Differences in transcriptional activation by the two allelic (L162V Polymorphic) variants of PPAR α after Omega-3 fatty acids treatment

PPAR Research

Volumn , Issue , 2009, Pages

  Rudkowska, Iwona ^a,b,c   Verreault, Mélanie ^a,b   Barbier, Olivier ^a,b   Vohl, Marie Claude ^a,b,c  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE FUNCTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; TRANSCRIPTION INITIATION;

EID: 62749097983     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2009/369602     Document Type: Article

References (32)

1. Kliewer S. A., Sundseth S. S., Jones S. A., Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4318 4323
2. Kersten S., Peroxisome proliferator activated receptors and lipoprotein metabolism PPAR Research 2008 2008 11
3. Yong E. L., Li J., Liu M. H., Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms α, β / δ and γ) and mechanisms of dyslipidemias Current Opinion in Lipidology 2008 19 2 106 112
4. Flavell D. M., Pineda Torra I., Jamshidi Y., Variation in the PPAR α gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects Diabetologia 2000 43 5 673 680
5. Tai E. S., Demissie S., Cupples L. A., Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 5 805 810
6. Tanaka T., Ordovas J. M., Delgado-Lista J., Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men Journal of Lipid Research 2007 48 6 1402 1408
7. Uthurralt J., Gordish-Dressman H., Bradbury M., PPAR α L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males BMC Medical Genetics 2007 8, article 55 1 11
8. Sparsø T., Hussain M. S., Andersen G., Relationships between the functional PPAR α Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people Molecular Genetics and Metabolism 2007 90 2 205 209
9. Robitaille J., Brouillette C., Houde A., Association between the PPAR α -L162V polymorphism and components of the metabolic syndrome Journal of Human Genetics 2004 49 9 482 489
10. Tai E. S., Corella D., Demissie S., Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study Journal of Nutrition 2005 135 3 397 403
11. Paradis A.-M., Fontaine-Bisson B., Bossé Y., The peroxisome proliferator-activated receptor α Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men American Journal of Clinical Nutrition 2005 81 2 523 530
12. Sapone A., Peters J. M., Sakai S., The human peroxisome proliferator-activated receptor α gene: identification and functional characterization of two natural allelic variants Pharmacogenetics 2000 10 4 321 333
13. Vu-Dac N., Schoonjans K., Kosykh V., Retinoids increase human apolipoprotein A-II expression through activation of the retinoid X receptor but not the retinoic acid receptor Molecular and Cellular Biology 1996 16 7 3350 3360
14. Jungling E., Kammermeier H., A one-vial method for routine extraction and quantification of free fatty acids in blood and tissue by HPLC Analytical Biochemistry 1988 171 1 150 157
15. Simpson H. S., Williamson C. M., Olivecrona T., Postprandial lipemia, fenofibrate and coronary artery disease Atherosclerosis 1990 85 2-3 193 202
16. Peters J. M., Hennuyer N., Staels B., Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor α -deficient mice The Journal of Biological Chemistry 1997 272 43 27307 27312
17. Costet P., Legendre C., Moré J., Edgar A., Galtier P., Pineau T., Peroxisome proliferator-activated receptor α -isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis The Journal of Biological Chemistry 1998 273 45 29577 29585
18. Duval C., Müller M., Kersten S., PPAR α and dyslipidemia Biochimica et Biophysica Acta 2007 1771 8 961 971
19. Zoete V., Grosdidier A., Michielin O., Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators Biochimica et Biophysica Acta 2007 1771 8 915 925
20. Liu M. H., Li J., Shen P., Husna B., Tai E. S., Yong E. L., A natural polymorphism in peroxisome proliferator-activated receptor- α hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin Molecular Endocrinology 2008 22 5 1078 1092
21. Caron-Dorval D., Paquet P., Paradis A.-M., Effect of the PPAR-alpha L162V polymorphism on the cardiovascular disease risk factor in response to n -3 polyunsaturated fatty acids Journal of Nutrigenetics and Nutrigenomics 2008 1 4 205 212
22. Balk E. M., Lichtenstein A. H., Chung M., Kupelnick B., Chew P., Lau J., Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review Atherosclerosis 2006 189 1 19 30
23. Harris W. S., n-3 fatty acids and serum lipoproteins: human studies American Journal of Clinical Nutrition 1997 65 5 1645S 1654S
24. Wong S.-H., Fisher E. A., Marsh J. B., Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells Arteriosclerosis 1989 9 6 836 841
25. Kobatake Y., Kuroda K., Jinnouchi H., Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet Journal of Nutritional Science and Vitaminology 1984 30 4 357 372
26. Willumsen N., Hexeberg S., Skorve J., Lundquist M., Berge R. K., Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats Journal of Lipid Research 1993 34 1 13 22
27. Ikeda I., Wakamatsu K., Inayoshi A., Imaizumi K., Sugano M., Yazawa K., α -linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats Journal of Nutrition 1994 124 10 1898 1906
28. Ikeda I., Cha J.-Y., Yanagita T., Effects of dietary α -linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and β -oxidation in rats Bioscience, Biotechnology and Biochemistry 1998 62 4 675 680
29. Rambjør G. S., Wålen A. I., Windsor S. L., Harris W. S., Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans Lipids 1996 31 1 S45 S49
30. Grimsgaard S., Bønaa K. H., Hansen J.-B., Nordøy A., Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids American Journal of Clinical Nutrition 1997 66 3 649 659
31. Sanderson L. M., de Groot P. J., Hooiveld G. J. E. J., Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics PLoS ONE 2008 3 2 e1681
32. de Vogel-van den Bosch H. M., Bünger M., de Groot P. J., Bosch-Vermeulen H., Hooiveld G. J. E. J., Müller M., PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression BMC Genomics 2008 9, article 231 1 13