메뉴 건너뛰기




Volumn 9, Issue 12, 2003, Pages 1491-1497

Muscle-specific Pparg deletion causes insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 0346027235     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm956     Document Type: Article
Times cited : (433)

References (49)
  • 1
    • 0031897103 scopus 로고    scopus 로고
    • Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey. 1988-1994
    • Harris, M.I. et al. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey. 1988-1994 Diabetes Care 21, 518-524 (1998).
    • (1998) Diabetes Care , vol.21 , pp. 518-524
    • Harris, M.I.1
  • 2
    • 0036719295 scopus 로고    scopus 로고
    • Epidemiology of the metabolic syndrome
    • Meigs, J.B. Epidemiology of the metabolic syndrome. Am. J. Manag. Care 8, S283-S292 (2002).
    • (2002) Am. J. Manag. Care , vol.8
    • Meigs, J.B.1
  • 3
    • 0037118703 scopus 로고    scopus 로고
    • Metabolic syndrome: Pathophysiology and implications for management of cardiovascular disease
    • Reaven, G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 106, 286-288 (2002).
    • (2002) Circulation , vol.106 , pp. 286-288
    • Reaven, G.1
  • 4
    • 0026517631 scopus 로고
    • Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects
    • Suter, S.L., Nolan, J.L., Wallace, P., Gumbiner, B. & Olefsky, J. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15, 193-203 (1992).
    • (1992) Diabetes Care , vol.15 , pp. 193-203
    • Suter, S.L.1    Nolan, J.L.2    Wallace, P.3    Gumbiner, B.4    Olefsky, J.5
  • 5
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saitiel, A.R. & Olefsky, J.M. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45, 1661-1669 (1996).
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saitiel, A.R.1    Olefsky, J.M.2
  • 6
    • 0029016829 scopus 로고
    • An anti-diabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ
    • Lehmann, J.M. et al. An anti-diabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J. Biol. Chem. 270, 12953-12956 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 7
    • 0025054203 scopus 로고
    • In vitro studies on the action of CS-0455, a new anti-diabetic agent
    • Ciaraldi, T.P., Gilmore, A. & Olefsky, J.M. In vitro studies on the action of CS-0455, a new anti-diabetic agent. Metabolism 39, 1056-1062 (1990).
    • (1990) Metabolism , vol.39 , pp. 1056-1062
    • Ciaraldi, T.P.1    Gilmore, A.2    Olefsky, J.M.3
  • 8
    • 0028111923 scopus 로고
    • Regulation of glucose transport by pioglitazone in cultured muscle cells
    • El-Kebbi, I., Rosner, S. & Pollet, R.J. Regulation of glucose transport by pioglitazone in cultured muscle cells. Metabolism 43, 953-958 (1994).
    • (1994) Metabolism , vol.43 , pp. 953-958
    • El-Kebbi, I.1    Rosner, S.2    Pollet, R.J.3
  • 9
    • 0026093631 scopus 로고
    • The effect of CP-68772, a thiazolidine derivative, on insulin sensitivity in lean and obese Zucker rats
    • Bowen, L., Steven, P.P., Stevenson, R. & Shulman, C.I. The effect of CP-68772, a thiazolidine derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 40, 1025-1030 (1991).
    • (1991) Metabolism , vol.40 , pp. 1025-1030
    • Bowen, L.1    Steven, P.P.2    Stevenson, R.3    Shulman, C.I.4
  • 10
    • 0024160854 scopus 로고    scopus 로고
    • Characterization of new oral antidiabetic agent CS-045: Studies in KK and ob/ob mice and Zucker fatty rats
    • Fujiwara, T., Yoshioka, S., Yoshioka, T., Ushiyama, I. & Horikoshi, H. Characterization of new oral antidiabetic agent CS-045: studies in KK and ob/ob mice and Zucker fatty rats. Diabetes 37, 1549-1558 (1998).
    • (1998) Diabetes , vol.37 , pp. 1549-1558
    • Fujiwara, T.1    Yoshioka, S.2    Yoshioka, T.3    Ushiyama, I.4    Horikoshi, H.5
  • 11
    • 0029999139 scopus 로고    scopus 로고
    • Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients
    • Kumar, S. et al. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Diabetologia 39, 701-709 (1996).
