen receptor modulators: An update on recent clinical findings
-
Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB: Selective estrogen receptor modulators: An update on recent clinical findings. Obstet. Gynecol. Surv. 63, 163-181 (2008).
-
(2008)
Obstet. Gynecol. Surv.
, vol.63
, pp. 163-181
-
-
Shelly, W.1
Draper, M.W.2
Krishnan, V.3
Wong, M.4
Jaffe, R.B.5
-
237
-
-
67651103000
-
Potential of selective estrogen receptor modulators as treatment
-
Peng J, Sengupta S, Jordan VC: Potential of selective estrogen receptor modulators as treatment. Anticancer Agents Med. Chem. 9, 481-499 (2009).
-
(2009)
Anticancer Agents Med. Chem.
, vol.9
, pp. 481-499
-
-
Peng, J.1
Sengupta, S.2
Jordan, V.C.3
-
238
-
-
2542635631
-
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor a
-
Cheung C, Akiyama TE, Ward JM et al.: Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor a. Cancer Res. 64, 3849-3854 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 3849-3854
-
-
Cheung, C.1
Akiyama, T.E.2
Ward, J.M.3
-
239
-
-
36949024511
-
The PPARa-humanized mouse: A model to investigate species differences in liver toxicity mediated by PPARa
-
Yang Q, Nagano T, Shah Y, Cheung C, Ito S, Gonzalez FJ: The PPARa-humanized mouse: A model to investigate species differences in liver toxicity mediated by PPARa. Toxicol. Sci. 101, 132-139 (2008).
-
(2008)
Toxicol. Sci.
, vol.101
, pp. 132-139
-
-
Yang, Q.1
Nagano, T.2
Shah, Y.3
Cheung, C.4
Ito, S.5
Gonzalez, F.J.6
-
240
-
-
12144291563
-
Peroxisome proliferator-activated receptor g is required in mature white and brown adipocytes for their survival in the mouse
-
Imai T, Takakuwa R, Marchand S et al.: Peroxisome proliferator-activated receptor g is required in mature white and brown adipocytes for their survival in the mouse. Proc. Natl Acad. Sci. USA 101, 4543-4547 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 4543-4547
-
-
Imai, T.1
Takakuwa, R.2
Marchand, S.3
-
241
-
-
13744249406
-
PPARg-mediated insulin sensitization: The importance of fat versus muscle
-
Kintscher U, Law RE: PPARg-mediated insulin sensitization: The importance of fat versus muscle. Am. J. Physiol. Endocrinol. Metab. 288, E287-E291 (2005).
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
-
-
Kintscher, U.1
Law, R.E.2
-
242
-
-
9144229185
-
Adipose-specific peroxisome proliferator-activated receptor g knockout causes insulin resisatnce in fat and liver but not in muscle
-
He W, Barak Y, Hevener et al.: Adipose-specific peroxisome proliferator-activated receptor g knockout causes insulin resisatnce in fat and liver but not in muscle. Proc. Natl Acad. Sci. USA 100, 15712-15717 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener3
-
243
-
-
20944439189
-
Deletion of PPARg in a adipose tissues of mice protects against high fat diet-induced obesity and insulin resisatnce
-
Jones JR, Barrick C, Kim K-A et al.: Deletion of PPARg in a adipose tissues of mice protects against high fat diet-induced obesity and insulin resisatnce. Proc. Natl Acad. Sci. USA 102, 6207-6212 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 6207-6212
-
-
Jones, J.R.1
Barrick, C.2
Kim, K.-A.3
-
244
-
-
0141446024
-
Liver peroxisome proliferator-activated receptor g contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
-
Gavrilova O, Haluzik M, Matsusue K et al.: Liver peroxisome proliferator-activated receptor g contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278, 34268-34276 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34268-34276
-
-
Gavrilova, O.1
Haluzik, M.2
Matsusue, K.3
-
245
-
-
0037373008
-
Liver-specific disruption of PPARg in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
-
Matsusue K, Haluzik M, Lambert G et al.: Liver-specific disruption of PPARg in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J. Clinical Invest. 111, 737-747 (2003).
-
(2003)
J. Clinical Invest.
, vol.111
, pp. 737-747
-
-
Matsusue, K.1
Haluzik, M.2
Lambert, G.3
-
246
-
-
85047693638
-
Muscle-specific PPARg-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
-
Norris AW, Chen L, Fisher SJ et al.: Muscle-specific PPARg-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Invest. 112, 608-618 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 608-618
-
-
Norris, A.W.1
Chen, L.2
Fisher, S.J.3
-
247
-
-
0346027235
-
Muscle-specific PPARg deletion causes insulin resistance
-
Hevener AL, He W, Barak Y et al.: Muscle-specific PPARg deletion causes insulin resistance. Nature Med. 9, 1491-1497 (2003).
-
(2003)
Nature Med.
, vol.9
, pp. 1491-1497
-
-
Hevener, A.L.1
He, W.2
Barak, Y.3
-
248
-
-
24044476859
-
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-g both induce cardiac hypertrophy in mice
-
Zhong S, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM: Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-g both induce cardiac hypertrophy in mice. Circ Res. 97, 372-379 (2005).
