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Volumn 35, Issue 2, 2005, Pages 82-92

Peroxisome proliferator-activated receptor γ: The more the merrier?

Author keywords

Atherosclerosis; Longevity and bone; Metabolism; Mouse models; PPAR

Indexed keywords

ADIPOKINETIC HORMONE; ADIPONECTIN; CELL NUCLEUS RECEPTOR; FATTY ACID; INSULIN; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; SIRTUIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA;

EID: 13544258629     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2005.01456.x     Document Type: Conference Paper
Times cited : (57)

References (114)
  • 1
    • 13544271401 scopus 로고    scopus 로고
    • Paleolithic nutrition: What can we learn from the past?
    • Mann NJ. Paleolithic nutrition: what can we learn from the past? Asia Pac J Clin Nutr 2004;13:S17-23.
    • (2004) Asia Pac J Clin Nutr , vol.13
    • Mann, N.J.1
  • 2
    • 0032588487 scopus 로고    scopus 로고
    • PPARγ, the ultimate thrifty gene
    • Auwerx J. PPARγ, the ultimate thrifty gene. Diabetologia 1999;42:1033-49.
    • (1999) Diabetologia , vol.42 , pp. 1033-1049
    • Auwerx, J.1
  • 3
    • 0035851187 scopus 로고    scopus 로고
    • PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth
    • Rosen ED, Spiegelman BM. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem 2001;276:37731-4.
    • (2001) J Biol Chem , vol.276 , pp. 37731-37734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 4
    • 0348143232 scopus 로고    scopus 로고
    • Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men
    • Burdge GC, Jones AE, Frye SM, Goodson L, Wootton SA. Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men. Eur J Clin Nutr 2003;57:1536-44.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 1536-1544
    • Burdge, G.C.1    Jones, A.E.2    Frye, S.M.3    Goodson, L.4    Wootton, S.A.5
  • 5
    • 2942716780 scopus 로고    scopus 로고
    • Modern science versus the stigma of obesity
    • Friedman JM. Modern science versus the stigma of obesity. Nat Med 2004;10:563-9.
    • (2004) Nat Med , vol.10 , pp. 563-569
    • Friedman, J.M.1
  • 6
    • 1642420745 scopus 로고    scopus 로고
    • Dietary fat and postprandial lipids
    • Sanders TA. Dietary fat and postprandial lipids. Curr Atheroscler Rep 2003;5:445-51.
    • (2003) Curr Atheroscler Rep , vol.5 , pp. 445-451
    • Sanders, T.A.1
  • 7
    • 0037330414 scopus 로고    scopus 로고
    • PPARγ agonists in the treatment of type II diabetes: Is increased fatness commensurate with long-term efficacy?
    • Larsen TM, Toubro S, Astrup A. PPARγ agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int J Obes Relat Metab Disord 2003;27:147-61.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 147-161
    • Larsen, T.M.1    Toubro, S.2    Astrup, A.3
  • 8
    • 0346219295 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on body weight in patients with diabetes mellitus
    • Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med 2003;115 (Suppl. 8A):42S-8S.
    • (2003) Am J Med , vol.115 , Issue.SUPPL. 8A
    • Fonseca, V.1
  • 9
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994;79:1147-56.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 10
    • 0036007025 scopus 로고    scopus 로고
    • PPARγ knockdown by engineered transcription factors: Exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis
    • Ren D, Collingwood TN, Rebar EJ, Wolffe AP, Camp HS. PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis. Genes Dev 2002;16:27-32.
    • (2002) Genes Dev , vol.16 , pp. 27-32
    • Ren, D.1    Collingwood, T.N.2    Rebar, E.J.3    Wolffe, A.P.4    Camp, H.S.5
  • 11
    • 0033213631 scopus 로고    scopus 로고
    • PPARγ is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS et al. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999;4:611-7.
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3    Bradwin, G.4    Moore, K.5    Milstone, D.S.6
  • 12
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator activated receptor (PPAR) in mediating effects of fibrates and fatty acids on gene expression
    • Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator activated receptor (PPAR) in mediating effects of fibrates and fatty acids on gene expression. J Lipid Res 1996;37:907-25.