    • (1996) Diabetologia , vol.39 , pp. 701-709
    • Kumar, S.1
  • 12
    • 0027983920 scopus 로고
    • Improvements in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan, J.J., Ludvik, B., Beerdsen P., Joyce, M. & Olefsky, J. Improvements in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331. 1188-1193 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3    Joyce, M.4    Olefsky, J.5
  • 13
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, β and γ in the adult rat
    • Braissant, O., Foufelle, F., Scott, C., Dauce, M. & Wahli, W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, β and γ in the adult rat. Endocrinology 137, 354-366 (1996).
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scott, C.3    Dauce, M.4    Wahli, W.5
  • 14
    • 0030835678 scopus 로고    scopus 로고
    • Organization, promoter analysis and expression of the human PPARγ gene
    • Fajas, L. et al. Organization, promoter analysis and expression of the human PPARγ gene. J. Biol. Chem. 272, 18779-18789 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 18779-18789
    • Fajas, L.1
  • 15
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I. & Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650 (1990).
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 16
    • 0028321529 scopus 로고
    • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    • Kliewer, S.A. et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1
  • 17
    • 0031898610 scopus 로고    scopus 로고
    • PPARγ: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman, B.M. PPARγ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507-514 (1998).
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 18
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf, D.J. & Evans, R.M. The RXR heterodimers and orphan receptors. Cell 83, 841-850 (1995).
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 20
    • 0028280168 scopus 로고
    • Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene
    • Harris, P.K. & Kletzien, R.F. Localization of a pioglitazone response element in the adipocyte fatty acid-binding protein gene. Mol. Pharamacol, 45, 439-445 (1994).
    • (1994) Mol. Pharamacol. , vol.45 , pp. 439-445
    • Harris, P.K.1    Kletzien, R.F.2
  • 21
    • 0342959286 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of PPARs and LXRα in humans: No alterations in adipose tissue of obese and NIDDM patients
    • Auboeuf, D. et al. Tissue distribution and quantification of the expression of PPARs and LXRα in humans: no alterations in adipose tissue of obese and NIDDM patients. Diabetes 48, 1319-1327 (1997).
    • (1997) Diabetes , vol.48 , pp. 1319-1327
    • Auboeuf, D.1
  • 22
    • 0033213631 scopus 로고    scopus 로고
    • PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen, E.D. et al. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell. 4 621-627 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 621-627
    • Rosen, E.D.1
  • 24
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocoticoids
    • Vidal-Puig, A.J. et al. Peroxisome-proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocoticoids. J. Clin. Invest. 99, 2416-2422 (1997).
    • (1997) J. Clin. Invest. , vol.99 , pp. 2416-2422
    • Vidal-Puig, A.J.1
  • 25
    • 0034696412 scopus 로고    scopus 로고
    • Expression and function of PPARγ in rat and human vascular smooth muscle cells
    • Law, R.E. et al. Expression and function of PPARγ in rat and human vascular smooth muscle cells. Circulation 101, 1311-1318 (2000).
    • (2000) Circulation , vol.101 , pp. 1311-1318
    • Law, R.E.1
  • 26
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-γ
    • Nagy, L., Tontonoz, P., Alvarez, J.G.A., Chen, H. & Evans, R.M. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-γ. Cell 93, 229-240 (1998).
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 27
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner
    • Motojima, K., Passilly, P., Peters, J.M., Gonzalez, F.J. & Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273, 16710-16714 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4    Latruffe, N.5
  • 28
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
    • Schoonjans, K., Staels, B. & Auwerx, J. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta 1302, 93-109 (1996).
    • (1996) Biochim. Biophys. Acta , vol.1302 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 29
    • 0029941669 scopus 로고    scopus 로고
    • Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator activated receptor γ
    • Sears, I.B., MacGinnitie, M.A., Kovacs, L.G. & Graves, R.A. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator activated receptor γ. Mol. Cell Biol. 16, 3410-3418 (1996).
    • (1996) Mol. Cell Biol. , vol.16 , pp. 3410-3418
    • Sears, I.B.1    MacGinnitie, M.A.2    Kovacs, L.G.3    Graves, R.A.4
  • 30
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E. & Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 31
    • 0028884048 scopus 로고
    • Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes: Association with increased insulin binding and cell-surface GLUT 4 as measured by photoaffinity labeling
    • Young, P.W. et al. Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes: association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling. Diabetes 44, 1087-1092 (1995).
