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Volumn 54, Issue 3, 2007, Pages 347-357

New therapeutic target for metabolic syndrome: PPARδ

Author keywords

Atherosclerosis; Fatty acids metabolism; Glucose metabolism; Metabolic syndrome; PPAR

Indexed keywords

2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; 2 [4 [2 [3 (2,4 DIFLUOROPHENYL) 1 HEPTYLUREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; AD 5075; GW 0742; GW 1514; GW 2090; GW 5101516; GW 610742; GW 647; GW 7647; GW 957; GW 9820; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIRINIXIC ACID; ROSIGLITAZONE; UNCLASSIFIED DRUG; WY 1339;

EID: 34547136480     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.KR-99     Document Type: Review
Times cited : (41)

References (62)
  • 1
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
    • Lefebvre P, Chinetti G, Fruchart JC, Staels B (2006) Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. J Clin Invest 116: 571-580.
    • (2006) J Clin Invest , vol.116 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.C.3    Staels, B.4
  • 3
    • 33644645013 scopus 로고    scopus 로고
    • PPARδ: A dagger in the heart of the metabolic syndrome
    • Barish GD, Narkae VA, Evans RM (2006) PPARδ: a dagger in the heart of the metabolic syndrome. J Clin Invest 116: 590-597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkae, V.A.2    Evans, R.M.3
  • 4
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferators activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
    • Leone TC, Weinheimer CJ, Kelly DP (1999) A critical role for the peroxisome proliferators activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 96: 7473-7478.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 5
  • 7
    • 0026785388 scopus 로고
    • Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
    • Schmidt A, Endo N, Rutledge SJ, Vogel R, Shinar D, Rodan GA (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol Endocrinol 6: 1634-1641.
    • (1992) Mol Endocrinol , vol.6 , pp. 1634-1641
    • Schmidt, A.1    Endo, N.2    Rutledge, S.J.3    Vogel, R.4    Shinar, D.5    Rodan, G.A.6
  • 8
    • 0034801882 scopus 로고    scopus 로고
    • Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding
    • Escher P, Braissant O, Basu-Modak S, Michalik L, Wahli W, Desvergne B (2001) Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 142: 4195-4202.
    • (2001) Endocrinology , vol.142 , pp. 4195-4202
    • Escher, P.1    Braissant, O.2    Basu-Modak, S.3    Michalik, L.4    Wahli, W.5    Desvergne, B.6
  • 10
  • 11
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator- activated receptor β (δ)
    • Peters JM, Lee SST, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD, Gonzalez FJ (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator- activated receptor β (δ). Mol Cell Biol 20: 5119-5128.
    • (2000) Mol Cell Biol , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.T.2    Li, W.3    Ward, J.M.4    Gavrilova, O.5    Everett, C.6    Reitman, M.L.7    Hudson, L.D.8    Gonzalez, F.J.9
  • 14
    • 33645802802 scopus 로고    scopus 로고
    • Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor β (δ)
    • Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Treno D, Wahli W, Desvergne B (2006) Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor β (δ). Mol Cell Biol 26: 3266-3281.
    • (2006) Mol Cell Biol , vol.26 , pp. 3266-3281
    • Nadra, K.1    Anghel, S.I.2    Joye, E.3    Tan, N.S.4    Basu-Modak, S.5    Treno, D.6    Wahli, W.7    Desvergne, B.8
  • 15
    • 0033618281 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor PPARδ promotes induction of PPARγ and adipocyte differentiation in 3T3C2 fibroblast
    • Bastie C, Holst D, Gaillard D, Jehl-Pietri C, Grimaldi PA (1999) Expression of peroxisome proliferator-activated receptor PPARδ promotes induction of PPARγ and adipocyte differentiation in 3T3C2 fibroblast. J Biol Chem 274: 21920-21925.
    • (1999) J Biol Chem , vol.274 , pp. 21920-21925
    • Bastie, C.1    Holst, D.2    Gaillard, D.3    Jehl-Pietri, C.4    Grimaldi, P.A.5
  • 16
    • 0034624046 scopus 로고    scopus 로고
    • Alterations of peroxisome proliferator-activated receptor δ activity affect fatty acid-controlled adipose differentiation
    • Bastie C, Luquet S, Holst D, Jehl-Pietri C, Grimaldi PA (2000) Alterations of peroxisome proliferator-activated receptor δ activity affect fatty acid-controlled adipose differentiation. J Biol Chem 275: 38768-38773.
    • (2000) J Biol Chem , vol.275 , pp. 38768-38773
    • Bastie, C.1    Luquet, S.2    Holst, D.3    Jehl-Pietri, C.4    Grimaldi, P.A.5
  • 17
    • 0035793577 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ (PPARδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
    • Hansen JB, Zhang H, Rasmussen TH, Petersen RK, Flindt EN, Kristiansen K (2001) Peroxisome proliferator-activated receptor δ (PPARδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling. J Biol Chem 276: 3175-3182.
