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Volumn 26, Issue 5, 2005, Pages 244-251

PPARs: Therapeutic targets for metabolic disease

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; 5 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL) 2 HYDROXYETHOXY]BENZYL] 2,4 THIAZOLIDINEDIONE; ANTIDIABETIC AGENT; CELL NUCLEUS RECEPTOR; COMPOUND 24; COMPOUND 48; FK 614; LY 510929; MURAGLITAZAR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; RAGAGLITAZAR; ROSIGLITAZONE; SIMVASTATIN; TESAGLITAZAR; TZD 18; UNCLASSIFIED DRUG; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID;

EID: 18044376795     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2005.03.003     Document Type: Review
Times cited : (631)

References (87)
  • 1
    • 0036183630 scopus 로고    scopus 로고
    • The mechanism of action of PPARs
    • J. Berger, and D.E. Moller The mechanism of action of PPARs Annu. Rev. Med. 53 2002 409 435
    • (2002) Annu. Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 2
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr. Rev. 20 1999 649 688
    • (1999) Endocr. Rev. , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 3
    • 0141611975 scopus 로고    scopus 로고
    • The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis
    • J. Plutzky The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis Am. J. Cardiol. 92 2003 34J 41J
    • (2003) Am. J. Cardiol. , vol.92
    • Plutzky, J.1
  • 4
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • R.M. Evans PPARs and the complex journey to obesity Nat. Med. 10 2004 355 361
    • (2004) Nat. Med. , vol.10 , pp. 355-361
    • Evans, R.M.1
  • 5
    • 0030835678 scopus 로고    scopus 로고
    • The organization, promoter analysis, and expression of the human PPARgamma gene
    • L. Fajas The organization, promoter analysis, and expression of the human PPARgamma gene J. Biol. Chem. 272 1997 18779 18789
    • (1997) J. Biol. Chem. , vol.272 , pp. 18779-18789
    • Fajas, L.1
  • 6
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor
    • P. Tontonoz Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor Cell 79 1994 1147 1156
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1
  • 7
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    • W. He Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle Proc. Natl. Acad. Sci. U. S. A. 100 2003 15712 15717
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15712-15717
    • He, W.1
  • 8
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Y. Barak PPAR gamma is required for placental, cardiac, and adipose tissue development Mol. Cell 4 1999 585 595
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1
  • 9
    • 0033212964 scopus 로고    scopus 로고
    • PPARγ mediates high fat diet-induced adipocyte hypertrophy and insulin resistance
    • N. Kubota PPARγ mediates high fat diet-induced adipocyte hypertrophy and insulin resistance Mol. Cell 4 1999 597 609
    • (1999) Mol. Cell , vol.4 , pp. 597-609
    • Kubota, N.1
  • 10
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • E.D. Rosen PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro Mol. Cell 4 1999 611 617
    • (1999) Mol. Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1
  • 11
    • 0033708410 scopus 로고    scopus 로고
    • Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
    • L. Chao Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones J. Clin. Invest. 106 2000 1221 1228
    • (2000) J. Clin. Invest. , vol.106 , pp. 1221-1228
    • Chao, L.1
  • 12
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific Pparg deletion causes insulin resistance
    • A.L. Hevener Muscle-specific Pparg deletion causes insulin resistance Nat. Med. 9 2003 1491 1497
    • (2003) Nat. Med. , vol.9 , pp. 1491-1497
    • Hevener, A.L.1
  • 13
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • A.W. Norris Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones J. Clin. Invest. 112 2003 608 618
    • (2003) J. Clin. Invest. , vol.112 , pp. 608-618
    • Norris, A.W.1
  • 14
    • 2542491213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma in diabetes and metabolism
    • S.M. Rangwala, and M.A. Lazar Peroxisome proliferator-activated receptor gamma in diabetes and metabolism Trends Pharmacol. Sci. 25 2004 331 336
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 331-336
    • Rangwala, S.M.1    Lazar, M.A.2
  • 15
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • H. Bays Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach J. Clin. Endocrinol. Metab. 89 2004 463 478
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 463-478
    • Bays, H.1
  • 16
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • A.B. Mayerson The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes Diabetes 51 2002 797 802
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1
  • 17
    • 0037567697 scopus 로고    scopus 로고
    • Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes
    • M. Bajaj Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes Diabetes 52 2003 1364 1370
