-
1
-
-
0024160877
-
Role of insulin resistance in human disease
-
Reaven, G.M. 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
2
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger, J., and Mollet, D.E. 2002. The mechanisms of action of PPARs. Annu. Rev. Med. 53:409-435.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 409-435
-
-
Berger, J.1
Mollet, D.E.2
-
3
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
Tontonoz, P., Hu, E., and Spiegelman, B.M. 1994. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 79:1147-1156.
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
4
-
-
0033213637
-
PPAR gamma is required for placental, cardiac, and adipose tissue development
-
Barak, Y., et al. 1999. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell. 4:585-595.
-
(1999)
Mol. Cell.
, vol.4
, pp. 585-595
-
-
Barak, Y.1
-
5
-
-
0033212964
-
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
-
Kubota, N., et al. 1999. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4:597-609.
-
(1999)
Mol. Cell.
, vol.4
, pp. 597-609
-
-
Kubota, N.1
-
6
-
-
0344375097
-
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome prolifetator-activated receptor-gamma
-
Savage, D.B., et al. 2003. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome prolifetator-activated receptor-gamma. Diabetes. 52:910-917.
-
(2003)
Diabetes
, vol.52
, pp. 910-917
-
-
Savage, D.B.1
-
7
-
-
0036146384
-
A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
-
Agarwal, A.K., and Garg, A. 2002. A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J. Clin. Endocrinol. Metab. 87:408-411.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 408-411
-
-
Agarwal, A.K.1
Garg, A.2
-
8
-
-
0036894397
-
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
-
Hegele, R.A., Cao, H., Ftankowski, C., Mathews, S.T., and Leff, T. 2002. PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes. 51:3586-3590.
-
(2002)
Diabetes
, vol.51
, pp. 3586-3590
-
-
Hegele, R.A.1
Cao, H.2
Ftankowski, C.3
Mathews, S.T.4
Leff, T.5
-
9
-
-
0031595923
-
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
Deeb, S.S., et al. 1998. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 20:284-287.
-
(1998)
Nat. Genet.
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
-
10
-
-
0032189782
-
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
-
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W., and Kahn, C.R. 1998. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl J. Med. 339:953-959.
-
(1998)
N. Engl J. Med.
, vol.339
, pp. 953-959
-
-
Ristow, M.1
Muller-Wieland, D.2
Pfeiffer, A.3
Krone, W.4
Kahn, C.R.5
-
11
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso, I., et al. 1999. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature. 402:880-883.
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
-
12
-
-
84944284695
-
Weight and blood pressure. Findings in hypertension screening of 1 million Americans
-
Stamler, R., Stamler, J., Riedlinger, W.F., Algera, G., and Roberts, R.H. 1978. Weight and blood pressure. Findings in hypertension screening of 1 million Americans. JAMA. 240:1607-1610.
-
(1978)
JAMA
, vol.240
, pp. 1607-1610
-
-
Stamler, R.1
Stamler, J.2
Riedlinger, W.F.3
Algera, G.4
Roberts, R.H.5
-
13
-
-
0031710787
-
Prevalence of insulin resistance in metabolic disorders: The Bruneck Study
-
Bonora, E., et al. 1998. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes. 47:1643-1649.
-
(1998)
Diabetes
, vol.47
, pp. 1643-1649
-
-
Bonora, E.1
-
14
-
-
0033860359
-
Insulin resistance and cardiovascular disease
-
Ginsberg, H.N. 2000. Insulin resistance and cardiovascular disease. J. Clin. Invest. 106:453-458.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 453-458
-
-
Ginsberg, H.N.1
-
15
-
-
0034095811
-
Physiology and pathophysiology of the adipose tissue renin-angiotensin system
-
Engeli, S., Negrel, R., and Sharma, A.M. 2000. Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension. 35:1270-1277.
-
(2000)
Hypertension
, vol.35
, pp. 1270-1277
-
-
Engeli, S.1
Negrel, R.2
Sharma, A.M.3
-
16
-
-
0036078427
-
Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat
-
Hainault, I., et al. 2002. Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat. Am. J. Physiol. Endocrinol. Metab. 282:E59-E66.
-
(2002)
Am. J. Physiol. Endocrinol. Metab.
, vol.282
-
-
Hainault, I.1
-
17
-
-
0035650575
-
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
-
Massiera, F., et al. 2001. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 15:2727-2729.
-
(2001)
FASEB J.
, vol.15
, pp. 2727-2729
-
-
Massiera, F.1
-
18
-
-
0027443636
-
Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats
-
Dubey, R.K., Zhang, H.Y., Reddy, S.R., Boegehold, M.A., and Kotchen, T.A. 1993. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am. J. Physiol. 265:R726-R732.
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Dubey, R.K.1
Zhang, H.Y.2
Reddy, S.R.3
Boegehold, M.A.4
Kotchen, T.A.5
-
19
-
-
0028901028
-
Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
-
Ogihara, T., Rakugi, H., Ikegami, H., Mikami, H., and Masuo, K. 1995. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am. J. Hypertens. 8:316-320.