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 13
    • 16944362008 scopus 로고    scopus 로고
    • Genomewide search for genes influencing percent body fat in Pima Indians: Suggestive linkage at chromosome 11Q21 Q22
    • Norman RA, Thompson DB, Foroud T, Garvey WT, Bennett PH, Bogardus C et al. Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11Q21 Q22. Am J Hum Genet 1997;60:166-73.
    • (1997) Am J Hum Genet , vol.60 , pp. 166-173
    • Norman, R.A.1    Thompson, D.B.2    Foroud, T.3    Garvey, W.T.4    Bennett, P.H.5    Bogardus, C.6
  • 14
    • 0242524453 scopus 로고    scopus 로고
    • The inherited basis of diabetes mellitus. Implications for the genetic analysis of complex traits
    • Florez JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus. Implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 2004;4:257-91.
    • (2004) Annu Rev Genomics Hum Genet , vol.4 , pp. 257-291
    • Florez, J.C.1    Hirschhorn, J.2    Altshuler, D.3
  • 15
    • 10644251916 scopus 로고    scopus 로고
    • PPARγ calls for activation in moderation. Lessons from genetics and pharmacology
    • Knouff C, Auwerx J. PPARγ calls for activation in moderation. Lessons from genetics and pharmacology. Endocr Rev 2004;25:899-918.
    • (2004) Endocr Rev , vol.25 , pp. 899-918
    • Knouff, C.1    Auwerx, J.2
  • 16
    • 0031595923 scopus 로고    scopus 로고
    • A Pro 12 Ala substitution in the human peroxisome proliferator-activated receptor γ2 is associated with decreased receptor activity, improved insulin sensitivity, and lowered body mass index
    • Deeb S, Fajas L, Nemoto M, Laakso M, Fujimoto W, Auwerx J. A Pro 12 Ala substitution in the human peroxisome proliferator-activated receptor γ2 is associated with decreased receptor activity, improved insulin sensitivity, and lowered body mass index. Nat Genet 1998;20:284-7.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.1    Fajas, L.2    Nemoto, M.3    Laakso, M.4    Fujimoto, W.5    Auwerx, J.6
  • 18
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ2 on thiazolidinedione-induced adipogenesis
    • Masugi J, Tamori Y, Mori H, Koike T, Kasuga M. Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 2000;268:178-82.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, H.3    Koike, T.4    Kasuga, M.5
  • 19
    • 0037677523 scopus 로고    scopus 로고
    • A functional variant in the peroxisome proliferator-activated receptor γ2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
    • Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ. A functional variant in the peroxisome proliferator-activated receptor γ2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. Diabetes 2003;52:1864-71.
    • (2003) Diabetes , vol.52 , pp. 1864-1871
    • Muller, Y.L.1    Bogardus, C.2    Beamer, B.A.3    Shuldiner, A.R.4    Baier, L.J.5
  • 20
    • 4444250259 scopus 로고    scopus 로고
    • High incidence of type 2 diabetes in peroxisome proliferator-activated receptor γ2 pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids
    • Pisabarro RE, Sanguinetti C, Stoll M, Prendez D. High incidence of type 2 diabetes in peroxisome proliferator-activated receptor γ2 pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids. Diabetes Care 2004;27:2251-4.
    • (2004) Diabetes Care , vol.27 , pp. 2251-2254
    • Pisabarro, R.E.1    Sanguinetti, C.2    Stoll, M.3    Prendez, D.4
  • 21
    • 3242724126 scopus 로고    scopus 로고
    • Gender-specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR) γ2 with longevity
    • Barbieri M, Bonafe M, Rizzo MR, Ragno E, Olivieri F, Marchegiani F et al. Gender-specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR) γ2 with longevity. Exp Gerontol 2004;39:1095-100.
