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Volumn 50, Issue 6, 2007, Pages 1201-1208

Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people

Author keywords

Genetic epidemiology; Glucose; Insulin resistance; Metabolic syndrome; PPAR delta; PPARD; Type 2 diabetes

Indexed keywords

ADULT; AEROBIC METABOLISM; AGE DISTRIBUTION; ARTICLE; BODY MASS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; EXON; FEMALE; GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC EPIDEMIOLOGY; GENETIC VARIABILITY; GENOTYPE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA GENE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

EID: 34247844401     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0668-2     Document Type: Article
Times cited : (34)

References (39)
  • 1
    • 18644384237 scopus 로고    scopus 로고
    • Genetics of common forms of glycaemia with pathological impact on vascular biology: Are we on the right track?
    • Andersen G, Hansen T, Pedersen O (2005) Genetics of common forms of glycaemia with pathological impact on vascular biology: are we on the right track? Curr Mol Med 5:261-274
    • (2005) Curr Mol Med , vol.5 , pp. 261-274
    • Andersen, G.1    Hansen, T.2    Pedersen, O.3
  • 2
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B (2006) Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. J Clin Invest 116:571-580
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 4
    • 0037417726 scopus 로고    scopus 로고
    • PPARα is a very low-density lipoprotein sensor in macrophages
    • Chawla A, Lee CH, Barak Y et al (2003) PPARα is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci USA 100:1268-1273
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1268-1273
    • Chawla, A.1    Lee, C.H.2    Barak, Y.3
  • 5
    • 33144455156 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage
    • Lee CH, Kang K, Mehl IR et al (2006) Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. Proc Natl Acad Sci USA 103:2434-2439
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2434-2439
    • Lee, C.H.1    Kang, K.2    Mehl, I.R.3
  • 6
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARδ
    • Wang YX, Zhang CL, Yu RT et al (2004) Regulation of muscle fiber type and running endurance by PPARδ. PLoS Biol 2:e294
    • (2004) PLoS Biol , vol.2
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 7
    • 0642303113 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
    • Luquet S, Lopez-Soriano J, Holst D et al (2003) Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability. FASEB J 17:2299-2301
    • (2003) FASEB J , vol.17 , pp. 2299-2301
    • Luquet, S.1    Lopez-Soriano, J.2    Holst, D.3
  • 8
    • 33644766913 scopus 로고    scopus 로고
    • PPARδ regulates glucose metabolism and insulin sensitivity
    • Lee CH, Olson P, Hevener A et al (2006) PPARδ regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci USA 103:3444-3449
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3444-3449
    • Lee, C.H.1    Olson, P.2    Hevener, A.3
  • 9
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S et al (2003) Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113:159-170
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3
  • 10
    • 9144271149 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    • Tanaka T, Yamamoto J, Iwasaki S et al (2003) Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 100:15924-15929
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15924-15929
    • Tanaka, T.1    Yamamoto, J.2    Iwasaki, S.3
  • 11
    • 0035942162 scopus 로고    scopus 로고
    • Aselective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • Oliver WR, Shenk JL, Snaith MR et al (2001) Aselective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA 98:5306-5311
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5306-5311
    • Oliver, W.R.1    Shenk, J.L.2    Snaith, M.R.3
  • 12
    • 0034685589 scopus 로고    scopus 로고
    • Activation of PPAR?̈ alters lipid metabolism in db/db mice
    • Leibowitz MD, Fiévet C, Hennuyer N et al (2000) Activation of PPAR?̈ alters lipid metabolism in db/db mice. FEBS Lett 473:333-336
    • (2000) FEBS Lett , vol.473 , pp. 333-336
    • Leibowitz, M.D.1    Fiévet, C.2    Hennuyer, N.3
  • 13
    • 7244238303 scopus 로고    scopus 로고
    • Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) ?́ and ?̈ and PPAR coactivator 1α in human skeletal muscle, but not lipid regulatory genes