    • (2001) J Biol Chem , vol.276 , pp. 3175-3182
    • Hansen, J.B.1    Zhang, H.2    Rasmussen, T.H.3    Petersen, R.K.4    Flindt, E.N.5    Kristiansen, K.6
  • 18
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM (2003) Peroxisome proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113: 159-170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 19
    • 25444463073 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1: A cell cholesterol exporter that protects against cardiovascular disease
    • Oram JF, Heinecke JW (2005) ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol Rev 85: 1343-1372.
    • (2005) Physiol Rev , vol.85 , pp. 1343-1372
    • Oram, J.F.1    Heinecke, J.W.2
  • 23
    • 2442692690 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor β/δ regulates very low density lipoprotein production and catabolism in mice on a western diet
    • Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer HB Jr, Gonzalez FJ (2004) Peroxisome proliferator-activated receptor β/δ regulates very low density lipoprotein production and catabolism in mice on a western diet. J Biol Chem 279: 20874-20881.
    • (2004) J Biol Chem , vol.279 , pp. 20874-20881
    • Akiyama, T.E.1    Lambert, G.2    Nicol, C.J.3    Matsusue, K.4    Peters, J.M.5    Brewer Jr, H.B.6    Gonzalez, F.J.7
  • 25
    • 0037192764 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells
    • Zhang J, Fu M, Zhu X, Xiao Y, Mou Y, Zheng H, Akinbami MA, Wang Q, Chen YE (2002) Peroxisome proliferator-activated receptor δ is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells. J Biol Chem 277: 11505-11512.
    • (2002) J Biol Chem , vol.277 , pp. 11505-11512
    • Zhang, J.1    Fu, M.2    Zhu, X.3    Xiao, Y.4    Mou, Y.5    Zheng, H.6    Akinbami, M.A.7    Wang, Q.8    Chen, Y.E.9
  • 26
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P (2002) Inflammation in atherosclerosis. Nature 420: 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 27
    • 0038460253 scopus 로고    scopus 로고
    • PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages
    • Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK (2003) PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages. Proc Natl Acad Sci USA 100: 6712-6717.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6712-6717
    • Welch, J.S.1    Ricote, M.2    Akiyama, T.E.3    Gonzalez, F.J.4    Glass, C.K.5
  • 28
    • 0142116239 scopus 로고    scopus 로고
    • Transcriptional repression of atherogenic inflammation: Modulation by PPARδ
    • Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM (2003) Transcriptional repression of atherogenic inflammation: modulation by PPARδ. Science 302: 453-457.
    • (2003) Science , vol.302 , pp. 453-457
    • Lee, C.H.1    Chawla, A.2    Urbiztondo, N.3    Liao, D.4    Boisvert, W.A.5    Evans, R.M.6
  • 31
    • 0037135623 scopus 로고    scopus 로고
    • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knockout mice
    • Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, Kraus WE (2002) Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knockout mice. J Biol Chem 277: 26089-26097.
    • (2002) J Biol Chem , vol.277 , pp. 26089-26097
    • Muoio, D.M.1    MacLean, P.S.2    Lang, D.B.3    Li, S.4    Houmard, J.A.5    Way, J.M.6    Winegar, D.A.7    Corton, J.C.8    Dohm, G.L.9    Kraus, W.E.10
  • 33
    • 0346849699 scopus 로고    scopus 로고
    • The peroxisome proliferators-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells
    • Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GEO (2003) The peroxisome proliferators-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol 17: 2477-2493.
    • (2003) Mol Endocrinol , vol.17 , pp. 2477-2493
    • Dressel, U.1    Allen, T.L.2    Pippal, J.B.3    Rohde, P.R.4    Lau, P.5    Muscat, G.E.O.6
  • 34
    • 0038460823 scopus 로고    scopus 로고
    • Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle
    • Holst D, Luquet S, Nogueira V, Kristiansen K, Leverve X, Grimaldi PA (2003) Nutritional regulation and role of peroxisome proliferator-activated receptor δ in fatty acid catabolism in skeletal muscle. Biochim Biophys Acta 1633: 43-50.
    • (2003) Biochim Biophys Acta , vol.1633 , pp. 43-50
    • Holst, D.1    Luquet, S.2    Nogueira, V.3    Kristiansen, K.4    Leverve, X.5    Grimaldi, P.A.6
  • 40
    • 0345735302 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor δ activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    • Cheng L, Ding G, Qin Q, Xiao Y, Woods D, Chen YE, Yang Q (2004) Peroxisome proliferators-activated receptor δ activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun 313: 277-286.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 277-286
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Xiao, Y.4    Woods, D.5    Chen, Y.E.6    Yang, Q.7
  • 41