    • (2004) Exp Gerontol , vol.39 , pp. 1095-1100
    • Barbieri, M.1    Bonafe, M.2    Rizzo, M.R.3    Ragno, E.4    Olivieri, F.5    Marchegiani, F.6
  • 22
    • 3042833890 scopus 로고    scopus 로고
    • Interactions between peroxisome proliferator-activated receptor-γ2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication
    • Yliharsila H, Eriksson JG, Forsen T, Laakso M, Uusitupa M, Osmond C et al. Interactions between peroxisome proliferator-activated receptor-γ2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication. J Hypertens 2004;22:1283-7.
    • (2004) J Hypertens , vol.22 , pp. 1283-1287
    • Yliharsila, H.1    Eriksson, J.G.2    Forsen, T.3    Laakso, M.4    Uusitupa, M.5    Osmond, C.6
  • 23
    • 4644292542 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism of the PPAR γ2 gene regulates weight from birth to adulthood
    • Pihlajamaki J, Vanhala M, Vanhala P, Laakso M. The Pro12Ala polymorphism of the PPAR γ2 gene regulates weight from birth to adulthood. Obes Res 2004;12:187-90.
    • (2004) Obes Res , vol.12 , pp. 187-190
    • Pihlajamaki, J.1    Vanhala, M.2    Vanhala, P.3    Laakso, M.4
  • 24
    • 0036146384 scopus 로고    scopus 로고
    • A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy
    • Agarwal AK, Garg A. A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy. J Clin Endocrinol Metab 2002;87:408-11.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.2
  • 25
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: A potential mechanism of insulin sensitization
    • Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARγ agonists: a potential mechanism of insulin sensitization. Endocrinology 2002;143:998-1007.
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3    Doebber, T.4    Wang, W.J.5    Zhang, B.B.6
  • 26
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • Hegele RA, Cao H, Frankowski C, Mathews ST, Leff T. PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes 2002;51:3586-90.
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 27
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
    • Savage DB, Tan GD, Acerini CL, Jebb SA, Agostini M, Gurnell M et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes 2003;52:910-7.
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1    Tan, G.D.2    Acerini, C.L.3    Jebb, S.A.4    Agostini, M.5    Gurnell, M.6
  • 28
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
    • Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, Soos MA et al. Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999;402:880-3.
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1    Gurnell, M.2    Crowley, V.E.3    Agostini, M.4    Schwabe, J.W.5    Soos, M.A.6
  • 29
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. New Engl J Med 1998;339:953-9.
    • (1998) New Engl J Med , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 31
    • 0033212964 scopus 로고    scopus 로고
    • PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K et al. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609.
    • (1999) Mol Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3    Tamemoto, H.4    Yamauchi, T.5    Komeda, K.6
  • 32
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPARγ deficiency
    • Miles PD, Barak Y, He W, Evans RM, Olefsky JM. Improved insulin-sensitivity in mice heterozygous for PPARγ deficiency. J Clin Invest 2000;105:287-92.
    • (2000) J Clin Invest , vol.105 , pp. 287-292
    • Miles, P.D.1    Barak, Y.2    He, W.3    Evans, R.M.4    Olefsky, J.M.5
  • 33
    • 0344630205 scopus 로고    scopus 로고
    • Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice
    • Koutnikova H, Cock TA, Watanabe M, Houten SM, Champy MF, Dierich A et al. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice. Proc Natl Acad Sci USA 2003;100:14457-62.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14457-14462
    • Koutnikova, H.1    Cock, T.A.2    Watanabe, M.3    Houten, S.M.4    Champy, M.F.5    Dierich, A.6
  • 34
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He W, Barak Y, Hevener A, Olson P, Liao D, Le J et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 2003;100:15712-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6
  • 35
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
    • Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N et al. Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci USA 2004;101:4543-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4543-4547
    • Imai, T.1    Takakuwa, R.2    Marchand, S.3    Dentz, E.4    Bornert, J.M.5    Messaddeq, N.6
  • 37
    • 0032582349 scopus 로고    scopus 로고
    • PPARγ 3 mRNA. A distinct PPARγ mRNA subtype transcribed from an independent promoter
    • Fajas L, Fruchart JC, Auwerx J. PPARγ 3 mRNA. A distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett 1998;438:55-60.