    • Watt MJ, Southgate RJ, Holmes AG, Febbraio MA (2004) Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) ?́ and ?̈ and PPAR coactivator 1α in human skeletal muscle, but not lipid regulatory genes. J Mol Endocrinol 33:533-544
    • (2004) J Mol Endocrinol , vol.33 , pp. 533-544
    • Watt, M.J.1    Southgate, R.J.2    Holmes, A.G.3    Febbraio, M.A.4
  • 14
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA (2005) Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 19:1498-1500
    • (2005) FASEB J , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3    Safdar, A.4    Tarnopolsky, M.A.5
  • 15
    • 0348134971 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    • Skogsberg J, McMahon AD, Karpe F, Hamsten A, Packard CJ, Ehrenborg E (2003) Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Intern Med 254:597-604
    • (2003) J Intern Med , vol.254 , pp. 597-604
    • Skogsberg, J.1    McMahon, A.D.2    Karpe, F.3    Hamsten, A.4    Packard, C.J.5    Ehrenborg, E.6
  • 17
    • 33745819570 scopus 로고    scopus 로고
    • Association of the T+294C polymorphism in PPARδ with low HDL cholesterol and coronary heart disease risk in women
    • Aberle J, Hopfer I, Beil FU, Seedorf U (2006) Association of the T+294C polymorphism in PPARδ with low HDL cholesterol and coronary heart disease risk in women. Int J Med Sci 3:108-111
    • (2006) Int J Med Sci , vol.3 , pp. 108-111
    • Aberle, J.1    Hopfer, I.2    Beil, F.U.3    Seedorf, U.4
  • 18
    • 0842334063 scopus 로고    scopus 로고
    • Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study
    • Chen S, Tsybouleva N, Ballantyne CM, Gotto AM, Marian AJ (2004) Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics 14:61-71
    • (2004) Pharmacogenetics , vol.14 , pp. 61-71
    • Chen, S.1    Tsybouleva, N.2    Ballantyne, C.M.3    Gotto, A.M.4    Marian, A.J.5
  • 19
    • 27644501387 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls
    • Gouni-Berthold I, Giannakidou E, Faust M, Berthold HK, Krone W (2005) The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls. Atherosclerosis 183:336-341
    • (2005) Atherosclerosis , vol.183 , pp. 336-341
    • Gouni-Berthold, I.1    Giannakidou, E.2    Faust, M.3    Berthold, H.K.4    Krone, W.5
  • 20
    • 33845256051 scopus 로고    scopus 로고
    • Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V
    • Aberle J, Hopfer I, Beil FU, Seedorf U (2006) Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. Int J Obes (Lond) 30:1709-1713
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1709-1713
    • Aberle, J.1    Hopfer, I.2    Beil, F.U.3    Seedorf, U.4
  • 21
    • 33847256899 scopus 로고    scopus 로고
    • Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta?-87T>C polymorphism and dietary fat in French-Canadians
    • Robitaille J, Gaudet D, Perusse L, Vohl MC (2007) Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta?-87T>C polymorphism and dietary fat in French-Canadians. Int J Obes (Lond) 31:411-417
    • (2007) Int J Obes (Lond) , vol.31 , pp. 411-417
    • Robitaille, J.1    Gaudet, D.2    Perusse, L.3    Vohl, M.C.4
  • 22
    • 33644688988 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the peroxisome proliferator-activated receptorδ gene are associated with skeletal muscle glucose uptake
    • Vänttinen M, Nuutila P, Kuulasmaa T et al (2005) Single nucleotide polymorphisms in the peroxisome proliferator-activated receptorδ gene are associated with skeletal muscle glucose uptake. Diabetes 54:3587-3591
    • (2005) Diabetes , vol.54 , pp. 3587-3591
    • Vänttinen, M.1    Nuutila, P.2    Kuulasmaa, T.3
  • 23
    • 33747060509 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: The STOP-NIDDM trial
    • Andrulionyte L, Peltola P, Chiasson JL, Laakso M (2006) Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 55:2148-2152
    • (2006) Diabetes , vol.55 , pp. 2148-2152
    • Andrulionyte, L.1    Peltola, P.2    Chiasson, J.L.3    Laakso, M.4
  • 24
    • 0346394178 scopus 로고    scopus 로고
    • A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: Baseline results Inter99 (1)
    • Jørgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glumer C, Pisinger C (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99 (1). Eur J Cardiovasc Prev Rehab 10:377-386
    • (2003) Eur J Cardiovasc Prev Rehab , vol.10 , pp. 377-386