-
(2005)
Circ Res.
, vol.97
, pp. 372-379
-
-
Zhong, S.1
Ivashchenko, C.Y.2
Russell, M.W.3
Milstone, D.S.4
Mortensen, R.M.5
-
249
-
-
66549127391
-
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-g deletion leads to hypotension
-
Chang L, Villacorta L, Zhang J et al.: Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-g deletion leads to hypotension. Circulation 119, 2161-2169 (2009).
-
(2009)
Circulation
, vol.119
, pp. 2161-2169
-
-
Chang, L.1
Villacorta, L.2
Zhang, J.3
-
250
-
-
62749196172
-
Distinct functions of vascular endothelial and smooth muscle PPARg in regulation of blood oressure and vascular tone
-
Wang N, Symons JD, Zhang H et al.: Distinct functions of vascular endothelial and smooth muscle PPARg in regulation of blood oressure and vascular tone. Toxicol. Pathol. 37, 21-27 (2009).
-
(2009)
Toxicol. Pathol.
, vol.37
, pp. 21-27
-
-
Wang, N.1
Symons, J.D.2
Zhang, H.3
-
251
-
-
39649100393
-
Interference with PPARg function in smooth muscle causes vascular dysfunction and hypertension
-
Halabi CM, Beyer AM, de Lange W et al.: Interference with PPARg function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 7, 215-226 (2008).
-
(2008)
Cell Metab.
, vol.7
, pp. 215-226
-
-
Halabi, C.M.1
Beyer, A.M.2
De Lange, W.3
-
252
-
-
70350433697
-
Disruption of endothelial peroxisome proliferator-activated receptor-g reduces vascular nitric oxide production
-
Kleinhenz JM, Kleinhenz DJ, You S et al.: Disruption of endothelial peroxisome proliferator-activated receptor-g reduces vascular nitric oxide production. Am. J. Physiol. Heart Circ. Physiol. 297, H1647-H1654 (2009).
-
(2009)
Am. J. Physiol. Heart Circ. Physiol.
, vol.297
-
-
Kleinhenz, J.M.1
Kleinhenz, D.J.2
You, S.3
-
253
-
-
17044430286
-
PPARg in endothelial cells influences high fat diet-induced hypertension
-
Nicol CJ, Adachi M, Akiyama TE, Gonzalez FJ: PPARg in endothelial cells influences high fat diet-induced hypertension. Am. J. Hypertens. 18, 549-556 (2005).
-
(2005)
Am. J. Hypertens.
, vol.18
, pp. 549-556
-
-
Nicol, C.J.1
Adachi, M.2
Akiyama, T.E.3
Gonzalez, F.J.4
-
254
-
-
34347354309
-
Macrophage-specific PPARg controls alternative activation and improve insulin resistance
-
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH et al.: Macrophage-specific PPARg controls alternative activation and improve insulin resistance. Nature 447, 1116-1121 (2007).
-
(2007)
Nature
, vol.447
, pp. 1116-1121
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
-
255
-
-
34948910262
-
Cradiomyocyte expression of PPARg leads to cardiac dysfunction in mice
-
Son NH, Park TS, Yamashita H et al.: Cradiomyocyte expression of PPARg leads to cardiac dysfunction in mice. J. Clin. Invest. 117, 2791-2801 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2791-2801
-
-
Son, N.H.1
Park, T.S.2
Yamashita, H.3
-
256
-
-
73649126161
-
Selective activation of PPARg in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
-
Amin RH, Mathews ST, Camp HS, Ding L, Left T: Selective activation of PPARg in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. Am. J. Physiol. Endocrinol. Metab. 298, E28-E37 (2009).
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Amin, R.H.1
Mathews, S.T.2
Camp, H.S.3
Ding, L.4
Left, T.5
-
257
-
-
3242720242
-
Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity
-
Zhang J, Fu M, Cui T et al.: Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity. Proc. Natl Acad. Sci. USA 101, 10703-10708 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10703-10708
-
-
Zhang, J.1
Fu, M.2
Cui, T.3
-
258
-
-
20044380758
-
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform
-
Medina-Gomez G, Virtue S, Lelliott C et al.: The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-γ2 isoform. Diabetes 54, 1706-1718 (2005).
-
(2005)
Diabetes
, vol.54
, pp. 1706-1718
-
-
Medina-Gomez, G.1
Virtue, S.2
Lelliott, C.3
-
259
-
-
0344630205
-
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARg hypomorphic mice
-
Koutnikova H, Cock TA, Watanabe M et al.: Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARg hypomorphic mice. Proc. Natl Acad. Sci. USA 100, 14457-114462 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14457-114462
-
-
Koutnikova, H.1
Cock, T.A.2
Watanabe, M.3
-
260
-
-
28044452217
-
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with Type 2 diabetes mellitus (the FIELD study): Randomized controlled trial
-
Keech A, Simes RJ, Barter P et al.: Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with Type 2 diabetes mellitus (the FIELD study): Randomized controlled trial. Lancet 26, 1849-1861 (2005).