    • (1998) FEBS Lett , vol.438 , pp. 55-60
    • Fajas, L.1    Fruchart, J.C.2    Auwerx, J.3
  • 38
    • 0030877565 scopus 로고    scopus 로고
    • Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor γ (PPARγ)
    • Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig A, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 1997;272:20230-5.
    • (1997) J Biol Chem , vol.272 , pp. 20230-20235
    • Werman, A.1    Hollenberg, A.2    Solanes, G.3    Bjorbaek, C.4    Vidal-Puig, A.5    Flier, J.S.6
  • 39
    • 0032979514 scopus 로고    scopus 로고
    • Differential regulation of peroxisome proliferator activated receptor γ1 (PPARγ1) and PPARγ2 mRNA expression in early stages of adipogenesis
    • Saladin R, Fajas L, Dana S, Halvorsen YD, Auwerx J, Briggs M. Differential regulation of peroxisome proliferator activated receptor γ1 (PPARγ1) and PPARγ2 mRNA expression in early stages of adipogenesis. Cell Growth Differentiation 1999;10:43-8.
    • (1999) Cell Growth Differentiation , vol.10 , pp. 43-48
    • Saladin, R.1    Fajas, L.2    Dana, S.3    Halvorsen, Y.D.4    Auwerx, J.5    Briggs, M.6
  • 40
    • 0036007025 scopus 로고    scopus 로고
    • PPARgamma knockdown by engineered transcription factors: Exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis
    • Ren D, Collingwood TN, Rebar EJ, Wolffe AP, Camp HS. PPARgamma knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis. Genes Dev 2002;16:27-32.
    • (2002) Genes Dev , vol.16 , pp. 27-32
    • Ren, D.1    Collingwood, T.N.2    Rebar, E.J.3    Wolffe, A.P.4    Camp, H.S.5
  • 41
    • 3242720242 scopus 로고    scopus 로고
    • Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity
    • Zhang J, Fu M, Cui T, Xiong C, Xu K, Zhong W et al. Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity. Proc Natl Acad Sci USA 2004;101:10703-8.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10703-10708
    • Zhang, J.1    Fu, M.2    Cui, T.3    Xiong, C.4    Xu, K.5    Zhong, W.6
  • 42
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR et al. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 2003;278:34268-76.
    • (2003) J Biol Chem , vol.278 , pp. 34268-34276
    • Gavrilova, O.1    Haluzik, M.2    Matsusue, K.3    Cutson, J.J.4    Johnson, L.5    Dietz, K.R.6
  • 43
    • 0037373008 scopus 로고    scopus 로고
    • Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    • Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM et al. Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 2003;111:737-47.
    • (2003) J Clin Invest , vol.111 , pp. 737-747
    • Matsusue, K.1    Haluzik, M.2    Lambert, G.3    Yim, S.H.4    Gavrilova, O.5    Ward, J.M.6
  • 44
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Morris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC et al. Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 2003;112:608-18.
    • (2003) J Clin Invest , vol.112 , pp. 608-618
    • Morris, A.W.1    Chen, L.2    Fisher, S.J.3    Szanto, I.4    Ristow, M.5    Jozsi, A.C.6
  • 46
    • 0141450254 scopus 로고    scopus 로고
    • Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    • Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH et al. Targeted elimination of peroxisome proliferator-activated receptor γ in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 2003,23:7222-9.
    • (2003) Mol Cell Biol , vol.23 , pp. 7222-7229
    • Rosen, E.D.1    Kulkarni, R.N.2    Sarraf, P.3    Ozcan, U.4    Okada, T.5    Hsu, C.H.6
  • 47
    • 17744376173 scopus 로고    scopus 로고
    • A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A, Boisvert WA, Lee C, Laffitte BA, Barak Y, Joseph SB et al. A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001;7:161-71.
    • (2001) Mol Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 48
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S et al. Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 2002;22:2607-19.
    • (2002) Mol Cell Biol , vol.22 , pp. 2607-2619
    • Akiyama, T.E.1    Sakai, S.2    Lambert, G.3    Nicol, C.J.4    Matsusue, K.5    Pimprale, S.6
  • 50
    • 4043151601 scopus 로고    scopus 로고
    • Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
    • Tsai YS, Kim HJ, Takahashi N, Kim HS, Hagaman JR, Kim JK et al. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ. J Clin Invest 2004;114:240-9.