    • Jørgensen, T.1    Borch-Johnsen, K.2    Thomsen, T.F.3    Ibsen, H.4    Glumer, C.5    Pisinger, C.6
  • 25
    • 34247896272 scopus 로고    scopus 로고
    • World Health Organization Study Group (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Tech Rep Ser WHO/NCD/NCS/99, 2nd edn.World Health Organization, Geneva
    • World Health Organization Study Group (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Tech Rep Ser WHO/NCD/NCS/99, 2nd edn.World Health Organization, Geneva
  • 26
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 27
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 28
    • 0034999807 scopus 로고    scopus 로고
    • Denaturing high-performance liquid chromatography: A review
    • Xiao W, Oefner PJ (2001) Denaturing high-performance liquid chromatography: a review. Hum Mutat 17:439-474
    • (2001) Hum Mutat , vol.17 , pp. 439-474
    • Xiao, W.1    Oefner, P.J.2
  • 29
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • The International HapMap Consortium
    • The International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437:1299-1320
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 30
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
    • Carlson CS, Eberle MA, RiederMJ, Yi Q, Kruglyak L, Nickerson DA (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 74:106-120
    • (2004) Am J Hum Genet , vol.74 , pp. 106-120
    • Carlson, C.S.1    Eberle, M.A.2    RiederMJ, Y.Q.3    Kruglyak, L.4    Nickerson, D.A.5
  • 31
    • 0036155283 scopus 로고    scopus 로고
    • Score tests for association between traits and haplotypes when linkage phase is ambiguous
    • Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70:425-434
    • (2002) Am J Hum Genet , vol.70 , pp. 425-434
    • Schaid, D.J.1    Rowland, C.M.2    Tines, D.E.3    Jacobson, R.M.4    Poland, G.A.5
  • 32
    • 0041672374 scopus 로고    scopus 로고
    • Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    • Lake SL, Lyon H, Tantisira K et al (2003) Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered 55:56-65
    • (2003) Hum Hered , vol.55 , pp. 56-65
    • Lake, S.L.1    Lyon, H.2    Tantisira, K.3
  • 33
    • 0030052609 scopus 로고    scopus 로고
    • Permutation tests for multiple loci affecting a quantitative character
    • Doerge RW, Churchill GA (1996) Permutation tests for multiple loci affecting a quantitative character. Genetics 142:285-294
    • (1996) Genetics , vol.142 , pp. 285-294
    • Doerge, R.W.1    Churchill, G.A.2
  • 34
    • 1842539516 scopus 로고    scopus 로고
    • A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
    • Nyholt DR (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769
    • (2004) Am J Hum Genet , vol.74 , pp. 765-769
    • Nyholt, D.R.1
  • 35
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel SB, Schaffner SF, Nguyen H et al (2002) The structure of haplotype blocks in the human genome. Science 296:2225-2229
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1    Schaffner, S.F.2    Nguyen, H.3
  • 36
    • 33644645013 scopus 로고    scopus 로고
    • PPARδ a dagger in the heart of the metabolic syndrome
    • Barish GD, Narkar VA, Evans RM (2006) PPARδ a dagger in the heart of the metabolic syndrome. J Clin Invest 116:590-597
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 37
    • 1442301053 scopus 로고    scopus 로고
    • Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity
    • Shin HD, Park BL, Kim LH et al (2004) Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Diabetes 53:847-851
    • (2004) Diabetes , vol.53 , pp. 847-851
    • Shin, H.D.1    Park, B.L.2    Kim, L.H.3
  • 38
    • 33750471977 scopus 로고    scopus 로고
    • Transferability of tag SNPs in genetic association studies in multiple populations
    • de Bakker PIW, Burtt NP, Graham RR et al (2006) Transferability of tag SNPs in genetic association studies in multiple populations. Nat Genet 38:1298-1303
    • (2006) Nat Genet , vol.38 , pp. 1298-1303
    • de Bakker, P.I.W.1    Burtt, N.P.2    Graham, R.R.3
  • 39
    • 33645767434 scopus 로고    scopus 로고
    • An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population
    • Montpetit A, Nelis M, Laflamme P et al (2006) An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genet 2:e27
    • (2006) PLoS Genet , vol.2
    • Montpetit, A.1    Nelis, M.2    Laflamme, P.3


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