-
(2005)
Lancet
, vol.26
, pp. 1849-1861
-
-
Keech, A.1
Simes, R.J.2
Barter, P.3
-
262
-
-
35148890313
-
PROactive 07: Pioglitazone in the treatment of type 2 diabetes: Results of the PROactive study
-
Erdman E, Dormandy J, Wilcox R, Massi-Benedetti M, Charbonnel B: PROactive: Pioglitazone in the treatment of Type 1 diabetes: Results of the PROactive study. Vasc. Health Risk Manag. 3, 355-370 (2007). (Pubitemid 47542597)
-
(2007)
Vascular Health and Risk Management
, vol.3
, Issue.4
, pp. 355-370
-
-
Erdmann, E.1
Dormandy, J.2
Wilcox, R.3
Massi-Benedetti, M.4
Charbonnel, B.5
-
263
-
-
33845405222
-
Glycemic durability of rosiglitazone, metformin or glyburide monotherapy
-
Kahn SE, Haffner SM, Heise MA et al.: Glycemic durability of rosiglitazone, metformin or glyburide monotherapy. N. Engl. J. Med. 355, 2427-2443 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2427-2443
-
-
Kahn, S.E.1
Haffner, S.M.2
Heise, M.A.3
-
264
-
-
33748748206
-
DREAM (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication) trial investigators: Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomized controlled trial
-
Gerstein HC, Yusuf J, Bosch J et al.: DREAM (Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication) trial investigators: Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomized controlled trial. Lancet 368, 1096-1105 (2006).
-
(2006)
Lancet
, vol.368
, pp. 1096-1105
-
-
Gerstein, H.C.1
Yusuf, J.2
Bosch, J.3
-
265
-
-
34250785602
-
Atrion to control cardiovascular risk in diabetes (ACCORD) trial: Design and methods
-
Buse JB: Atrion to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods. Am. J. Cradiol. 99 (Suppl. 1), S21-S33 (2007).
-
(2007)
Am. J. Cradiol.
, vol.99
, Issue.SUPPL. 1
-
-
Buse, J.B.1
-
266
-
-
67149146438
-
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type diabetes (RECORD): A multicenter, randomized, open-label trial
-
Home PD, Pocock SJ, Beck-Nielsen H et al.: Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type diabetes (RECORD): A multicenter, randomized, open-label trial. Lancet 373, 2125-2135 (2009).
-
(2009)
Lancet
, vol.373
, pp. 2125-2135
-
-
Home, P.D.1
Pocock, S.J.2
Beck-Nielsen, H.3
-
267
-
-
41649084422
-
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: The PERISCOPE randomized controlled trial
-
DOI 10.1001/jama.299.13.1561
-
Nissen SE, Nicholls SJ, Wolski K et al.: Compariosn of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with Type 2 diabetes: The PERISCOPE randomized controlled trial. JAMA 299, 1561-1573 (2008). (Pubitemid 351482795)
-
(2008)
JAMA - Journal of the American Medical Association
, vol.299
, Issue.13
, pp. 1561-1573
-
-
Nissen, S.E.1
Nicholls, S.J.2
Wolski, K.3
Nesto, R.4
Kupfer, S.5
Perez, A.6
Jure, H.7
De Larochelliere, R.8
Staniloae, C.S.9
Mavromatis, K.10
Saw, J.11
Hu, B.12
Lincoff, A.M.13
Tuzcu, E.M.14
-
268
-
-
70449467324
-
CHICAGO, PERISCOPE and PROactive: CV risk modification in diabetes with pioglitazone
-
Betterge DJ: CHICAGO, PERISCOPE and PROactive: CV risk modification in diabetes with pioglitazone. Fundam. Clin. Pharmacol. 23, 675-679 (2009).
-
(2009)
Fundam. Clin. Pharmacol.
, vol.23
, pp. 675-679
-
-
Betterge, D.J.1
-
269
-
-
68549085333
-
The clinical implications of the CHICAGO study for the management of cardiovascular risk in patients with Type 2 diabetes
-
Polonsky T, Mazzone T, Dvaidson M: The clinical implications of the CHICAGO study for the management of cardiovascular risk in patients with Type 2 diabetes. Trends Cardiovasc. Med. 19, 94-99 (2009).
-
(2009)
Trends Cardiovasc. Med.
, vol.19
, pp. 94-99
-
-
Polonsky, T.1
Mazzone, T.2
Dvaidson, M.3
-
270
-
-
33745265251
-
Rationale, design, and methods for glycemic control in the Bypass Angioplasty Revascularization Investigation 2 diabetes (BARI 2D) trial
-
Magee ME, Isley WL: Rationale, design, and methods for glycemic control in the Bypass Angioplasty Revascularization Investigation 2 diabetes (BARI 2D) trial. Am. J. Cardiol. 97(Suppl. 1), 20-30 (2006).
-
(2006)
Am. J. Cardiol.
, vol.97
, Issue.SUPPL. 1
, pp. 20-30
-
-
Magee, M.E.1
Isley, W.L.2
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