    • (2004) J Clin Invest , vol.114 , pp. 240-249
    • Tsai, Y.S.1    Kim, H.J.2    Takahashi, N.3    Kim, H.S.4    Hagaman, J.R.5    Kim, J.K.6
  • 51
    • 4043072234 scopus 로고    scopus 로고
    • Unbuckling lipodystrophy from insulin resistance and hypertension
    • Hegele RA, Leff T. Unbuckling lipodystrophy from insulin resistance and hypertension. J Clin Invest 2004;114:163-5.
    • (2004) J Clin Invest , vol.114 , pp. 163-165
    • Hegele, R.A.1    Leff, T.2
  • 52
    • 1442288375 scopus 로고    scopus 로고
    • PPARγ agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice
    • Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPARγ agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension 2004;43:661-6.
    • (2004) Hypertension , vol.43 , pp. 661-666
    • Ryan, M.J.1    Didion, S.P.2    Mathur, S.3    Faraci, F.M.4    Sigmund, C.D.5
  • 53
    • 0346157985 scopus 로고    scopus 로고
    • Pioglitazone prevents hypertension and reduces oxidarive stress in diet-induced obesity
    • Dobrian AD, Schriver SD, Khraibi AA, Prewitt RL. Pioglitazone prevents hypertension and reduces oxidarive stress in diet-induced obesity. Hypertension 2004;43:48-56.
    • (2004) Hypertension , vol.43 , pp. 48-56
    • Dobrian, A.D.1    Schriver, S.D.2    Khraibi, A.A.3    Prewitt, R.L.4
  • 54
    • 2642557181 scopus 로고    scopus 로고
    • A unique PPARγ ligand with potent insulin-sensitizing yet weak adipogenic activity
    • Rocchi S, Picard F, Vamecq J, Gelman L, Potier N, Zeyer D et al. A unique PPARγ ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 2001;8:737-7.
    • (2001) Mol Cell , vol.8 , pp. 737-737
    • Rocchi, S.1    Picard, F.2    Vamecq, J.3    Gelman, L.4    Potier, N.5    Zeyer, D.6
  • 55
    • 0034681773 scopus 로고    scopus 로고
    • Thiazolidinediones: An update
    • Schoonjans K, Auwerx J. Thiazolidinediones: an update. Lancet 2000;355:1008-10.
    • (2000) Lancet , vol.355 , pp. 1008-1010
    • Schoonjans, K.1    Auwerx, J.2
  • 56
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen H, Thiazolidinediones. N Engl J Med 2004;351:1106-18.
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 57
    • 0036399805 scopus 로고    scopus 로고
    • PPARγ and glucose homeostasis
    • Picard F, Auwerx J. PPARγ and glucose homeostasis. Annu Rev Nutr 2002;22:167-97.
    • (2002) Annu Rev Nutr , vol.22 , pp. 167-197
    • Picard, F.1    Auwerx, J.2
  • 58
    • 13544253065 scopus 로고    scopus 로고
    • Metabolic syndrome: A clinical and molecular perspective
    • in press
    • Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 2005 (in press).
    • (2005) Annu Rev Med
    • Moller, D.E.1    Kaufman, K.D.2
  • 59
    • 12144291700 scopus 로고    scopus 로고
    • Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor γ
    • Agostini M, Gurnell M, Savage DB, Wood EM, Smith AG, Rajanayagam O et al. Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor γ. Endocrinology 2004;145:1527-38.
    • (2004) Endocrinology , vol.145 , pp. 1527-1538
    • Agostini, M.1    Gurnell, M.2    Savage, D.B.3    Wood, E.M.4    Smith, A.G.5    Rajanayagam, O.6
  • 60
    • 1642546582 scopus 로고    scopus 로고
    • Hormone resistance: It's SMRT to fight repression
    • Burnstein KL, Luetje CW. Hormone resistance: it's SMRT to fight repression. Endocrinology 2004;145:1525-6.