-
(1995)
Am. J. Hypertens.
, vol.8
, pp. 316-320
-
-
Ogihara, T.1
Rakugi, H.2
Ikegami, H.3
Mikami, H.4
Masuo, K.5
-
20
-
-
0344333464
-
Peroxisome prolifetator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
-
Marx, N., Schonbeck, U., Lazar, M.A., Libby, P., and Plutzky, J. 1998. Peroxisome prolifetator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ. Res. 83:1097-1103.
-
(1998)
Circ. Res.
, vol.83
, pp. 1097-1103
-
-
Marx, N.1
Schonbeck, U.2
Lazar, M.A.3
Libby, P.4
Plutzky, J.5
-
21
-
-
0033520304
-
Petoxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
-
Delerive, P., et al. 1999. Petoxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ. Res. 85:394-402.
-
(1999)
Circ. Res.
, vol.85
, pp. 394-402
-
-
Delerive, P.1
-
22
-
-
0032587328
-
PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease
-
Marx, N., Bourcier, T., Sukhova, G.K., Libby, P., and Plutzky, J. 1999. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb. Vasc. Biol. 19:546-551.
-
(1999)
Arterioscler Thromb. Vasc. Biol.
, vol.19
, pp. 546-551
-
-
Marx, N.1
Bourcier, T.2
Sukhova, G.K.3
Libby, P.4
Plutzky, J.5
-
23
-
-
0033387870
-
Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney
-
Yang, T., et al. 1999. Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. Am. J. Physiol. 277:F966-F973.
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Yang, T.1
-
24
-
-
0034633847
-
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells
-
Takeda, K., et al. 2000. Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. Circulation. 102:1834-1839.
-
(2000)
Circulation
, vol.102
, pp. 1834-1839
-
-
Takeda, K.1
-
25
-
-
0032576551
-
Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases
-
Matsubara, H. 1998. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ. Res. 83:1182-1191.
-
(1998)
Circ. Res.
, vol.83
, pp. 1182-1191
-
-
Matsubara, H.1
-
26
-
-
0033973843
-
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency
-
Miles, P.D., Barak, Y., He, W., Evans, R.M., and Olefsky, J.M. 2000. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J. Clin. Invest. 105:287-292.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 287-292
-
-
Miles, P.D.1
Barak, Y.2
He, W.3
Evans, R.M.4
Olefsky, J.M.5
-
27
-
-
0037066014
-
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo
-
Asakawa, M., et al. 2002. Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo. Circulation. 105:1240-1246.
-
(2002)
Circulation
, vol.105
, pp. 1240-1246
-
-
Asakawa, M.1
-
28
-
-
0037872709
-
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
-
Kulkarni, R.N., et al. 2003. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes. 52:1528-1534.
-
(2003)
Diabetes
, vol.52
, pp. 1528-1534
-
-
Kulkarni, R.N.1
-
29
-
-
0034079629
-
Genetic modifiers of the insulin resistance phenotype in mice
-
Kido, Y., Philippe, N., Schaffer, A.A., and Accili, D. 2000. Genetic modifiers of the insulin resistance phenotype in mice. Diabetes. 49:589-596.
-
(2000)
Diabetes
, vol.49
, pp. 589-596
-
-
Kido, Y.1
Philippe, N.2
Schaffer, A.A.3
Accili, D.4
-
30
-
-
18644382993
-
Digenic inheritance of severe insulin resistance in a human pedigree
-
Savage, D.B., et al. 2002. Digenic inheritance of severe insulin resistance in a human pedigree. Nat. Genet. 31:379-384.
-
(2002)
Nat. Genet.
, vol.31
, pp. 379-384
-
-
Savage, D.B.1
-
31
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang, C.Y., et al. 2001. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 105:745-755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
-
32
-
-
0034781057
-
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha
-
Tuttle, R.L., et al. 2001. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat. Med. 7:1133-1137.
-
(2001)
Nat. Med.
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
-
33
-
-
0035815650
-
Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation
-
Medvedev, A.N., Snedden, S.K., Raimbault, S., Ricquier, D., and Collins, S. 2001. Transcriptional regulation of the mouse uncoupling protein-2 gene. Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. J. Biol. Chem. 276:10817-10823.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 10817-10823
-
-
Medvedev, A.N.1
Snedden, S.K.2
Raimbault, S.3
Ricquier, D.4
Collins, S.5
-
34
-
-
0034119138
-
The perils of portliness: Causes and consequences of visceral adiposity
-
Montague, C.T., and O'Rahilly, S. 2000. The perils of portliness: causes and consequences of visceral adiposity. Diabetes. 49:883-888.
-
(2000)
Diabetes
, vol.49
, pp. 883-888
-
-
Montague, C.T.1
O'Rahilly, S.2
-
35
-
-
0032934104
-
Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes
-
Kelly, I.E., Han, T.S., Walsh, K., and Lean, M.E. 1999. Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes. Diabetes Care. 22:288-293.