    • (1995) Diabetes , vol.44 , pp. 1087-1092
    • Young, P.W.1
  • 32
    • 0031595111 scopus 로고    scopus 로고
    • PPARγ induces the insulin-dependent glucose transporter, GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes
    • Wu, Z., Xie, Y., Bucher, N.L.R. & Farmer, S.R. PPARγ induces the insulin-dependent glucose transporter, GLUT4 in the absence of C/EBPα during the conversion of 3T3 fibroblasts into adipocytes. J. Clin. Invest. 101, 22-32 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 22-32
    • Wu, Z.1    Xie, Y.2    Bucher, N.L.R.3    Farmer, S.R.4
  • 33
    • 0034064359 scopus 로고    scopus 로고
    • Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
    • Loviscach, M. et al. Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action. Diabetologia 43, 304-311 (2000).
    • (2000) Diabetologia , vol.43 , pp. 304-311
    • Loviscach, M.1
  • 34
    • 0033213637 scopus 로고    scopus 로고
    • PPARγ is required for placental, cardiac and adipose tissue development
    • Barak, Y. et al. PPARγ is required for placental, cardiac and adipose tissue development. Mol. Cell 4, 585-595 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1
  • 35
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning, J.C. et al. A muscle-specific insulin receptor knockout exhibits features of metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2, 559-569 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1
  • 36
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
    • Miles, P.D.G., Barak, Y., He, W., Evans, R.M. & Olefsky, J.M. Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency. J. Clin. Invest. 105, 287-292 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 287-292
    • Miles, P.D.G.1    Barak, Y.2    He, W.3    Evans, R.M.4    Olefsky, J.M.5
  • 37
    • 0037474274 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • Lee, Y.H., Giraud, J., Davis, R.J. & White, M.F. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278, 2896-2902 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 38
    • 0346491662 scopus 로고    scopus 로고
    • Liver PPARγ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • in the press
    • Gavrilova, O. et al. Liver PPARγ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. (in the press).
    • J. Biol. Chem.
    • Gavrilova, O.1
  • 39
    • 0035091701 scopus 로고    scopus 로고
    • Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferators activated receptor γ activation has coordinate effects on gene expression in multiple insulin sensitive tissues
    • Way, J.M. et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferators activated receptor γ activation has coordinate effects on gene expression in multiple insulin sensitive tissues. Endocrinology 142, 1269-1277 (2001).
    • (2001) Endocrinology , vol.142 , pp. 1269-1277
    • Way, J.M.1
  • 40
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B.M. & Flier, J.S. Adipogenesis and obesity: rounding out the big picture. Cell 87, 377-389 (1996).
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 41
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn, B.B. & Flier, J.S. Obesity and insulin resistance. J. Clin. Invest. 106, 473-481 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 43
    • 0033966768 scopus 로고    scopus 로고
    • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    • Kido, Y. et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2, J. Clin. Invest. 105, 199-205 (1999).
    • (1999) J. Clin. Invest. , vol.105 , pp. 199-205
    • Kido, Y.1
  • 44
    • 0023464211 scopus 로고
    • In vivo glucose metabolism in the awake rat: Tracer and insulin clamp studies
    • Smith, D. et al. In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies. Metabolism 36, 1176-1186 (1987).
    • (1987) Metabolism , vol.36 , pp. 1176-1186
    • Smith, D.1
  • 45
    • 0031443874 scopus 로고    scopus 로고
    • Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells
    • O'Goman, S., Dagenais, N.A., Qain, M. & Marchuk, Y. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl. Acad. Sci. USA 94, 14602-14607 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14602-14607
    • O'Goman, S.1    Dagenais, N.A.2    Qain, M.3    Marchuk, Y.4
  • 46
    • 0033695511 scopus 로고    scopus 로고
    • Reduced insulin-stimulated glucose transport in denervated muscle is associated with impaired Akt-α activation
    • Wilkes, J. & Bonen, A. Reduced insulin-stimulated glucose transport in denervated muscle is associated with impaired Akt-α activation. Am. J. Physiol. Endocrinol. Metab. 279, E912-E919 (2000).
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279
    • Wilkes, J.1    Bonen, A.2
  • 48
    • 0018885161 scopus 로고
    • Skeletal muscle triacylglycerol in the rat: Methods for sampling and measurement, and studies of biological variability
    • Frayn, K.N. & Maycock, P.F. Skeletal muscle triacylglycerol in the rat: methods for sampling and measurement, and studies of biological variability. J. Lipid Res. 21, 139-144 (1980).
    • (1980) J. Lipid Res. , vol.21 , pp. 139-144
    • Frayn, K.N.1    Maycock, P.F.2
  • 49
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele, R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. NY Acad. Sci. 82, 420-430 (1959).
    • (1959) Ann. NY Acad. Sci. , vol.82 , pp. 420-430
    • Steele, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.