    • (2003) Diabetes , vol.52 , pp. 1364-1370
    • Bajaj, M.1
  • 18
    • 0000708629 scopus 로고    scopus 로고
    • Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes
    • T. Kawai Effects of troglitazone on fat distribution in the treatment of male type 2 diabetes Metabolism 48 1999 1102 1107
    • (1999) Metabolism , vol.48 , pp. 1102-1107
    • Kawai, T.1
  • 19
    • 0036072223 scopus 로고    scopus 로고
    • Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
    • Y. Miyazaki Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients J. Clin. Endocrinol. Metab. 87 2002 2784 2791
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 2784-2791
    • Miyazaki, Y.1
  • 20
    • 0037312845 scopus 로고    scopus 로고
    • PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: Mechanisms for modulation of postprandial lipemia and differential adipose accretion
    • M. Laplante PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion Diabetes 52 2003 291 299
    • (2003) Diabetes , vol.52 , pp. 291-299
    • Laplante, M.1
  • 21
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • A. Okuno Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats J. Clin. Invest. 101 1998 1354 1361
    • (1998) J. Clin. Invest. , vol.101 , pp. 1354-1361
    • Okuno, A.1
  • 22
    • 0038142248 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes
    • G. Boden Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes Metabolism 52 2003 753 759
    • (2003) Metabolism , vol.52 , pp. 753-759
    • Boden, G.1
  • 23
    • 0030657602 scopus 로고    scopus 로고
    • Regional adipocity in man
    • P. Arner Regional adipocity in man J. Endocrinol. 155 1997 191 192
    • (1997) J. Endocrinol. , vol.155 , pp. 191-192
    • Arner, P.1
  • 24
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • R.A. Hegele PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy Diabetes 51 2002 3586 3590
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1
  • 25
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    • D.B. Savage Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma Diabetes 52 2003 910 917
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1
  • 26
    • 0042330251 scopus 로고    scopus 로고
    • Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
    • M.W. Rajala, and P.E. Scherer Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 144 2003 3765 3773
    • (2003) Endocrinology , vol.144 , pp. 3765-3773
    • Rajala, M.W.1    Scherer, P.E.2
  • 27
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • A.H. Berg The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947 953
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1
  • 28
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • T. Yamauchi The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nat. Med. 7 2001 941 946
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 29
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: A potential mechanism of insulin sensitization
    • T.P. Combs Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization Endocrinology 143 2002 998 1007
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1
  • 30
    • 0842313004 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients
    • M. Bajaj Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients J. Clin. Endocrinol. Metab. 89 2004 200 206
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 200-206
    • Bajaj, M.1
  • 31
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • H. Xu Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112 2003 1821 1830
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1
  • 33
    • 2642563899 scopus 로고    scopus 로고
    • Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines
    • H. Ruan, and H.F. Lodish Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines Curr. Opin. Lipidol. 15 2004 297 302
    • (2004) Curr. Opin. Lipidol. , vol.15 , pp. 297-302
    • Ruan, H.1    Lodish, H.F.2
  • 34
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • A.C. Li Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice J. Clin. Invest. 106 2000 523 531
    • (2000) J. Clin. Invest. , vol.106 , pp. 523-531
    • Li, A.C.1
  • 35
    • 0035097590 scopus 로고    scopus 로고
    • Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
    • Z. Chen Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL Arterioscler. Thromb. Vasc. Biol. 21 2001 372 377
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 372-377
    • Chen, Z.1
  • 36
    • 0842311509 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma: Implications for cardiovascular disease
    • W.A. Hsueh, and D. Bruemmer Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease Hypertension 43 2004 297 305
    • (2004) Hypertension , vol.43 , pp. 297-305
    • Hsueh, W.A.1    Bruemmer, D.2
  • 37
    • 0035138625 scopus 로고    scopus 로고
    • PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    • G. Chinetti PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nat. Med. 7 2001 53 58
    • (2001) Nat. Med. , vol.7 , pp. 53-58
    • Chinetti, G.1
