Deletion of peroxisome proliferator-activated receptor-α induces an alteration of cardiac functions

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 1, 2006, Pages

  Loichot, Cécile ^a   Jesel, Laurence ^a   Tesse, Angela ^a   Tabernero, Antonia ^a   Schoonjans, Kristina ^b   Roul, Gérard ^a   Carpusca, Irina ^a   Auwerx, Johan ^b,c   Andriantsitohaina, Ramaroson ^a,d  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c INSTITUT CLINIQUE DE LA SOURIS   (France)

^d UNIVERSITÉ D'ANGERS   (France)

Author keywords

Cardiac 1 adrenergic receptor protein expression; Cardiomyopathy; Peroxisome proliferator activated receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART RATE; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPHYGMOMANOMETRY; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BLOOD PRESSURE; GENE DELETION; HEART VENTRICLES; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; PPAR ALPHA; RECEPTORS, ADRENERGIC, BETA-1; VENTRICULAR FUNCTION, LEFT;

EID: 33745712686     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01065.2004     Document Type: Article

References (15)

1. Barger PM and Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 10: 238-245, 2000.
2. Bing RJ. The metabolism of the heart. Harvey Lect 50: 27-70, 1955.
3. Bogdanov KY, Spurgeon HA, Vinogradova TM, and Lakatta EG. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. Am J Physiol Heart Circ Physiol 274: H571-H579, 1998.
4. Campbell FM, Kozak R, Wagner A, Alterejos JY, Dyck JR, Belke DD, Severson DL, Kelly DP, and Lopaschuk GD. A role for peroxisome proliferator-activated receptor-α (PPAR-α) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPAR-α are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. J Biol Chem 277: 4098-4103, 2002.
5. Chiu HC, Kovac A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, and Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 107: 813-822, 2001.
6. Djouadi F, Brandt J, Weinheimer CJ, Leone TC, Gonzalez FJ, and Kelly DP. The role of the peroxisome proliferator-activated receptor-α (PPARα) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids 60: 339-343, 1999.
7. Djouadi F, Weinheimer CJ, Saffitz JE, , Pitchford C, Bastin J, Gonzalez FJ, and Kelly DP. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice. J Clin Invest 102: 1083-1091, 1998.
8. Finck BN and Kelly DP. Peroxisome proliferator-activated receptor α (PPARα) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol 34: 1249-1257, 2002.
9. Issemann I and Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645-650, 1990.
10. Kelly DP and Strauss AW. Inherited cardiomyopathies. N Engl J Med 330: 913-919, 1994.
11. Kersten S, Desvergne B, and Wahli W. Roles of PPARs in health and disease. Nature 405: 421-424, 2000.
12. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, and Gonzalez FJ. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022, 1995.
13. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, and Backx PH. The molecular physiology of the cardiac transient outward potassium current (ITO) in normal and diseased myocardium. J Mol Cell Cardiol 33: 851-872, 2001.
14. Tabernero A, Schoonjans K, Jesel L, Carpusca I, Auwerx J, and Andriantsitohaina R. Activation of the peroxisome proliferator-activated receptor-α protects against myocardial ischaemic injury and improves endothelial vasodilatation. BMC Pharmacol 2: 10-20, 2002.
15. Watanabe K, Fujii H, Takahashi T, Kodama M, Aizawa Y, Ohta Y, Ono T, Hasegawa G, Naito M, Nakajima T, Kamijo Y, Gonzalez FJ, and Aoyama T. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor-α associated with age-dependent cardiac toxicity. J Biol Chem 275: 22293-22299, 2000.