    • (2004) Endocrinology , vol.145 , pp. 1525-1526
    • Burnstein, K.L.1    Luetje, C.W.2
  • 61
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC-2100, which is a weak PPARγ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • Fukui Y, Masui S, Osada S, Umesono K, Motojima K. A new thiazolidinedione, NC-2100, which is a weak PPARγ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 2000;49:759-67.
    • (2000) Diabetes , vol.49 , pp. 759-767
    • Fukui, Y.1    Masui, S.2    Osada, S.3    Umesono, K.4    Motojima, K.5
  • 62
    • 0032484224 scopus 로고    scopus 로고
    • A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties
    • Reginato MJ, Bailey ST, Krakow SL, Minami C, Ishii S, Tanaka H et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties. J Biol Chem 1998;273:32679-84.
    • (1998) J Biol Chem , vol.273 , pp. 32679-32684
    • Reginato, M.J.1    Bailey, S.T.2    Krakow, S.L.3    Minami, C.4    Ishii, S.5    Tanaka, H.6
  • 63
    • 0033766035 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor-gamma (PPARγ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes
    • Mukherjee R, Hoener PA, Jow L, Bilakovics J, Klausing K, Mais DE et al. A selective peroxisome proliferator-activated receptor-gamma (PPARγ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes. Mol Endocrinol 2000;14:1425-33.
    • (2000) Mol Endocrinol , vol.14 , pp. 1425-1433
    • Mukherjee, R.1    Hoener, P.A.2    Jow, L.3    Bilakovics, J.4    Klausing, K.5    Mais, D.E.6
  • 64
    • 0036843143 scopus 로고    scopus 로고
    • A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity
    • Rieusset J, Touri F, Michalik L, Escher P, Desvergne B, Niesor E et al. A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 2002;16:2628-44.
    • (2002) Mol Endocrinol , vol.16 , pp. 2628-2644
    • Rieusset, J.1    Touri, F.2    Michalik, L.3    Escher, P.4    Desvergne, B.5    Niesor, E.6
  • 65
    • 85047685428 scopus 로고    scopus 로고
    • Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes
    • Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 2001;108:1001-13.
    • (2001) J Clin Invest , vol.108 , pp. 1001-1013
    • Yamauchi, T.1    Waki, H.2    Kamon, J.3    Murakami, K.4    Motojima, K.5    Komeda, K.6
  • 66
    • 2542491213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ in diabetes and metabolism
    • Rangwala SM, Lazar MA. Peroxisome proliferator-activated receptor γ in diabetes and metabolism. Trends Pharmacol Sci 2004;25:331-6.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 331-336
    • Rangwala, S.M.1    Lazar, M.A.2
  • 67
    • 4344692482 scopus 로고    scopus 로고
    • Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases
    • Takano H, Hasegawa H, Zou Y, Komuro I. Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases. Curr Pharm Des 2004;10:2779-86.
    • (2004) Curr Pharm des , vol.10 , pp. 2779-2786
    • Takano, H.1    Hasegawa, H.2    Zou, Y.3    Komuro, I.4
  • 68
    • 0033600165 scopus 로고    scopus 로고
    • Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPARγ expression in osteoblasts
    • Ogawa S, Urano T, Hosoi T, Miyao M, Hoshino S, Fujita M et al. Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPARγ expression in osteoblasts. Biochem Biophys Res Commun 1999;260:122-6.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 122-126
    • Ogawa, S.1    Urano, T.2    Hosoi, T.3    Miyao, M.4    Hoshino, S.5    Fujita, M.6
  • 69
    • 0031912333 scopus 로고    scopus 로고
    • A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans
    • Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Lebel P, Dallongeville J et al. A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans. Hum Mol Genet 1998;7:435-40.
    • (1998) Hum Mol Genet , vol.7 , pp. 435-440
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3    Cottel, D.4    Lebel, P.5    Dallongeville, J.6
  • 72
    • 2142652189 scopus 로고    scopus 로고
    • PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004;113:846-55.