-
(1999)
Diabetes Care
, vol.22
, pp. 288-293
-
-
Kelly, I.E.1
Han, T.S.2
Walsh, K.3
Lean, M.E.4
-
36
-
-
0034663140
-
Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes
-
Arioglu, E., et al. 2000. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann. Intern. Med. 133:263-274.
-
(2000)
Ann. Intern. Med.
, vol.133
, pp. 263-274
-
-
Arioglu, E.1
-
37
-
-
0037312845
-
PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: Mechanisms for modulation of postprandial lipemia and differential adipose accretion
-
Laplante, M., et al. 2003. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Diabetes. 52:291-299.
-
(2003)
Diabetes
, vol.52
, pp. 291-299
-
-
Laplante, M.1
-
38
-
-
0031678588
-
Depot-related gene expression in human subcutaneous and omental adipocytes
-
Montague, C.T., et al. 1998. Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes. 47:1384-1391.
-
(1998)
Diabetes
, vol.47
, pp. 1384-1391
-
-
Montague, C.T.1
-
39
-
-
0036875133
-
Differential gene expression between visceral and subcutaneous fat depots
-
Atzmon, G., et al. 2002. Differential gene expression between visceral and subcutaneous fat depots. Horm. Metab. Res. 34:622-628.
-
(2002)
Horm. Metab. Res.
, vol.34
, pp. 622-628
-
-
Atzmon, G.1
-
40
-
-
0025441454
-
Insulin, insulin sensitivity and hypertension
-
Ferrari, P., and Weidmann, P. 1990. Insulin, insulin sensitivity and hypertension. J. Hypertens. 8:491-500.
-
(1990)
J. Hypertens.
, vol.8
, pp. 491-500
-
-
Ferrari, P.1
Weidmann, P.2
-
41
-
-
0032993428
-
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats
-
Walker, A.B., Chattington, P.D., Buckingham, R.E., and Williams, G. 1999. The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats. Diabetes. 48:1448-1453.
-
(1999)
Diabetes
, vol.48
, pp. 1448-1453
-
-
Walker, A.B.1
Chattington, P.D.2
Buckingham, R.E.3
Williams, G.4
-
42
-
-
0033564213
-
Targeting genes for self-excision in the germ line
-
Bunting, M., Bernstein, K.E., Greet, J.M., Capecchi, M.R., and Thomas, K.R. 1999. Targeting genes for self-excision in the germ line. Genes Dev. 13:1524-1528.
-
(1999)
Genes Dev.
, vol.13
, pp. 1524-1528
-
-
Bunting, M.1
Bernstein, K.E.2
Greet, J.M.3
Capecchi, M.R.4
Thomas, K.R.5
-
43
-
-
0026536066
-
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
-
Piedrahita, J.A., Zhang, S.H., Hagaman, J.R., Oliver, P.M., and Maeda, N. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 89:4471-4475.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 4471-4475
-
-
Piedrahita, J.A.1
Zhang, S.H.2
Hagaman, J.R.3
Oliver, P.M.4
Maeda, N.5
-
44
-
-
0035214264
-
A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes
-
Glorian, M., et al. 2001. A single element in the phosphoenolpyruvate carboxykinase gene mediates thiazolidinedione action specifically in adipocytes. Biochimie. 83:933-943.
-
(2001)
Biochimie
, vol.83
, pp. 933-943
-
-
Glorian, M.1
-
45
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
-
Pende, M., et al. 2000. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature. 408:994-997.
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
-
46
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi, T., et al. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:941-946.
-
(2001)
Nat. Med.
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
-
47
-
-
0033917321
-
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
-
Kim, J.K., et al. 2000. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J. Clin. Invest. 105:1791-1797.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1791-1797
-
-
Kim, J.K.1
-
48
-
-
0029006463
-
A noninvasive computerized tail-cuff system for measuring blood pressure in mice
-
Krege, J.H., Hodgin, J.B., Hagaman, J.R., and Smithies, O. 1995. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension. 25:1111-1115.
-
(1995)
Hypertension
, vol.25
, pp. 1111-1115
-
-
Krege, J.H.1
Hodgin, J.B.2
Hagaman, J.R.3
Smithies, O.4
-
49
-
-
0347671203
-
Long-term telemetric measurement of cardiovascular parameters in awake mice: A physiological genomics tool
-
Butz, G.M., and Davisson, R.L. 2001. Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool. Physiol. Genomics. 5:89-97.
-
(2001)
Physiol. Genomics
, vol.5
, pp. 89-97
-
-
Butz, G.M.1
Davisson, R.L.2
-
50
-
-
0033975276
-
Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II
-
Oliverio, M.I., Best, C.F., Smithies, O., and Coffman, T.M. 2000. Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Hypertension. 35:550-554.
-
(2000)
Hypertension
, vol.35
, pp. 550-554
-
-
Oliverio, M.I.1
Best, C.F.2
Smithies, O.3
Coffman, T.M.4
|