High-fat feeding in cardiomyocyte-restricted PPARδ knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes

Journal of Molecular and Cellular Cardiology

Volumn 47, Issue 4, 2009, Pages 536-543

  Li, Yuquan ^a   Cheng, Lihong ^b   Qin, Qianhong ^b   Liu, Jian ^a   Lo, Woo kuen ^c   Brako, Lowrence A ^c   Yang, Qinglin ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac hypertrophy; Cardiomyopathy; Fasting; Fatty acid oxidation; Gene transcription; High fat diet; Lipid metabolism; Lipotoxicity; Long chain fatty acid; Metabolic syndrome; Metabolism and the heart; Mice; Myocardial metabolism; Obesity; Peroxisome proliferator activated receptor

Indexed keywords

FATTY ACID; LIPID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENZYME INACTIVATION; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION REGULATION; HEART DISEASE; HEART MITOCHONDRION; HEART MUSCLE CELL; KNOCKOUT MOUSE; LIPID BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SARCOMERE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; DIETARY FATS; FASTING; FATTY ACIDS; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; PHENOTYPE; PPAR ALPHA; PPAR DELTA; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATORS; UP-REGULATION;

MUS;

EID: 69249212275     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.07.001     Document Type: Article

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