    • 9144262378 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    • Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q (2004) Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 10: 1245-1250.
    • (2004) Nat Med , vol.10 , pp. 1245-1250
    • Cheng, L.1    Ding, G.2    Qin, Q.3    Huang, Y.4    Lewis, W.5    He, N.6    Evans, R.M.7    Schneider, M.D.8    Brako, F.A.9    Xiao, Y.10    Chen, Y.E.11    Yang, Q.12
  • 42
    • 13844296494 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor β/δ: A new antihypertrophic drug target?
    • Petrashevskaya NN, Schwarz A (2005) Peroxisome proliferators-activated receptor β/δ: A new antihypertrophic drug target? Cardiovasc Res 65: 770-771.
    • (2005) Cardiovasc Res , vol.65 , pp. 770-771
    • Petrashevskaya, N.N.1    Schwarz, A.2
  • 43
    • 20444466460 scopus 로고    scopus 로고
    • Nuclear factor-κB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy
    • Planavila A, Laguna JC, Vázques-Carrera M (2005) Nuclear factor-κB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. J Biol Chem 280: 17464-17471.
    • (2005) J Biol Chem , vol.280 , pp. 17464-17471
    • Planavila, A.1    Laguna, J.C.2    Vázques-Carrera, M.3
  • 45
    • 33744519163 scopus 로고    scopus 로고
    • PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes
    • Ding G, Cheng L, Qin Q, Frontin S, Yang Q (2006) PPARδ modulates lipopolysaccharide-induced TNFα inflammation signaling in cultured cardiomyocytes. J Mol Cell Cardiol 40: 821-828.
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 821-828
    • Ding, G.1    Cheng, L.2    Qin, Q.3    Frontin, S.4    Yang, Q.5
  • 46
    • 30744460411 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis
    • Pesant M, Sueur S, Dutartre P, Tallandier M, Grimaldi PA, Rochette L, Connat JL (2006) Peroxisome proliferators-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis. Cardiovasc Res 69: 440-449.
    • (2006) Cardiovasc Res , vol.69 , pp. 440-449
    • Pesant, M.1    Sueur, S.2    Dutartre, P.3    Tallandier, M.4    Grimaldi, P.A.5    Rochette, L.6    Connat, J.L.7
  • 47
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He TC, Chan TA, Vogelstein B, Kinzler KW (1999) PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99: 335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 49
    • 0036606010 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
    • Shao J, Sheng H, DuBois RN (2002) Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res 62: 3282-3288.
    • (2002) Cancer Res , vol.62 , pp. 3282-3288
    • Shao, J.1    Sheng, H.2    DuBois, R.N.3
  • 50
    • 1942470331 scopus 로고    scopus 로고
    • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth
    • Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth. Nat Med 10: 245-247.
    • (2004) Nat Med , vol.10 , pp. 245-247
    • Gupta, R.A.1    Wang, D.2    Katkuri, S.3    Wang, H.4    Dey, S.K.5    DuBois, R.N.6
  • 51
    • 0035956850 scopus 로고    scopus 로고
    • Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells
    • Park BH, Vogelstein B, Kinzler KW (2001) Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells. Proc Natl Acad Sci USA 98: 2598-2603.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2598-2603
    • Park, B.H.1    Vogelstein, B.2    Kinzler, K.W.3
  • 57
    • 0348134971 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
    • Skogsberg J, McMahson AD, Karpe F, Hamsten A, Packard CJ, Ehrenborg E (2003) Peroxisome proliferator-activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Int Med 254: 597-604.
    • (2003) J Int Med , vol.254 , pp. 597-604
    • Skogsberg, J.1    McMahson, A.D.2    Karpe, F.3    Hamsten, A.4    Packard, C.J.5    Ehrenborg, E.6
  • 58
    • 33745819570 scopus 로고    scopus 로고
    • Association of the T+294C polymorphism in PPARδ with low cholesterol and coronary heart disease risk in women
    • Aberle J, Hopfer I, Beil FU, Seedorf U (2006) Association of the T+294C polymorphism in PPARδ with low cholesterol and coronary heart disease risk in women. Int J Med Sci 3: 108-111.
    • (2006) Int J Med Sci , vol.3 , pp. 108-111
    • Aberle, J.1    Hopfer, I.2    Beil, F.U.3    Seedorf, U.4
  • 59
    • 27644501387 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls
    • Gouni-Berthold I, Giannakidou E, Faust M, Berthold HK, Krone W (2005) The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls. Atherosclerosis 183: 336-341.
    • (2005) Atherosclerosis , vol.183 , pp. 336-341
    • Gouni-Berthold, I.1    Giannakidou, E.2    Faust, M.3    Berthold, H.K.4    Krone, W.5
  • 61
    • 33747060509 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes
    • Andrulionyté L, Peltola P, Chiasson JL, Laakso M (2006) Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes. Diabetes 55: 2148-2152.
    • (2006) Diabetes , vol.55 , pp. 2148-2152
    • Andrulionyté, L.1    Peltola, P.2    Chiasson, J.L.3    Laakso, M.4


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