Is there an interaction between PPARD T294C and PPARGC1A Gly482Ser polymorphisms and human endurance performance?: Experimental Physiology

Experimental Physiology

Volumn 94, Issue 11, 2009, Pages 1147-1152

  Eynon, Nir ^a   Meckel, Yoav ^a   Alves, Alberto Jorge ^b   Yamin, Chen ^a   Sagiv, Michael ^a   Goldhammer, Ehud ^c,d   Sagiv, Moran ^a  

^a The Zinman College of Physical Education and Sports Sciences at the Wingate Institute   (Israel)

^b UNIVERSITY OF PORTO   (Portugal)

^c BNAI ZION MEDICAL CENTER   (Israel)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SERINE;

ADULT; ARTICLE; ATHLETIC PERFORMANCE; CONTROLLED STUDY; ENDURANCE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; ISRAEL; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPORT; STATISTICAL ANALYSIS;

EID: 70350087550     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.049668     Document Type: Article

References (35)

1. Akhmetov II, Astranenkova IV Rogozkin VA (2007). Association of PPARD gene polymorphism with human physical performance. [article in Russian] Mol Biol (Mosk) 41, 852 857.
2. Attie AD Kendziorski CM (2003). PGC-1α at the crossroads of type 2 diabetes. Nat Genet 34, 244 245.
3. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP Holloszy JO (2002). Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 16, 1879 1886.
4. Berger J Moller DE (2002). The mechanisms of action of PPARs. Annu Rev Med 53, 409 435.
5. Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B Bouchard C (2009). The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 41, 35 73.
6. Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr., Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM Collins FS (2007). Replicating genotype-phenotype associations. Nature 447, 655 660.
7. Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P Muscat GE (2003). The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol 17, 2477 2493.
8. Eynon N, Meckel Y, Sagiv M, Yamin C, Amir R, Sagiv M, Goldhammer E, Duarte JA Oliveira J (2009). Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes? Scand J Med Sci Sports. DOI : 10.1111/j.1600-0838.2009.00930.x.
9. Furnsinn C, Willson TM Brunmair B (2007). Peroxisome proliferator- activated receptor-δ, a regulator of oxidative capacity, fuel switching and cholesterol transport. Diabetologia 50, 8 17.
10. Handschin C Spiegelman BM (2008). The role of exercise and PGC1α in inflammation and chronic disease. Nature 454, 463 469.
11. Hautala AJ, Leon AS, Skinner JS, Rao DC, Bouchard C Rankinen T (2007). Peroxisome proliferator-activated receptor-δ polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study. Am J Physiol Heart Circ Physiol 292, H2498 H2505.
12. Henderson J, Withford-Cave JM, Duffy DL, Cole SJ, Sawyer NA, Gulbin JP, Hahn A, Trent RJ Yu B (2005). The EPAS1 gene influences the aerobic-anaerobic contribution in elite endurance athletes. Hum Genet 118, 416 423.
13. Holst D, Luquet S, Nogueira V, Kristiansen K, Leverve X Grimaldi PA (2003). Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle. Biochim Biophys Acta 1633, 43 50.
14. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA Desvergne B (1997). DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region. J Biol Chem 272, 25252 25259.
15. Liang H Ward WF (2006). PGC-1α: a key regulator of energy metabolism. Adv Physiol Educ 30, 145 151.
16. Lucia A, Gomez-Gallego F, Barroso I, Rabadan M, Bandres F, San Juan AF, Chicharro JL, Ekelund U, Brage S, Earnest CP, Wareham NJ Franks PW (2005). PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men. J Appl Physiol 99, 344 348.
17. Luquet S, Lopez-Soriano J, Holst D, Fredenrich A, Melki J, Rassoulzadegan M Grimaldi PA (2003). Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability. FASEB J 17, 2299 2301.
18. Mahoney DJ, Parise G, Melov S, Safdar A Tarnopolsky MA (2005). Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 19, 1498 1500.
19. Mathai AS, Bonen A, Benton CR, Robinson DL Graham TE (2008). Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle. J Appl Physiol 105, 1098 1105.
20. Nikolaidis MG, Jamurtas AZ, Paschalis V, Fatouros IG, Koutedakis Y Kouretas D (2008). The effect of muscle-damaging exercise on blood and skeletal muscle oxidative stress: magnitude and time-course considerations. Sports Med 38, 579 606.
21. Norrbom J, Sundberg CJ, Ameln H, Kraus WE, Jansson E Gustafsson T (2004). PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol 96, 189 194.
22. Pilegaard H Richter EA (2008). PGC-1α: important for exercise performance? J Appl Physiol 104, 1264 1265.
23. Pilegaard H, Saltin B Neufer PD (2003). Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle. J Physiol 546, 851 858.
24. Powers SK Jackson MJ (2008). Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev 88, 1243 1276.
25. Russell AP, Feilchenfeldt J, Schreiber S, Praz M, Crettenand A, Gobelet C, Meier CA, Bell DR, Kralli A, Giacobino JP Deriaz O (2003). Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle. Diabetes 52, 2874 2881.
26. Sharp NC (2008). The human genome and sport, including epigenetics and athleticogenomics: a brief look at a rapidly changing field. J Sports Sci 26, 1127 1133.
27. Skogsberg J, Kannisto K, Cassel TN, Hamsten A, Eriksson P Ehrenborg E (2003). Evidence that peroxisome proliferator-activated receptor δ influences cholesterol metabolism in men. Arterioscler Thromb Vasc Biol 23, 637 643.
28. Spencer MR Gastin PB (2001). Energy system contribution during 200- to 1500 m running in highly trained athletes. Med Sci Sports Exerc 33, 157 162.
29. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K Sugawara K (2002). Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 8, 6 48.
30. Tanaka T, Yamamoto J, Iwasaki S, Asaba H, Hamura H, Ikeda Y, Watanabe M, Magoori K, Ioka RX, Tachibana K, Watanabe Y, Uchiyama Y, Sumi K, Iguchi H, Ito S, Doi T, Hamakubo T, Naito M, Auwerx J, Yanagisawa M, Kodama T Sakai J (2003). Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A 100, 15924 15929.
31. van Rooij E, Marshall WS Olson EN (2008). Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res 103, 919 928.
32. Walsh S, Liu D, Metter EJ, Ferrucci L Roth SM (2008). ACTN3 genotype is associated with muscle phenotypes in women across the adult age span. J Appl Physiol 105, 1486 1491.
33. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H Evans RM (2003). Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113, 159 170.
34. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H Evans RM (2004). Regulation of muscle fiber type and running endurance by PPARδ. PLoS Biol 2, e294.
35. Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S North K (2003). ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 73, 627 631.