  • 38
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • A. Chawla A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Mol. Cell 7 2001 161 171
    • (2001) Mol. Cell , vol.7 , pp. 161-171
    • Chawla, A.1
  • 39
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • T.E. Akiyama Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux Mol. Cell. Biol. 22 2002 2607 2619
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1
  • 40
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • M. Ricote The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation Nature 391 1998 79 82
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1
  • 41
    • 0038460253 scopus 로고    scopus 로고
    • PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    • J.S. Welch PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages Proc. Natl. Acad. Sci. U. S. A. 100 2003 6712 6717
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6712-6717
    • Welch, J.S.1
  • 42
    • 0034637218 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes
    • U. Kintscher Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes Eur. J. Pharmacol. 401 2000 259 270
    • (2000) Eur. J. Pharmacol. , vol.401 , pp. 259-270
    • Kintscher, U.1
  • 43
    • 0032475922 scopus 로고    scopus 로고
    • Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
    • G. Chinetti Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages J. Biol. Chem. 273 1998 25573 25580
    • (1998) J. Biol. Chem. , vol.273 , pp. 25573-25580
    • Chinetti, G.1
  • 44
    • 0346668393 scopus 로고    scopus 로고
    • A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
    • D. Bruemmer A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth Eur. J. Pharmacol. 466 2003 225 234
    • (2003) Eur. J. Pharmacol. , vol.466 , pp. 225-234
    • Bruemmer, D.1
  • 45
    • 0037503920 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
    • D. Bruemmer Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells Mol. Endocrinol. 17 2003 1005 1018
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1005-1018
    • Bruemmer, D.1
  • 46
    • 0141886991 scopus 로고    scopus 로고
    • Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells
    • D. Bruemmer Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells Circ. Res. 93 2003 e38 e47
    • (2003) Circ. Res. , vol.93
    • Bruemmer, D.1
  • 47
    • 0031724132 scopus 로고    scopus 로고
    • Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes
    • J. Minamikawa Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes J. Clin. Endocrinol. Metab. 83 1998 1818 1820
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 1818-1820
    • Minamikawa, J.1
  • 48
    • 0037022910 scopus 로고    scopus 로고
    • Inflammation and atherosclerosis
    • P. Libby Inflammation and atherosclerosis Circulation 105 2002 1135 1143
    • (2002) Circulation , vol.105 , pp. 1135-1143
    • Libby, P.1
  • 49
    • 0037324289 scopus 로고    scopus 로고
    • Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease
    • N. Marx Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease Arterioscler. Thromb. Vasc. Biol. 23 2003 283 288
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 283-288
    • Marx, N.1
  • 50
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system
    • J.K. Reddy, and T. Hashimoto Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system Annu. Rev. Nutr. 21 2001 193 230
    • (2001) Annu. Rev. Nutr. , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 51
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • S. Kersten Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting J. Clin. Invest. 103 1999 1489 1498
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1
  • 52
    • 0033695265 scopus 로고    scopus 로고
    • Emerging concepts in metabolic abnormalities associated with coronary artery disease
    • J. Plutzky Emerging concepts in metabolic abnormalities associated with coronary artery disease Curr. Opin. Cardiol. 15 2000 416 421
    • (2000) Curr. Opin. Cardiol. , vol.15 , pp. 416-421
    • Plutzky, J.1
  • 53
    • 0033741188 scopus 로고    scopus 로고
    • Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk
    • M.F. Linton, and S. Fazio Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk Curr. Atheroscler. Rep. 2 2000 29 35
    • (2000) Curr. Atheroscler. Rep. , vol.2 , pp. 29-35
    • Linton, M.F.1    Fazio, S.2
  • 54
    • 0028036723 scopus 로고
    • Negative regulation of the human apolipoprotein A-1 promoter by fibrates can be attenuated by interaction of the peroxisome proliferator activated receptor with its response element
    • N. Vu-Dac Negative regulation of the human apolipoprotein A-1 promoter by fibrates can be attenuated by interaction of the peroxisome proliferator activated receptor with its response element J. Biol. Chem. 269 1994 31012 31018
    • (1994) J. Biol. Chem. , vol.269 , pp. 31012-31018
    • Vu-Dac, N.1
  • 55
    • 0029119082 scopus 로고
    • Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor
    • N. Vu-Dac Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor J. Clin. Invest. 96 1995 741 750
    • (1995) J. Clin. Invest. , vol.96 , pp. 741-750
    • Vu-Dac, N.1
  • 56
    • 0242490816 scopus 로고    scopus 로고
    • Pharmacotherapy for dyslipidaemia - Current therapies and future agents
    • H. Bays, and E.A. Stein Pharmacotherapy for dyslipidaemia - current therapies and future agents Expert Opin. Pharmacother. 4 2003 1901 1938
    • (2003) Expert Opin. Pharmacother. , vol.4 , pp. 1901-1938
    • Bays, H.1    Stein, E.A.2
  • 57
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells
    • N. Marx Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells Circ. Res. 94 2004 1168 1178
    • (2004) Circ. Res. , vol.94 , pp. 1168-1178
    • Marx, N.1
  • 58
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • R. Ross Atherosclerosis-an inflammatory disease New Engl. J. Med. 340 1999 115 126
    • (1999) New Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 59
    • 0033594810 scopus 로고    scopus 로고
    • PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • N. Marx PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells Circulation 99 1999 3125 3131
    • (1999) Circulation , vol.99 , pp. 3125-3131
    • Marx, N.1
  • 60
    • 11144355198 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells
    • K. Goya Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells Arterioscler. Thromb. Vasc. Biol. 24 2004 658 663
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , pp. 658-663
    • Goya, K.1
  • 61
    • 0032565868 scopus 로고    scopus 로고
    • Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators
    • B. Staels Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators Nature 393 1998 790 793
    • (1998) Nature , vol.393 , pp. 790-793
    • Staels, B.1
  • 62
    • 0034705071 scopus 로고    scopus 로고
    • CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors
    • G. Chinetti CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors Circulation 101 2000 2411 2417
    • (2000) Circulation , vol.101 , pp. 2411-2417
    • Chinetti, G.1
  • 63
    • 0034614270 scopus 로고    scopus 로고
    • Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells
    • H. Shu Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells Biochem. Biophys. Res. Commun. 267 2000 345 349
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , pp. 345-349
    • Shu, H.1
  • 64
    • 0035895326 scopus 로고    scopus 로고
    • PPARalpha activators inhibit tissue factor expression and activity in human monocytes
    • N. Marx PPARalpha activators inhibit tissue factor expression and activity in human monocytes Circulation 103 2001 213 219
    • (2001) Circulation , vol.103 , pp. 213-219
    • Marx, N.1
  • 65
    • 0035895313 scopus 로고    scopus 로고
    • PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages
    • B.P. Neve PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages Circulation 103 2001 207 212
    • (2001) Circulation , vol.103 , pp. 207-212
    • Neve, B.P.1
  • 66
    • 9144271375 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha and atherosclerosis: From basic mechanisms to clinical implications
    • Z. Israelian-Konaraki, and P.D. Reaven Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications Cardiology 103 2005 1 9
    • (2005) Cardiology , vol.103 , pp. 1-9
    • Israelian-Konaraki, Z.1    Reaven, P.D.2
  • 67
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin, and cardiovascular disease: Subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT)
    • H.B. Rubins Diabetes, plasma insulin, and cardiovascular disease: subgroup analysis from the Department of Veterans Affairs high-density lipoprotein intervention trial (VA-HIT) Arch. Intern. Med. 162 2002 2597 2604
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2597-2604
    • Rubins, H.B.1
  • 68
    • 0035924613 scopus 로고    scopus 로고
    • Treating lipid abnormalities in patients with type 2 diabetes mellitus
    • G. Steiner Treating lipid abnormalities in patients with type 2 diabetes mellitus Am. J. Cardiol. 88 2001 37N 40N
    • (2001) Am. J. Cardiol. , vol.88
    • Steiner, G.1
  • 69
    • 0034685589 scopus 로고    scopus 로고
    • Activation of PPARdelta alters lipid metabolism in db/db mice
    • M.D. Leibowitz Activation of PPARdelta alters lipid metabolism in db/db mice FEBS Lett. 473 2000 333 336
    • (2000) FEBS Lett. , vol.473 , pp. 333-336
    • Leibowitz, M.D.1
  • 70
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • W.R. Oliver A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport Proc. Natl. Acad. Sci. U. S. A. 98 2001 5306 5311
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 5306-5311
    • Oliver, W.R.1
  • 71
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    • T. Tanaka Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome Proc. Natl. Acad. Sci. U. S. A. 100 2003 15924 15929
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15924-15929
    • Tanaka, T.1
  • 72
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    • Y.X. Wang Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity Cell 113 2003 159 170