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1    Ohba, S.2    Kamekura, S.3    Yamaguchi, M.4    Chung, U.I.5    Kubota, N.6
  • 74
    • 0036779687 scopus 로고    scopus 로고
    • Emerging roles of PPARs in inflammation and immunity
    • Daynes RA, Jones DC. Emerging roles of PPARs in inflammation and immunity. Nat Rev Immunol 2002;2:748-59.
    • (2002) Nat Rev Immunol , vol.2 , pp. 748-759
    • Daynes, R.A.1    Jones, D.C.2
  • 75
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93:241-52.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 77
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation. Nature 1998;391:79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 78
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-6.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 80
    • 0035132330 scopus 로고    scopus 로고
    • PPARγ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans AJ. PPARγ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 2001;7:48-52.
    • (2001) Nat Med , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, A.J.6
  • 81
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
    • Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 1998;93:229-40.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3    Chen, H.4    Evans, R.M.5
  • 82
    • 0035097590 scopus 로고    scopus 로고
    • Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: Pleiotropic effects on CD36 expression and HDL
    • Chen Z, Ishibashi S, Perrey S, Osuga J, Gotoda T, Kitamine T et al. Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL. Arterioscler Thromb Vasc Biol 2001;21:372-7.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 372-377
    • Chen, Z.1    Ishibashi, S.2    Perrey, S.3    Osuga, J.4    Gotoda, T.5    Kitamine, T.6
  • 83
    • 0035957006 scopus 로고    scopus 로고
    • Reduction of atherosclerosis in apolipoprotein e knockout mice by activation of the retinoid X receptor
    • Claudel T, Leibowitz MD, Fievet C, Tailleux A, Wagner B, Repa JJ et al. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci USA 2001;98:2610-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2610-2615
    • Claudel, T.1    Leibowitz, M.D.2    Fievet, C.3    Tailleux, A.4    Wagner, B.5    Repa, J.J.6
  • 84
    • 0035093258 scopus 로고    scopus 로고
    • Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice
    • Collins AR, Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G, et al. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 2001;21:365-71.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 365-371
    • Collins, A.R.1    Meehan, W.P.2    Kintscher, U.3    Jackson, S.4    Wakino, S.5    Noh, G.6
  • 85
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • Li AC, Brown KK, Silvestre MJ, Willson TM, Palinski W, Glass CK. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 2000;106:523-31.
    • (2000) J Clin Invest , vol.106 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 86
    • 4444337443 scopus 로고    scopus 로고
    • Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages
    • Szanto A, Benko S, Szatmari I, Balint BL, Furtos I, Ruhl R et al. Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. Mol Cell Biol 2004;24:8154-66.
    • (2004) Mol Cell Biol , vol.24 , pp. 8154-8166
    • Szanto, A.1    Benko, S.2    Szatmari, I.3    Balint, B.L.4    Furtos, I.5    Ruhl, R.6
  • 87
    • 0036851863 scopus 로고    scopus 로고
    • The liver X receptor gene team: Potential new players in atherosclerosis
    • Repa JJ, Mangelsdorf DJ. The liver X receptor gene team: potential new players in atherosclerosis. Nate Med 2002;8:1243-8.
    • (2002) Nate Med , vol.8 , pp. 1243-1248
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 88
    • 0037625000 scopus 로고    scopus 로고
    • Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    • Ridker PM, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Plutzky J et al. Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arterioscler Thromb Vasc Biol 2003;23:859-63.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 859-863
    • Ridker, P.M.1    Cook, N.R.2    Cheng, S.3    Erlich, H.A.4    Lindpaintner, K.5    Plutzky, J.6
  • 90
    • 0037674923 scopus 로고    scopus 로고
    • Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-γ ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation
    • de Dios ST, Bruemmer D, Dilley RJ, Ivey ME, Jennings GL, Law RE et al. Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-γ ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation 2003;107:2548-50.