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1
  • 73
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of Muscle Fiber Type and Running Endurance by PPARd
    • Y.X. Wang Regulation of Muscle Fiber Type and Running Endurance by PPARd PLoS Biol. 2 2004 1532 1539
    • (2004) PLoS Biol. , vol.2 , pp. 1532-1539
    • Wang, Y.X.1
  • 74
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • H. Yki-Jarvinen Thiazolidinediones N. Engl. J. Med. 351 2004 1106 1118
    • (2004) N. Engl. J. Med. , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 75
    • 12444273748 scopus 로고    scopus 로고
    • Distinct properties and advantages of a novel peroxisome proliferator-activated receptor [gamma] selective modulator
    • J.P. Berger Distinct properties and advantages of a novel peroxisome proliferator-activated receptor [gamma] selective modulator Mol. Endocrinol. 17 2003 662 676
    • (2003) Mol. Endocrinol. , vol.17 , pp. 662-676
    • Berger, J.P.1
  • 76
    • 1242337440 scopus 로고    scopus 로고
    • An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats
    • K. Arakawa An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats Clin. Exp. Pharmacol. Physiol. 31 2004 8 13
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 8-13
    • Arakawa, K.1
  • 77
    • 0036373440 scopus 로고    scopus 로고
    • SERMs: Evolutionary chemistry, revolutionary biology
    • C.P. Miller SERMs: evolutionary chemistry, revolutionary biology Curr. Pharm. Des. 8 2002 2089 2111
    • (2002) Curr. Pharm. Des. , vol.8 , pp. 2089-2111
    • Miller, C.P.1
  • 78
    • 10644293716 scopus 로고    scopus 로고
    • Benzoyl 2-methyl indoles as selective PPARgamma modulators
    • J.J. Acton 3rd Benzoyl 2-methyl indoles as selective PPARgamma modulators Bioorg. Med. Chem. Lett. 15 2005 357 362
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 357-362
    • Acton III, J.J.1
  • 79
    • 2942724296 scopus 로고    scopus 로고
    • Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614
    • H. Minoura Pharmacological characteristics of a novel nonthiazolidinedione insulin sensitizer, FK614 Eur. J. Pharmacol. 494 2004 273 281
    • (2004) Eur. J. Pharmacol. , vol.494 , pp. 273-281
    • Minoura, H.1
  • 80
    • 2142667823 scopus 로고    scopus 로고
    • Thiazolidinediones and Blood Lipids in Type 2 Diabetes. A Summary Analysis
    • J.P. Van Wijk Thiazolidinediones and Blood Lipids in Type 2 Diabetes. A Summary Analysis Arterioscler. Thromb. Vasc. Biol. 7 2003 7
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.7 , pp. 7
    • Van Wijk, J.P.1
  • 81
    • 11144355905 scopus 로고    scopus 로고
    • MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities
    • T.W. Doebber MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities Biochem. Biophys. Res. Commun. 318 2004 323 328
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 323-328
    • Doebber, T.W.1
  • 82
    • 12144286421 scopus 로고    scopus 로고
    • A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis
    • Q. Guo A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis Endocrinology 145 2004 1640 1648
    • (2004) Endocrinology , vol.145 , pp. 1640-1648
    • Guo, Q.1
  • 83
    • 2342628600 scopus 로고    scopus 로고
    • Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: A novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists
    • Y. Xu Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists J. Med. Chem. 47 2004 2422 2425
    • (2004) J. Med. Chem. , vol.47 , pp. 2422-2425
    • Xu, Y.1
  • 84
    • 2542612265 scopus 로고    scopus 로고
    • (2R)-2-ethylchromane-2-carboxylic acids: Discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents
    • H. Koyama (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents J. Med. Chem. 47 2004 3255 3263
    • (2004) J. Med. Chem. , vol.47 , pp. 3255-3263
    • Koyama, H.1
  • 85
    • 3042634455 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo-a study using the novel PPARalpha/gamma agonist tesaglitazar
    • B.D. Hegarty Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo-a study using the novel PPARalpha/gamma agonist tesaglitazar Endocrinology 145 2004 3158 3164
    • (2004) Endocrinology , vol.145 , pp. 3158-3164
    • Hegarty, B.D.1
  • 86
    • 0142216121 scopus 로고    scopus 로고
    • Ragaglitazar: A novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models
    • R. Chakrabarti Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models Br. J. Pharmacol. 140 2003 527 537
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 527-537
    • Chakrabarti, R.1
  • 87
    • 2542462552 scopus 로고    scopus 로고
    • Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects: A 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm
    • M.F. Saad Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects: a 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm Diabetes Care 27 2004 1324 1329
    • (2004) Diabetes Care , vol.27 , pp. 1324-1329
    • Saad, M.F.1


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