    • (2003) Circulation , vol.107 , pp. 2548-2550
    • Dios, S.T.1    Bruemmer, D.2    Dilley, R.J.3    Ivey, M.E.4    Jennings, G.L.5    Law, R.E.6
  • 91
    • 0034920087 scopus 로고    scopus 로고
    • Rapid communication: Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
    • Koshiyama H, Shimono D, Kuwamura N, Minamikawa J, Nakamura Y. Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab 2001;86:3452-6.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3452-3456
    • Koshiyama, H.1    Shimono, D.2    Kuwamura, N.3    Minamikawa, J.4    Nakamura, Y.5
  • 92
    • 0347772237 scopus 로고    scopus 로고
    • Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus
    • Sekiya M, Suzuki J, Watanabe K, Funada J, Otani T, Akutsu H. Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus. Jpn Circ J 2001;65:487-90.
    • (2001) Jpn Circ J , vol.65 , pp. 487-490
    • Sekiya, M.1    Suzuki, J.2    Watanabe, K.3    Funada, J.4    Otani, T.5    Akutsu, H.6
  • 93
    • 0034332862 scopus 로고    scopus 로고
    • Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: A serial intravascular ultrasound study
    • Takagi T, Akasaka T, Yamamuro A, Honda Y, Hozumi T, Morioka S et al. Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study. J Am Coll Cardiol 2000;36:1529-35.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1529-1535
    • Takagi, T.1    Akasaka, T.2    Yamamuro, A.3    Honda, Y.4    Hozumi, T.5    Morioka, S.6
  • 94
    • 2942716674 scopus 로고    scopus 로고
    • The Roy Walford legacy: Diet restriction from molecules to mice to monkeys to man and onto mimetics
    • Lane MA, de Cabo R, Mattison J, Anson RM, Roth GS, Ingram DK. The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Exp Gerontol 2004;39:897-902.
    • (2004) Exp Gerontol , vol.39 , pp. 897-902
    • Lane, M.A.1    De Cabo, R.2    Mattison, J.3    Anson, R.M.4    Roth, G.S.5    Ingram, D.K.6
  • 95
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996;273:59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 97
    • 0141720388 scopus 로고    scopus 로고
    • Calorie restriction and aging: Review of the literature and implications for studies in humans
    • Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr 2003;78:361-9.
    • (2003) Am J Clin Nutr , vol.78 , pp. 361-369
    • Heilbronn, L.K.1    Ravussin, E.2
  • 98
    • 0346725865 scopus 로고    scopus 로고
    • Caloric restriction and insulin-like growth factors in aging and cancer
    • Sell C. Caloric restriction and insulin-like growth factors in aging and cancer. Harm Metab Res 2003;35:705-11.
    • (2003) Harm Metab Res , vol.35 , pp. 705-711
    • Sell, C.1
  • 99
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003;299:572-4.
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 100
    • 0037312020 scopus 로고    scopus 로고
    • How does calorie restriction work?
    • Koubova J, Guarente L. How does calorie restriction work? Genes Dev 2003;17:313-21.
    • (2003) Genes Dev , vol.17 , pp. 313-321
    • Koubova, J.1    Guarente, L.2
  • 101
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 2002;295:2450-2.
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 102
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 2002;296:530-4.
    • (2002) Science , vol.296 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3    Datta, S.R.4    Fornace Jr., A.J.5    Distefano, P.S.6
  • 103
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000;408:255-62.
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 104
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004;73:417-35.
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 105
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004;305:390-2.
    • (2004) Science , vol.305 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3    Wall, N.R.4    Hekking, B.5    Kessler, B.6
  • 106
    • 2342516817 scopus 로고    scopus 로고
    • Fragile fugue. p53 in aging, cancer and IGF signaling
    • Campisi J. Fragile fugue. p53 in aging, cancer and IGF signaling. Nat Med 2004;10:231-2.
    • (2004) Nat Med , vol.10 , pp. 231-232
    • Campisi, J.1
  • 107
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-5.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 108
    • 4143050290 scopus 로고    scopus 로고
    • The interaction between FOXO and SIRT1: Tipping the balance towards survival
    • Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol 2004;14:408-12.
    • (2004) Trends Cell Biol , vol.14 , pp. 408-412
    • Giannakou, M.E.1    Partridge, L.2
  • 109
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo DS, Gersham B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004;429:562-6.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gersham, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 114
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004;430:686-9.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.